The effect of visual suggestion on exercise motivation and outcomes

Theories of suggestion and motivation were used to examine if college students exercising in an environment with low or high motivation posters would affect mood, perceived exertion, and exercise workload (i.e., RPM and speed). A total of 134 students (62 males, 72 females) were randomly assigned to one of three conditions while exercising: relaxing posters (i.e., tropical nature), motivational posters (i.e., competitive bikers), or no posters (i.e., control). Participants completed 20 minutes of exercise at their own pace. Measures of mood were taken immediately prior to and following exercise. Exercise workload was recorded throughout. Results indicate that participants in the relaxing condition experienced higher levels of tension than those in the other two conditions. Participants in the motivational condition reported higher levels of relaxation. A consistency bias may have made participants uncomfortable in an exercise environment with relaxing images that are inconsistent with a typical exercise atmosphere

Clima social familiar y ansiedad en estudiantes de la facultad de ciencias de la salud de una universidad en la ciudad Cajamarca, 2021

El objetivo de la investigación fue determinar la relación entre el clima social familiar y la ansiedad en estudiantes de la facultad de ciencias de la salud de una universidad en la ciudad de Cajamarca. En una muestra no probabilística de tipo intencional, involucrando a 119 estudiantes mujeres (74,8%) y hombres (25%) del 9° y 10° ciclo académico, durante el año 2021. La metodología fue básica, con un enfoque cuantitativo y un diseño no experimental - correlacional. Los instrumentos de medición utilizados fueron la escala del Clima Social en la Familia (FES) y la escala de ansiedad WCHA1. Entre los resultados se obtuvo una relación entre el clima social familiar y la ansiedad (r= -0.628), siendo moderada e inversa, además, se identificaron los niveles de clima familiar, obteniendo mayor prevalencia el nivel promedio 42% y en ansiedad el nivel bajo 63%, asimismo, se encontraron relaciones entre todas las dimensiones del clima social familiar con la ansiedad, dimensión relaciones (r= -0.471) débil e inversa; dimensión desarrollo (r=0.237) débil y directa; dimensión estabilidad (r= -0.337), débil e inversa. En conclusión, se dedujo que a medida que aumente el clima social familiar, disminuirá el índice de ansiedad y viceversa

BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.

Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface. Previously, we identified the ubiquitously expressed tumour suppressor BRCA1-associated protein 1 (BAP1) as a central factor of a novel molecular node controlling early mouse placentation. However, functional insights into how BAP1 regulates trophoblast biology are still missing. Using CRISPR/Cas9 knockout and overexpression technology in mouse trophoblast stem cells, here we demonstrate that the downregulation of BAP1 protein is essential to trigger epithelial-mesenchymal transition (EMT) during trophoblast differentiation associated with a gain of invasiveness. Moreover, we show that the function of BAP1 in suppressing EMT progression is dependent on the binding of BAP1 to additional sex comb-like (ASXL1/2) proteins to form the polycomb repressive deubiquitinase (PR-DUB) complex. Finally, both endogenous expression patterns and BAP1 overexpression experiments in human trophoblast stem cells suggest that the molecular function of BAP1 in regulating trophoblast differentiation and EMT progression is conserved in mice and humans. Our results reveal that the physiological modulation of BAP1 determines the invasive properties of the trophoblast, delineating a new role of the BAP1 PR-DUB complex in regulating early placentation

European Society for Immunodeficiencies (ESID) and European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN RITA) Complement Guideline : Deficiencies, Diagnosis, and Management

This guideline aims to describe the complement system and the functions of the constituent pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the innate immune system, with multiple membrane-bound and soluble components. There are three distinct enzymatic cascade pathways within the complement system, the classical, alternative and lectin pathways, which converge with the cleavage of central C3. Complement deficiencies account for similar to 5% of PIDs. The clinical consequences of inherited defects in the complement system are protean and include increased susceptibility to infection, autoimmune diseases (e.g., systemic lupus erythematosus), age-related macular degeneration, renal disorders (e.g., atypical hemolytic uremic syndrome) and angioedema. Modern complement analysis allows an in-depth insight into the functional and molecular basis of nearly all complement deficiencies. However, therapeutic options remain relatively limited for the majority of complement deficiencies with the exception of hereditary angioedema and inhibition of an overactivated complement system in regulation defects. Current management strategies for complement disorders associated with infection include education, family testing, vaccinations, antibiotics and emergency planning.Peer reviewe

高効率線形送信法におけるPWM包絡線発生法の研究

電気通信大学200

Coronatine-insensitive 1 (COI1) mediates transcriptional responses of <i>Arabidopsis thaliana</i> to external potassium supply

The ability to adjust growth and development to the availability of mineral nutrients in the soil is an essential life skill of plants but the underlying signaling pathways are poorly understood. In &lt;i&gt;Arabidopsis thaliana&lt;/i&gt;, shortage of potassium (K) induces a number of genes related to the phytohormone jasmonic acid (JA). Using comparative microarray analysis of wild-type and coi1-16 mutant plants, we classified transcriptional responses to K with respect to their dependence on COI1, a central component of oxylipin signaling. Expression profiles obtained in a short-term experiment clearly distinguished between COI1-dependent and COI1-independent K-responsive genes, and identified both known and novel targets of JA-COI1-signaling. During long-term K-deficiency, coi-16 mutants displayed de novo responses covering similar functions as COI1-targets except for defense. A putative role of JA for enhancing the defense potential of K-deficient plants was further supported by the observation that plants grown on low K were less damaged by thrips than plants grown with sufficient K