43 research outputs found
A Contract for Success: Increasing Student Engagement and Confidence through Grade Contracts
This paper explores the impact of grade contracts upon student engagement and confidence in classes. The co-researchers designed a grade contract based upon those described in the literature by Danielewicz & Elbow (2009) and Inoue (2014), and integrating departmental learning outcomes. The contracts were used in the co-researchers’ Spring 2018, Fall 2018, and Spring 2019 First-Year Writing (ENG101 and ENG102) and upper division English (ENG345 and ENG405) courses. Through an IRB-approved study, student reactions to the use of grade contracts were assessed in three ways: coding students’ reflective essays completed at the end of each semester, conducting interviews with student volunteers, and administering a voluntary online attitudinal survey. This paper paper addresses the results of the attitudinal survey; future work will share findings from the other data sources and ongoing surveys. 41 students participated in the survey. Initial findings suggest that the majority of students responded positively to the implementation of a grade contract and would like to see grade contracts used in more of their classes. Responses suggest that much of the appeal for students comes from the transparency of expectations laid out in the grade contract, resulting in greater student agency
The Commons: Tools for Reading, Writing, and Rhetoric
The Commons: Tools for Reading, Writing, and Rhetoric gives instructors and students of college writing courses a single source for information on metacognitive critical reading, rhetorical awareness, and MLA formatting basics as well as interesting and relevant reading and viewing content. Its approach is interdisciplinary, bringing in material from ecology, sociology, psychology, technology, popular culture, political science, cultural studies, and literature. Each essay, website, video, infographic, and poem has been carefully chosen to speak to the Eastern Kentucky University community, but everyone can find something that speaks to our common human experience and our need to communicate and connect with one another.https://encompass.eku.edu/ekuopen/1003/thumbnail.jp
First Constraints on Source Counts at 350 Microns
We have imaged a 6 arcminute region in the Bo\"otes Deep Field
using the 350 m-optimised second generation Submillimeter High Angular
Resolution Camera (SHARC II), achieving a peak 1 sensitivity of 5
mJy. We detect three sources above 3, and determine a spurious source
detection rate of 1.09 in our maps. In the absence of detections, we
rely on deep 24 m and 20 cm imaging to deduce which sources are most
likely to be genuine, giving two real sources. From this we derive an integral
source count of 0.84 sources arcmin at mJy,
which is consistent with 350 m source count models that have an
IR-luminous galaxy population evolving with redshift. We use these constraints
to consider the future for ground-based short-submillimetre surveys.Comment: accepted for publication in The Astrophysical Journa
Spitzer Photometry of WISE-Selected Brown Dwarf and Hyper-Luminous Infrared Galaxy Candidates
We present Spitzer 3.6 and 4.5 m photometry and positions for a sample
of 1510 brown dwarf candidates identified by the WISE all-sky survey. Of these,
166 have been spectroscopically classified as objects with spectral types M(1),
L(7), T(146), and Y(12); Sixteen other objects are non-(sub)stellar in nature.
The remainder are most likely distant L and T dwarfs lacking spectroscopic
verification, other Y dwarf candidates still awaiting follow-up, and assorted
other objects whose Spitzer photometry reveals them to be background sources.
We present a catalog of Spitzer photometry for all astrophysical sources
identified in these fields and use this catalog to identify 7 fainter (4.5
m 17.0 mag) brown dwarf candidates, which are possibly wide-field
companions to the original WISE sources. To test this hypothesis, we use a
sample of 919 Spitzer observations around WISE-selected high-redshift
hyper-luminous infrared galaxy (HyLIRG) candidates. For this control sample we
find another 6 brown dwarf candidates, suggesting that the 7 companion
candidates are not physically associated. In fact, only one of these 7 Spitzer
brown dwarf candidates has a photometric distance estimate consistent with
being a companion to the WISE brown dwarf candidate. Other than this there is
no evidence for any widely separated ( 20 AU) ultra-cool binaries. As an
adjunct to this paper, we make available a source catalog of 7.33
objects detected in all of these Spitzer follow-up fields for use
by the astronomical community. The complete catalog includes the Spitzer 3.6
and 4.5 m photometry, along with positionally matched and
photometry from USNO-B; , , and photometry from 2MASS; and ,
, , and photometry from the WISE all-sky catalog
Submillimeter Follow-up of WISE-Selected Hyperluminous Galaxies
We have used the Caltech Submillimeter Observatory (CSO) to follow-up a
sample of WISE-selected, hyperluminous galaxies, so called W1W2-dropout
galaxies. This is a rare (~ 1000 all-sky) population of galaxies at high
redshift (peaks at z=2-3), that are faint or undetected by WISE at 3.4 and 4.6
um, yet are clearly detected at 12 and 22 um. The optical spectra of most of
these galaxies show significant AGN activity. We observed 14 high-redshift (z >
1.7) W1W2-dropout galaxies with SHARC-II at 350 to 850 um, with 9 detections;
and observed 18 with Bolocam at 1.1 mm, with five detections. Warm Spitzer
follow-up of 25 targets at 3.6 and 4.5 um, as well as optical spectra of 12
targets are also presented in the paper. Combining WISE data with observations
from warm Spitzer and CSO, we constructed their mid-IR to millimeter spectral
energy distributions (SEDs). These SEDs have a consistent shape, showing
significantly higher mid-IR to submm ratios than other galaxy templates,
suggesting a hotter dust temperature. We estimate their dust temperatures to be
60-120 K using a single-temperature model. Their infrared luminosities are well
over 10^{13} Lsun. These SEDs are not well fitted with existing galaxy
templates, suggesting they are a new population with very high luminosity and
hot dust. They are likely among the most luminous galaxies in the Universe. We
argue that they are extreme cases of luminous, hot dust-obscured galaxies
(DOGs), possibly representing a short evolutionary phase during galaxy merging
and evolution. A better understanding of their long-wavelength properties needs
ALMA as well as Herschel data.Comment: Will be Published on Sep 1, 2012 by Ap
MHO1, an Evolutionarily Conserved Gene, Is Synthetic Lethal with PLC1; Mho1p Has a Role in Invasive Growth
The novel protein Memo (Mediator of ErbB2 driven cell motility) was identified in a screen for ErbB2 interacting proteins and found to have an essential function in cell motility. Memo is evolutionarily conserved with homologs found in all branches of life; the human and yeast proteins have a similarity of >50%. In the present study we used the model organism S. cerevisiae to characterize the Memo-homologue Mho1 (Yjr008wp) and to investigate its function in yeast. In a synthetic lethal screen we found MHO1 as a novel synthetic lethal partner of PLC1, which encodes the single phospholipase C in yeast. Double-deleted cells lacking MHO1 and PLC1, proliferate for up to ten generations. Introduction of human Memo into the memoΔplc1Δ strain rescued the synthetic lethal phenotype suggesting that yeast and human proteins have similar functions. Mho1 is present in the cytoplasm and the nucleus of yeast cells; the same distribution of Memo was found in mammalian cells. None of the Memo homologues have a characteristic nuclear localization sequence, however, a conserved nuclear export sequence is found in all. In mammalian cells, blocking nuclear export with Leptomycin B led to nuclear Memo accumulation, suggesting that it is actively exported from the nucleus. In yeast MHO1 expression is induced by stress conditions. Since invasive growth in S. cerevisiea is also stress-induced, we tested Mho1's role in this response. MHO1 deletion had no effect on invasion induced by nutrient deprivation, however, Mho1 overexpression blocked the invasive ability of yeast cells, suggesting that Mho1 might be acting in a dominant negative manner. Taken together, our results show that MHO1 is a novel synthetic lethal interactor with PLC1, and that both gene products are required for proliferation. Moreover, a role for Memo in cell motility/invasion appears to be conserved across species
Ten-year mortality, disease progression, and treatment-related side effects in men with localised prostate cancer from the ProtecT randomised controlled trial according to treatment received
Background
The ProtecT trial reported intention-to-treat analysis of men with localised prostate cancer randomly allocated to active monitoring (AM), radical prostatectomy, and external beam radiotherapy.
Objective
To report outcomes according to treatment received in men in randomised and treatment choice cohorts.
Design, setting, and participants
This study focuses on secondary care. Men with clinically localised prostate cancer at one of nine UK centres were invited to participate in the treatment trial comparing AM, radical prostatectomy, and radiotherapy.
Intervention
Two cohorts included 1643 men who agreed to be randomised and 997 who declined randomisation and chose treatment.
Outcome measurements and statistical analysis
Analysis was carried out to assess mortality, metastasis and progression and health-related quality of life impacts on urinary, bowel, and sexual function using patient-reported outcome measures. Analysis was based on comparisons between groups defined by treatment received for both randomised and treatment choice cohorts in turn, with pooled estimates of intervention effect obtained using meta-analysis. Differences were estimated with adjustment for known prognostic factors using propensity scores.
Results and limitations
According to treatment received, more men receiving AM died of PCa (AM 1.85%, surgery 0.67%, radiotherapy 0.73%), whilst this difference remained consistent with chance in the randomised cohort (p = 0.08); stronger evidence was found in the exploratory analyses (randomised plus choice cohort) when AM was compared with the combined radical treatment group (p = 0.003). There was also strong evidence that metastasis (AM 5.6%, surgery 2.4%, radiotherapy 2.7%) and disease progression (AM 20.35%, surgery 5.87%, radiotherapy 6.62%) were more common in the AM group. Compared with AM, there were higher risks of sexual dysfunction (95% at 6 mo) and urinary incontinence (55% at 6 mo) after surgery, and of sexual dysfunction (88% at 6 mo) and bowel dysfunction (5% at 6 mo) after radiotherapy. The key limitations are the potential for bias when comparing groups defined by treatment received and changes in the protocol for AM during the lengthy follow-up required in trials of screen-detected PCa.
Conclusions
Analyses according to treatment received showed increased rates of disease-related events and lower rates of patient-reported harms in men managed by AM compared with men managed by radical treatment, and stronger evidence of greater PCa mortality in the AM group.
Patient summary
More than 95 out of every 100 men with low or intermediate risk localised prostate cancer do not die of prostate cancer within 10 yr, irrespective of whether treatment is by means of monitoring, surgery, or radiotherapy. Side effects on sexual and bladder function are better after active monitoring, but the risks of spreading of prostate cancer are more common
Dissociable learning processes, associative theory, and testimonial reviews: A comment on Smith and Church (2018
Smith and Church (Psychonomic Bulletin & Review, 25, 1565–1584 2018) present a “testimonial” review of dissociable learning processes in comparative and cognitive psychology, by which we mean they include only the portion of the available evidence that is consistent with their conclusions. For example, they conclude that learning the information-integration category-learning task with immediate feedback is implicit, but do not consider the evidence that people readily report explicit strategies in this task, nor that this task can be accommodated by accounts that make no distinction between implicit and explicit processes. They also consider some of the neuroscience relating to information-integration category learning, but do not report those aspects that are more consistent with an explicit than an implicit account. They further conclude that delay conditioning in humans is implicit, but do not report evidence that delay conditioning requires awareness; nor do they present the evidence that conditioned taste aversion, which should be explicit under their account, can be implicit. We agree with Smith and Church that it is helpful to have a clear definition of associative theory, but suggest that their definition may be unnecessarily restrictive. We propose an alternative definition of associative theory and briefly describe an experimental procedure that we think may better distinguish between associative and non-associative processes