Engineering Thermoresponsive Polyether-Based Nanogels for Temperature Dependent Skin Penetration

Highly biocompatible thermoresponsive nanogels (tNGs) based on oligo ethylene glycol (OEG) as thermoresponsive unit and dendritic polyglycerol (dPG) as cross-linker, were precisely engineered in terms of size and volume phase transition temperature (VPTT). Preliminary uptake studies into human skin were realized to show the temperaturedependent internalization behavior of these systems.Fil: Asadian Birjand, M.. Freie Universität; AlemaniaFil: Bergueiro, J.. Freie Universität; AlemaniaFil: Rancan, F.. Charité-Universitätsmedizin; AlemaniaFil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Freie Universität; AlemaniaFil: Mutihac, R. C.. Freie Universität; AlemaniaFil: Achazi, K.. Freie Universität; AlemaniaFil: Dernedde, J.. Charité-Universitätsmedizin; AlemaniaFil: Blume Peytavi, U.. Charité-Universitätsmedizin; AlemaniaFil: Vogt, A.. Charité-Universitätsmedizin; AlemaniaFil: Calderon, M.. Freie Universität; Alemani