Nutraceuticals for the treatment of migraine prophylaxis

Headache is one of the most common disorders of the nervous system. Headache is further classified into migraine, tension-type headache, and cluster headache. Migraine occurs in about 12% of people age 12 and older in the United States (17% of women and 6% of men). It is about three times more common in women than men. It is estimated that every 10 seconds someone in the United States goes to the emergency room with a migraine or headache due to the excruciating pain, severe nausea or dehydration, drug interactions, or side effects from headache medications. In recent years there has been a growing interest and demand from the public for ‘natural’ treatments such as vitamins and supplements in trying to control migraine headaches. A variety of natural supplements, vitamins and herbal preparations have been promoted as having efficacy in migraine prophylaxis. This mini-review analyzes the various natural and herbal therapies for the prophylaxis and treatment of migraine

(R2053) Analysis of MAP/PH/1 Queueing Model Subject to Two-stage Vacation Policy with Imperfect Service, Setup Time, Breakdown, Delay Time, Phase Type Repair and Reneging Customer

In this paper, we study a continuous-time single server queueing system with an infinite system of capacity, a two-stage vacation policy with imperfect service, setup, breakdown, delay time, phase-type of repair and customer reneging. The Markovian Arrival Process is used for the arrival of a customer and the phase-type distribution is used when offering service. This encompasses the policy of two vacations: a single working vacation and multiple vacations. Using the Matrix-Analytic Method to approach the system generates an invariant probability vector for this model. Henceforth, the busy period, waiting time distribution and cost analysis are the additional findings. The indicators are secured as a result of this performance. The outcomes result of numerical order can be graphically interpreted in the form of 2D and 3D

Dissolution testing of prednisone and salicylic acid calibrator tablets at different tablet locations

Dissolution testing is routinely carried out in the pharmaceutical industry to determine the rate of dissolution of solid dosage forms. This test is one of the several tests that pharmaceutical companies typically conduct on oral dosage formulations (e.g., tablets) to determine compliance. The USP Dissolution Testing Apparatus 2 is the most common of the apparatuses listed in the USP. However, it has been shown previously that the dissolution profile of a tablet undergoing dissolution in the USP Dissolution Apparatus 2 can be affected by the tablet location in the apparatus. In this work, the dissolution rates of both non-disintegrating tablets (salicylic acid) and disintegrating tablets (Prednisone) were experimentally determined for many different tablet locations, both centered on the vessel bottom and off-center. The location of the tablet was experimentally varied in very small increments in order to determine the exact location where a transition in the dissolution profile occurred. It was found that in a small region (2-4 mm in radius) centered around the vessel centerline just below the impeller the dissolution profiles were similar to those observed with a centered tablet. However, outside this region the dissolution profiles were found to be significantly different, as indicated by the values of the Similarity Factor f1 and the Difference Factor f2. These finding are consistent with previous hydrodynamic investigations that showed the existence of a poorly mixed zone below the USP Apparatus 2 impeller. The results of this work can guide the practitioner on when to accept dissolution testing results based on tablet location

Comparative study of Intravenous Ferric Carboxymaltose and Iron Sucrose in the management of postnatal Iron Deficiency Anaemia

INTRODUCTION: Anemia is defined as decreased oxygen carrying capacity of blood. It is one of the major illness affecting more than 50% of antenatal and postnatal women in developing countries like India leading to increased maternal mortality and morbidity. Most common type is the nutritional anemia – IRON DEFICIENCY ANAEMIA. Menstruation and pregnancy put women at a higher risk for anemia. Iron deficiency anemia in pregnant mother is mainly due to increased demand or due to poor absorption. This unmet need during antenatal period may lead to anemia in postnatal mother. Postnatal anemia may also result from acute blood loss during delivery and also even due to multiple birth without adequate spacing. OBJECTIVE: The objective of this study is to compare the efficacy of ferric carboxymaltose and iron sucrose in the management of postnatal iron deficiency anaemia. MATERIALS AND METHODS: 100 postnatal women with haemoglobin level between 8-10gm were randomly selected and allocated into two groups. One group received iron sucrose and another group received FCM. For iron sucrose 200mg is administered as a single dose and repeated on alternate days as required. In FCM 1000mg can be administered as a single dose. The haemoglobin, blood indices, and serum ferritin is measured before and after 2nd and 4th week. RESULTS: The improvement in haemoglobin level, serum ferritin level, patient’s quality of life is seen with both iron sucrose and FCM. The mean improvement in haemoglobin level with iron sucrose is about 2.35g at four weeks whereas in ferric carboxymaltose the increment is about 2.83g.The mean improvement in MCV is about 85.44 from baseline 80.12 (fl) in iron sucrose whereas in FCM it increases about 88.18 from 78.94. Serum ferritin increases about 199.98 from 37.2 in iron sucrose. In FCM serum ferritin increases to about 266.02 from 31.5. The side effects in FCM are lower than iron sucrose. CONCLUSION: The improvement in Haemoglobin, serum ferritin FCM are greater and faster than iron sucrose. Large single dose can be given with FCM when compared with iron sucrose. So FCM appears to be significant than iron sucrose in the management of postnatal iron deficiency anaemia

The Land-based Diet of the Sangam People and the Development of the Culinary Hierarchy

The ancient Tamils lived with nature. They ate naturally available food and satiated their hunger. Naturally occurring foods were terrestrial foods. They ate such land-based food without any change. They were then subjected to various ripening procedures and eaten. This food culture tradition can be seen in the Sangam Songs. The food culture of the Tamils has undergone many changes and can also be regarded as a gradual development. Sangam People made a living by eating land-based food according to the situation. The study reveals the culture and the cultural attitude of consumption for the development of social civilization when one observes the movement from a naturally eaten state of uncooked food to the stage of cooking and eating food in the cooked state, by making it a mixture of food, processing and eating it

Comparison of Selected Motor Skill Related Performance and Academic Achievement among the Sixth Grade Respondents

The purpose of the study was designed to find out the comparison of selected motor skill related performance and academic achievement among the sixth grade respondents. During the academic year 2012 – 2013, 30 boys and 30 girls studying in government higher secondary school, Silattur, Erichi, Aranthangi, Pudukkottai, Tamilnadu, India were selected to achieve the purpose of the study. They were selected based on their academic achievement in the quarterly examination as above average, average and below average achievers making up a total of 60 respondents. The age of the respondents ranges from 12 to 14 years. The academic achievement of the respondents in the quarterly examination was considered as independent variables for this study. The criterion variables selected for the study are motor skills related performance such as 50 mts run and vertical jump. The data were statistically analyzed by using Two Way (2x3) Analysis of Variance (ANOVA) for evaluating the influence of the two criterion variables. The obtained results have three F- ratio, two for main effect; the first F- ratio for rows (referring to gender) and columns (referring to academic achievement) and one for interaction (referring to the gender and academic achievement). The obtained F- ratio for column (referring to the gender and academic achievement) was significant. Scheffe‘s Test was used as Post Hoc Test separately for column to find out the significant difference between paired mean. In all the conditions, the significant level was fixed as 0.05 level, which was considered to be appropriate. The result reveals that there existed significant difference between the above average achievers and average achievers; above average achievers and below average achievers; and average achievers and below average achievers of gender on power. There existed significant difference between genders irrespective of academic achievement on speed. Hence it reveals that there was no significant difference between average achievers and below average achievers; and above average achievers and average achievers of gender on power. Further, it also reveals that there no significant difference on speed among the gender at different academic achievement

Novel possibility spherical fuzzy soft set model and its application for a decision making

We talk about possibility spherical fuzzy soft set (shortly PSFS set) has much stronger ability than possibility Pythagorean fuzzy soft set (shortly PPFS set) and intuitionistic fuzzy soft set. The PSFS soft set is a generalization of PPFS set and soft set. Here we talk through some operations consisting of complement, union, intersection, AND and OR. We verify that the De Morgan’s laws, associate laws and distributive laws are satisfied in the case of PSFS sets. Also we discuss comparative analysis for the soft set model under the scheme of PSFS sets. Finally, an illustrative example is mentioned for the soft set model using PSFS set.Publisher's Versio

(R1500) Type-I Generalized Spherical Interval Valued Fuzzy Soft Sets in Medical Diagnosis for Decision Making

In the present communication, we introduce the concept of Type-I generalized spherical interval valued fuzzy soft set and define some operations. It is a generalization of the interval valued fuzzy soft set and the spherical fuzzy soft set. The spherical interval valued fuzzy soft set theory satisfies the condition that the sum of its degrees of positive, neutral, and negative membership does not exceed unity and that these parameters are assigned independently. We also propose an algorithm to solve the decision making problem based on a Type-I generalized soft set model. We introduce a similarity measure based on the Type-I generalized soft set model for two Type-I generalized spherical interval valued fuzzy soft sets and discuss its application in a medical diagnosis problem. Illustrative examples are mentioned to show that they can be successfully used to solve problems with uncertainties

Novel possibility Pythagorean interval valued fuzzy soft set method for a decision making

We discuss the theory of possibility Pythagorean interval valued fuzzy soft set, possibility interval valued fuzzy soft set and define some related the operations namely complement, union, intersection, AND and OR. The possibility Pythagorean interval valued fuzzy soft sets are a generalization of soft sets. Notably, we showed DeMorgan’s laws that are valid in possibility Pythagorean interval valued fuzzy soft set theory. Also, we propose an algorithm to solve the decision making problem based on soft set method. To compare two possibilities Pythagorean interval valued fuzzy soft sets for dealing with decision making problems and find a similarity measure is obtained. Finally, an illustrative example is discussed to prove that they can be effectively used to solve problems with uncertainties.Publisher's Versio

Women with Migraine Having High Risk of Hypertension, Heart Disease and Stroke : A Quick Survey

Biomedical informatics is a field which mainly concentrates on the effective usage of medical data often provided by the use of technology and people to improve individual health. Currently headache is a significant trouble among human with regard to several causes. Tension, stress, Obesity and medication overuse are the main reasons for the occurrence of headache. The objective of this study is to conduct a systematic review of the effects of biomedical informatics applications with related to headaches. A data frame with 4152 observations on 133 subjects for 9 variables is taken for the study and from this a subset of data on migraine treatments collected by Tammy Kostecki-Dillon consist of headache entries kept in a treatment program. Patients entered the program at different times over a period of about 3 years. It is observed that women are having the high risk of occurrence migraines. This leads to higher degree of occurrence of hypertension and cardiovascular disorder in women than in men