Analysis of Alloy 718 surfaces milled by abrasive waterjet and post-processed by plain waterjet technology

This work analyzes the surfaces obtained in Alloy 718 when they are milled by Abrasive Waterjet (AWJ) at different conditions. This analysis revealed that all surfaces have a homogeneous roughness in the transversal and the longitudinal directions, present embedded abrasive particles and have hardened about 50% with respect to the untreated bulk Alloy 718. On the other hand, Plain Waterjet (PWJ) technology was used for removing the abrasive particles embedded in surfaces of Alloy 718 milled previously by AWJ technology. The effect of this process on the surface characteristics is also analyzed. For all tested conditions, this technology removed all the particles embedded in the surface. In addition, the PWJ technology process in general smoothened the surfaces produced by AWJ milling and it also released near-surface stresses.The authors acknowledge the support of the Ministry of Economy and Competitiveness of the Spanish Government for support of project EVOCA II (reference DPI2013-45308-P)

Surface properties and fatigue failure analysis of alloy 718 surfaces milled by abrasive and plain waterjet

This work analyzes the surfaces obtained in alloy 718 when they are milled by abrasive waterjet (AWJ) at different conditions, and the effect of main process parameters on the characteristics of these surfaces. This analysis revealed that all surfaces have a homogeneous roughness in the transversal and the longitudinal directions, present embedded abrasive particles and have hardened about 50% with respect to the untreated bulk alloy 718. In addition, plain waterjet (PWJ) technology was used for removing the abrasive particles embedded in surfaces of alloy 718 milled previously by AWJ technology. The effect of this process on the surface characteristics is also analyzed. For all tested conditions, this technology removed all the particles embedded in the surface. In addition, the PWJ technology process in general smoothened the surfaces produced by AWJ milling and it also released near-surface stress. Finally, fatigue tests revealed lower performance of the treated specimens in comparison to untreated specimens, due to crack-like surface irregularities introduced by the treatments.The authors acknowledge the support of the Ministry of Economy and Competitiveness of the Spanish Government for support of project EVOCA II (reference DPI2013-45308-P)

Composite Cutting with Abrasive Water Jet

Abrasive Water Jet (AWJ) technology has demonstrated to be an interesting manufacturing process for space, aircraft, boat and automotive sectors due to its specific advantages when machining composite materials. However, AWJ cutting of composite laminates possesses several challenges. It is necessary to develop a methodology to adapt the process parameters for each type of FRP & CFRP material which will allow AWJ trimming operations to be easily carried out on composite materials, since machine manufacturers still do not provide good databases for composite cutting. The presented work aims at studying the behaviour of a machinability model in composite materials. The machinability index for various composite materials with different thicknesses was found experimentally, which showed very different results for different materials. A study of the effect of the abrasive waterjet process parameters on the quality of cut (taper and surface roughness) was carried out

Design and integration of WAAM technology and in situ monitoring system in a gantry machine

Wire arc additive manufacturing, WAAM, is a popular wire-feed additive manufacturing technology that creates components through the deposition of material layer-by-layer. WAAM has become a promising alternative to conventional machining due to its high deposition rate, environmental friendliness and cost-competitiveness. In this research work, an adaptation of a gantry machine with in-situ monitoring and a control system has been carried out, in order to expose the ability of the WAAM technology to fabricate complex-shaped parts. The retrofitting of the machine has been done in several layers called respectively hardware, control and software layers. For the validation of the implemented system, a stainless steel 316L demonstrator has been manufactured, and the required stages have been employed, including part design (CAD), process parameters selection, tool-path definition (CAM) and part manufacturing. This study has shown the feasibility of the adapted machine for additive manufacturing as a controlled process.The authors acknowledge the European Commission for support from project AMAZE (FP7-2012-NMP-ICT-FoF, project 313781) and the Basque Government for support from project EUSK-ADDI (Etorgai 2014)

Providing access to urban green spaces: A participatory benefit-cost analysis in Spain

This is the final version. Available on open access from MDPI via the DOI in this recordThe opening up of green spaces could provide significant benefits to society. This study develops a framework to assess the economic benefits and costs of public interventions providing citizen access to urban green spaces. The Thinking Fadura project in Getxo (Spain) was used as a case study. A method for participatory benefit-cost analysis is developed, where a stakeholder-participatory evaluation is combined with a standard cost-benefit analysis. The participatory evaluation followed a bottom-up approach in a sequential evaluation including three main focal points: key stakeholders and experts, visitors and the general public. The assessment demonstrates that the Thinking Fadura project’s benefits outweigh the costs. The results suggest that projects designed with the purpose of improving green space accessibility to the general public can be beneficial from a societal perspective. The highest economic benefits were an increase in the amenity and recreational value and an increase in people’s physical activity. The participatory evaluation indicates that giving access to people of lower socio-economic status and vulnerable groups and improving recreational use were perceived as the most beneficial. An increase in noise, dirt, and risk of criminal activities as well as potential conflicts between green space users were perceived as the most negative impacts of opening a previously restricted area to the general public. The economic assessment of Thinking Fadura project could serve as a model in the decision-making process in locations where the use of greenspaces is restricted.European Union Horizon 202

Sex-specific associations of basal steroid hormones and neuropeptides with Conduct Disorder and neuroendocrine mediation of environmental risk

Conduct Disorder (CD) is characterized by severe aggressive and antisocial behavior. The stress hormone system has frequently been investigated as a neurobiological correlate of CD, while other interacting neuroendocrine biomarkers of sex hormone or neuropeptide systems have rarely been studied, especially in females. We examined multiple basal neuroendocrine biomarkers in female and male adolescents with CD compared to healthy controls (HCs), and explored whether they mediate effects of environmental risk factors on CD. Within the FemNAT-CD study, salivary cortisol, alpha-amylase, testosterone, dehydroepiandrosterone-sulfate (DHEA-S), estradiol, progesterone, oxytocin, and arginine-vasopressin were measured under basal conditions in 166 pubertal adolescents with CD, and 194 sex-, age-, and puberty-matched HCs (60% females, 9-18 years). Further, environmental risk factors were assessed. Single hormone analyses showed higher DHEA-S, and lower estradiol and progesterone levels in both females and males with CD relative to HCs. When accounting for interactions between neuroendocrine systems, a male-specific sex hormone factor (testosterone/DHEA-S) predicted male CD, while estradiol and a stress-system factor (cortisol/alpha-amylase) interacting with oxytocin predicted female CD. Estradiol, progesterone, and oxytocin partly explained associations between early environmental risk and CD. Findings provide evidence for sex-specific associations between basal neuroendocrine measures and CD. Especially altered sex hormones (androgen increases in males, estrogen reductions in females) robustly related to CD, while basal stress-system measures did not. Early environmental risk factors for CD may act partly through their effects on the neuroendocrine system, especially in females. Limitations (e.g., basal neuroendocrine assessment, different sample sizes per sex, pubertal participants, exploratory mediation analyses) are discussed

Prevalence, Incidence, and Outcomes of Hyperkalaemia in Patients with Chronic Heart Failure and Reduced Ejection Fraction from a Spanish Multicentre Study: SPANIK-HF Design and Baseline Characteristics

[Abstract] Hyperkalaemia is a growing concern in the treatment of patients with heart failure and reduced ejection fraction (HFrEF) as it limits the use of some prognostic-modifying drugs and has a negative impact on prognosis. The objective of the present study was to estimate the prevalence of hyperkalaemia in outpatients with HFrEF and its impact on achieving optimal medical treatment. For this purpose, a multicentre, prospective, and observational study was carried out on consecutive HFrEF patients who were monitored as outpatients in heart failure (HF) units and who, in the opinion of their doctor, received optimal medical treatment. A total of 565 HFrEF patients were included from 16 specialised HF units. The mean age was 66 ± 12 years, 78% were male, 45% had an ischemic cause, 39% had atrial fibrillation, 43% were diabetic, 42% had a glomerular filtration rate < 60 mL/min/1.7 m2, and the mean left ventricular ejection fraction was 31 ± 7%. Treatment at the study entry included: 76% on diuretics, 13% on ivabradine, 7% on digoxin, 18.9% on angiotensin-conversing enzyme inhibitors (ACEi), 11.3% on angiotensin receptors blockers (ARBs), 63.8% on angiotensin-neprilysin inhibitors (ARNi), 78.5% on mineralocorticoid receptor antagonists (MRAs), and 92.9% on beta-blockers. Potassium levels in the baseline analysis were: ≤5 mEq/L = 80.5%, 5.1–5.4 mEq/L = 13.8%, 5.5–5.9 mEq/L = 4.6%, and ≥6 mEq/L = 1.06%. Hyperkalaemia was the reason for not prescribing or reaching the target dose of an MRAs in 34.8% and 12.5% of patients, respectively. The impact of hyperkalaemia on not prescribing or dropping below the target dose in relation to ACEi, ARBs, and ARNi was significantly less. In conclusion, hyperkalaemia is a frequent problem in the management of patients with HFrEF and a limiting factor in the optimisation of medical treatment.AstraZeneca Farmacéutica; ESR-17-1324

Vitamin D Receptor Deficiency and Low Vitamin D Diet Stimulate Aortic Calcification and Osteogenic Key Factor Expression in Mice

Low levels of 25-hydroxy vitamin D (25(OH)D) are associated with cardiovascular diseases. Herein, we tested the hypothesis that vitamin D deficiency could be a causal factor in atherosclerotic vascular changes and vascular calcification. Aortic root sections of vitamin D receptor knockout (VDR−/−) mice that were stained for vascular calcification and immunostained for osteoblastic differentiation factors showed more calcified areas and a higher expression of the osteogenic key factors Msx2, Bmp2, and Runx2 than the wild-type mice (P<0.01). Data from LDL receptor knockout (LDLR−/−) mice that were fed western diet with either low (50 IU/kg), recommended (1,000 IU/kg), or high (10,000 IU/kg) amounts of vitamin D3 over 16 weeks revealed increasing plasma concentrations of 25(OH)D (P<0.001) with increasing intake of vitamin D, whereas levels of calcium and phosphorus in plasma and femur were not influenced by the dietary treatment. Mice treated with the low vitamin D diet had more calcified lesions and a higher expression of Msx2, Bmp2, and Runx2 in aortic roots than mice fed recommended or high amounts of vitamin D (P<0.001). Taken together, these findings indicate vitamin D deficiency as a risk factor for aortic valve and aortic vessel calcification and a stimulator of osteogenic key factor expression in these vascular areas