Nou gènere i nova nova espècie de cranc portunoid: Archaeoportunus isabenensis, de l’Eocè Inferior d’Osca (Aragó) i Lleida (Catalunya)

Crabs recovered from marly strata of the upper Roda Formation (Ypresian) at Isàvena (Huesca, Aragón), and the Ypresian of Lleida (Catalonia), exhibit a clear set of characteristics, mainly in chelipeds and dorsal carapace that favour assignment to the superfamily Portunoidea, and confirm a close relationship with the family Portunidae. However, the presence of important and easily distinguished features, such as the strongly marked dorsal ridges or notably narrow sternum, leads us to erect a new genus and species, Archeoportunus isabenensis gen. nov., sp. nov., and a new family, the Archaeoportunidae fam. nov. The ventral features of the new taxon, in particular the fairly narrow sternum which notably becomes even narrower posteriorly, the strongly downturned sternites 1-4, bearing strong swellings, and the general adaptation of sternum, pleon and pereiopods, substantiates the basal condition of the new taxon within the Portunoidea and also contributes to current knowledge of evolutionary issues within that group. This publication principally serves to validate the nomenclatural acts in Artal et al. (2013), in order to fulfil the requirements outlined in ICZN (2012).Els crancs recuperats en els estrats margosos de la formació Roda (Ipresià), a Isàvena (Osca, Aragó) així com a l’Ipresià de Lleida (Catalunya), presenten un conjunt de caràcters, principalment en els quelípedes i en la closca dorsal que permeten la seva assignació a la superfamília Portunoidea, al mateix temps que confirmen una relació propera amb la família Portunidae. Tanmateix, la presència d’estructures fàcilment distingibles com les carenes dorsals molt marcades o l’estèrnum estret, ens duu a erigir un nou gènere i espècie, Archaoportunus isabenensis, així com una nova família, Archaeoportunidae. Les estructures ventrals del nou tàxon, en particular l’estèrnum toràcic que s’estreteix posteriorment, les esternites toràciques 1-4 fortament arquejades i amb prominents inflors, i l’adaptació general de l’estèrnum, plèon i pereopodis, corrobora la condició basal del nou tàxon dins dels Portunoidea i a la vegada contribueix al coneixement de l’evolució d’aquest grup. La present publicació serveix per a validar els actes de nomenclatura establerts en Artal et al. (2013) per tal de complir els requisits descrits a ICZN (2012)

Filling the early Eocene gap of paguroids (Decapoda, Anomura): a new highly diversified fauna from the Spanish Pyrenees (Serraduy Formation, Graus-Tremp Basin)

A highly diversified fauna of hermit crabs associated with reef environments from the Serraduy Formation (lower Eocene) in the southern Pyrenees (Huesca, Spain) is described. Other European Eocene outcrops have yielded paguroids associated with a single environment; however, the studied association represents one of the highest paguroid diversities in a single Eocene outcrop worldwide. The new material increases the diversity of known fossil paguroids, including eight species from which six are new: Clibanarius isabenaensis n. sp., Parapetrochirus serratus n. sp., Dardanus balaitus n. sp., ?Petrochirus sp., Eocalcinus veteris n. sp., ?Pagurus sp., Paguristes perlatus n. sp., and Anisopagurus primigenius n. sp. We erected a new combination for Paguristes sossanensis De Angeli and Caporiondo, 2009 and Paguristes cecconi De Angeli and Caporiondo, 2017 and transfer them to the genus Clibanarius. This association contains the oldest record of the genera Eocalcinus and Anisopagurus. Our data demonstrate that paguroids were diverse by the early Eocene in coral-reef environments and fill an important gap between the poorly known Paleocene assemblages and the more diverse mid- to late Eocene ones

A highly diverse dromioid crab assemblage (Decapoda, Brachyura) associated with pinnacle reefs in the lower Eocene of Spain

A highly diverse fauna of dromioid brachyurans from the Serraduy Formation (lower Eocene) in the western Pyrenees (Huesca, Spain) is described and illustrated. Recorded taxa are Mclaynotopus longispinosus new genus new species, Torodromia elongata n. gen. n. sp., Basidromilites glaessneri n. gen. n. sp., ?Basidromilites sp., Sierradromia gladiator n. gen. n. sp., Kromtitis isabenensis n. sp., and ?Basinotopus sp. Other European outcrops have yielded dromioids in association with specific environments, likely coral and sponge reef and siliciclastic soft bottoms; but the present material constitutes the most diverse dromioid assemblage from the lower Eocene worldwide. These dromioids co-occurred with a rich invertebrate fauna and lived near coral–algal reef mounds. Sedimentological data suggest that most of the fauna accumulated in fore reef settings as a result of storm activity. The present material greatly increases the diversity of known dromioid crabs associated with Eocene reef environments.UUID: http://zoobank.org/aed8cafa-7c64-4e70-bd45-9f357fc37a2

Geometric motivic Poincar\'e series of quasi-ordinary singularities

The geometric motivic Poincar\'e series of a germ $(S,0)$ of complex algebraic variety takes into account the classes in the Grothendieck ring of the jets of arcs through $(S,0)$. Denef and Loeser proved that this series has a rational form. We give an explicit description of this invariant when $(S,0)$ is an irreducible germ of quasi-ordinary hypersurface singularity in terms of the Newton polyhedra of the logarithmic jacobian ideals. These ideals are determined by the characteristic monomials of a quasi-ordinary branch parametrizing $(S,0)$

Planck-LFI 44-GHz back end module

This work describes the principle of operation, assembly and performance of one branch of the 44 GHz back end module (BEM) for the Planck low frequency instrument (LFI). This subsystem constitutes a fully representative branch of the qualification-model version (QM). It includes waveguide to microstrip transition, GaAs pseudomorphic high electron mobility transistor (PHEMT) low noise amplifiers (LNA), bandpass filter, square-law detector and dc amplifier. The fundamentals of the design of the RF part are described and all of the components have been tested individually before integration. Using single tone and wideband noise stimuli, the output voltage has been measured for several input powers, in order to obtain the sensitivity factor of the complete BEM. The effective bandwidth and the equivalent noise temperature have been calculated from the measurements, taking into account the frequency dependence on the noise source and the BEM. Finally, the low frequency output power spectrum has been obtained and a maximum 1/f knee frequency around 200 Hz has been measured with a 3 dB output signal video bandwidth above 50 KHz.Peer Reviewe

Very Low-Noise Differential Radiometer at 30 GHz for the PLANCK LFI

The PLANCK mission of the European Space Agency is devoted to produce sky maps of the cosmic microwave background radiation. The low-frequency instrument is a wide-band cryogenic microwave radiometer array operating at 30, 44, and 70 GHz. The design, test techniques, and performance of the complete differential radiometer at 30 GHz are presented. This elegant breadboard 30-GHz radiometer is composed of a front-end module (FEM) assembled at the Jodrell Bank Observatory, Cheshire, U.K., and a back-end module assembled at the Universidad de Cantabria, Cantabria, Spain, and Telecomunicacio/spl acute/, Universitat Polite/spl acute/cnica de Catalunya, Barcelona, Spain. The system noise temperature was excellent, mainly due to the very low noise performance of the FEM amplifiers, which achieved an average noise temperature of 9.4 K.Peer Reviewe

Módulo posterior del radiómetro Planck a 30 GHz: modelo de calificación

The Back End Module at 30 GHz for the Planck mission has been manufactured in its Qualification Model version. Design, integration and main performances are described. Electrical, thermal and vibration tests, already done for space qualification, are summarised. This module consists basically in four identical branches based on broadband low noise amplification, direct detection and video amplification

Stroke prevalence among the Spanish elderly: an analysis based on screening surveys

BACKGROUND: This study sought to describe stroke prevalence in Spanish elderly populations and compare it against that of other European countries. METHODS: We identified screening surveys -both published and unpublished- in Spanish populations, which fulfilled specific quality requirements and targeted prevalence of stroke in populations aged 70 years and over. Surveys covering seven geographically different populations with prevalence years in the period 1991–2002 were selected, and the respective authors were then asked to provide descriptions of the methodology and raw age-specific data by completing a questionnaire. In addition, five reported screening surveys in European populations furnished useful data for comparison purposes. Prevalence data were combined, using direct adjustment and logistic regression. RESULTS: The overall study population, resident in central and north-eastern Spain, totalled 10,647 persons and yielded 715 cases. Age-adjusted prevalences, using the European standard population, were 7.3% for men, 5.6% for women, and 6.4% for both sexes. Prevalence was significantly lower in women, OR 0.79 95% CI 0.68–0.93, increased with age, particularly among women, and displayed a threefold spatial variation with statistically significant differences. Prevalences were highest, 8.7%, in suburban, and lowest, 3.8%, in rural populations. Compared to pooled Spanish populations, statistically significant differences were seen in eight Italian populations, OR 1.39 95%CI (1.18–1.64), and in Kungsholmen, Sweden, OR 0.40 95%CI (0.27–0.58). CONCLUSION: Prevalence in central and north-eastern Spain is higher in males and in suburban areas, and displays a threefold geographic variation, with women constituting the majority of elderly stroke sufferers. Compared to reported European data, stroke prevalence in Spain can be said to be medium and presents similar age- and sex-specific traits

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function

Non-alcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases, including non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. Currently, understanding the multiple and complex molecular pathways implicated in NAFLD onset and progression is a major priority. The transcription factor p63, which belongs to a family comprising p53, p63, and p73,1 is one of many factors that contributes to the development of liver steatosis. The role of p63 as a tumor suppressor and in cell maintenance and renewal is well studied, but we have recently reported that it is also relevant in the control of lipid metabolism.2 p63 encodes multiple isoforms that can be grouped into 2 categories; isoforms with an acidic transactivation domain (TA) and those without this domain (domain negative). The TAp63α isoform is elevated in the liver of animal models of NAFLD as well as in liver biopsies from obese patients with NAFLD. Furthermore, downregulation of p63α in the liver attenuates liver steatosis in diet-induced obese (DIO) mice, while the activation of TAp63α increases hepatic fat content, mediated by the activation of IKKβ and endoplasmic reticulum stress.2 A specialized form of autophagy that degrades lipid droplets, termed “lipophagy”, is a major pathway of lipid mobilization in hepatocytes. Lipophagy is elevated in hepatoma cells upon exposure to free fatty acids,3 and reduces the fatty acid load in mouse hepatocytes.4 Its impairment has been associated with the development of fatty liver and insulin resistance3,5; in contrast, the autophagic flux is increased during the activation of hepatic stellate cells.6 In the present study, we used an unbiased proteomics approach to gain insight into novel proteins modulating lipid metabolism in the liver of mice with genetic knockdown or overexpression of TAp63α. We found that autophagy-related gene 3 (ATG3) was upregulated by TAp63α activation and downregulated after p63α inhibition. ATG3 is elevated in several animal models of NAFLD and in the liver of patients with NAFLD. Genetic overexpression of ATG3 increased the lipid load in hepatocytes, while its repression alleviated TAp63α- and diet-induced steatosis. ATG3 exerted its role in lipid metabolism by regulating SIRT1 and mitochondrial function. Collectively, these findings identify ATG3 as a novel factor implicated in the development of steatosisThis work has been supported by grants from FEDER/Ministerio de Ciencia, Innovación y Universidades-Agencia Estatal de Investigación (PA: RTI2018-095134-B-100; DS and LH: SAF2017-83813-C3-1-R; MLMC: RTC2019-007125-1; CD: BFU2017-87721; ML: RTI2018–101840-B-I00; GS; PID2019-104399RB-I00; RN: RTI2018-099413-B-I00 and RED2018-102379-T; MLMC: SAF2017-87301-R; TCD: RTI2018-096759-A-100), FEDER/Instituto de Salud Carlos III (AGR: PI19/00123), Xunta de Galicia (ML: 2016-PG068; RN: 2015-CP080 and 2016-PG057), Fundación BBVA (RN, GS and MLM), Proyectos Investigación en Salud (MLMC: DTS20/00138), Sistema Universitario Vasco (PA: IT971-16); Fundación Atresmedia (ML and RN), Fundación La Caixa (M.L., R.N. and M.C.), Gilead Sciences International Research Scholars Program in Liver Disease (MVR), Marató TV3 Foundation (DS: 201627), Government of Catalonia (DS: 2017SGR278) and European Foundation for the Study of Diabetes (RN and GS). This research also received funding from the European Community’s H2020 Framework Programme (ERC Synergy Grant-2019-WATCH- 810331, to RN, VP and MS). Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Hepáticas y Digestivas (CIBERehd) and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem). CIBERobn, CIBERehd and CIBERdem are initiatives of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. We thank MINECO for the Severo Ochoa Excellence Accreditation to CIC bioGUNE (SEV-2016-0644)S