PENGARUH KUALITAS PRODUK, KUALITAS PELAYANAN DAN CITRA MEREK TERHADAP KEPUTUSAN PEMBELIAN BATIK (Studi Pada Omah Batik Ngesti Pandowo, Semarang)

Creative industry especially in fashion sector have a high potential to boost Indonesian economy. One of the business sector of fashion industry in Indonesia is batik craft business. Omah Batik Ngesti Pandowo is one of a micro, small, and medium enterprise in Semarang that working on batik craft. In the past 5 years, the product sales of Omah Batik Ngesti Pandowo has been increasing. However, Omah Batik Ngesti Pandowo has not reach the target of sales in each year. This research aims to know the influence of Product Quality, Service Quality, and Brand Image towards Buying Decision of Omah Batik Ngesti Pandowo products The type of research is explanatory research. The sample used is 100 respondents. The sampling techniques are accidental and purposive sampling. The respondents are the consumers who already bought batik products at Omah Batik Ngesti Pandowo. Analysis method used in this research are validity and reliability test, correlation coefficient, coefficient of determination, simple linear regression, multiple linear regression, and test of significance (t-test and F) proceed by SPSS. Based on the research is known that the variable of Product Quality influencing Buying Decision for 57,7%. The variable of Service Quality influencing the Buying Decision for 56,4%. The variable of Brand Image influencing the Buying Decision for 40,8%. While Product Quality, Service Quality, and Brand Image are giving contribution for 65,2% simultaneously. This is means that the better product quality, service quality, and brand image are, the higher buying decision is of batik craft product in Omah Batik Ngesti Pandowo. Based on that research, the researcher suggests that Omah Batik Ngesti Pandowo can continue to innovate more in producing product with motives and models that are in trend, implementing standard of appearance for the employees, providing better parking area and creating product with distinctive characteristic to increase consumers’ buying decisio

Study of target volume effect on efficiency index and paddick comformty index for arteriovenous malformation treatment plans by gamma knife

الهدف نظرًا   لأن الطاقة هي نتاج الحجم مرات الجرعة ، يتم إعطاء الأحجام ترجيحًا يتناسب مع الجرعة التي تلقتها. هذه نتيجة أن الطاقة هي مقياس لمقدار المادة التي تم امتصاصها. مؤشر الكفاءة عبارة عن إحصائية واحدة يمكن استخدامها لتقييم جودة الخطة بكفاءة من خلال مراعاة التغطية والانتقائية ومؤشر التدرج والحجم ، ومن الممكن استخدام هذه الإحصائية لقياس كفاءة خطتين مختلفتين لنفس الحجم المستهدف. مؤشر المطابقة هو قياس مدى توافق حجم توزيع الجرعة الإشعاعية مع حجم وشكل الحجم المستهدف. في هذا البحث تم دراسة تذبذب مؤشر الكفاءة والحقل مع فروق حجم الهدف. الطريقة تم حساب مؤشر الكفاءة وبيانات مؤشر المطابقة لكل من العلاجات السريرية الثلاثين التي تم جدولتها باستخدام خطة Leksell Gamma ومقارنتها بالحجم المستهدف. النتيجة: تراوحت قيمة 50٪ ل 30 خطة SRS السريرية من 44٪ إلى 84٪ بمتوسط ​​قيمة 63٪ وقيمة المطابقة 47٪ إلى 82٪ بمتوسط ​​قيمة 60.6٪ ، وأظهرت هذه الدراسة أيضًا علاقة قوية بين الهدف الحجم وهذه الفهارس. يتم إعطاء أحجام الاستنتاجات ترجيحًا يتناسب مع الجرعة التي امتصتها لأن الطاقة هي نتاج حجم مرات الجرعة ، حيث سيكون هناك ارتباط بين تحسينات الكفاءة والمطابقة وزيادة الحجم المستهدف

Perbandingan Unjuk Kerja Resin Penukar Ion Basa Kuat Dowex Marathon A dengan Purolite pada Proses Pemurnian Biogas Skala Pilot Plant

Adsorption of carbon dioxide is a vital process in biogas purification. A previous study has narrowed down the choice of ion exchange resins for the adsorption process into two commercial resins, Dowex Marathon A, and Purolite. Dowex Marathon A boasts the advantage of having no need of any pretreatments to use. Purolite, although needing pretreatment before USAge, costs only roughly a third of Dowex Marathon A. The objective of the study is to decide on which resin is best suited to commercially produce biogas free from pollutants, most of which is carbon dioxide. Both resins at their fresh state were tested for durability by checking on levels of carbon dioxide content at set time intervals. Results suggest the Purolite resin to be more durable than the Dowex Marathon A resin. Data of gas passing through Dowex showed relatively high concentration of CO2 after 10 minutes of operation. While Purolite showed its first signs of CO2 after 20 minutes of operation. Further tests are conducted to compare fresh and regenerated Pirolite resins. Comparison between fresh and postregeneration Purolite showed relatively consistent results where the regenerated resin showed its first signs of CO2 after 25 minutes

Mechanical and thermal properties of the waste low and high density polyethylene-nanoclay composites

In extension with the previous work, recycling of the waste polyolefins by dissolution/reprecipitation method, has been investigated. The goal of study was to explore the influence of organo-modified/unmodified sodium montmorillonite clays, on the behaviours of waste polyolefins inclusive low density polyethylene (LDPE) and high density polyethylene (HDPE). 1-5 wt % of unmodified (MMT) and Organo-modified clay (OMMT) were added to the polyolefins, to prepare polyolefin-clay nanocomposites by melt intercalation method. X-ray diffraction (XRD) and Field Emission Scanning Electron Microscope (FESEM) were used to estimate the dispersion of clay in the polymer matrices and the morphology of nanocomposites. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) were used to analyse the change in the thermic properties of the waste polyolefins nanocomposites. The XRD and FESEM results showed an intercalated structure in the HDPE and LDPE with Organo-clay nanocomposites, whereas no exfoliation was observed with unmodified clay in both waste HDPE and LDPE, respectively. DSC and TGA, showed an improved thermal behaviours in the HDPE/Organo-clay nanocomposites (3 wt%) clay loading. Melting temperature and crystallization percentage were observed to increase in 1, 2, and 3 wt% loadings. In waste LDPE/clay nanocomposites, no improvement was established in the thermal stability

IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways

Vascular endothelium provides a selective barrier between the blood and tissues, participates in wound healing and angiogenesis, and regulates tissue recruitment of inflammatory cells. Nuclear factor (NF)-κB transcription factors are pivotal regulators of survival and inflammation, and have been suggested as potential therapeutic targets in cancer and inflammatory diseases. Here we show that mice lacking IKKβ, the primary kinase mediating NF-κB activation, are smaller than littermates and born at less than the expected Mendelian frequency in association with hypotrophic and hypovascular placentae. IKKβ-deleted endothelium manifests increased vascular permeability and reduced migration. Surprisingly, we find that these defects result from loss of kinase-independent effects of IKKβ on activation of the serine-threonine kinase, Akt. Together, these data demonstrate essential roles for IKKβ in regulating endothelial permeability and migration, as well as an unanticipated connection between IKKβ and Akt signalling

c-Jun NH2-Terminal Kinase Activity in Subcutaneous Adipose Tissue but Not Nuclear Factor-κB Activity in Peripheral Blood Mononuclear Cells Is an Independent Determinant of Insulin Resistance in Healthy Individuals

OBJECTIVE Chronic low-grade activation of the immune system (CLAIS) predicts type 2 diabetes via a decrease in insulin sensitivity. Our study investigated potential relationships between nuclear factor-κB (NF-κB) and c-Jun NH2-terminal kinase (JNK) pathways—two pathways proposed as the link between CLAIS and insulin resistance. RESEARCH DESIGN AND METHODS Adiposity (dual-energy X-ray absorptiometry), waist-to-hip ratio (WHR), and insulin sensitivity (M, hyperinsulinemic-euglycemic clamp) were measured in 22 healthy nondiabetic volunteers (aged 29 ± 11 years, body fat 28 ± 11%). NF-κB activity (DNA-binding assay) and JNK1/2 activity (phosphorylated JNK) were assessed in biopsies of the vastus lateralis muscle and subcutaneous adipose tissue and in peripheral blood mononuclear cell (PBMC) lysates. RESULTS NF-κB activities in PBMCs and muscle were positively associated with WHR after adjustment for age, sex, and percent body fat (both P 0.1), although it was inversely related to M (r = −0.54, P < 0.05) and explained 29% of its variance. When both NF-κB and JNK1/2 were examined statistically, only JNK1/2 activity in adipose tissue was a significant determinant of insulin resistance (P = 0.02). CONCLUSIONS JNK1/2 activity in adipose tissue but not NF-κB activity in PBMCs is an independent determinant of insulin resistance in healthy individual

Negative Regulators of Insulin Signaling Revealed in a Genome-Wide Functional Screen

Type 2 diabetes develops due to a combination of insulin resistance and β-cell failure and current therapeutics aim at both of these underlying causes. Several negative regulators of insulin signaling are known and are the subject of drug discovery efforts. We sought to identify novel contributors to insulin resistance and hence potentially novel targets for therapeutic intervention.An arrayed cDNA library encoding 18,441 human transcripts was screened for inhibitors of insulin signaling and revealed known inhibitors and numerous potential novel regulators. The novel hits included proteins of various functional classes such as kinases, phosphatases, transcription factors, and GTPase associated proteins. A series of secondary assays confirmed the relevance of the primary screen hits to insulin signaling and provided further insight into their modes of action.Among the novel hits was PALD (KIAA1274, paladin), a previously uncharacterized protein that when overexpressed led to inhibition of insulin's ability to down regulate a FOXO1A-driven reporter gene, reduced upstream insulin-stimulated AKT phosphorylation, and decreased insulin receptor (IR) abundance. Conversely, knockdown of PALD gene expression resulted in increased IR abundance, enhanced insulin-stimulated AKT phosphorylation, and an improvement in insulin's ability to suppress FOXO1A-driven reporter gene activity. The present data demonstrate that the application of arrayed genome-wide screening technologies to insulin signaling is fruitful and is likely to reveal novel drug targets for insulin resistance and the metabolic syndrome

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

OBJECTIVE: Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity. RESEARCH DESIGN AND METHODS: Adipose tissue was obtained from lean and obese women undergoing bariatric surgery. Metabolic markers were measured in fasting serum and ATMs characterized by immunohistology, flow cytometry, and tissue culture studies. RESULTS ATMs comprised CD11c(+)CD206(+) cells in "crown" aggregates and solitary CD11c(-)CD206(+) cells at adipocyte junctions. In obese women, CD11c(+) ATM density was greater in subcutaneous than omental adipose tissue and correlated with markers of insulin resistance. CD11c(+) ATMs were distinguished by high expression of integrins and antigen presentation molecules; interleukin (IL)-1beta, -6, -8, and -10; tumor necrosis factor-alpha; and CC chemokine ligand-3, indicative of an activated, proinflammatory state. In addition, CD11c(+) ATMs were enriched for mitochondria and for RNA transcripts encoding mitochondrial, proteasomal, and lysosomal proteins, fatty acid metabolism enzymes, and T-cell chemoattractants, whereas CD11c(-) ATMs were enriched for transcripts involved in tissue maintenance and repair. Tissue culture medium conditioned by CD11c(+) ATMs, but not CD11c(-) ATMs or other stromovascular cells, impaired insulin-stimulated glucose uptake by human adipocytes. CONCLUSIONS: These findings identify proinflammatory CD11c(+) ATMs as markers of insulin resistance in human obesity. In addition, the machinery of CD11c(+) ATMs indicates they metabolize lipid and may initiate adaptive immune responses