Flow Blurring-Enabled Production of Polymer Filaments from Poly(ethylene oxide) Solutions

Flow blurring (FB) atomizers are relatively simple yet robust devices used for the generation of sprays from solutions of a wide range of viscosities. In this work, we have demonstrated that FB devices may also be applied for massive production of liquid filaments from polymeric solutions. They can later be transformed into solid filaments and fibers, leading to the production of so-called fiber mats. The liquid precursors consisted of poly(ethylene oxide) (PEO) solutions of varying molecular weights (105 [100k] to 4 × 106 g/mol [4M]) and concentrations. The FB device was operated in the gas pressure range of 3−6 bar. Except for solutions of PEO 100k, all solutions exhibited a shear thinning behavior. For massive filament production, a threshold polymer concentration (ct) was identified for each molecular weight. Below such concentration, the atomization resulted in droplets (the classical FB functioning mode). Such a threshold value decreased as the PEO molecular weight increased, and it coincides with the polymer coil overlap concentration, c*. The viscoelastic nature of the solutions was also observed to increase with the molecular weight. A 3.2 dependency of the zero-shear rate viscosity on a so-called Bueche parameter was found for filament production, whereas a nearly linear dependency was found for droplet production. In general, the mean diameter of the filaments decreased as they traveled downstream from the atomization point. Furthermore, at a given distance from the atomizer outlet and gas pressure, the mean filament diameter slightly shifted toward larger sizes with increasing PEO molecular weight. The tendency agrees well with the calculated filaments’ Deborah number, which increases with PEO molecular weight. The approach presented herein describes a highthroughput and efficient method for the massive production of viscous filaments. These may be transformed into fibers by an on-line drying step.Ministerio de Economía y Competitividad DPI2016-78887-C3-1-

Neuraminidase-activated microglia compromise the viability of ependymocytes

Neuraminidase (NA) is a sialidase present in the envelope/wall of some virus/bacteria responsible for brain infections, such as flu, mumps or meningitis. The intracerebroventricular injection of NA in the rat brain provokes ependymal detachment and death, and an acute inflammatory process. Although inflammation reverses, ependymal lining is not regenerated. Complement system activation within the CSF contributes to ependymal damage, but is not the only cause (Granados-Duran et al, 2016). Here we aimed to investigate if microglial activation might also play a role. For this purpose we used pure isolated ependymocytes (Grondona et al, 2013) and ventricular wall explants, which were co-cultured with microglial cells, both in basal conditions and with agents that induce microglial activation: NA, LPS, or Pam3CSK4 (synthetic lipopeptide). The viability of the ependymal cells was assessed by trypan blue exclusion. The viability of isolated ependymocytes was reduced when NA or LPS were added to the culture, compared to controls without additives. In the absence of microglia, NA or LPS did not compromise viability significantly, indicating that microglia was involved in ependymocytes death. The addition of NA to cultured explants reduced ependymocytes viability only when microglial cells were present in the culture; a similar reduction was observed when LPS or Pam3CSK4 were added. Conversely, explants cultured in the absence of microglia did not suffer a significant decrease in ependymocytes viability upon NA addition to the medium. We hypothesized that cytokines released by activated microglia, such as IL1β or TNFα, could mediate ependymocytes death. RT-PCR performed in RNA obtained from pure ependymocytes confirmed the presence of IL1β and TNFα receptors in ependymal cells. Nevertheless further experiments are required to confirm this hypothesis. We conclude that microglia activated by NA mediates, at least in part, ependymal cell death, what might be relevant for neuroinflammatory diseases mediated by NA bearing virus/bacteria.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Spontaneous symmetry breaking as a resource for noncritically squeezed light

In the last years we have proposed the use of the mechanism of spontaneous symmetry breaking with the purpose of generating perfect quadrature squeezing. Here we review previous work dealing with spatial (translational and rotational) symmetries, both on optical parametric oscillators and four-wave mixing cavities, as well as present new results. We then extend the phenomenon to the polarization state of the signal field, hence introducing spontaneous polarization symmetry breaking. Finally we propose a Jaynes-Cummings model in which the phenomenon can be investigated at the single-photon-pair level in a non-dissipative case, with the purpose of understanding it from a most fundamental point of view.Comment: Review for the proceedings of SPIE Photonics Europe. 11 pages, 5 figures

Nondiffractive sonic crystals

We predict theoretically the nondiffractive propagation of sonic waves in periodic acoustic media (sonic crystals), by expansion into a set of plane waves (Bloch mode expansion), and by finite difference time domain calculations of finite beams. We also give analytical evaluations of the parameters for nondiffractive propagation, as well as the minimum size of the nondiffractively propagating acoustic beams.Comment: 7 figures, submitted to J. Acoust. Soc. A

Focality and Asymmetry in Multi-battle Contests

This article examines behavior in two-person constant-sum Colonel Blotto games in which each player maximizes the expected total value of the battlefields won. A lottery contest success function is employed in each battlefield. Recent experimental research on such games provides only partial support for Nash equilibrium behavior. We hypothesize that the salience of battlefields affects strategic behavior (the salient target hypothesis). We present a controlled test of this hypothesis – against Nash predictions – when the sources of salience come from certain asymmetries in either battlefield values or labels (as in Schelling (1960)). In both cases, subjects over-allocate the resource to the salient battlefields relative to the Nash prediction. However, the effect is stronger with salient values. In the absence of salience, we replicate previous results in the literature supporting the Nash prediction

Focality and Asymmetry in Multi-battle Contests

This article examines the influence of focality in Colonel Blotto games with a lottery contest success function (CSF), where the equilibrium is unique and in pure strategies. We hypothesise that the salience of battlefields affects strategic behaviour (the salient target hypothesis) and present a controlled test of this hypothesis against Nash predictions, checking the robustness of equilibrium play. When the sources of salience come from asymmetries in battlefield values or labels (as in Schelling, 1960), subjects over-allocate the resource to the salient battlefields relative to the Nash prediction. However, the effect is stronger with salient values. In the absence of salience, we find support for the Nash prediction

Teratoma ovárico en una perra : caso clínico

En este artículo se describe el caso clínico de una perra de tres años en la que se halló de manera casual un quiste dermoide ovárico, tipo especial y poco habitual de los teratomas ováricos. El animal acudió a la consulta por un cuadro de apatía y desinterés por los cachorros una semana después del parto, observándose a la exploración hipertermia, secreción mamaria anormal y descarga vulvar purulenta. El estudio citológico, analítico, radiológico y ecográfico abdominal diagnosticaron una mamitis-metritis post parto. Sin embargo, al realizar la radiografía abdominal, se evidenció una masa de densidad tejido blando situada caudalmente al riñón derecho que ecográficamente se observó como una gran estructura quística. El diagnóstico histopatológico definitivo de un quiste dermoide ovárico se obtuvo tras la realización de la ovariohisterectomía, que en este caso fue curativa ante la ausencia de malignidad. Los tumores ováricos de las células germinales son muy poco frecuentes en la perra por lo que el objetivo del presente artículo no sólo es la descripción de un quiste dermoide sino también la revisión de la escasa bibliografía existente acerca de los tipos, incidencia, síntomas, patogenia, diagnóstico, pronóstico y tratamiento de los tumores ováricos en la especie canina

Optics of Astigmatism and Retinal Image Quality

In the first part of this chapter, the optical condition of astigmatism is defined. The main causes and available classifications of ocular astigmatism are briefly described. The most relevant optical properties of image formation in an astigmatic eye are analysed and compared to that of an emmetropic eye and an eye with spherical ametropia. The spectacle prescription and axis notation for astigmatism are introduced, and the correction of astigmatism by means of lenses is briefly described. The formation of the retinal image for extended objects and the related blurring are also analysed, and the real limits of tolerance of uncorrected astigmatism are provided. Simulations of retinal images in astigmatic eyes, obtained by means of commercial optical design software, are also presented. Finally, the clinical assessment of retinal image quality by means of wavefront aberrometry and double-pass systems in eyes with astigmatism is presented, and current trends in research related to this topic are highlighted.Peer ReviewedPostprint (published version