17 research outputs found

    Bégout, Bruce. Le ParK.Trad. Rubén Martín Giráldez.

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    Bégout, Bruce. Le ParK.Trad. Rubén Martín Giráldez. Barcelona: Siberia, 2014. 137 pp

    Por un parkour filosófico cotidiano

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    Reinterpretar el problema de la vida cotidiana para la filosofía es lo que se propone Por un parkour filosófico cotidiano . Para ello, en primer lugar, se analiza el concepto de cotidianidad desarrollado por tres importantes filósofos, a saber: Husserl, Heidegger y Wittgenstein. En segundo lugar, se toma como modelo de análisis la reinvención de la práctica cotidiana del caminar que realiza el parkour a lo largo de las calles en donde éste se practica diariamente. Dicha reinvención del caminar permite burlar, como una táctica, el poder hegemónico impuesto, a manera de estrategia, por la organización urbanística, la cual cuadricula el modo de vida del hombre corriente. Pero es sólo él, el hombre diseminado en las calles, quien es capaz de manipular y transformar para su beneficio lo que se le ha impuesto alrededor.To reinterpret the problem of the everyday life for the philosophy is what For a philosophical daialy parkour proposes. For it, firstly, the concept of everyday life developed by three important philosophers, namely: Husserl, Heidegger and Wittgenstein, is analyzed. Secondly, the reinvention of the everyday practice of walking, that fulfils the parkour along the streets where it is practised every day, is taken as a model of analysis. The above mentioned reinvention of walking allows deceiving, as a tactics, the hegemonic well versed power, like strategy, for the urban development organization, which squared pattern the way life of the ordinary man. But he, the man spread in the streets, is capable of manipulating and transforming for his benefit what has imposed him around.Filósofo (a)Pregrad

    Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

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    Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease
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