El nuevo puente sobre el río Pisuerga de la ronda sur de Valladolid

The project for the work of a new bridge over Pisuerga river is described in this article. Considering how peculiar the topography of the place is, the idea of a truss-bridge is suggested, planning its construction thinking of the bearings that have to support the bridge and its constructive system, intending first its durability.Se describe el proyecto de obra del nuevo puente sobre el río Pisuerga. Teniendo en cuenta lo peculiar de la topografía del lugar, se sugiere la idea de puente atirantado, planteándose su construcción en el tipo de apoyos que ha de presentar dicho puente y su sistema constructivo, considerando, de manera especial, su durabilidad

A software based DVB-T2 time frequency slicing evaluation framework

DVB-T2 is the second generation terrestrial broadcast system developed within the DVB consortium. Based on multi-carrier transmission OFDM, DVB-T2 introduces many innovative tools offering high flexibility to broadcasters. Among many other new techniques DVB-T2 defines an optional Time-Frequency-Slicing (TFS) profile. In TFS slices of a PLP are sent over multiple and non necessarily adjacent RF frequency channels. This technique provides a gain associated to propagation diversity, as well as an intrinsic multiplexation gain. Following a software defined radio approach this paper presents a flexible DVB-T2 Time Frequency Slicing evaluation framework built to study the practical performance of DVB-T2 Time Frequency Slicing configurations under realistic channel scenarios. The paper focuses on the diversity gain associated to propagation diversity

Ocular Decompression Retinopathy with Macular Edema after Deep Sclerectomy with Intrascleral Implantation

We report a case of ocular decompression retinopathy (ODR) with macular edema, diagnosed by optical coherence tomography, after a deep sclerectomy (DS) with an intrascleral implant, resolved with medical therapy 6 months later. The medical literature reports that in 14% of patients suffering from ODR, a pars plana vitrectomy was required, and 15% of patients had a poor final visual acuity. An otherwise healthy 75-year-old man with high myopia and a primary open-angle glaucoma, with previous intraocular pressure (IOP) of 24 mm Hg, underwent a DS with intrascleral implant without complications. The patient suffered postoperatively from ODR with macular edema that required medical therapy with nonsteroidal anti-inflammatory eye drops (Nepafenac® 0.3%) for a period of 6 months. ODR is an infrequent complication that may occur after any surgical or medical procedure that causes a sudden IOP decrease. The presence of macular edema is only reported in 5% of cases and can occur in patients who report a decreased visual acuity, commonly associated with a retinal hemorrhage. We have described a case of ODR with macular edema after DS with intrascleral implant. Although ODR is considered to cause a low level of morbidity, in some patients this may not be the case

Clinical and Economic Impact of Community-Onset Urinary Tract Infections Caused by ESBL-Producing Klebsiella pneumoniae Requiring Hospitalization in Spain : An Observational Cohort Study

Objective : To analyze the clinical and economic impact of community-onset urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae requiring hospitalization. Methods : A retrospective cohort study that included all adults with a UTI caused by K. pneumoniae that were admitted to a tertiary care hospital in Barcelona, Spain, between 2011 and 2015. Demographic, clinical, and economic data were analyzed. Results : One hundred and seventy-three episodes of UTIs caused by K. pneumoniae were studied; 112 were non-ESBL-producing and 61 were ESBL-producing. Multivariate analysis identified ESBL production, acute confusional state associated with UTI, shock, and the time taken to obtain adequate treatment as risk factors for clinical failure during the first seven days. An economic analysis showed differences between ESBL-producing and non-ESBL-producing K. pneumoniae for the total cost of hospitalization per episode (mean EUR 6718 vs EUR 3688, respectively). Multivariate analysis of the higher costs of UTI episodes found statistically significant differences for ESBL production and the time taken to obtain adequate treatment. Conclusion : UTIs caused by ESBL-producing K. pneumoniae requiring hospitalization and the time taken to obtain adequate antimicrobial therapy are associated with worse clinical and economic outcomes

I Jornadas sobre Arte, Ecología y Uso Público de Espacios Naturales Protegidos

Publicación de las Jornadas que celebró el mes de marzo de 2016, en el Parque Nacional Las Tablas de Daimiel, la asociación Cultura de Ribera con el objetivo de hacer de la cultura y el arte elementos para la conservación de nuestros Espacios Naturales Protegidos. Además de dar unas nociones sobre el paisaje y el territorio de La Mancha Húmeda, en la obra, se traza un panorama histórico sobre Las Tablas y su importancia como el primer Parque Nacional que fue declarado, en gran medida, gracias a la presión ciudadana y del, por entonces, incipiente movimiento ecologista. También se puede encontrar una visión ética de la conservación medioambiental, los antecedentes históricos y experiencias actuales del arte como vector para la conservación de los Espacios Naturales Protegidos y una reflexión sobre el papel del arte y las humanidades en el contexto de la crisis ecológica global. La obra se cierra con un artículo sobre la figura de Ignacio Meco, artista que en su obra aunaba arte y conservación del medio y que tuvo su casa taller en la Zona de Protección de Las Tablas

Third Millennium Bridge over the Ebro river in Zaragoza

RESUMEN. El Puente del Tercer Milenio, que cruza el río Ebro al oeste de la ciudad de Zaragoza, es el principal acceso rodado al recinto de la Exposición Internacional que se celebra en este año 2008. Esta obra está llamada a convertirse en una referencia internacional en la ingeniería de puentes por múltiples motivos, entre los que destacan la calidad de su diseño, tanto estético como estructural, sus dimensiones, sus innovaciones técnicas en materiales y sistemas constructivos y su función urbanística.ABSTRACT. The Third Millennium Bridge cross the Ebro river to the west of Zaragoza is the main vehicles access to International Exposition of this year 2008. Probably, this structure will become a international reference in bridge engineering for many reasons. The quality of the design, structural and aesthetical, the size, the technical innovations in materials and construction systems can be emphasized among other things

The «Puerta de las Rozas» cable-stayed bridge over the A-6, Madrid

RESUMEN. Desde el verano de 2007 está en servicio el nuevo puente atirantado “Puerta de las Rozas” que vuela sobre la A-6 creando un nuevo acceso a la ciudad de las Rozas. Esta nueva y reconocible imagen para los muchos usuarios de la carretera de la Coruña en su entrada a Madrid es el fruto tres años de trabajo en sus distintas fases de encaje, concurso, proyecto y ejecución. Se trata de un puente atirantado asimétrico de 102 m de luz con un ancho de tablero de 20 m, suspendido por 9 parejas de tirantes de un único mástil formado por dos células triangulares que incluyen los tirantes rígidos de contrarresto anclados a contrapeso.ABSTRACT. The new “Puerta de las Rozas cable-stayed bridge, set over the A-6 motorway has been in service since the summer of 2007 and creates a new access to the suburb of Las Rozas. This new and instantly recognizable image for many of the users of the Coruña motorway at its approach to Madrid, is the result of three years work from the original ideal stage, through to tender, design and construction. The bridge is a 102 m span asymmetric cable-stayed bridge with a 20 m wide deck, suspended by nine pairs of cables from a single tower formed by two triangular cells which include the rigid restraints anchored to a counterweight

Resveratrol inhibits nonalcoholic fatty liver disease in rats

Es reproducción del documenteo publicado en http://dx.doi.org/10.1186/1471-230X-8-40Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) is high. NAFLD is linked to obesity, diabetes mellitus, and hypertriglyceridemia. Approximately 20% of patients with NAFLD will eventually develop cirrhosis. Our purpose was to investigate whether resveratrol decreased hepatic steatosis in an animal model of steatosis, and whether this therapeutic approach resulted in a decrease in tumor necrosis factor alpha (TNF-alpha) production, lipid peroxidation and oxidative stress. Methods: Male Wistar CRL: Wi (Han) (225 g) rats were randomized into three groups. A control group (n = 12) was given free access to regular dry rat chow for 4 weeks. The steatosis (n = 12) and resveratrol (n = 12) groups were given free access to feed (a high carbohydrate-fat free modified diet) and water 4 days per week, and fasted for the remaining 3 days for 4 weeks. Rats in the resveratrol group were given resveratrol 10 mg daily by the oral route. All rats were killed at 4 weeks and assessed for fatty infiltration and bacterial translocation. Levels of TNF-alpha in serum, hepatic malondialdehyde (MDA), oxidative stress (superoxide dismutase, glutathione peroxidase, catalase and nitric oxide synthase) and biochemical parameters were measured. Results: Fat deposition was decreased in the resveratrol group as compared to the steatosis group (Grade 1 vs Grade 3, P < 0.05). TNF-alpha and MDA levels were significantly increased in the steatosis group (TNF-alpha; 33.4 +/- 5.2 vs 26.24 +/- 3.47 pg/ml and MDA; 9.08 +/- 0.8 vs 3.17 +/- 1.45 mu M respectively, P < 0.05). This was accompanied by increased superoxide dismutase, glutathione peroxidase and catalase and decreased nitric oxide synthase in the liver of resveratrol group significantly (P < 0.05 vs steatosis group). Bacterial translocation was not found in any of the groups. Glucose levels were decreased in the group of rats given resveratrol (P < 0.05). Conclusion: Resveratrol decreased NAFLD severity in rats. This effect was mediated, at least in part, by TNF-alpha inhibition and antioxidant activities

Metabolomics analysis of type 2 diabetes remission identifies 12 metabolites with predictive capacity: a CORDIOPREV clinical trial study.

Type 2 diabetes mellitus (T2DM) is one of the most widely spread diseases, affecting around 90% of the patients with diabetes. Metabolomics has proven useful in diabetes research discovering new biomarkers to assist in therapeutical studies and elucidating pathways of interest. However, this technique has not yet been applied to a cohort of patients that have remitted from T2DM. All patients with a newly diagnosed T2DM at baseline (n = 190) were included. An untargeted metabolomics approach was employed to identify metabolic differences between individuals who remitted (RE), and those who did not (non-RE) from T2DM, during a 5-year study of dietary intervention. The biostatistical pipeline consisted of an orthogonal projection on the latent structure discriminant analysis (O-PLS DA), a generalized linear model (GLM), a receiver operating characteristic (ROC), a DeLong test, a Cox regression, and pathway analyses. The model identified a significant increase in 12 metabolites in the non-RE group compared to the RE group. Cox proportional hazard models, calculated using these 12 metabolites, showed that patients in the high-score tercile had significantly (p-value < 0.001) higher remission probabilities (Hazard Ratio, HR, high versus low = 2.70) than those in the lowest tercile. The predictive power of these metabolites was further studied using GLMs and ROCs. The area under the curve (AUC) of the clinical variables alone is 0.61, but this increases up to 0.72 if the 12 metabolites are considered. A DeLong test shows that this difference is statistically significant (p-value = 0.01). Our study identified 12 endogenous metabolites with the potential to predict T2DM remission following a dietary intervention. These metabolites, combined with clinical variables, can be used to provide, in clinical practice, a more precise therapy. ClinicalTrials.gov, NCT00924937.The CORDIOPREV study is supported by the Ministerio de Economia y Competitividad, Spain, under the grants AGL2012/39615, PIE14/00005, and PIE14/00031 associated to J.L.-M.; AGL2015-67896-P to J.L.-M. and A.C.; CP14/00114 to A.C.; PI19/00299 to A.C.; DTS19/00007 to A.C.; FIS PI13/00023 to J.D.-L., PI16/01777 to F.P.-J. and P.P.-M.; Antonio Camargo is supported by an ISCIII research contract (Programa Miguel-Servet CPII19/00007); Marina Mora-Ortiz has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 847468; ‘Fundacion Patrimonio Comunal Olivarero’, Junta de Andalucía (Consejería de Salud, Consejeria de Agricultura y Pesca, Consejería de Innovacion, Ciencia y Empresa), ‘Diputaciones de Jaen y Cordoba’, ‘Centro de Excelencia en Investigación sobre Aceite de Oliva y Salud’ and ‘Ministerio de Medio Ambiente, Medio Rural y Marino’, Gobierno de España; ‘Consejeria de Innovación, Ciencia y Empresa, Proyectos de Investigación de Excelencia’, Junta de Andalucía under the grant CVI-7450 obtaiend by J.L.-M.; and we would also like to thank the ‘Fondo Europeo de Desarrollo Regional (FEDER)’.S