MatrixDB, the extracellular matrix interaction database

MatrixDB (http://matrixdb.ibcp.fr) is a freely available database focused on interactions established by extracellular proteins and polysaccharides. Only few databases report protein–polysaccharide interactions and, to the best of our knowledge, there is no other database of extracellular interactions. MatrixDB takes into account the multimeric nature of several extracellular protein families for the curation of interactions, and reports interactions with individual polypeptide chains or with multimers, considered as permanent complexes, when appropriate. MatrixDB is a member of the International Molecular Exchange consortium (IMEx) and has adopted the PSI-MI standards for the curation and the exchange of interaction data. MatrixDB stores experimental data from our laboratory, data from literature curation, data imported from IMEx databases, and data from the Human Protein Reference Database. MatrixDB is focused on mammalian interactions, but aims to integrate interaction datasets of model organisms when available. MatrixDB provides direct links to databases recapitulating mutations in genes encoding extracellular proteins, to UniGene and to the Human Protein Atlas that shows expression and localization of proteins in a large variety of normal human tissues and cells. MatrixDB allows researchers to perform customized queries and to build tissue- and disease-specific interaction networks that can be visualized and analyzed with Cytoscape or Medusa

Atitudes parentais em relação à educação inclusiva Parental attitudes toward inclusive education

Com o objetivo de descrever as atitudes parentais em relação à inclusão escolar, 445 pais de alunos de primeira à quarta série do ensino fundamental de duas escolas municipais da cidade de São Paulo, responderam um questionário e uma escala de atitudes tipo Likert denominada Inventário Geral de Atitudes quanto à Educação Inclusiva (IGAEI). Participaram do estudo 169 (37,98%) pais de alunos com necessidades educacionais especiais em processo de inclusão (G1) e 276 (62,02%) progenitores de discentes que, de acordo com as instituições, não possuíam tal característica (G2). Os instrumentos foram aplicados coletivamente em reunião de pais e mestres com resposta individual. Os resultados obtidos revelam que ambos os grupos de pais tendiam a possuir atitudes favoráveis em relação à educação inclusiva. Porém, as atitudes dos pais de estudantes com necessidades educacionais especiais eram mais favoráveis à inclusão. São apresentados, ainda, resultados referentes a outras variáveis pesquisadas, como, por exemplo, tipos de necessidades educacionais em processo de inclusão. O estudo tende a corroborar resultados obtidos em pesquisas realizadas em outros países, ainda que algumas discrepâncias tenham sido percebidas. Conclui-se enfatizando a necessidade de mais pesquisas sobre o tema no contexto brasileiro e ressaltando a importância dos pais no desenvolvimento de sistemas educacionais inclusivos.<br>In order to describe parental attitudes toward school inclusion, 445 parents of elementary school students from first to fourth grade of two municipal schools of the city of São Paulo answered a questionnaire and the Likert scale General Inventory of Attitudes toward Inclusive Education (IGAEI) for assessing attitudes. The participants were 169 (37,98%) parents of students with special educational needs included in regular schools (G1) and 276 (62,02%) parents of students the school directors said did not have special needs (G2). The instruments were collectively applied during a parent teacher meeting using individual answer sheets. The results showed that both groups of parents tended to have positive attitudes in relation to inclusive education. However, parents of special educational needs students' attitudes were more positive. Results referring to other researched variables, i.e. types of special educational needs in inclusion process, are also presented. This study tends to corroborate research results from other countries, though some discrepancies have been perceived. In conclusion, this study highlights the importance of parental involvement in the development of inclusive educational systems and suggests that more research is required in the Brazilian educational context

Psychological profile and unexpected pain in oral lichen planus: A case–control multicenter SIPMO studya

Objectives: To analyze psychological profiles, pain, and oral symptoms in patients with oral lichen planus (OLP). Materials and methods: 300 patients with keratotic OLP (K-OLP; reticular, papular, plaque-like subtypes), 300 patients with predominant non-keratotic OLP (nK-OLP; erythematosus atrophic, erosive, ulcerative, bullous subtypes), and 300 controls were recruited in 15 universities. The number of oral sites involved and oral symptoms were recorded. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS) were administered. Results: The OLP patients, especially the nK-OLP, showed higher scores in the NRS, T-PRI, HAM-D, HAM-A and PSQI compared with the controls (p-value&nbsp;&lt;.001**). A positive correlation between the NRS, T-PRI, HAM-A, HAM-D, and PSQI was found with the number of oral symptoms and number of oral sites involved. Pain was reported in 67.3% of nK-OLP and 49.7% of K-OLP cases with poor correspondence between the site of lesions and the site of the symptoms. Conclusions: Mood disorders are frequently associated with OLP with an unexpected symptomatology correlated with the number of oral symptoms and with the extension of disease suggesting a peripheral neuropathy

Psychological profile and unexpected pain in oral lichen planus: A case\u2013control multicenter SIPMO studya

Objectives: To analyze psychological profiles, pain, and oral symptoms in patients with oral lichen planus (OLP). Materials and methods: 300 patients with keratotic OLP (K-OLP; reticular, papular, plaque-like subtypes), 300 patients with predominant non-keratotic OLP (nK-OLP; erythematosus atrophic, erosive, ulcerative, bullous subtypes), and 300 controls were recruited in 15 universities. The number of oral sites involved and oral symptoms were recorded. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS) were administered. Results: The OLP patients, especially the nK-OLP, showed higher scores in the NRS, T-PRI, HAM-D, HAM-A and PSQI compared with the controls (p-value&nbsp;&lt;.001**). A positive correlation between the NRS, T-PRI, HAM-A, HAM-D, and PSQI was found with the number of oral symptoms and number of oral sites involved. Pain was reported in 67.3% of nK-OLP and 49.7% of K-OLP cases with poor correspondence between the site of lesions and the site of the symptoms. Conclusions: Mood disorders are frequently associated with OLP with an unexpected symptomatology correlated with the number of oral symptoms and with the extension of disease suggesting a peripheral neuropathy