Comparison of antimüllerian hormone levels and antral follicle count as predictor of ovarian response to controlled ovarian stimulation in good-prognosis patients at individual fertility clinics in two multicenter trials

Objective To compare antimüllerian hormone (AMH) and antral follicle count (AFC) as predictors of ovarian response to controlled ovarian stimulation at individual fertility clinics. Design Retrospective analysis of individual study center data in two multicenter trials. Centers that provided >10 patients were included in the analysis. Setting A total of 19 (n = 519 patients) and 18 study centers (n = 686 patients) participating in a long GnRH agonist trial (MERIT) and a GnRH antagonist trial (MEGASET), respectively. Patient(s) Infertile women of good prognosis. Intervention(s) Long GnRH agonist or GnRH antagonist cycles. Main Outcome Measure(s) Correlation between AMH and AFC, and oocyte yield by each study center for each trial. Results(s) Antimüllerian hormone was more strongly correlated with oocyte yield than AFC: r = 0.56 vs. r = 0.28 in the GnRH agonist cohort, and r = 0.55 vs. r = 0.33 in the GnRH antagonist cohort. The correlation was numerically higher for AMH than for AFC at a significantly higher proportion of study centers: 17 (89%) and 15 (83%) centers in the long GnRH agonist and GnRH antagonist trial, respectively. Assessment of the relative capacity of AMH and AFC for predicting oocyte yield demonstrated that AMH dominated the model: AMH, R2 = 0.29 and 0.23; AFC: R2 = 0.07 and 0.07; AMH + AFC: R2 = 0.30 and 0.23 for long GnRH agonist and GnRH antagonist trials, respectively. Conclusions(s) Antimüllerian hormone was a stronger predictor of ovarian response to gonadotropin therapy than AFC at the study center level in both randomized trials utilizing GnRH agonist and GnRH antagonist protocols. Antral follicle count provided no added predictive value beyond AMH.</p

Estimating Tariff Equivalents of Nontariff Barriers

International Relations/Trade,

SMA and Spitzer Observations of Bok Glouble CB17: A Candidate First Hydrostatic Core?

We present high angular resolution SMA and Spitzer observations toward the Bok globule CB17. SMA 1.3mm dust continuum images reveal within CB17 two sources with an angular separation of about 21" (about 5250 AU at a distance of 250 pc). The northwestern continuum source, referred to as CB17 IRS, dominates the infrared emission in the Spitzer images, drives a bipolar outflow extending in the northwest-southeast direction, and is classified as a low luminosity Class0/I transition object (L_bol ~ 0.5 L_sun). The southeastern continuum source, referred to as CB17 MMS, has faint dust continuum emission in the SMA 1.3mm observations (about 6 sigma detection; ~3.8 mJy), but is not detected in the deep Spitzer infrared images at wavelengths from 3.6 to 70 micron. Its bolometric luminosity and temperature, estimated from its spectral energy distribution, are less than 0.04 L_sun and 16 K, respectively. The SMA CO(2-1) observations suggest that CB17 MMS may drive a low-velocity molecular outflow (about 2.5 km/s), extending in the east-west direction. Comparisons with prestellar cores and Class0 protostars suggest that CB17 MMS is more evolved than prestellar cores but less evolved than Class0 protostars. The observed characteristics of CB17 MMS are consistent with the theoretical predictions from radiative/magneto hydrodynamical simulations of a first hydrostatic core, but there is also the possibility that CB17 MMS is an extremely low luminosity protostar deeply embedded in an edge-on circumstellar disk. Further observations are needed to study the properties of CB17 MMS and to address more precisely its evolutionary stage.Comment: 33 pages, 11 figures, to be published by Ap

Peasant enterprise and processes of monetisation in highland Peru: the case of pucara

The main theme of the thesis can be summarised as an attempt to explore some classical theoretical statementsabout the so-called 'progressive' character of commercial activities in the Highlands of Peru, and on the other hand,to examine certain methodological issues arising from earlier investigations in the area (see Arguedas, 1957; AlersMontalvo,1967; Adams, 1959; Long and Roberts, 1974, and 1978). In order to explore these two dimensions, the analysis concentrates upon determining the functions of small-scale commercial activities in a rural context, relating them to the existing agrarian structure, patterns of income distribution, consumption and diversification of economic activities at community level, and more systematically to processes of distribution and exchange at regional and national levels. The study focuses upon the role of rural, non-agricultural activities, a persisting feature of the Peruvian economy, which has provided the basis for the development of small-scale, economically dynamic entreprise that has, on the one hand impeded proletarianisation in the rural sector, and yeton the other, increased socio-economic differentiation. To understand this apparently contradictory dynamic, the nature of subordinated groups within the structure of underdevelopment is examined. It is argued that one must not consider such groups merely as a target for manipulation by capitalist interests, which has been the tendency of some writers from both the modernisation and dependency schools. Indeed, these subordinated groups (consisting in the rural sector of small-scale agriculturalists and traders etc.) have throughout much of the history of Peru has been placed outside the principal lines of development strategy adopted by the State and external interests. A sounder interpretation rests, I believe, upon a systematic analysis of the economic and social functions of small-scale enterprise, which, given the weakness of Peruvian capitalism, assumes a complementary dynamic which in certain important ways counterbalances the penetration of the capitalist mode of production The co-existence and inter-penetration of various capitalist and non-capitalist relations in Peruvian society gives a 'flexibility' to social and economic processes: it is this flexibility that is studied in depth through the analysis of small-scale commercial activities. The argument is developed using detailed field data concerning the village of Pucara in the Mantaro region, concentrating on the importance of cash income for the functioning of the household economy, the role of non-agricultural occupations, and the part played by kinship and interpersonal networks in the process of social reproduction of the household unit

Assessing molecular outflows and turbulence in the protostellar cluster Serpens South

Molecular outflows driven by protostellar cluster members likely impact their surroundings and contribute to turbulence, affecting subsequent star formation. The very young Serpens South cluster consists of a particularly high density and fraction of protostars, yielding a relevant case study for protostellar outflows and their impact on the cluster environment. We combined CO $J=1-0$ observations of this region using the Combined Array for Research in Millimeter-wave Astronomy (CARMA) and the Institut de Radioastronomie Millim\'{e}trique (IRAM) 30 m single dish telescope. The combined map allows us to probe CO outflows within the central, most active region at size scales of 0.01 pc to 0.8 pc. We account for effects of line opacity and excitation temperature variations by incorporating $^{12}$CO and $^{13}$CO data for the $J=1-0$ and $J=3-2$ transitions (using Atacama Pathfinder Experiment and Caltech Submillimeter Observatory observations for the higher CO transitions), and we calculate mass, momentum, and energy of the molecular outflows in this region. The outflow mass loss rate, force, and luminosity, compared with diagnostics of turbulence and gravity, suggest that outflows drive a sufficient amount of energy to sustain turbulence, but not enough energy to substantially counter the gravitational potential energy and disrupt the clump. Further, we compare Serpens South with the slightly more evolved cluster NGC 1333, and we propose an empirical scenario for outflow-cluster interaction at different evolutionary stages.Comment: 26 pages, 15 figures, accepted for publication in the Astrophysical Journa

El Compromiso de enseñar química con criterios de sostenibilidad: la química verde

Los beneficios que aporta la química a la sociedad son muchos, sin embargo no goza de gran aceptación popular. La enseñanza de la química orientada a criterios de sostenibilidad podría mejorar su aceptación social y su interés. La química verde ha ido avanzando en las áreas de investigación y desarrollo. Su punto clave es que sin usar ni producir sustancias peligrosas, el riesgo es nulo y no es necesario el tratamiento de residuos. La mayoría de los procesos de síntesis desarrollados con criterios de sostenibilidad son demasiado complejos para la enseñanza no universitaria. Sin embargo, puede ser viable la introducción de conceptos asequibles a través la presentación de casos.Els beneficis que aporta la química a la societat són nombrosos, tot i així no té gaire acceptació popular. L’ensenyament de la química orientada a criteris de sostenibilitat podria millorar la seva acceptació social i el seu interès. La química verda ha anat avançant en les àrees de recerca i desenvolupament. El seu punt clau és que sense utilitzar ni produir substàncies perilloses el risc és nul i no es necessari el tractament de residus. La major part dels processos de síntesi desenvolupats amb criteris de sostenibilitat són massa complexes per a l’ensenyament no universitari. Tanmateix, pot ser viable la introducció de conceptes assequibles mitjançant la presentació de casos

The UN in the lab

We consider two alternatives to inaction for governments combating terrorism, which we term Defense and Prevention. Defense consists of investing in resources that reduce the impact of an attack, and generates a negative externality to other governments, making their countries a more attractive objective for terrorists. In contrast, Prevention, which consists of investing in resources that reduce the ability of the terrorist organization to mount an attack, creates a positive externality by reducing the overall threat of terrorism for all. This interaction is captured using a simple 3×3 “Nested Prisoner’s Dilemma” game, with a single Nash equilibrium where both countries choose Defense. Due to the structure of this interaction, countries can benefit from coordination of policy choices, and international institutions (such as the UN) can be utilized to facilitate coordination by implementing agreements to share the burden of Prevention. We introduce an institution that implements a burden-sharing policy for Prevention, and investigate experimentally whether subjects coordinate on a cooperative strategy more frequently under different levels of cost sharing. In all treatments, burden sharing leaves the Prisoner’s Dilemma structure and Nash equilibrium of the game unchanged. We compare three levels of burden sharing to a baseline in a between-subjects design, and find that burden sharing generates a non-linear effect on the choice of the efficient Prevention strategy and overall performance. Only an institution supporting a high level of mandatory burden sharing generates a significant improvement in the use of the Prevention strategy

Sharing the Burden of Collective Security in the European Union. Research Note

This article compares European Union (EU) burden-sharing in security governance distinguishing between assurance, prevention, protection, and compellence policies. We employ joint-product models and examine the variation in the level of publicness, the asymmetry of the distribution of costs and benefits, and aggregation technologies in each policy domain. Joint-product models predict equal burden sharing for protection and assurance because of their respective weakest-link and summation aggregation technologies with symmetric costs. Prevention is also characterized by the technology of summation, but asymmetry of costs implies uneven burden-sharing. Uneven burden-sharing is predicted for compellence because it has the largest asymmetry of costs and a best-shot aggregation technology. Evaluating burden-sharing relative to a country?s ability to contribute, Kendall tau-tests examine the rank-correlation between security burden and the capacity of EU member states. These tests show that the smaller EU members disproportionately shoulder the costs of assurance and protection; wealthier EU members carry a somewhat disproportionate burden in the provision of prevention, and larger EU members in the provision of compellence. When analyzing contributions relative to expected benefits, asymmetric marginal costs can largely explain uneven burden-sharing. The main conclusion is that the aggregated burden of collective security governance in the EU is shared quite evenly