Cálculo mental de primitivas e integración numérica

Los orígenes del Cálculo Integral se remontan a Eudoxo de Cnido (390-337) y Arquímedes (287- 212), pero el primero que definió el concepto de integral definida como el límite de sumas integrales y, por tanto, podían ser integrables funciones discontinuas fue Cauchy (1814). Con ello se disipó la creencia que consideraba que la integración era la operación inversa de la diferenciación. Desde entonces, una de las preocupaciones de los matemáticos ha sido la conceptualización para hacer más comprensible el concepto, por una parte, y la ampliación del conjunto de las funciones integrables, por otra. (Riemann, 1854, Darboux, 1875, Stieljes, 1894; Lebesgue, 1904, …)

Effect of Salmonella Typhimurium on the proteome of Pig Gut

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Antihypertensive Mechanism of Lactoferrin-Derived Peptides: Angiotensin Receptor Blocking Effect

Texto del artículo, no incluye figuras ni tablas.Looking for antihypertensive mechanisms beyond ACE inhibition, we assessed whether lactoferrin (LF)-derived peptides can act as receptor blockers to inhibit vasoconstriction induced by angiotensin II or endothelin-1. The lactoferricin B (LfcinB)-derived peptide LfcinB20–25 (RRWQWR), the low molecular weight LF hydrolysate (LFH < 3 kDa), and two peptides identified in LFH < 3 kDa (LIWKL and RPYL) were tested in ex vivo assays of vasoactive responses. The peptide RPYL was tested in radioligand receptor binding assays. Both LFH < 3 kDa and individual peptides inhibited angiotensin II-induced vasoconstriction. RPYL showed the highest ex vivo inhibitory effect and also inhibited binding of [125I]-(Sar1,Ile8)-angiotensin II to AT1 receptors. By contrast, neither LFH < 3 kDa nor RPYL inhibited endothelin-1 and depolarization-induced vasoconstrictions. In conclusion, LF-derived peptides selectively inhibit angiotensin II-induced vasoconstriction by blocking angiotensin AT1 receptors. Therefore, inhibition of angiotensin II-induced vasocontriction is suggested as a mechanism contributing along with ACE inhibition to the antihypertensive effect of some LF-derived peptides.This work was supported by Grants AGL2010-21009 from Ministerio de Educación y Ciencia – FEDER, Consolider Ingenio 2010, Fun-C-Food, CSD2007-00063, and network RETICS INVICTUS – RD12/0014/0004 from Instituto de Salud Carlos III. R. Fernández-Musoles is the recipient of a fellowship from Ministerio de Educación y Ciencia (BES-2008-004472).Peer reviewe

The Role of Women on Dairy Goat Farms in Southern Spain

One of the factors involved in goat milk production is the role of women as farmers. The aim of this study was to evaluate the role of women on dairy goat farms, considering: (1) the profile of women occupationally involved, (2) the organization of the women’s work, (3) the degree of involvement by women in the decision-making on these farms, and (4) the influence of women’s work on productive results. This study was conducted on 52 dairy goat farms in southern Spain. A descriptive analysis and means comparisons were performed to describe the farms where any women were involved or not. In 61.5% of the farms, at least one woman was involved, with an age of 42.2 ± 8.8 years. Very few women were farm owners, although women took binding decisions in 81.25% of these farms. Their work is dedicated to milking and caring for the kids. Women had a positive influence on the productive variables analysed, and for mastitis in herds, the incidence was lower in herds where women participated (p < 0.01). In conclusion, it is recommended to include women’s work as a factor when characterizing dairy goats farms’ systems to evaluate their positive effect on a farm’s performance

Estimation of photovoltaic potential for electricity self-sufficiency: A study case of military facilities in northwest Spain

Renewable energies, including photovoltaic energy, are attracting widespread international attention, in reaction to worsening environmental problems and the diminishing long-term sustainability of fossil fuel energies. In this work, the potential benefits of installing photovoltaic panels on several buildings at the Spanish Naval Military School (Escuela Naval Militar, ENM) of Mar ın are considered. The two salient advantages are significant economic savings from the production and the sale of electricity to the Spanish Electricity Network and achieving selfsufficiency in electricity requirements. Consequently, the main objective of this work is to estimate the energy potential of photovoltaic installations on the roofs of the ENM buildings. This is the first time that a project of this nature and size is presented to the Spanish Navy. To that end, a three-dimensional geographic analysis of the buildings is performed using three freeware software: Trimble SketchUp, Skelion, and Photovoltaic Geographical Information System. An economic study is also conducted to determine the feasibility of the installations, by estimating the Net Present Value of the photovoltaic installation and the Internal Rate of Return associated with the project. Subsequently, a sensitivity analysis that considers the most important parameters for the calculation of the amortization period is reported. The results show that the installation could fulfill the ENM electrical demands and could, in addition, generate significant economic benefits. The conclusions end with a recommendation to consider the merits of the proposed solution.Regional Government of Castilla y Le on (Ref. BU034U16), under European Regional Development Fund, and the Spanish Ministry of Economy, Industry and Competitiveness under the IþD þ i state programme Challenges for the Society (Ref. ENE-2014-54601-R). One of the authors, David Gonz alez Pe~na, thanks Junta de Castilla-Le on for economic support (PIRTU Program, ORDEN EDU/301/2015

Transcriptional analysis of porcine intestinal mucosa infected with Salmonella Typhimurium revealed a massive inflammatory response and disruption of bile acid absorption in ileum

Infected pork meat is an important source of non-typhoidal human salmonellosis. Understanding of molecular mechanisms involved in disease pathogenesis is important for the development of therapeutic and preventive strategies. Thus, hereby we study the transcriptional profiles along the porcine intestine during infection with Salmonella Typhimurium, as well as post-transcriptional gene modulation by microRNAs (miRNA). Sixteen piglets were orally challenged with S. Typhimurium. Samples from jejunum, ileum and colon, collected 1, 2 and 6 days post infection (dpi) were hybridized to mRNA and miRNA expression microarrays and analyzed. Jejunum showed a reduced transcriptional response indicating mild inflammation only at 2 dpi. In ileum inflammatory genes were overexpressed (e.g., IL-1B, IL-6, IL-8, IL1RAP, TNFα), indicating a strong immune response at all times of infection. Infection also down-regulated genes of the FXR pathway (e.g., NR1H4, FABP6, APOA1, SLC10A2), indicating disruption of the bile acid absorption in ileum. This result was confirmed by decreased high-density lipoprotein cholesterol in serum of infected pigs. Ileal inflammatory gene expression changes peaked at 2 dpi and tended to resolve at 6 dpi. Furthermore, miRNA analysis of ileum at 2 dpi revealed 62 miRNAs potentially regulating target genes involved in this inflammatory process (e.g., miR-374 and miR-451). In colon, genes involved in epithelial adherence, proliferation and cellular reorganization were down-regulated at 2 and 6 dpi. In summary, here we show the transcriptional changes occurring at the intestine at different time points of the infection, which are mainly related to inflammation and disruption of the bile acid metabolism. © 2016 Uribe et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated

Transcriptional analysis of porcine intestinal mucosa infected with Salmonella Typhimurium revealed a massive inflammatory response and disruption of bile acid absorption in ileum

© 2016 Uribe et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.[EN]Infected pork meat is an important source of non-typhoidal human salmonellosis. Understanding of molecular mechanisms involved in disease pathogenesis is important for the development of therapeutic and preventive strategies. Thus, hereby we study the transcriptional profiles along the porcine intestine during infection with Salmonella Typhimurium, as well as post-transcriptional gene modulation by microRNAs (miRNA). Sixteen piglets were orally challenged with S. Typhimurium. Samples from jejunum, ileum and colon, collected 1, 2 and 6 days post infection (dpi) were hybridized to mRNA and miRNA expression microarrays and analyzed. Jejunum showed a reduced transcriptional response indicating mild inflammation only at 2 dpi. In ileum inflammatory genes were overexpressed (e.g., IL-1B, IL-6, IL-8, IL1RAP, TNFα), indicating a strong immune response at all times of infection. Infection also down-regulated genes of the FXR pathway (e.g., NR1H4, FABP6, APOA1, SLC10A2), indicating disruption of the bile acid absorption in ileum. This result was confirmed by decreased high-density lipoprotein cholesterol in serum of infected pigs. Ileal inflammatory gene expression changes peaked at 2 dpi and tended to resolve at 6 dpi. Furthermore, miRNA analysis of ileum at 2 dpi revealed 62 miRNAs potentially regulating target genes involved in this inflammatory process (e.g., miR-374 and miR-451). In colon, genes involved in epithelial adherence, proliferation and cellular reorganization were down-regulated at 2 and 6 dpi. In summary, here we show the transcriptional changes occurring at the intestine at different time points of the infection, which are mainly related to inflammation and disruption of the bile acid metabolism.SIWe thank Erena Ruiz Mora, Juana Molina and Reyes Alvarez for their technical assistance, and Eloisa Andújar and Mónica Pérez from the Genomic Unit of CABIMER for their excellent array technical assistance. This work was supported by the Spanish Ministry of Economy and Competitiveness (AGL2011-28904 and AGL2014-54089-R). JHU is a predoctoral researcher supported by the FPI Research Program of the Spanish Ministry of Economy and Competitiveness (BES-2012-058642). SZL is a postdoctoral researcher supported by the Postdoctoral Trainee Program of the Spanish Ministry of Economy and Competitiveness (FPDI-2013-15619)

Kidney Function and Cardiovascular Events in Postmenopausal Women: The Impact of Race and Ethnicity in the Women’s Health Initiative

Kidney disease disproportionately affects minority populations including African Americans and Hispanics; therefore, understanding the relationship of kidney function to cardiovascular (CV) outcomes within different racial/ethnic groups is of considerable interest. We investigated the relationship between kidney function and CV events and assessed effect modification by race/ethnicity in the Women’s Health Initiative