La Albumina humana su utilización en diferentes patologías y su actual

 La albumina humana se viene utilizando desde 1945 en diferentes patologías y en los últimos años ha aumentado el número de patologías donde se usa este medicamento, los métodos de purificación a través de todos estos años se han venido mejorando y simplificando, lo que eleva su calidad y permite la reducción de los precios del medicamento. En la Universidad de Pamplona, se ha realizado el proceso completo, desde la simplificación del método de producción, sin pérdida de calidad, como la producción piloto de la albumina para análisis internacional de calidad. Los resultados obtenidos por métodos de alta fidelidad, demuestran una pureza superior al 99.98%, lo que eleva este producto de la Universidad de Pamplona a nivel internacional como un producto con capacidad competitiva en calidad y precio

Superpixel quality in microscopy images: the impact of noise & denoising

Microscopy is a valuable imaging tool in various biomedical research areas. Recent developments have made high resolution acquisition possible within a relatively short time. State-of-the-art imaging equipment such as serial block-face electron microscopes acquire gigabytes of data in a matter of hours. In order to make these amounts of data manageable, a more data-efficient representation is required. A popular approach for such data efficiency are superpixels which are designed to cluster homogeneous regions without crossing object boundaries. The use of superpixels as a pre-processing step has shown significant improvements in making computationally intensive computer vision analysis algorithms more tractable on large amounts of data. However, microscopy datasets in particular can be degraded by noise and most superpixel algorithms do not take this artifact into account. In this paper, we give a quantitative and qualitative comparison of superpixels generated on original and denoised images. We show that several advanced superpixel techniques are hampered by noise artifacts and require denoising and parameter tuning as a pre-processing step. The evaluation is performed on the Berkeley segmentation dataset as well as on fluorescence and scanning electron microscopy data

Fundamentos de redes y enrutamiento básico

A medida que transcurre el tiempo podemos observar que las redes informáticas se hacen cada día más necesarias en todos los ámbitos de nuestra cotidianidad. Esta es una de las mayores razones por lo cual el estudio de las redes de comunicación ha obtenido una gran importancia en las ultimas décadas, hasta el punto de existir grandes areas de investigación acerca de este tema en reconocidas universidades y la creación de empresas dedicadas únicamente al estudio de redes. ¿Pero qué nos permite hacer una red de comunicación? Una red de comunicación nos brinda la posibilidad de compartir con carácter universal la información entre grupos de computadoras y sus usuarios; un componente vital de la era de la información. La generalización de la computadora personal (PC) y de la red de área local (LAN) durante la década de los ochenta ha dado lugar a la posibilidad de acceder a información en bases de datos remotas, cargar aplicaciones desde puntos de ultramar, enviar mensajes a otros países y compartir archivos, todo ello desde un computador personal. Al realizar un estudio de las redes de comunicación hay que tener en cuenta que estas son un conjunto de técnicas, conexiones físicas y programas informáticos empleados para conectar dos o más computadoras. Los usuarios de una red pueden compartir ficheros, impresoras y otros recursos, enviar mensajes electrónicos y ejecutar programas en otros computadores. 1 Para conocer los objetivos de este trabajo, puede consultarlo en la carpeta PROPUESTA que aparece en el CD correspondiente a esta monografía.Incluye bibliografí

Mono and bimetallic Cu-Ni structured catalysts for the water gas shift reaction

The water-gas shift (WGS) reaction over structured Cu, Ni, and bimetallic Cu-Ni supported on active carbon (AC) catalysts was investigated. The structured catalysts were prepared in pellets form and applied in the medium range WGS reaction. A good activity in the 180-350 °C temperature range was registered being the bimetallic Cu-Ni:2-1/AC catalyst the best catalyst. The presence of Cu mitigates the methanation activity of Ni favoring the shift process. In addition the active carbon gasification reaction was not observed for the Cu-containing catalyst converting the active carbon in a very convenient support for the WGS reaction. The stability of the bimetallic Cu-Ni:2-1/AC catalyst under continuous operation conditions, as well as its tolerance towards start/stop cycles was also evaluated.Ministerio de Economía y Competitividad ENE2013-47880-C3-2-

On the equivalence between hierarchical segmentations and ultrametric watersheds

We study hierarchical segmentation in the framework of edge-weighted graphs. We define ultrametric watersheds as topological watersheds null on the minima. We prove that there exists a bijection between the set of ultrametric watersheds and the set of hierarchical segmentations. We end this paper by showing how to use the proposed framework in practice in the example of constrained connectivity; in particular it allows to compute such a hierarchy following a classical watershed-based morphological scheme, which provides an efficient algorithm to compute the whole hierarchy.Comment: 19 pages, double-colum

Supersymmetric mass spectra and the seesaw type-I scale

We calculate supersymmetric mass spectra with cMSSM boundary conditions and a type-I seesaw mechanism added to explain current neutrino data. Using published, estimated errors on SUSY mass observables for a combined LHC+ILC analysis, we perform a theoretical $\chi^2$ analysis to identify parameter regions where pure cMSSM and cMSSM plus seesaw type-I might be distinguishable with LHC+ILC data. The most important observables are determined to be the (left) smuon and selectron masses and the splitting between them, respectively. Splitting in the (left) smuon and selectrons is tiny in most of cMSSM parameter space, but can be quite sizeable for large values of the seesaw scale, $m_{SS}$. Thus, for very roughly $m_{SS} \ge 10^{14}$ GeV hints for type-I seesaw might appear in SUSY mass measurements. Since our numerical results depend sensitively on forecasted error bars, we discuss in some detail the accuracies, which need to be achieved, before a realistic analysis searching for signs of type-I seesaw in SUSY spectra can be carried out.Comment: 17 pages, 7 figure

On morphological hierarchical representations for image processing and spatial data clustering

Hierarchical data representations in the context of classi cation and data clustering were put forward during the fties. Recently, hierarchical image representations have gained renewed interest for segmentation purposes. In this paper, we briefly survey fundamental results on hierarchical clustering and then detail recent paradigms developed for the hierarchical representation of images in the framework of mathematical morphology: constrained connectivity and ultrametric watersheds. Constrained connectivity can be viewed as a way to constrain an initial hierarchy in such a way that a set of desired constraints are satis ed. The framework of ultrametric watersheds provides a generic scheme for computing any hierarchical connected clustering, in particular when such a hierarchy is constrained. The suitability of this framework for solving practical problems is illustrated with applications in remote sensing

Inherited Deletion of 1q, Hyperparathyroidism and Signs of Y-chromosomal Influence in a Patient with Turner Syndrome

We report a detailed phenotypic, cytogenetic and molecular characterization of a patient prenatally diagnosed with Turner syndrome (TS). In addition to having typical TS clinical characteristics including webbed neck, high arched palate and coarctation of the aorta, the patient had features less frequently seen in TS. These included recurrent parathyroid adenomas, growth along the 75th-90th centiles on the TS height curve despite minimal treatment with growth hormone, behavioral problems and evidence of gonadal dysgenesis with testicular-like structures, such as seminiferous tubules lined by Sertoli cells and a contiguous nodule of Leydig cells. While fluorescence in situ hybridization (FISH) failed to detect Y-chromosome material in gonadal tissue or blood samples, chromosomal microarray analysis (CMA) confirmed X monosomy and a 4.69 Mb copy number loss on 1q31.2q31.3 (bp 192,715,814 to 197,401,180). This region contains the CDC73 gene which has been associated with hyperparathyroidism-jaw tumor syndrome, features of which include recurrent, functional parathyroid adenomas and behavioral issues. This case illustrates how atypical features in a TS patient, such as robust growth and recurrent parathyroid adenomas, may suggest an underlying molecular etiology that should be explored by additional genetic diagnostic modalities. It is therefore appropriate in such cases to conduct further genetic testing, such as CMA and FISH, to explore other diagnostic possibilities and possibly prevent further complications