La eficiencia de la inversión e impacto en el desarrollo humano desde el proyecto de seguridad alimentaria realizado por el Ministerio de Economía Familiar Comunitaria Cooperativa y Asociativa (MEFCCA) en los Municipios de Sébaco y Darío en el segundo semestre del 2013

La presente investigación se realizó en los municipios de Sèbaco y Darío a los beneficiarios del proyecto de seguridad alimentaria aplicado en el 2010 por el ministerio de economía familiar, con el propósito de conocer la eficiencia de la inversión e impacto en el desarrollo humano de los beneficiarios, la información utilizada fue obtenida mediante instrumentos como encuestas realizadas a los beneficiarios, entrevistas a los técnicos del proyecto y al promotor del mismo, también se aplicaron grupos focales a los beneficiarios. La población de este estudio fue de 480 beneficiarios donde se obtuvo una muestra de 98 beneficiarios, los cuales fueron divididos en dos sub grupos de 49 cada uno. Los resultados muestran que la inversión en este proyecto no fue eficiente, no se entregaron los insumos en total o lo que contemplaba el proyecto, los instrumentos utilizados para la caracterización e identificación no fueron los adecuados, el proyecto no tuvo un impacto en el desarrollo humano de los beneficiarios, estos resultados fueron a causa del mal clima que se vivió en ese momento por el fenómeno del niño y en parte por la mala ejecución del proyecto, donde no se capacitó al personal para llevarlo a cabo. El modelo que utiliza el ministerio de economía familiar es el capital semilla, en este caso se les brindó financiamiento por medio de insumos para producir y se esperaba que con esto se creara un fondo revolvente para hacer un proyecto sostenibl

A Survey on Dietary Supplement Consumption in Amateur and Professional Rugby Players

Purpose: the aim of the present study was to analyse the pattern of dietary supplements (DS) consumption on federated rugby players, including the analysis of differences based on the sex and competitive level (professional vs. amateurs). Material and methods: 144 rugby players (83 male and 61 female), of whom 69 were professionals and 75 amateurs, were recruited for the study. All the participants filled out a specific questionnaire about DS consumption including questions related to the consumption of DS and their effects on sport performance and health status. Results: 65.3% of participants declared consuming at least one DS, with a higher prevalence in males than females (77.1% vs. 49.2%) and in professionals thanin amateur players (79.7% vs. 52.0%). The main reason for consumption was to enhance sport performance (62.3%) with differences only based on sex (74.3% males vs. 43.2% females). The most common purchase sites were the Internet (45.6%) and specialised stores (39.8%). As to the moment of ingestion, professionals did this most frequently during competition and training (56.4% vs. 28.2%), whereas amateur players did so only during competition (20.5% vs. 3.6%). Moreover, professional player intake most frequently in post-exercise (65.5% vs. 35.9%), whereas amateur during pre-exercise (30.8% vs. 5.5%). The DS most consumed included whey protein (44%), caffeine (42%), sports drinks (38%), energy bars (34%) and creatine monohydrate (31%), with a higher prevalence in male and professional players of whey protein and creatine monohydrate. Conclusions: The main reason for DS consumption is for enhancing sports performance). Professional players more frequently purchase them on the Internet and consume DS during training and competition period and in the post-exercise, whereas amateur players consume during competition and pre-exercise. Related to the main form of DS consumption, it is observed that a moderate consumption of DS could be considered ergogenic, such as whey protein, sport bar and creatine, while an absence of other DS could be considered ergogenic

Anthropometric Profile Assessed by Bioimpedance and Anthropometry Measures of Male and Female Rugby Players Competing in the Spanish National League

Different rugby positions make different demands on players. It therefore follows that optimum body composition may vary according to the position played. Using anthropometry and bioimpedance analysis (BIA) to assess body composition, the present study aimed to compare the effect of sex and position on body composition variables using anthropometry and BIA methods. A total of 100 competitive rugby players (35 women and 65 men) competing in the First Spanish National League were recruited voluntarily and for convenience for this study. In the laboratory, body composition was assessed by anthropometry, following the recommendations established by the International Society for the Advancement of Kinanthropometry (ISAK), and by direct segmental multi-frequency BIA, following the guidelines established by the Spanish Group of Kinanthropometry (GREC) of the Spanish Federation of Sports Medicine (FEMEDE). We found sex-related differences in height, weight, body mass index and body fat (%) by anthropometry and in body lean mass (%) by DSM-BIA, in 4 of the 6 skinfolds assessed (p < 0.05). We also observed position-related differences in all the variables assessed (p < 0.05) except for lean body mass, as measured by both methods of determining body composition, and front thigh skinfold. Body composition and ∑6skinfolds differs according to sex and playing position, backs (16.6 ± 3.8% and 92.3 ± 33.9 mm,) vs. forwards (20.0 ± 6.7 and 115.3 ± 37.6 mm), and the muscle-adipose (meso-endomorphic somatotype) development predominated in both sexes. Thus, forwards of both sexes are taller, heavier and fatter, possibly due to the specific demands of this position. In addition, body composition measurements vary according to the method used (DSM-BIA vs. anthropometry), indicating that anthropometry is probably the best body composition assessment method

Propiedades psicométricas del Test de Habilidades para la Vida en una muestra de jóvenes mexicanos

The aim of the present study was the adaptation and evaluation of the psychometric properties of the life skills test in young Mexicans. Sample, 275 young students of upper secondary education and undergraduate degree, 43.6% of the Centro Universitario del Sur, 37.8% Centro Universitario de los Valles, and 18.5% of upper secondary education of the University of Guadalajara of the state of Jalisco, México. The 30.5 males and 69.5% women, the range between 16 and 29 years, ME 20 and 2.39. As for the occupation, 90.9% referred to be a student, 8.7% studied and worked and. 4% studied and home. Instrument: Life skills Test. Results. They demonstrate that the life skills test has adequate psychometric properties in this population, so it is an appropriate instrument to measure life skills in young Mexicans.El objetivo de este trabajo fue la adaptación y evaluación de las propiedades psicométricas de la prueba de habilidades para la vida en jóvenes mexicanos. Muestra, 275 jóvenes estudiantes de educación media superior y licenciatura (pregrado), 43.6% del Centro Universitario del Sur, 37.8% del Centro Universitario Valles y 18.5% de Educación Media Superior de la Universidad de Guadalajara del Estado de Jalisco, México. El 30.5 varones y el 69.5% mujeres, el rango de entre 16 y 29 años, ME 20 y DE 2.39. En cuanto a la ocupación, el 90.9% refirió ser estudiante, el 8.7% estudiaba y trabajaba y el .4% estudiaba y se dedicaba al hogar. Instrumento: Test de Habilidades para la Vida. Resultados. Demuestran que el test de habilidades para la vida tiene adecuadas propiedades psicométricas en esta población, por lo que resulta ser un instrumento adecuado para medir las habilidades para la vida en jóvenes mexicano

Deciphering the record of hyaenic activity in the Early Pleistocene site of Fuente Nueva-3 (Baza Basin, SE Spain)

FN3 is an open air site, dated ~1.4 Ma. Their archaeological levels preserve evidences of human presence, consisting in lithic artefacts and cuts and percussion marks on bones. The lithic remains are associated with abundant macromammals bones with a very wide size range, from proboscideans to small mustelids. Carnivores are represented, mainly, by isolated teeth, bellowing to canids, ursids, felids and hyaenids, and their activity is recorded by the presence of different tooth marks types. However, there exists an important difference in the carnivore record between the levels, consisting in the presence of more than 200 coprolites in the Upper Level, whereas in the Lower Level these elements are practically absent. For the identification of the defecating organism, different analyses have been performed. The morphological study evidences the presence of the seven shape-types of pellets, although the most common morphologies are round, oval and disk. The colour of hyena faeces is also very characteristic, colour analysis of FN3 coprolites shows a predominance of whitish and very pale brown tonalities. To determine the composition, the samples were studied by XRD, XRF and SEM. The results have revealed that the coprolites mostly consist of calcium phosphate. These data are consistent with the expected composition of faeces in an organism that ingests a large amount of bones, in addition, macroscopic observation of the coprolites surface evidence the presence of numerous fragments of digested bones within them. All these features allow us to adscribe the FN3 coprolites to the hyaena Pachycrocuta brevirostris, species of which several teeth have been found at this site.This record manifests a great difference between both archaeological levels, showing in the Upper Level a scenario were hominin and hyaenids coexisted and competed for food resources, whereas in the Lower Level hyaenas were practically absent, and the main modifying agent was early Homo.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Sharing food with hyenas: a latrine of Pachycrocuta brevirostris in the Early Pleistocene assemblage of Fuente Nueva-3 (Orce, Baza Basin, SE Spain)

The Early Pleistocene archeological site of Fuente Nueva-3 (FN3) preserves some of the oldest evidence of hominin presence in Western Europe, including a huge assemblage of Oldowan tools and evidence of butchering and marrow processing of large mammal bones. Moreover, there is also evidence of the regular presence of carnivores at the site, including a small proportion of bones that show tooth marks, the majority of which can be attributed to the giant, short-faced hyena Pachycrocuta brevirostris, and there are 220 coprolites, most of them from the Upper Archeological Level. In order to identify the defecating agent, we analyze here the coprolites and compare them with other specimens from the literature and with scats from zoo spotted hyenas (Crocuta crocuta). The morphology, color, size, and chemical composition of the FN3 coprolites allow us to attribute them to the hyena P. brevirostris, which is also represented at the site by fossil specimens. In addition, we evaluate the origin of the accumulation of coprolites and discuss on the role played by the scavenging hyenas in the accumulation and modification of the bone remains unearthed at the site, which allows evaluating the contribution of the giant hyena to this Early Pleistocene site. Finally, based on the lithology of layer 5 of the Upper Archeological Level, fine sands and clays deposited in a salt-lake environment, we hypothesize that this layer may have acted as a quicksand where large-sized animals like elephants were trapped and their carcasses lured scavenging carnivores.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEJunta de AndalucíaGeneralitat de CatalunyaMinisterio de Ciencia e InnovaciónComunidad de Madridpu

A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy.

Metabolic adaptation is considered an emerging hallmark of cancer, whereby cancer cells exhibit high rates of glucose consumption with consequent lactate production. To ensure rapid efflux of lactate, most cancer cells express high levels of monocarboxylate transporters (MCTs), which therefore may constitute suitable therapeutic targets. The impact of MCT inhibition, along with the clinical impact of altered cellular metabolism during prostate cancer (PCa) initiation and progression, has not been described. Using a large cohort of human prostate tissues of different grades, in silico data, in vitro and ex vivo studies, we demonstrate the metabolic heterogeneity of PCa and its clinical relevance. We show an increased glycolytic phenotype in advanced stages of PCa and its correlation with poor prognosis. Finally, we present evidence supporting MCTs as suitable targets in PCa, affecting not only cancer cell proliferation and survival but also the expression of a number of hypoxia-inducible factor target genes associated with poor prognosis. Herein, we suggest that patients with highly glycolytic tumours have poorer outcome, supporting the notion of targeting glycolytic tumour cells in prostate cancer through the use of MCT inhibitors.Pertega-Gomes N. and Sousa S. received fellowships from the Portuguese Foundation for Science and Technology (FCT), refs. SFRH/BD/61027/2009, and PTDC/SAU-MET/113415/2009, respectively. Felisbino S. received a fellowship from the Sao Paulo Research Foundation (FAPESP) ref. 2013/08830-2 and 2013/06802-1. We thank the core facilities at the Cancer Research UK Cambridge Institute led by James Hadfield (Genomics), Matt Eldridge (Bioinformatics) and Allen Hazelhurst (BRU). We also thank the support and critical advice on the project given by Christian Frezza and Marco Sciacovelli from The MRC Cancer Cell Unit and Professor Rui Henrique from Portuguese Institute of Oncology for providing samples from patients with metastatic prostate cancer.This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1002/path.454

Identification of potential therapeutic targets in prostate cancer through a cross-species approach.

Genetically engineered mouse models of cancer can be used to filter genome-wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development and progression. In this study, we have generated RNAseq data from tumours arising in two established mouse models of prostate cancer, PB-Cre/PtenloxP/loxP and p53loxP/loxPRbloxP/loxP, and integrated this with published human prostate cancer expression data to pinpoint cancer-associated gene expression changes that are conserved between the two species. To identify potential therapeutic targets, we then filtered this information for genes that are either known or predicted to be druggable. Using this approach, we revealed a functional role for the kinase MELK as a driver and potential therapeutic target in prostate cancer. We found that MELK expression was required for cell survival, affected the expression of genes associated with prostate cancer progression and was associated with biochemical recurrence

The karst site of Las Palomas (Guadalteba County, Málaga, Spain): A preliminary study of its MiddleeLate Pleistocene archaeopaleontological record

Cleaning works in the cave of Las Palomas in Teba (Málaga, Spain), developed by the Guadalteba Consortium, have provided a number of lithic tools and knapping products that may be ascribed to the Mode III technotypological tradition as well as remains of a number of large mammal species typical of MiddleeLate Pleistocene times. Topographic measurements help to place this ancient cave within a karst landform. This discovery opens up new perspectives in the research on the Neanderthal groups that inhabited the valleys of Guadalteba and Turón rivers in the middle basin of the Guadalhorce River, and thus in the southern region of the Iberian Peninsula