Técnicas de encaminamiento en redes ad-hoc basadas en criterios de potencia y batería

Las redes ad hoc están formadas únicamente por terminales móviles que funcionan a partir de baterías, es decir, no hay estaciones base. El consumo de energía es, por lo tanto, un punto muy importante ala hora de diseñar la red. Paramax.imizar el tiempo de vida de una red ad hoc, el consumo de energía tiene que ser distribuido de forma equitati va entre el conjunto de nodos que la forman, y a la vez ha de rIÚnirnizarse el consumo total de energía para cada transmisión. Los algoritmosdeencarninarniento clásicos para ad hoc no tienen en cuenta la energía y por tanto no consiguen maximizar el tiempo de vida de la red. En este artículo se hace un estudio del estado del arte en métricas de encaminamiento que tengan en cuenta la batería al seleccionar las rutas y se proponen nuevas métricas al respecto. Dichas métricas se comparan mediante simulación intentando llegar a un compromiso entre parámetros como el tiempo de vida de la red y la calidad de servicio, entre otros.Peer Reviewe

Técnicas de encaminamiento en redes ad-hoc basadas en criterios de potencia y batería

Las redes ad hoc están formadas únicamente por terminales móviles que funcionan a partir de baterías, es decir, no hay estaciones base. El consumo de energía es, por lo tanto, un punto muy importante ala hora de diseñar la red. Paramax.imizar el tiempo de vida de una red ad hoc, el consumo de energía tiene que ser distribuido de forma equitati va entre el conjunto de nodos que la forman, y a la vez ha de rIÚnirnizarse el consumo total de energía para cada transmisión. Los algoritmosdeencarninarniento clásicos para ad hoc no tienen en cuenta la energía y por tanto no consiguen maximizar el tiempo de vida de la red. En este artículo se hace un estudio del estado del arte en métricas de encaminamiento que tengan en cuenta la batería al seleccionar las rutas y se proponen nuevas métricas al respecto. Dichas métricas se comparan mediante simulación intentando llegar a un compromiso entre parámetros como el tiempo de vida de la red y la calidad de servicio, entre otros.Peer Reviewe

Valoración pronóstica de las complicaciones vasculares en el trasplante renal mediante el uso de ecopotenciadores

El estudio en el trasplante renal abarco una serie de diferentes técnias o exploraciones, desde un análisis morfoestructural del injerto mediante ecografía, hasta la valoración funcional con el uso de métodos diagnósticos no radiológicos. El paciente trasplantado era sometido a una cadena de técnicas diagnosticas, realizadas en las primeras 24 horas posttrasplante. Las técnicas radiológicas empleadas fueron la ecografía Modo B, Doppler Color-Espectral y la Ecografía con contraste ecográfico. El posterior análisis mediante las Curvas de captación, obtenidas a su vez del postprocesado del estudio con ecografía con contraste, ayuda a determinar si la presencia de patologia vascular aguda, incluyendo trombosis vasculares (arteriales y/o venosas), Infartos o isquenias corticales y Necrosis Vasomotora o Necrosis tubular aguda. Estas entidades se compararon y se analizaron en relación con otras variables (antropometricas, factores de riesgo, otras modalidades ecográficas y renograma nuclear).Departamento de Biología Celular,Histología y Farmacologí

Internal Carotid Artery Reconstruction with a “Mega Flow Diverter”: First Experience with the 6×50 mm DERIVO Embolization Device

Endoluminal reconstruction with a flow diverter device has emerged as a viable and often preferable alternative to traditional techniques for the treatment of intracranial aneurysms. Precise measurement and device selection are mandatory steps when considering flow diverters usage in order to avoid potential complications. In this sense, incomplete wall-apposition has been described as a predictive factor for immediate in-stent and delayed thrombosis after stent use. One significant usage limitation of flow diverter devices is the parent artery diameter, since the maximum opening of the sizes available are recommended for vessel diameters between 5.2–5.75 mm. Here we present the first clinical use of the largest flow diverter available, the 6×50 mm DERIVO embolization device (Acandis GmbH & Co. KG, Pforzheim, Germany), into the arterial circulation for a cervical internal carotid artery endovascular reconstruction. This is a new device for large or fusiform aneurysms requiring flow diversion, especially located in the vertebrobasilar system or extracranial segments

Tropane alkaloid distribution in Atropa baetica plants

8 pages, 2 figures, 1 table, 22 references. The authors are grateful to Dr. T. Saenz for kindly providing access to valuable cited references, Prof. S. Lavee for his comments on the manuscript, and Dr. A. Aparicio for providing the mature plant materialFifteen different tropane alkaloids and derivatives were identified by GC-MS in various plant organs of Atropa baetica. The main root and leaves displayed the largest number of tropane alkaloids, most of which were also present in lateral roots. In contrast, only five of these alkaloids appeared in stem tissue. Quantitative analysis by HPLC showed the presence of the two major tropane alkaloids, atropine and scopolamine, in all the samples studied. Atropine was more abundant, with the highest concentration in the main root (ca. 10.0 mg/g dry wt) followed by leaves (ca. 3.0 mg/g dry wt); scopolamine was present in highest concentration in the main root (0.6 mg/g dry wt) followed by leaves (0.4 mg/g dry wt). The lowest concentrations of these compounds were detected in stem tissue, followed by the lateral roots. The main root constitutes the major tropane alkaloid storage site; moreover, the distribution of these compounds does not appear to be organ dependent. These latter two characteristics are in contrast to closely related Atropa genera.This research was funded by the Ministry of Education of the Spanish government (C.I.C.Y.C.) project no. AMB94-1372.Peer reviewe

The Roman Necropolis of Carmona, Spain: 10 years of research

The first tomb of a Roman Necropolis in the area of Carmona (Seville, Spain) was accidentally discovered in 1830. Few more tombs were exhumed between 1868 and 1869. These tombs were plundered until the beginning of the archaeological excavations in 1882. This necropolis, located in the town of Carmona, represents one of the most significant Roman burial sites in Southern Spain, and was in use during the 1st and 2nd centuries AD. Initially, the necropolis was used as quarry from which stone blocks were extracted and used for building construction. The quarry was then abandoned and reused as necropolis due to the workability of the rock. The Necropolis has suffered numerous and extensive interventions since its discovery. The first one was the adaptation of the necropolis for visits in 1885, including the construction of a trail, design of gardens around the tombs and plantation of trees. Nowadays, the gardens are considered one of the most deteriorating factors affecting the conservation of the tombs due to irrigation and consequent percolation of water inside the tombs, in addition to the damage caused by roots. Taking into account the cultural, artistic and religious importance of the Necropolis of Carmona, its preservation and conservation are a major issue, both from cultural and economic points of view. This importance emphasizes the need to define accurate and sustainable intervention protocols based on a deep understanding of the environmental and/or anthropogenic-induced deterioration processes. The design of effective preservation and/or conservation strategies should be based on exhaustive in situ surveys and laboratory investigations. Here we review 10 years of research in the Necropolis and we focus on the Circular mausoleum, as a case study, including an assessment of its conservation state, and the identification of the main deteriorating agents. In addition, an intervention proposal for the preservation of the Circular Mausoleum was presented.Peer Reviewe

Next-Generation DNA Sequencing-Based Gene Panel for Diagnosis and Genetic Risk Stratification in Onco-Hematology.

A suitable diagnostic classification of myeloid neoplasms and acute leukemias requires testing for a large number of molecular biomarkers. Next-generation sequencing is a technology able to integrate identification of the vast majority of them in a single test. This manuscript includes the design, analytical validation and clinical feasibility evaluation of a molecular diagnostic kit for onco-hematological diseases. It is based on sequencing of the coding regions of 76 genes (seeking single-nucleotide variants, small insertions or deletions and CNVs), as well as the search for fusions in 27 target genes. The kit has also been designed to detect large CNVs throughout the genome by including specific probes and employing a custom bioinformatics approach. The analytical and clinical feasibility validation of the Haematology OncoKitDx panel has been carried out from the sequencing of 170 patient samples from 6 hospitals (in addition to the use of commercial reference samples). The analytical validation showed sensitivity and specificity close to 100% for all the parameters evaluated, with a detection limit of 2% for SNVs and SVs, and 20% for CNVs. Clinically relevant mutations were detected in 94% of all patients. An analysis of the correlation between the genetic risk classification of AML (according to ELN 2017) established by the hospitals and that obtained by the Haematology OncoKitDx panel showed an almost perfect correlation (K = 0.94). Among the AML samples with a molecular diagnosis, established by the centers according to the WHO, the Haematology OncoKitDx analysis showed the same result in 97% of them. The panel was able to adequately differentiate between MPN subtypes and also detected alterations that modified the diagnosis (FIP1L1-PDGFRA). Likewise, the cytogenetic risk derived from the CNV plot generated by the NGS panel correlated substantially with the results of the conventional karyotype (K = 0.71) among MDS samples. In addition, the panel detected the main biomarkers of prognostic value among patients with ALL. This validated solution enables a reliable analysis of a large number of molecular biomarkers from a DNA sample in a single assay

La portada del Palacio de Pedro I. Investigación y restauración

43 páginas, 63 figuras, 13 referencias.Sin duda el elemento más representativo de todo el conjunto del Alcázar de Sevilla se la fachada construida por Pedro I para su palacio. Se trata de una pieza emblemática dentro de la arquitectura hispana y seguramente por ello sea la más admirada y reproducida en imágenes de todo el Alcázar. Dentro de la planificación general de conservación que lleva adelante el Patronato del Real Alcázar, se encomendó a la Escuela de Estudios Árabes del Consejo superior de Investigaciones Científicas (CSIC) analizar el estado de conservación de este importante elemento del conjunto y proponer las acciones a desarrollar. con este motivo se planteó un programa de actuaciones en distintas fases con el fin de lograr el objetivo propuesto de garantizar su conservación futura en las mejores condiciones posibles. concluidas las fases de estudios previos y la primera fase de restauración que ha afectado al cuerpo central de la fachada, se presenta en este artículo un avance de los resultados obtenidos que esperamos tengan su desarrollo completo en una amplia monografía cuando todo el proceso haya llegado a su fin.Peer reviewe