Evolution of the formal quality indicators of the web spaces of university libraries in Spain

The need to measure and assess the electronic information made available by the Web has given rise to the development of indicators that can be used to evaluate the final quality of this information. Web spaces of the informational units, which include virtual university libraries, are prime candidates for such a process of assessment. The present study has a look at the quality of the informational services supplied by virtual university libraries in Spain, adopting as the variable of analysis the evolution that certain quality indicators of a formal character have exhibited over an exemplary period of six months. The interpretation of our results makes manifest an overall satisfactory evolution, though the breakdown by regions or Autonomous Communities of Spain reveals deficiencies in some cases

El candidato: factor clave del intercambio político

El presente trabajo analiza la importancia de los distintos componentes del producto político en el proceso de intercambio electoral, centrándonos en el ámbito de la política municipal. Se demuestra que el candidato es el principal exponente de una opción política. Consideración que es refrendada por los propios actores de la política municipal. Dicha preponderancia de este elemento del intercambio político nos empuja a analizar longitudinalmente el perfil sociodemográfico a lo largo de los siete mandatos electorales. Analizamos las variables básicas explicativas del perfil sociodemográfico que puedan tener una influencia sobre la actitud de los políticos.The present paper analyses the importance of the different components from the political product in the process of electoral interchange, focusing on the scope of the municipal policy. It is demonstrated that the candidate is the main component of a political option. The players of the municipal policy authenticate the consideration. The superiority of this element of the political interchange pushes us to longitudinally analyse the socio-demographic profile throughout seven electoral mandates. We analysed the explanatory basic variables of the socio-demographic profile that can have an influence on the attitude of the politicians

Digital control implementation to reduce the cost and improve the performance of the control stage of an industrial switch-mode power supply

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. D. A. Díez, O. M. García, J. A. Oliver, P. Alou, F. Moreno, B. Duret, J. A. Cobos, F. V. Canales, and A. de Castro, "Digital control implementation to reduce the cost and improve the performance of the control stage of an industrial switch-mode power supply", in 2011 IEEE Energy Conversion Congress and Exposition (ECCE), Phoenix (AZ), 2011, pp. 2930 - 2935The main objective of this work is the design and implementation of the digital control stage of a 280W AC/DC industrial power supply in a single low-cost microcontroller to replace the analog control stage. The switch-mode power supply (SMPS) consists of a PFC boost converter with fixed frequency operation and a variable frequency LLC series resonant DC/DC converter. Input voltage range is 85VRMS-550VRMS and the output voltage range is 24V-28V. A digital controller is especially suitable for this kind of SMPS to implement its multiple functionalities and to keep the efficiency and the performance high over the wide range of input voltages. Additional advantages of the digital control are reliability and size. The optimized design and implementation of the digital control stage it is presented. Experimental results show the stable operation of the controlled system and an estimation of the cost reduction achieved with the digital control stage

Léxico, sintaxis y semántica de algunos transpositores complejos

Al pie del cañón representa una locución prototípica, pues en ella no se puede suprimir, agregar ni cambiar ningún componente, ni morfológico ni léxico: *pie de cañón, *a los pies del cañón, *en el pie de cañón, *a la pata del obús…, sin que pierda un valor léxico, ‘con constancia’, que no resulta de la reunión sintáctica de pie y cañón. En la flor de la vida tiene al menos dos variables: de la edad, de su vida. Así que el estatuto de las locuciones es cuestión de grado. En a flor de piel la locución se reduce a a flor ‘en la superficie’, persistente en a flor de agua, de tierra, de suelo, etc., ya que estos sintagmas no solo pueden intercambiarse, sino que cada uno complementa la locución con su valor léxico de sintagma libre

Digital Control Implementation to Reduce the Cost and Improve the Performance of the Control Stage of an Industrial Switched-Mode Power Supply

The main objective of this work is the design and implementation of the digital control stage of a 280W AC/DC industrial power supply in a single low-cost microcontroller to replace the analog control stage. The switch-mode power supply (SMPS) consists of a PFC boost converter with fixed frequency operation and a variable frequency LLC series resonant DC/DC converter. Input voltage range is 85VRMS-550VRMS and the output voltage range is 24V-28V. A digital controller is especially suitable for this kind of SMPS to implement its multiple functionalities and to keep the efficiency and the performance high over the wide range of input voltages. Additional advantages of the digital control are reliability and size. The optimized design and implementation of the digital control stage it is presented. Experimental results show the stable operation of the controlled system and an estimation of the cost reduction achieved with the digital control stage

Experimental assessment of different mixing air ventilation systems on ventilation performance and exposure to exhaled contaminants in hospital rooms

Producción CientíficaThis study evaluates the convenience of the use of four different mixing ventilation configurations in individual hospital rooms (IHR) based on ventilation performance and health workers (HW) exposure to the contaminants released by a confined patient (CP). Two supply configurations: grilles in the upper part of a wall (G) and swirl ceiling diffusers (S), combined with two different exhaust grilles positions in the opposite wall: upper part (U) and lower part (D) are tested using typical IHR set up. Occupants are represented by thermal breathing manikins, CP lies on a bed while HW stands close to it. Three air renewal rates are tested to determine their influence in the studied variables, 6, 9 and 12 ACH covering the whole range of ventilation requirements of such spaces. The experimental conditions considering the thermal comfort of the occupants are taken into account. Different ventilation configurations create different air distribution patterns inside the room. G configurations lead to high HW transient exposure values while S maintain low values that decrease when ACH is increased, so this second configuration is preferred for IHRs. Results are also compared with a displacement ventilation (DV) study highlighting the convenience of this strategy for IHRs. © 2018 Elsevier B.V.Ministerio de Economia y Competitividad , Secretaría de Estado de Investigación, Desarrollo e Innovación, Spain, to the National R&D project with reference DPI2014-55357-C2-2-R , entitled “Ventilation system influence on airborne transmission of human exhaled bioaerosols. Cross infection risk evaluation”. Cofinanced by the European Regional Development Fund (ERDF)

Papel de la tecnología en la educación científica: una dimensión olvidada

El actual movimiento en pro de una 'alfabetización tecnológica' ha venido a cuestionar algunos supuestos implícitos en la orientación de la educación científica que se traducen, de facto, en el olvido de la dimensión tecnológica. En este trabajo se analizan dichos supuestos y se extraen algunas implicaciones que representan un enriquecimiento de la educación científica con la incorporación de aspectos esenciales hasta aquí ignorados. Se pretende, así mismo, mostrar la existencia de una convergencia básica en torno a unas propuestas de enseñanza-aprendizaje de las ciencias que superen las estrategias basadas en la simple transmisión-recepción de conocimientos, subrayando la contribución de la dimensión tecnológica al desarrollo de dichas propuestas

Perspectivas actuales de las fuentes del Derecho

Presentación / Rafael de Asís Roig. - Fuentes del Derecho y comunidad civil / Dionisio Llamazares Fernández. - Las fuentes del derecho y su problemática actual / Antonio Enrique Pérez Luño. - Fuentes del Derecho y sociedad civil : la participación de ésta en la creación normativa, desde la perspectiva del ordenamiento jurídico internacional / Montserrat Abad Castelos. - La tutela de la libertad religiosa en la Unión Europea y su incidencia en el ordenamiento interno español / Adoración Castro Jover. - Sistema normativo de la Unión Europea (naturaleza de las fuentes) / Carlos Moreiro González. - La incidencia de la Unión Europea en el sistema interno de fuentes de los Estados miembros / Ana Garriga Domínguez. - Las fuentes del Derecho Islámico / Mario Losano. - Multiculturalidad, Derecho islámico y ordenamiento secular; los supuestos de la poligamia y el repudio / Agustín Motilla de la Calle. - Interculturalidad y fuentes del Derecho : algunas reflexiones desde el Derecho Internacional / Carlos Fernández Liesa . - La definitiva secularización de la legislación sobre la interrupción del embarazo en España / Daniel Capodiferro Cubero. - Interculturalidade e Fontes do Direito. - A ética da racionalidade do outro como princípio e critério objetivo na análise da interculturalidade e sua relação quanto à legitimação das fontes do direito / Artur César de Souza. - El papel de los nuevos movimientos sociales en la regulación jurídica de la globalización / Jose Antonio García Saez. - Relaciones entre ordenamientos jurídicos en el ámbito de la Unión Europea / Cristina Hermida del LLano. - La incidencia «interesada» de la Directiva 2003/86/CE en la última reforma de la Ley de extranjería española / Encarnación La Spina. - La lex mercatoria : una excepción a la legitimidad del orden jurídico-político moderno / Francisco López Ruiz. - Un paralelismo entre las teorías de los principios y la jurisprudencia de conceptos: la ruptura del puente entre las fuentes del Derecho y la sociedad civil / Luis Lloredo Alix. - La configuración de un derecho cultural sobre lo religioso como una propuesta para la plena integración de las personas de origen musulman residentes en Europa / Andrés Murcia González. - Sobre algunas concepciones de la jurisprudencia en la cultura jurídica norteamericana / Oscar Pérez de la Fuent

Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library

Redox homeostasis in trypanosomatids is based on the low-molecular-weight trypanothione, an essential dithiol molecule that is synthetized by trypanothione synthetase (TryS) and maintained in its reduced state by trypa- nothione disulfide reductase (TryR). The fact that both enzymes are indispensable for parasite survival and absent in the mammalian hosts makes them ideal drug targets against leishmaniasis. Although many efforts have been directed to developing TryR inhibitors, much less attention has been focused on TryS. The screening of an in-house library of 144 diverse molecules using two parallel biochemical assays allowed us to detect 13 inhibitors of L. infantum TryS. Compounds 1 and 3 were characterized as competitive inhibitors with Ki values in the low micromolar range and plausible binding modes for them were identified by automated ligand docking against refined protein structures obtained through computational simulation of an entire catalytic cycle. The proposed binding site for both inhibitors overlaps the polyamine site in the enzyme and, additionally, 1 also occupies part of the ATP site. Compound 4 behaves as a mixed hyperbolic inhibitor with a Ki of 0.8 μM. The activity of 5 is clearly dependent on the concentration of the polyamine substrate, but its kinetic behavior is clearly not compatible with a competitive mode of inhibition. Analysis of the activity of the six best inhibitors against intracellular amastigotes identified 5 as the most potent leishmanicidal candidate, with an EC50 value of 0.6 μM and a selectivity index of 35.This work has been supported by the Spanish MICINN (Projects PID2019-104070RB-C21 and PID2019-104070RBC22), the Spanish National Research Council (CSIC, Projects CSIC-PIE-201980E100 and CSIC-PIE-201980E028), and the Comunidad de Madrid (PLATESA2-CM ref S-2018/BAA-4370). The MCIN is also acknowledged for the pre- doctoral fellowship to M.A.C.Peer reviewe