Efectos de la asistencia, densidad de la misma y la capacidad del pabellón en las victorias conseguidas en casa en función de la conferencia en la NBA

Los equipos que juegan en casa ganan más del 50% de los partidos. El estudio de los efectos relacionados con el apoyo del público ha sido poco analizado. El objetivo de este trabajo fue identificar los efectos de la capacidad del pabellón, la asistencia a los partidos y la densidad de la misma en las victorias conseguidas en casa. Se analizaron los resultados por equipo de 7 temporadas de la NBA (N=210). Los datos fueron extraídos de la página web especializada Basketball-Reference.com. La asistencia media, la capacidad del pabellón y la densidad de la asistencia y su relación con el número de victorias en casa fueron analizadas. Se utilizó un análisis de regresión para analizar los efectos de estas variables en el número de victorias en casa. Los resultados muestran un efecto estadísticamente significativo de la asistencia media al pabellón en ambas conferencias, y de la capacidad del pabellón en la conferencia oeste. El tamaño del público ya se ha demostrado como uno de los predictores más potentes de las victorias en casa. El aumento de la asistencia al pabellón va a llevar a un aumento del rendimiento de equipo. Los clubes deben promover políticas que hagan más atractivo desplazarse al pabellón por parte de los aficionados, aumentando la asistencia y, por tanto, el número de victorias en casa

Entrenamiento perceptivo en la portera de balonmano ante la trayectoria del tiro

This study aimed to analyze the application of a perceptive-motor training program effect in the handball goalkeeper and value the efficacy according to the shot trajectories, differentiating the moments of its application, under conditions of real practice. Two female goalkeepers were selected deliberately. A quasi-experimental case design of type A-B-A was utilized. The trained specialist registered the data in real time individually and after, watching the games recorded, out agreed by consensus. For the statistical processing the t of Student test for independent measures was carried out, an averages meaning contrast test and an anova followed by the post hoc Tukey test. The application of the program allowed to improve the effectiveness in the shot interception for the trajectories analyzed except those of half height.Este estudio ha analizado el efecto de la aplicación de un programa de entrenamiento perceptivo-motor en la portera de balonmano y valorado su eficacia en función de las trayectorias de lanzamiento, diferenciando los momentos de su aplicación, bajo condiciones de práctica real. Se seleccionaron dos porteras de forma intencionada. Se utilizó un diseño cuasiexperimental de caso único tipo A-B-A. Los observadores entrenados registraron los datos a tiempo real de forma individual y a posteriori, visionando los vídeos grabados, de forma consensuada. Para el tratamiento estadístico se realizó la prueba t de Student para medidas independientes, una prueba de contraste de significación de medias y un anova seguido por la prueba post hoc de Tukey. La aplicación del programa permitió mejorar la efectividad en la interceptación de los lanzamientos para las trayectorias analizadas salvo los de media altura

¿Afecta la fase de juego al diseño de las tareas de un equipo de baloncesto de formación?

During the season, the main role of the coach is to design and plan the tasks that help achieve the objectives sequentially set. The aim of this study is to describe the existing differences between the tasks designed in function of the game phase. To do so, 388 tasks were collected during a season of a basketball team. This comparison is due to the fact that the coach performs the training under a comprehensive approach and chooses a wave model of work in which tasks are alternated with an aim of attack and defense. Finally, this study presents a critical and reliable analysis on the design and training plan with a global vision that shows the differences found in the tasks in function of the game phase.Durante la temporada, el papel principal del entrenador es el de diseñar y plantear las tareas que ayuden a conseguir los objetivos planteados de manera secuencial. El objetivo de este trabajo fue describir si existen diferencias entre las tareas que son diseñadas en función de la fase de juego. Para ello, se recogieron 388 tareas durante una temporada de un equipo de baloncesto. Esta comparativa se debe a que el entrenador, realiza los entrenamientos bajo enfoque comprensivo y elige un modelo ondulatorio del trabajo en el que se alternan tareas con finalidad de ataque y defensa. Finalmente, este trabajo presenta un análisis crítico y fiable sobre el diseño y el planteamiento de los entrenamientos con una visión global que recoge las diferencias encontradas en las tareas en función de la fase de juego

Treatment variability and its relationships to outcomes among patients with Wernicke's encephalopathy: A multicenter retrospective study

Background: Despite guidelines and recommendations, Wernicke's encephalopathy (WE) treatment lacks evidence, leading to clinical practice variability.Aims: Given the overall lack of information on thiamine use for WE treatment, we analyzed data from a large, well-characterized multicenter sample of patients with WE, examining thiamine dosages; factors associated with the use of different doses, frequencies, and routes; and the influence of differences in thiamine treatment on the outcome.Methods: This retrospective study was conducted with data from 443 patients from 21 centers obtained from a nationwide registry of the Spanish Society of Internal Medicine (from 2000 to 2012). Discharge codes and Caine criteria were applied for WE diagnosis, and treatment-related (thiamine dosage, frequency, and route of administration) demographic, clinical, and outcome variables were analyzed.Results: We found marked variability in WE treatment and a low rate of high-dose intravenous thiamine administration. Seventy-eight patients out of 373 (20.9%) received > 300 mg/day of thiamine as initial dose. Patients fulfilling the Caine criteria or presenting with the classic WE triad more frequently received parenteral treatment. Delayed diagnosis (after 24 h hospitalization), the fulfillment of more than two Caine criteria at diagnosis, mental status alterations, and folic acid deficiency were associated significantly with the lack of complete recovery. Malnutrition, reduced consciousness, folic acid deficiency, and the lack of timely thiamine treatment were risk factors for mortality.Conclusions: Our results clearly show extreme variability in thiamine dosages and routes used in the management of WE. Measures should be implemented to ensure adherence to current guidelines and to correct potential nutritional deficits in patients with alcohol use disorders or other risk factors for WE

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks : The GR@ACE project

Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. Results: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. Discussion: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele