Subacute nodopathy with conduction blocks and anti-neurofascin 140/186 antibodies: an ultrastructural study

International audienc

Implementation and comparison of two pharmacometric tools for model-based therapeutic drug monitoring and precision dosing of daptomycin

Daptomycin is a candidate for therapeutic drug monitoring (TDM). The objectives of this work were to implement and compare two pharmacometric tools for daptomycin TDM and precision dosing. A nonparametric population PK model developed from patients with bone and joint infection was implemented into the BestDose software. A published parametric model was imported into Tucuxi. We compared the performance of the two models in a validation dataset based on mean error (ME) and mean absolute percent error (MAPE) of individual predictions, estimated exposure and predicted doses necessary to achieve daptomycin efficacy and safety PK/PD targets. The BestDose model described the data very well in the learning dataset. In the validation dataset (94 patients, 264 concentrations), 21.3% of patients were underexposed (AUC24h 24.3 mg/L) on the first TDM occasion. The BestDose model performed slightly better than the model in Tucuxi (ME = −0.13 ± 5.16 vs. −1.90 ± 6.99 mg/L, p < 0.001), but overall results were in agreement between the two models. A significant proportion of patients exhibited underexposure or overexposure to daptomycin after the initial dosage, which supports TDM. The two models may be useful for model-informed precision dosing

Supratentorial clear cell ependymomas with branching capillaries demonstrate characteristic clinicopathological features and pathological activation of nuclear factor-kappaB signaling

International audienceClear cell ependymoma is one of the 4 main histological subtypes of ependymomas defined by the World Health Organization (WHO) classification of tumors of the CNS. DNA methylation profiling can distinguish 4 subgroups of intracranial ependymomas, including supratentorial (ST) ependymomas with Yes-associated protein 1 fusion (YAP1), ST ependymomas with fusion of v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), posterior fossa ependymomas with balanced genome, and posterior fossa ependymomas with chromosomal instability. In addition, trisomy 19 is a genomic hallmark of ependymomas with rich branching capillaries. However, the relation of histological and molecular subtypes is unclear

25 années d’archéologie royale (1990-2015)

Le colloque « 25 années d’archéologie royale, 1990-2015 » a été organisé pour faire le bilan des recherches menées dans les domaines de Versailles, Trianon et Marly au cours de ce quart de siècle, mais aussi des travaux récents réalisés dans les autres domaines royaux. Il a été l’occasion de mesurer l’extension chronologique de l’archéologie : désormais la période moderne fait résolument partie de son champ de compétence. L’archéologie des jardins, son corollaire, devenue une discipline scientifique à part entière, a été amplement évoquée. Enfin l’apport des sciences originellement étrangères à l’archéologie a été souligné : géologie, malacologie, parasitologie... La première intervention archéologique dans le domaine de Versailles a eu lieu en 1990, à l’occasion du lancement de la replantation du parc, après le passage de la tempête du 3 février. Cette replantation devant s’accompagner de la restitution des aménagements – souvent disparus – qu’avait conçus André Le Nôtre, l’investigation archéologique s’est imposée. Depuis 1990, ce sont près d’une douzaine d’opérations qui ont été conduites dans le domaine de Versailles, la plupart dans le parc. Quelques chantiers ont néanmoins été menés hors de cet espace, notamment dans les cours du château et du Grand Commun, et dans le domaine de Trianon Le rattachement, en 2009, du domaine de Marly à celui de Versailles a réuni sous une même administration les trois châteaux fondés par Louis XIV. Rasé peu de temps après la Révolution, il ne reste de Marly qu’un écrin vide, mais ce site magnifique renferme des richesses en sous-sol. Cependant, Versailles et ses satellites ne sont pas les seuls châteaux royaux à s’ouvrir à l’archéologie : les Tuileries, Vincennes, Saint-Germain, Fontainebleau et Chambord ont fait aussi l’objet de recherches, en archéologie médiévale d’abord (à Vincennes), puis, rapidement, cette recherche s’est étendue aux époques postérieures. Le parti a été pris de se limiter pour ce colloque à l’Époque moderne. Colloque organisé par le Centre de recherche du château de Versailles. Voir le programme complet. Responsable scientifique : Annick Heitzmann Partenaires : Établissement public du château, du musée et du domaine national de Versailles, DRAC Île-de-France et Service régional de l’archéologie, INRAP, Association Volutes, Musée-promenade de Marly-le-Roi Louveciennes. En partenariat avec le réseau Archéologia.be. Dix-sept communications au colloque sur vingt sont publiées ici, sous la direction d’Annick Heitzmann. Les autres sont consultables sous forme audio. The conference “25 Years of Royal Archaeology, 1990–2015” was organized to review not only the research undertaken in the domains of Versailles, Trianon and Marly over the last quarter century, but also recent work in other royal domains. It was the opportunity to measure the chronological extension of the archaeology: the modern period is now resolutely within its field of competence. The archaeology of the gardens, their corollaries, which has become a scientific discipline in its own right, was widely alluded to. Finally, the contribution of sciences originally foreign to archaeology has been emphasized: geology, malacology, parasitology, for example. The first archaeological intervention in the ​​Versailles domain took place in 1990, at the same time as the replanting of the park, after the storm of 3 February. As this replantation was to be accompanied by the restitution of the layouts – that had often disappeared – which André Le Nôtre had designed, archaeological investigation was essential. Since 1990 almost a dozen operations have been conducted in the ​​Versailles domain, most of them in the park. Some projects were undertaken at other sites, particularly in the courtyards of the château and the Grand Commun, and in the Trianon domain. The incorporation, in 2009, of the Marly domain with that of Versailles brought the three castles founded by Louis XIV together under one administration. Razed shortly after the Revolution, there is only one empty enclosure at Marly, but this magnificent site contains wealth below the ground. However Versailles and its satellites are not the only royal castles that have opened to archaeology: the Tuileries, Vincennes, Saint-Germain, Fontainebleau and Chambord have also been the subject of research, first in medieval archaeology (Vincennes) then the research rapidly extended to later periods. It was decided that this conference would confine itself to the modern era. Conference organized by the Centre de Recherche du château de Versailles. See the full programme. Research Director: Annick Heitzmann Partners: Public Establishment of the Palace, the Museum and the National Estate of Versailles, DRAC Île-de-France and Regional Services for Archaeology, INRAP, Association Volutes, Musée-Promenade de Marly-le-Roi Louveciennes. With the partnerhship of the Archéologia.be network. Seventeen of the twenty conference papers are published here, edited by Annick Heitzmann. The others are available in audio format

Representational scaffolding in digital simulations – learning professional practices in higher education

To advance the learning of professional practices in teacher education and medical education, this conceptual paper introduces the idea of representational scaffolding for digital simulations in higher education. We outline the ideas of core practices in two important fields of higher education, namely teacher and medical education. To facilitate future professionals’ learning of relevant practices, we emphasize the role of approximation of practice through the use of digital simulations, as they offer multiple options for selecting and adjusting representations of practice situations. Furthermore, we introduce the idea of representational scaffolding to adjust the demands of the learning task in simulations by selecting and modifying representations of practice to match relevant learner characteristics. Building on research on problem-solving and scientific reasoning, we identify leverage points for employing representational scaffolding. We suggest four sets of representational scaffolds that target relevant features of practice situations in simulations: informational complexity, typicality, required agency, and situation dynamics. Representational scaffolds might be implemented in a strategy for approximating practice that involves the media design, sequencing, and adaptation of representational scaffolding. The outlined conceptualization of representational scaffolding can systematize the design and adaptation of digital simulations in higher education and might contribute to the advancement of future professionals’ learning to further engage in professional practices. This conceptual paper offers a necessary foundation and terminology for approaching related future research. https://doi.org/10.1108/ILS-06-2022-007

Prognostic Relevance of Histomolecular Classification of Diffuse Adult High-Grade Gliomas with Necrosis

CERVOXY COLLInternational audienc

Archéologie et histoire des jeux de paume en France: De Versailles à la Marseillaise (XVI^e-XVIII^e siècle)

International audienceÀ l’origine, en Europe, de pratiquement tous les jeux impliquant une balle frappée ou lancée avec un instrument tenu à la main — plus de deux cents répertoriés à ce jour —, le jeu de paume a une longue histoire. Ni le terme ni la notion de « sport » n’existent aux époques médiévale et moderne, mais de nombreux jeux d’exercices sont pratiqués depuis bien longtemps. Un voyageur anglais, Sir Robert Dallington, estime en 1598 que le nombre de jeux de paume était en France deux fois supérieur à celui des églises ! Que reste-t-il de tant de lieux construits par les aristocrates ou aménagés dans les villages entre la fin du XVe siècle et celle du XVIIIe siècle ? Les auteurs de cet ouvrage répondent dans cette première synthèse jamais parue. Les informations issues des écrits, des archives, mais aussi de récits et de manuels, et les représentations graphiques, qu’il s’agisse de plans, de dessins ou de tableaux, sont enfin rendues concrètes grâce aux données issues de la dizaine de fouilles archéologiques menées depuis le milieu des années 2000. Ensemble, ces spécialistes racontent l’histoire de ce qui semble bien avoir été une passion française