Evidence of Springwater Acidification in the Vosges Mountains (North-East of France): Influence of Bedrock Buffering Capacity

Investigations on springwater acidity were carried out in the Vosges mountains (north-eastern France). Acid or poorly buffered spring and streamwaters were detected in the same area. The proportion of acid springwaters (pH < 5.6) is about 20% among 220 springs. The springwater pH on granite are equally spread between 5.0 and 6.8 whereas on sandstone a majority of springs is in the range 5.6 to 6.2. As a whole, but mainly on sandstone, from the 1960's to 1990's, the shape of the pH distributions shifts toward greater acidity. In the sandstone area, trends in pH, alkalinity, total hardness (corresponding to divalent cations), sulfate and nitrate were considered over the 30 yr period (1963-1996) in relation to the bedrock chemical composition. Kendall seasonal tau coefficients indicate that decreasing trends were significant for the first three parameters. Linear regression on the smoothed mean value revealed 18 and 90% decrease for pH and alkalinity respectively, for springwaters draining poor-base cation sandstone whereas only 8 and 30% decrease respectively, was observed on clay-enriched sandstone. On silica-enriched sandstone, alkalinity began to decrease in the early 70's as well as pH. Loss of alkalinity only occurred in the early 80's for springs draining clay enriched sandstone. This can be interpreted as a titration process by acid atmospheric inputs of the buffering capacity of weathering and exchange processes in the soils and the catchment bedrock. The nitrate presents an increasing step in the early seventies but possibly as a result of change in analytical technics and/or increase in atmospheric inputs mainly resulting from increase in fertiliser inputs in agricultural areas or in car traffic. Surprisingly no change in sulfate was noticed in any groups of springs probably as a result of the adsorption/mobilisation in the soils. These long-term trends in spring waters (1963-1996) confirmed the soil and streamwater acidification trends already mentioned in this region, in relation to acid atmospheric inputs since no climate nor forestry practice changes have been detected over the period. Moreover, in spite of acid atmospheric input reductions, no recovery can presently be detected

A stochastic filter for fluid motion tracking

In this paper we present a method for the tracking of fluid flows velocity fields. The technique we propose is formalized within sequential Bayesian filter framework. The filter we propose here combines an Itô diffusion process coming from a stochastic formulation of the vorticity-velocity form of Navier-Stokes equation and discrete measurements extracted from an image sequence. The resulting tracker provides robust and consistent estimations of instantaneous motion fields along the whole image sequence. In order to handle a state space of reasonable dimension for the s-tochastic filtering problem, we represent the motion field as a combination of adapted basis functions. The used basis functions ensue from a mollification of Biot-Savart integral and a discretization of the vorticity and divergence maps of the fluid vector field. The efficiency of the method is demonstrated on a long real world sequence showing a vortex launch at tip of airplane wing. 1

Reasoning, Learning, and Creativity: Frontal Lobe Function and Human Decision-Making

Computational modeling and behavioral experimentation suggest that human frontal lobe function is capable of monitoring three or four concurrent behavioral strategies in order to select the most suitable one during decision-making

Submerged membrane bioreactor for waste water treatment: determination of the shear stresses produced by coarse bubbles

Submerged membrane bioreactor for waste water treatment: determination of the shear stresses produced by coarse bubble

Blocking the receptor EP3 to PGE2 as a way to safely prevent atherothrombosis

Aspirin inhibits the platelet production of thromboxane A2 and its beneficial effect on myocardial infarction was demonstrated more than two decades ago. This result validated the strategy aimed at targeting platelet function to prevent myocardial infarction. Since then, numerous drugs targeting various activators of platelets have been developed to further improve prevention. However, the beneficial effect of all these drugs on atherothrombosis is limited by an increased risk of bleeding, because they target thrombosis effectors which are also key players in hemostasis. Since aspirin blocks the generation of numerous prostanoids, including inhibitors of platelet activation, targeting one of them might allow the antithrombotic activity to be maintained without promoting bleeding. In examining the roles of various arachidonic acid metabolites on atherothrombosis, we studied the prostaglandin E2 (PGE2). In vivo, PGE2 facilitates the responses of platelets to all their various activators through its receptor EP3. PGE2 is produced in relatively high amounts in the context of chronic inflammation such as atherosclerosis, and aggravates murine atherothrombosis. Conversely, PGE2 is not involved in hemostasis. As expected, blocking EP3 strikingly reduced atherothrombosis in mice without impacting bleeding tests. In a recent paper published in Prostaglandins &amp; Other Lipid Mediators, we reviewed literature data about the effect of PGE2 and its receptor EP3 on platelet thrombosis and hemostasis in mice and humans. We concluded that cumulated data now justifies validating the role of EP3 blockers with phase III trials to safely improve the prevention of myocardial infarction

Evidence for different binding sites on the 33-kDa protein for DCMU, atrazine and QB

AbstractTwo DCMU-resistant strains of the cyanobacterium Synechocystis 6714 were used to analyse the binding sites of DCMU, atrazine and QB. DCMUr-IIA was DCMU and atrazine resistant; it presented an impaired electron flow and its 33-kDa protein was weakly attached to the membrane. DCMUr-IIB, derived from the former, simultaneously regained atrazine sensitivity, normal electron flow and a tight linkage of the 33-kDa protein to the membrane. This mutant shows that loss of DCMU binding does not necessarily affect the binding of either atrazine or QB. The role of the 33-kDa protein is discussed

Peer to peer multidimensional overlays: Approximating complex structures

Peer to peer overlay networks have proven to be a good support for storing and retrieving data in a fully decentralized way. A sound approach is to structure them in such a way that they reflect the structure of the application. Peers represent objects of the application so that neighbours in the peer to peer network are objects having similar characteristics from the application's point of view. Such structured peer to peer overlay networks provide a natural support for range queries. While some complex structures such as a Voronoï tessellation, where each peer is associated to a cell in the space, are clearly relevant to structure the objects, the associated cost to compute and maintain these structures is usually extremely high for dimensions larger than 2. We argue that an approximation of a complex structure is enough to provide a native support of range queries. This stems fromthe fact that neighbours are importantwhile the exact space partitioning associated to a given peer is not as crucial. In this paper we present the design, analysis and evaluation of RayNet, a loosely structured Voronoï-based overlay network. RayNet organizes peers in an approximation of a Voronoï tessellation in a fully decentralized way. It relies on a Monte-Carlo algorithm to estimate the size of a cell and on an epidemic protocol to discover neighbours. In order to ensure efficient (polylogarithmic) routing, RayNet is inspired from the Kleinberg's small world model where each peer gets connected to close neighbours (its approximate Voronoï neighbours in Raynet) and shortcuts, long range neighbours, implemented using an existing Kleinberg-like peer sampling

Claudin 1 in Breast Tumorigenesis: Revelation of a Possible Novel “Claudin High” Subset of Breast Cancers

Claudins are the major component of the tight junctions in epithelial cells and as such play a key role in the polarized location of ion channels, receptors, and enzymes to the different membrane domains. In that regard, claudins are necessary for the harmonious development of a functional epithelium. Moreover, defective tight junctions have been associated with the development of neoplastic phenotype in epithelial cells. Breakdown of cell-cell interactions and deregulation of the expression of junctional proteins are therefore believed to be key steps in invasion and metastasis. Several studies suggest that the claudins are major participants in breast tumorigenesis. In this paper, we discuss recent advances in our understanding of the potential role of claudin 1 in breast cancer. We also discuss the significance of a subset of estrogen receptor negative breast cancers which express “high” levels of the claudin 1 protein. We propose that claudin 1 functions both as a tumor suppressor as well as a tumor enhancer/facilitator in breast cancer