Fault-controlled and stratabound Dolostones in the Late Aptian-earliest Albian Benassal Formation (Maestrat Basin, E Spain): petrology and geochemistry constrains

Fault-controlled hydrothermal dolomitization of the Late Aptian to earliest Albian Benassal Fm shallow water carbonates resulted in the seismic-scale stratabound dolostone geobodies that characterize the Benicàssim case study (Maestrat Basin, E Spain). Petrological and geochemical data indicate that dolomite cement (DC1) filling intergranular porosity in grain-dominated facies constituted the initial stage of dolomitization. The bulk of the dolostone is formed by a replacive nonplanar-a to planar-s dolomite (RD1) crystal mosaic with very low porosity and characteristic retentive fabric. Neomorphic recrystallization of RD1 to form replacive dolomite RD2 occurred by successive dolomitizing fluid flow. The replacement sequence DC1-RD1-RD2 is characterized by a depletion in the oxygen isotopic composition (mean δ18O(V-PDB) values from −6.92, to −8.55, to −9.86¿), which is interpreted to result from progressively higher temperature fluids. Clear dolomite overgrowths (overdolomitization) precipitated during the last stage of replacement. Strontium isotopic composition suggests that the most likely origin of magnesium was Cretaceous seawater-derived brines that were heated and enriched in radiogenic strontium and iron while circulating through the Paleozoic basement and/or Permo-Triassic red beds. Burial curves and analytical data indicate that the replacement took place at burial depths between 500 and 750 m, and by hydrothermal fluids exceeding temperatures of 80 °C. Following the partial dolomitization of the host rock, porosity considerably increased in dolostones by burial corrosion related to the circulation of acidic fluids derived from the emplacement of the Mississippi Valley-Type deposits. Overpressured acidic fluids circulated along faults, fractures and open stylolites. Saddle dolomite and ore-stage calcite cement filled most of the newly created vuggy porosity. Subsequent to MVT mineralization, precipitation of calcite cements resulted from the migration of meteoric-derived fluids during uplift and subaerial exposure. This late calcite cement destroyed most of the dolostone porosity and constitutes the main cause for its present day poor reservoir qualit

3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice

International audienc

Host Genetic Factors and Vaccine-Induced Immunity to HBV Infection: Haplotype Analysis

Hepatitis B virus (HBV) infection remains a significant health burden world-wide, although vaccines help decrease this problem. We previously identified associations of single nucleotide polymorphisms in several candidate genes with vaccine-induced peak antibody level (anti-HBs), which is predictive of long-term vaccine efficacy and protection against infection and persistent carriage; here we report on a haplotype-based analysis. A total of 688 SNPs from 117 genes were examined for a two, three and four sliding window haplotype analysis in a Gambian cohort. Analysis was performed on 197 unrelated individuals, 454 individuals from 174 families, and the combined sample (N = 651). Global and individual haplotype association tests were carried out (adjusted for covariates), employing peak anti-HBs level as outcome. Five genes (CD44, CD58, CDC42, IL19 and IL1R1) had at least one significant haplotype in the unrelated or family analysis as well as the combined analysis. Previous single locus results were confirmed for CD44 (combined global p = 9.1×10−5 for rs353644-rs353630-rs7937602) and CD58 (combined global p = 0.008 for rs1414275-rs11588376-rs1016140). Haplotypes in CDC42, IL19 and IL1R1 also associated with peak anti-HBs level. We have identified strong haplotype effects on HBV vaccine-induced antibody level in five genes, three of which, CDC42, IL19 and IL1R1, did not show evidence of association in a single SNP analyses and corroborated the majority of these effects in two datasets. The haplotype analysis identified associations with HBV vaccine-induced immunity in several new genes

Notes on the relationship between Kripke-Beth semantics and pretopologies

Consiglio Nazionale delle Ricerche (CNR). Biblioteca Centrale / CNR - Consiglio Nazionale delle RichercheSIGLEITItal

Mineral chemistry as a tool for optimization the mineral processing in the Central Andean Tin Belt

The Central Andean tin belt is a metallogenic province, well-known by Sn, Ag, Pb, Zn, and W. However, in the Bolivian sector there is potential for strategic elements, mainly Indium, but still uncertain. In the present study, we characterized several deposits from the Poopó, Oruro, and Santa Fe mine districts. This work is focused in determining the mineralogy and metal richness in these deposits to evaluate their real extractive potential. Electron microprobe analysis were performed in order to characterize the chemical composition of minerals. Ore mineral assemblage is represented by oxides, sulfides and sulfosalts. Cassiterite constitutes the earliest mineralization. Subsequently, several generations of galena, sphalerite ± pyrite, chalcopyrite, arsenopyrite and chalcocite occurred. Sn is also present in sulfides as several members of stannite group, such as stannoidite, hocartite, kësterite, petrukite, sakuraiite, pirquitasite and stannite. An important bunch of sulfosalts rich in Sn, Pb, Ag, Cu, Sb and Bi, such as franckeite, potosiite, berndtite, teallite, tetrahedrite, freibergite, tennantite, gustavite, andorite, ourayite, miargyrite, cylindrite, boulangerite, jamesonite, zinckenite, viaeneite, bismuthinite and bismite also occur in high amounts. Usually, they appear in crystalls of small grain size, of few µm. During processing Zn, Pb and Ag are recovered from most of the phases where they are present. However, Sn recovery is only effective from cassiterite and, when Snbearing minerals are in sulfide form, ore concentration is not successful. The extreme case occurs in the Poopó mine, where Sn is not exploited although the geochemical characterization revels high amounts of Sn, thus it is mainly found as stannite-group minerals. Element concentrations in Poopó samples also show high content in Ag, Zn, Sb and As. Geochemical characterization necessary for to establish an adequate processing flux diagram to optimize the mining activity.Peer ReviewedPostprint (published version

Mineral chemistry as a tool for optimization the mineral processing in the Central Andean Tin Belt

The Central Andean tin belt is a metallogenic province, well-known by Sn, Ag, Pb, Zn, and W. However, in the Bolivian sector there is potential for strategic elements, mainly Indium, but still uncertain. In the present study, we characterized several deposits from the Poopó, Oruro, and Santa Fe mine districts. This work is focused in determining the mineralogy and metal richness in these deposits to evaluate their real extractive potential. Electron microprobe analysis were performed in order to characterize the chemical composition of minerals. Ore mineral assemblage is represented by oxides, sulfides and sulfosalts. Cassiterite constitutes the earliest mineralization. Subsequently, several generations of galena, sphalerite ± pyrite, chalcopyrite, arsenopyrite and chalcocite occurred. Sn is also present in sulfides as several members of stannite group, such as stannoidite, hocartite, kësterite, petrukite, sakuraiite, pirquitasite and stannite. An important bunch of sulfosalts rich in Sn, Pb, Ag, Cu, Sb and Bi, such as franckeite, potosiite, berndtite, teallite, tetrahedrite, freibergite, tennantite, gustavite, andorite, ourayite, miargyrite, cylindrite, boulangerite, jamesonite, zinckenite, viaeneite, bismuthinite and bismite also occur in high amounts. Usually, they appear in crystalls of small grain size, of few µm. During processing Zn, Pb and Ag are recovered from most of the phases where they are present. However, Sn recovery is only effective from cassiterite and, when Snbearing minerals are in sulfide form, ore concentration is not successful. The extreme case occurs in the Poopó mine, where Sn is not exploited although the geochemical characterization revels high amounts of Sn, thus it is mainly found as stannite-group minerals. Element concentrations in Poopó samples also show high content in Ag, Zn, Sb and As. Geochemical characterization necessary for to establish an adequate processing flux diagram to optimize the mining activity.Peer ReviewedPostprint (published version

Mineral chemistry as a tool for optimization the mineral processing in the Central Andean Tin Belt

The Central Andean tin belt is a metallogenic province, well-known by Sn, Ag, Pb, Zn, and W. However, in theBolivian sector there is potential for strategic elements, mainly Indium, but still uncertain. In the present study, we characterized several deposits from the Poopó, Oruro, and Santa Fe mine districts. This work is focused in determining the mineralogy and metal richness in these deposits to evaluate their real extractive potential.Electron microprobe analysis were performed in order to characterize the chemical composition of minerals. Oremineral assemblage is represented by oxides, sulfides and sulfosalts. Cassiterite constitutes the earliest mineralization. Subsequently, several generations of galena, sphalerite ± pyrite, chalcopyrite, arsenopyrite and chalcocite occurred. Sn is also present in sulfides as several members of stannite group, such as stannoidite, hocartite, kësterite, petrukite, sakuraiite, pirquitasite and stannite.An important bunch of sulfosalts rich in Sn, Pb, Ag, Cu, Sb and Bi, such as franckeite, potosiite, berndtite, teallite, tetrahedrite, freibergite, tennantite, gustavite, andorite, ourayite, miargyrite, cylindrite, boulangerite, jamesonite, zinckenite, viaeneite, bismuthinite and bismite also occur in high amounts. Usually, they appear in crystalls of small grain size, of few µm.During processing Zn, Pb and Ag are recovered from most of the phases where they are present. However, Snrecovery is only effective from cassiterite and, when Snbearing minerals are in sulfide form, ore concentration is not successful. The extreme case occurs in the Poopó mine, where Sn is not exploited although the geochemicalcharacterization revels high amounts of Sn, thus it is mainly found as stannite-group minerals. Element concentrations in Poopó samples also show high content in Ag, Zn, Sb and As. Geochemical characterization necessary for to establish an adequate processing flux diagram to optimize the mining activity.Peer Reviewe

Fault-controlled and stratabound dolostones in the Late Aptianeearliest Albian Benassal Formation (Maestrat Basin, E Spain): Petrology and geochemistry constrains

International audienceFault-controlled hydrothermal dolomitization of the Late Aptian to earliest Albian Benassal Fm shallow water carbonates resulted in the seismic-scale stratabound dolostone geobodies that characterize the Benicassim case study (Maestrat Basin, E Spain). Petrological and geochemical data indicate that dolomite cement (DC1) filling intergranular porosity in grain-dominated facies constituted the initial stage ofdolomitization. The bulk of the dolostone is formed by a replacive nonplanar-a to planar-s dolomite (RD1) crystal mosaic with very low porosity and characteristic retentive fabric. Neomorphic recrystallization of RD1 to form replacive dolomite RD2 occurred by successive dolomitizing fluid flow. Thereplacement sequence DC1-RD1-RD2 is characterized by a depletion in the oxygen isotopic composition (mean d18O(V-PDB) values from -6.92, to -8.55, to -9.86‰), which is interpreted to result from progressively higher temperature fluids. Clear dolomite overgrowths (overdolomitization) precipitated during the last stage of replacement. Strontium isotopic composition suggests that the most likely origin of magnesium was Cretaceous seawater-derived brines that were heated and enriched in radiogenic strontium and iron while circulating through the Paleozoic basement and/or Permo-Triassic red beds. Burial curves and analytical data indicate that the replacement took place at burial depths between 500and 750 m, and by hydrothermal fluids exceeding temperatures of 80°C. Following the partial dolomitization of the host rock, porosity considerably increased in dolostones by burial corrosion related to the circulation of acidic fluids derived from the emplacement of the Mississippi Valley-Type deposits. Overpressured acidic fluids circulated along faults, fractures and open stylolites. Saddle dolomite and ore-stage calcite cement filled most of the newly created vuggy porosity. Subsequent to MVT mineralization, precipitation of calcite cements resulted from the migration of meteoric-derived fluids during uplift and subaerial exposure. This late calcite cement destroyed most of the dolostone porosity and constitutes the main cause for its present day poor reservoir quality

Fault-controlled and stratabound dolostones in the Late Aptian-earliest Albian Benassal Formation (Maestrat Basin, E Spain): Petrology and geochemistry constrains

Peer Reviewe