IV-Rente : zu attraktiv für Junge oder Mittel letzter Wahl?

In der Schweiz wird Stimmung gemacht und werden Verdächtigungen geschürt gegen BezügerInnen von IV-Rentenleistungen. Bei psychisch Kranken und bei Jungen ist das Misstrauen besonders gross. Es gibt aber auch (leisere) Stimmen, die dagegen halten: Die Zunahme habe mit erhöhtem Druck und dem Abbau von wenig qualifizierten Arbeitsplätzen zu tun

Musculoskeletal pain and effort-reward imbalance- a systematic review

BACKGROUND: Musculoskeletal pain may be triggered by physical strains and psychosocial risk factors. The effort-reward imbalance model (ERI model) is a stress model which measures psychosocial factors in the working world. The question is whether workers with an effort-reward imbalance report musculoskeletal pain more frequently than those with no effort-reward imbalance. A systematic review using a best evidence synthesis approach was conducted to answer this question. METHODS: A literature search was conducted for the period from 1996 to 2012, using three databases (Pubmed, Embase and PsycINFO). The research criteria related to psychosocial, work-related stress as per the ERI model and to musculoskeletal pain. A quality score was developed using various quality criteria to assess the standard of the studies. The level of evidence was graded as in (Am J Ind Med 39:180–193, 2001). RESULTS: After applying the inclusion criteria, a total of 19 studies were included in the review: 15 cross-sectional studies, three prospective studies and one case–control study. 74% of all studies exhibited good methodological quality, 53% collected data using the original ERI questionnaire, and in 42% of the studies, there was adequate control for physical working conditions. Furthermore, different cut-off points were used to classify exposed and non-exposed individuals. On the basis of 13 studies with a positive, statistically significant association, a moderate level of evidence was inferred for the association between effort-reward imbalance and musculoskeletal pain. The evidence for a role of over-commitment and for its interaction with effort-reward imbalance was rated as inconclusive - on the basis of eight and five studies, respectively. CONCLUSIONS: On the basis of the available evidence, no reliable conclusion may be drawn about any association between the psychosocial factors ascertained using the ERI model and musculoskeletal pain. Before a reliable statement can be made on the association between ERI and musculoskeletal pain, additional longitudinal studies must be performed - with a standardised method for recording and classifying exposure, as well as control of physical confounders. Appropriate preventive measures can then be specified

A Subtle Interplay Between Three Pex11 Proteins Shapes De Novo Formation and Fission of Peroxisomes

The organization of eukaryotic cells into membrane-bound compartments must be faithfully sustained for survival of the cell. A subtle equilibrium exists between the degradation and the proliferation of organelles. Commonly, proliferation is initiated by a membrane remodeling process. Here, we dissect the function of proteins driving organelle proliferation in the particular case of peroxisomes. These organelles are formed either through a growth and division process from existing peroxisomes or de novo from the endoplasmic reticulum (ER). Among the proteins involved in the biogenesis of peroxisomes, peroxins, members of the Pex11 protein family participate in peroxisomal membrane alterations. In the yeast Saccharomyces cerevisiae, the Pex11 family consists of three proteins, Pex11p, Pex25p and Pex27p. Here we demonstrate that yeast mutants lacking peroxisomes require the presence of Pex25p to regenerate this organelle de novo. We also provide evidence showing that Pex27p inhibits peroxisomal function and illustrate that Pex25p initiates elongation of the peroxisomal membrane. Our data establish that although structurally conserved each of the three Pex11 protein family members plays a distinct role. While ScPex11p promotes the proliferation of peroxisomes already present in the cell, ScPex25p initiates remodeling at the peroxisomal membrane and ScPex27p acts to counter this activity. In addition, we reveal that ScPex25p acts in concert with Pex3p in the initiation of de novo peroxisome biogenesis from the ER

Cancer-Related Distress: How Often Does It Co-occur With a Mental Disorder? – Results of a Secondary Analysis

Objectives: The Distress Thermometer (DT) is a validated and widely used screening tool to identify clinically relevant distress in cancer patients. It is unclear, to which extend subjectively perceived distress measured by the DT is related to objective burden (mental disorder). We therefore examine the co-occurrence of a mental disorder for different DT thresholds and explore the diagnostic properties of the DT in detecting a mental disorder. Methods: In this multicenter cross-sectional study, we included 4,020 patients with mixed cancer diagnoses. After selection of relevant cases, weighting procedure and imputation of missing data we evaluated the data of N = 3,212 patients. We used the DT to assess perceived distress and the standardized Composite International Diagnostic Interview for Oncology (CIDI-O) to assess the 4-week prevalence of mental disorders. The association between distress and any mental disorder (MD) is calculated using Pearson correlations. Relative risks for MD in patients with/without distress and the co-occurrence of distress and MD were calculated with Poisson regression. To assess the operating characteristics between distress and MD, we present the area under the curve (AUC). Results: 22.9% of the participants had a cut-off DT level of 5 and were affected by MD. Each level of distress co-occurs with MD. The proportion of patients diagnosed with MD was not greater than the proportion of patients without MD until distress levels of DT = 6 were reached. The correlation between DT and MD was r = 0.27. The ROCanalysis shows the area under curve (AUC) = 0.67, which is classified as unsatisfactory. With increasing distress severity, patients are not more likely to have a mental disorder. Conclusion: Our results suggests viewing and treating cancer-related distress as a relatively distinct psychological entity. Cancer-related distress may be associated with an increased risk for a mental disorder and vice versa, but the overlap of both concepts is very moderate

Hubungan Kelincahan dengan Keterampilan Menggiring Bola pada Siswa Kelas V.e Sdn 006 Pangkalankerinci Kab. Pelalawan

Based on the researcher\u27s observation of students in class V,E of SDN 006 Pangkalan Kerinci Pelalawan District. Researcher found many student have deficiency of dribbling, visible when the student dribble imperfect, as the ball away from the feet, so that the ball easily captured opponent. It is influenced by physical conditions that agility. The purpose of this research is to see the correlation between agility with ball dribbling skills of Student class V.E of SDN 006 Pangkalan Kerinci Pelalawan District. Population in this research is all Student in class V of SDN 006 Pangkalan Kerinci Pelalawan District amount 22 people. Based on population that is not so large and within the limits the researchers set the whole population is used as a sample. The research sample as many as 22 people. Research instrument used suttle run test to agility and dribbling ball test. Data were analyzed by product moment correlation. Based on research results, it can be concluded as follows : that is result obtained from Student in class V.E of SDN 006 Pangkalan Kerinci Pelalawan District. Shows that there is correlation of the agility (X) with dribbling (Y) , which shows correlation rhitung = 0,462>rtabel = 0,43

Can faecal glucocorticoid metabolites be used to monitor body condition in wild Upland geese Chloephaga picta leucoptera?

The measurement of faecal glucocorticoid metabolites is used as a non-invasive technique to study stress in animal populations. They have been used most widely in mammals, and mammalian studies have also treated issues such as sample stability and storage methods. In birds, faecal corticosterone metabolite (CM) assays have been validated for a small number of species, and adequate storage under field conditions has not been addressed explicitly in previous studies. Furthermore, while it is well-established that baseline plasma corticosterone levels in birds rise with declining body condition, no study so far investigated if this relationship is also reflected in faecal samples. We here present data of a field study in wild Upland geese Chloephaga picta leucoptera on the Falkland Islands, testing different storage methods and investigating the relationship of faecal CM concentrations to body condition and reproductive parameters. We found that faecal CM measures are significantly repeatable within individuals, higher in individuals with lower body condition in both male and female wild Upland geese and higher in later breeding females with smaller broods. These results suggest that measuring faecal CM values may be a valuable non-invasive tool to monitor the relative condition or health of individuals and populations, especially in areas where there still is intense hunting practice

Cutoff scores of the Eating Disorder Examination–Questionnaire for the German population

Objective The Eating Disorder Examination-Questionnaire (EDE-Q) is one of the most widely used self-report measures for the assessment of eating disorder (ED) symptomatology. However, proposed cutoff scores that may indicate the presence of an ED have been heterogeneous. Therefore, the current study derived cutoff scores from two large samples: one representative for the German population and one composed of persons with EDs at admission to inpatient treatment. Method Receiver operating characteristic analysis was used with the EDE-Q global score as independent variable and group (controls: n = 2519, patients: n = 2038) as dependent variable. These analyses were also conducted separately with the patient group divided into persons with anorexia nervosa (AN; n = 1456), bulimia nervosa (BN; n = 370), and other EDs (n = 212) and after matching groups for age and sex distribution. Results The EDE-Q global score discriminated well between controls and patients (AUC >91%, sensitivity >.84, specificity >.79). A score of 1.6 discriminated best between controls and patients in general and persons with AN in particular. Optimal thresholds for discriminating between controls and persons with BN and other EDs ranged between scores of 1.8 and 2.4. Discussion In the German population, cutoff scores between 1.6 and 2.4 may be used to screen for the presence or absence of an ED or evaluate treatment outcome, with slightly higher cutoff scores for persons with BN and other EDs than for persons with AN. Public Significance Questionnaire scores have little value when it is unclear which scores indicate the likely presence of an ED, as such scores can be used to estimate the prevalence of or screen for EDs in the general population and evaluate outcome at the end of ED treatment. The current study indicates a score around 2 on the EDE-Q as an optimal threshold for this

Secondary task engagement, risk-taking, and safety-related equipment use in Gerrnan bicycle and e-scooter riders - an observation

lt has been shown that engagement in secondary tasks may contribute to cyclists crash risk [1 ], meditated by cycling errors or risky behaviors. For influences on secondary task: engagement, it is generally found that phone use is negatively correlated with age. In most studies, males are more found engaged in phone tasks than females. lt was also found that users of a bicycle-sharing program more often to wear headphones and engage in more unsafe behavior. The use of safety gear (e.g., wearing a helmet, using reflectors) is often negatively correlated with distracted cycling. Also, cyclists engaged in a secondary task exhibit other risky behaviors more often [2]. The present study's first aim was to get (an updated) estimate of the observable frequency of different secondary tasks, use of additional safety equipment, and rule violations while riding bicycles and e-scooters in Germany. The second aim was to examine possible differences in secondary task: engagement, use of additional safety equipment, and rule violations between different types of users of the cycling infrastructure, i.e., riders of conventional bikes, e-bikes, scooters, and e-scooters. A third aim was to explore whether riders' secondary task engagement is related to active safety precautions (e.g., wearing a helmet), traffic rule violations, and at-fault conflicts and if there are rider profiles regarding safety-related behaviors. As the study is explorative, no hypotheses were formulated. [From: Introduction