Dance as a means of educational inclusion

Uno de los objetivos de la educación, es de reducir o eliminar las barreras que pudieran obstaculizar la participación de las personas en el proceso de enseñanza-aprendizaje. En este sentido, la UNESCO destaca la educación como un vehículo transcendental para conseguir la inclusión social de quienes pudieran estar en riesgo o en situación de exclusión, siendo la danza un medio muy valioso para paliar estas desigualdades. Siguiendo el protocolo PRISMA, se realizó una revisión sistemática a partir de una búsqueda en Web of Sciencie y Scopus, utilizando como criterios de búsqueda “danza” “educación” e “inclusión” tanto en español como en inglés, que arrojó un total de 419 resultados de los cuales se seleccionaron 23. Las investigaciones muestran que el concepto de danza puede entenderse como el arte de mover el cuerpo al ritmo de una música, expresando emociones, ideas, pensamientos o historias. Este arte incide en el proceso de formación del ser humano, estimulando el desarrollo intelectual, motor, afectivo y social de los individuos. El baile es utilizado para alcanzar el bienestar físico y psicológico, y permite al individuo reforzar su identidad grupal y sentido comunitario, independientemente de sus capacidades, habilidades o competencias. Los pocos estudios existentes que emplean la danza como vía de inserción social, evidencian un fomento de oportunidades de participación y desarrollo de las personas, pero para ello se requiere un proceso de transformación que permita la eliminación de barreras socialmente impuestas y una reforma educativa.Este trabajo ha sido financiado por la Universidad de Málaga (Campus de Excelencia Internacional Andalucía Tech) y por el Ministerio de Educación, Cultura y Deporte a través de las ayudas para la Formación de Profesorado Universitario (FPU17/01554) y a través de las Becas de Colaboración con departamentos universitarios para el curso 2020/2021

Ionoluminescence induced by swift heavy ions in silica and quartz: A comparative analysis

Ionoluminescence (IL) of the two SiO 2 phases, amorphous silica and crystalline quartz, has been comparatively investigated in this work, in order to learn about the structural defects generated by means of ion irradiation and the role of crystalline order on the damage processes. Irradiations have been performed with Cl at 10 MeV and Br at 15 MeV, corresponding to the electronic stopping regime (i.e., where the electronic stopping power S e is dominant) and well above the amorphization threshold. The light-emission kinetics for the two main emission bands, located at 1.9 eV (652 nm) and 2.7 eV (459 nm), has been measured under the same ion irradiation conditions as a function of fluence for both, silica and quartz. The role of electronic stopping power has been also investigated and discussed within current views for electronic damage. Our experiments provide a rich phenomenological background that should help to elucidate the mechanisms responsible for light emission and defect creationThis work has been supported by Spanish Ministry MICINN through the project MAT-2008-06794-C03-03, JCI-2009-05681, and by Madrid Community through the project TECHNOFUSION (S2009/ENE-1679). OPR is grateful to CONACyT, Mexico, for extending a postdoctoral fellowshi

The first zeolite with a tri-directional extra-large 14-ring pore system derived using a phosphonium-based organic molecule

[EN] A new germanosilicate zeolite (denoted as ITQ-53) with extra-large pores has been synthesised using tri-tertbutylmethylphosphonium cation as the organic structure directing agent (OSDA). Rotation electron diffraction (RED) was used to identify ITQ-53 from an initially-synthesised sample containing impurities, and to solve its structure. The structure was refined against PXRD data of pure ITQ-53 samples obtained after synthesis optimisation. ITQ-53 is the first example of extra-large pore zeolites with tri-directional interconnected 14 x 14 x 14-ring channels. It is stable up to at least 650 degrees C. The structure of ITQ-53 changes from monoclinic to orthorhombic upon calcination.This work was supported by the Spanish Government (MAT2012-38567-C02-01, Consolider Ingenio 2010-Multicat CSD-2009-00050 and Severo Ochoa SEV-2012-0267), the Swedish Research Council (VR), the Swedish Governmental Agency for Innovation Systems (VINNOVA) and the Knut & Alice Wallenberg Foundation through a grant for purchasing the TEMs and the project grant 3DEM-NATUR. Yifeng Yun thanks the China Scholarship Council (CSC).Yun, Y.; Hernández Rodríguez, M.; Wan, W.; Zou, X.; Jorda Moret, JL.; Cantin Sanz, A.; Rey Garcia, F.... (2015). The first zeolite with a tri-directional extra-large 14-ring pore system derived using a phosphonium-based organic molecule. Chemical Communications. 51(36):7602-7605. https://doi.org/10.1039/c4cc10317cS760276055136C. Baerlocher and L.McCusker, Database of Zeolite Structures: http://www.iza-structure.org/databases/Estermann, M., McCusker, L. B., Baerlocher, C., Merrouche, A., & Kessler, H. (1991). A synthetic gallophosphate molecular sieve with a 20-tetrahedral-atom pore opening. Nature, 352(6333), 320-323. doi:10.1038/352320a0Su, J., Wang, Y., Lin, J., Liang, J., Sun, J., & Zou, X. (2013). A silicogermanate with 20-ring channels directed by a simple quaternary ammonium cation. Dalton Trans., 42(5), 1360-1363. doi:10.1039/c2dt32231eWei, Y., Tian, Z., Gies, H., Xu, R., Ma, H., Pei, R., … Lin, L. (2010). Ionothermal Synthesis of an Aluminophosphate Molecular Sieve with 20-Ring Pore Openings. Angewandte Chemie International Edition, 49(31), 5367-5370. doi:10.1002/anie.201000320Sun, J., Bonneau, C., Cantín, Á., Corma, A., Díaz-Cabañas, M. J., Moliner, M., … Zou, X. (2009). The ITQ-37 mesoporous chiral zeolite. Nature, 458(7242), 1154-1157. doi:10.1038/nature07957Corma, A., Diaz-Cabanas, M. J., Jiang, J., Afeworki, M., Dorset, D. L., Soled, S. L., & Strohmaier, K. G. (2010). Extra-large pore zeolite (ITQ-40) with the lowest framework density containing double four- and double three-rings. Proceedings of the National Academy of Sciences, 107(32), 13997-14002. doi:10.1073/pnas.1003009107Dorset, D. L., Strohmaier, K. G., Kliewer, C. E., Corma, A., Díaz-Cabañas, M. J., Rey, F., & Gilmore, C. J. (2008). Crystal Structure of ITQ-26, a 3D Framework with Extra-Large Pores. Chemistry of Materials, 20(16), 5325-5331. doi:10.1021/cm801126tDorset, D. L., Kennedy, G. J., Strohmaier, K. G., Diaz-Cabañas, M. J., Rey, F., & Corma, A. (2006). P-Derived Organic Cations as Structure-Directing Agents:  Synthesis of a High-Silica Zeolite (ITQ-27) with a Two-Dimensional 12-Ring Channel System. Journal of the American Chemical Society, 128(27), 8862-8867. doi:10.1021/ja061206oCorma, A., Diaz-Cabanas, M. J., Jorda, J. L., Rey, F., Sastre, G., & Strohmaier, K. G. (2008). A Zeolitic Structure (ITQ-34) with Connected 9- and 10-Ring Channels Obtained with Phosphonium Cations as Structure Directing Agents. Journal of the American Chemical Society, 130(49), 16482-16483. doi:10.1021/ja806903cHernández-Rodríguez, M., Jordá, J. L., Rey, F., & Corma, A. (2012). Synthesis and Structure Determination of a New Microporous Zeolite with Large Cavities Connected by Small Pores. Journal of the American Chemical Society, 134(32), 13232-13235. doi:10.1021/ja306013kSimancas, R., Jordá, J. L., Rey, F., Corma, A., Cantín, A., Peral, I., & Popescu, C. (2014). A New Microporous Zeolitic Silicoborate (ITQ-52) with Interconnected Small and Medium Pores. Journal of the American Chemical Society, 136(9), 3342-3345. doi:10.1021/ja411915cSimancas, R., Dari, D., Velamazan, N., Navarro, M. T., Cantin, A., Jorda, J. L., … Rey, F. (2010). Modular Organic Structure-Directing Agents for the Synthesis of Zeolites. Science, 330(6008), 1219-1222. doi:10.1126/science.1196240Hua, W., Chen, H., Yu, Z.-B., Zou, X., Lin, J., & Sun, J. (2014). A Germanosilicate Structure with 11×11×12-Ring Channels Solved by Electron Crystallography. Angewandte Chemie International Edition, 53(23), 5868-5871. doi:10.1002/anie.201309766Yun, Y., Wan, W., Rabbani, F., Su, J., Xu, H., Hovmöller, S., … Zou, X. (2014). Phase identification and structure determination from multiphase crystalline powder samples by rotation electron diffraction. Journal of Applied Crystallography, 47(6), 2048-2054. doi:10.1107/s1600576714023875Zhang, D., Oleynikov, P., Hovmöller, S., & Zou, X. (2010). Collecting 3D electron diffraction data by the rotation method. Zeitschrift für Kristallographie, 225(2-3). doi:10.1524/zkri.2010.1202X. Zou , S.Hovmoller and P.Oleynikov, Electron Crystallography: Electron Microscopy and Electron Diffraction, Oxford University Press, 2011, ISBN: 978-0-19-958020-0Wan, W., Sun, J., Su, J., Hovmöller, S., & Zou, X. (2013). Three-dimensional rotation electron diffraction: softwareREDfor automated data collection and data processing. Journal of Applied Crystallography, 46(6), 1863-1873. doi:10.1107/s0021889813027714Martinez-Franco, R., Moliner, M., Yun, Y., Sun, J., Wan, W., Zou, X., & Corma, A. (2013). Synthesis of an extra-large molecular sieve using proton sponges as organic structure-directing agents. Proceedings of the National Academy of Sciences, 110(10), 3749-3754. doi:10.1073/pnas.1220733110Su, J., Kapaca, E., Liu, L., Georgieva, V., Wan, W., Sun, J., … Zou, X. (2014). Structure analysis of zeolites by rotation electron diffraction (RED). Microporous and Mesoporous Materials, 189, 115-125. doi:10.1016/j.micromeso.2013.10.014Guo, P., Liu, L., Yun, Y., Su, J., Wan, W., Gies, H., … Zou, X. (2014). Ab initio structure determination of interlayer expanded zeolites by single crystal rotation electron diffraction. Dalton Trans., 43(27), 10593-10601. doi:10.1039/c4dt00458bJiang, J., Yun, Y., Zou, X., Jorda, J. L., & Corma, A. (2015). ITQ-54: a multi-dimensional extra-large pore zeolite with 20 × 14 × 12-ring channels. Chemical Science, 6(1), 480-485. doi:10.1039/c4sc02577fWillhammar, T., Burton, A. W., Yun, Y., Sun, J., Afeworki, M., Strohmaier, K. G., … Zou, X. (2014). EMM-23: A Stable High-Silica Multidimensional Zeolite with Extra-Large Trilobe-Shaped Channels. Journal of the American Chemical Society, 136(39), 13570-13573. doi:10.1021/ja507615bPatinec, V., Wright, P. A., Lightfoot, P., Aitken, R. A., & Cox, P. A. (1999). Synthesis of a novel microporous magnesioaluminophosphate, STA-6, containing an unbound azamacrocycle †. Journal of the Chemical Society, Dalton Transactions, (22), 3909-3911. doi:10.1039/a907259dWragg, D. S., Morris, R., Burton, A. W., Zones, S. I., Ong, K., & Lee, G. (2007). The Synthesis and Structure of SSZ-73:  an All-Silica Zeolite with an Unusual Framework Topology. Chemistry of Materials, 19(16), 3924-3932. doi:10.1021/cm0705284Sheldrick, G. M. (2007). A short history ofSHELX. Acta Crystallographica Section A Foundations of Crystallography, 64(1), 112-122. doi:10.1107/s0108767307043930Jiang, J., Jorda, J. L., Diaz-Cabanas, M. J., Yu, J., & Corma, A. (2010). The Synthesis of an Extra-Large-Pore Zeolite with Double Three-Ring Building Units and a Low Framework Density. Angewandte Chemie International Edition, 49(29), 4986-4988. doi:10.1002/anie.201001506R. A. Young , The Rietveld Method, Oxford University Press, 1995VANKONINGSVELD, H., JANSEN, J., & VANBEKKUM, H. (1990). The monoclinic framework structure of zeolite H-ZSM-5. Comparison with the orthorhombic framework of as-synthesized ZSM-5. Zeolites, 10(4), 235-242. doi:10.1016/0144-2449(94)90134-1Fang, L., Liu, L., Yun, Y., Inge, A. K., Wan, W., Zou, X., & Gao, F. (2014). SU-77: An Open-Framework Germanate Containing 12 × 10 × 10-Ring Channels Solved by Combining Rotation Electron Diffraction and Powder X-ray Diffraction. Crystal Growth & Design, 14(10), 5072-5078. doi:10.1021/cg500681kWessels, T., Baerlocher, C., McCusker, L. B., & Creyghton, E. J. (1999). An Ordered Form of the Extra-Large-Pore Zeolite UTD-1:  Synthesis and Structure Analysis from Powder Diffraction Data. Journal of the American Chemical Society, 121(26), 6242-6247. doi:10.1021/ja990771

Polysialylated neuropilin-2 enhances human dendritic cell migration through the basic C-terminal region of CCL21.

Free Access at: http://glycob.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=20488940Dendritic cell (DC) migration to secondary lymphoid organs is a critical step to properly exert its role in immunity; and predominantly depends on the interaction of the chemokine receptor CCR7 with its ligands CCL21 and CCL19. Polysialic acid (PSA) has been recently reported to control CCL21-directed migration of mature DCs. Here; we first demonstrate that PSA present on human mature monocyte-derived dendritic cells did not enhance chemotactic responses to CCL19. We have also explored the molecular mechanisms underlying the selective enhancing effect of PSA on CCL21-driven chemotaxis of DCs. In this regard; we found out that prevention of DC polysialylation decreased CCL21 activation of JNK and Akt signaling pathways; both associated with CCR7-mediated chemotaxis. We also report that the enhanced PSA-mediated effect on DC migration towards CCL21 relied on the highly basic C-terminal region of this chemokine; and depended on the PSA acceptor molecule neuropilin-2 (NRP2) and on the polysialyltransferase ST8SiaIV. Altogether; our data indicate that the CCR7/CCL21/NRP2/ST8SiaIV functional axis constitutes an important guidance clue for DC targeting to lymphoid organs.This work was supported by research grant from Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo (FISPI0708879 to MAV).Peer reviewe

Machine learning approximations to predict epigenetic age acceleration in stroke patients

Age acceleration (Age-A) is a useful tool that is able to predict a broad range of health outcomes. It is necessary to determine DNA methylation levels to estimate it, and it is known that Age-A is influenced by environmental, lifestyle, and vascular risk factors (VRF). The aim of this study is to estimate the contribution of these easily measurable factors to Age-A in patients with cerebrovascular disease (CVD), using different machine learning (ML) approximations, and try to find a more accessible model able to predict Age-A. We studied a CVD cohort of 952 patients with information about VRF, lifestyle habits, and target organ damage. We estimated Age-A using Hannum\u27s epigenetic clock, and trained six different models to predict Age-A: a conventional linear regression model, four ML models (elastic net regression (EN), K-Nearest neighbors, random forest, and support vector machine models), and one deep learning approximation (multilayer perceptron (MLP) model). The best-performing models were EN and MLP; although, the predictive capability was modest (

Galician multidisciplinary consensus about the use of lipid-lowering drugs

Se desarrolla un consenso multidisciplinar sobre el uso de hipolipemiantes, pues las cifras de consumo de hipolipemiantes han aumentado considerablemente en los ultimos años, Las últimas guías publicadas han levantado bastante polémica y se considera necesario la realización de este consenso e identificar los niveles de riesgo de los pacientes, para tratar las dislipemias y normalizar el uso de hipolipemientes. Se realiza una mención especial al tratamiento de la dislipemia en la enfermedad renal crónica

The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018)

Introduction:Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, and Klebsiella aerogenes) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018.Methods: A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0.Results: A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa, VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017–2018 compared to 2014–2016.Discussion: Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms

Temas Socio-Jurídicos. Volumen 14 No. 31 Diciembre de 1996

Con la edición número 31 de la Revista Temas Socio-jurídicos se pone a disposición de la comunidad universitaria parte de la actividad desarrollada por los docentes y estudiantes de la Facultad de Derecho de la Universidad Autónoma de Bucaramanga durante el segundo semestre de 1996.With the 31st edition of the Socio-legal Issues Magazine, part of the activity carried out by the teachers and students of the Faculty of Law of the Autonomous University of Bucaramanga during the second semester of 1996

A new microporous zeolitic silicoborate (ITQ-52) with interconnected small and medium pores

A new zeolite (named as ITQ-52) having large cavities and small and medium channels has been synthesized. This was achieved by using a new family of amino-phosphonium cations as organic structure directing agents (OSDA). These cations contain P−C and P−N bonds, and therefore they lie between previously reported P-containing OSDA, such as tetraalkylphosphonium and phosphazenes. In this study, it has been found that 1,4- butanediylbis[tris(dimethylamino)]phosphonium dication is a very efficient OSDA for crystallization of several zeolites, and in some particular conditions, the new zeolite ITQ-52 was synthesized as a pure phase. The structure of ITQ-52 has been solved using high-resolution synchrotron X-ray powder diffraction data of the calcined solid. This new zeolite crystallizes in the space group I2/m, with cell parameters a = 17.511 Å, b = 17.907 Å, c = 12.367 Å, and β = 90.22°. The topology of ITQ-52 can be described as a replication of a composite building unit with ring notation [435461] that gives rise to the formation of an interconnected 8R and 10R channel system.We thank financial support by the Spanish Government (MAT2012-38567-C02-01, MAT2012-38567-C02-02, Consolider Ingenio 2010-Multicat CSD-2009-00050 and Severo Ochoa SEV-2012-0267). R.S. acknowledges to UPV for a FPI predoctoral fellowship. Authors thank ALBA Light Source for beam allocation at beamline MSPD. We thank G. Sastre and J. A. Vidal for computational calculations and MAS NMR experiments, respectively.Simancas Coloma, R.; Jorda Moret, JL.; Rey Garcia, F.; Corma Canós, A.; Cantin Sanz, A.; Peral, I.; Popescu, C. (2014). A new microporous zeolitic silicoborate (ITQ-52) with interconnected small and medium pores. Journal of the American Chemical Society. 136(9):3342-3345. doi:10.1021/ja411915cS33423345136

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection