A problematic zygopleuroid gastropod Acanthostrophia revisited

SEM examination of the type series of Acathostrophia acanthica CONTI & FISCHER, 1984 from Middle Jurassic of Italy has shown that this gastropod most likely belongs to the family Protorculidae as previously suggested by NÜTZEL (1998). It is also similar to some Jurassic species of Polygyrinidae, which might also be related to Protorculidae. The supposition of KAIM et al. (2008) that Acanthostrophia is an early member of Abyssochrysidae could not be confirmed

A bajocian (Middle jurassic) marine gastropod assemblage from the badamu formation, Central Iran

Nine species of gastropods are reported from the Bajocian (Middle Jurassic) part of the Badamu Formation of Central Iran. This is the first report of a gastropod assemblage of this age from the shelves of the Kimmerian Continent. Seven species belong to the Vetigastropoda and two to the Caenogastropoda. Two new species, the pleurotomariid Bathrotomaria iranica sp. nov. and the eucyclid Eucycloidea badamuensis sp. nov., are described. The remaining species are left in open nomenclature owing to poor preservation. The composition of the gastropod association is strongly reminiscent of other Tethyan gastropod faunas, in particular those from the southern shores of the Tethys (India and Arabia) and from southern Europe. This indicates a relatively uniform distribution of gastropod faunas along the Middle Jurassic shores of the western Tethys.Fil: Ferrari, Silvia Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Geología y Paleontología.; ArgentinaFil: Binazadeh, Tayyeb. Shahid Bahonar University; IránFil: Kaim, Andrzej. Institute of Paleobiology, Polish Academy of Sciences; Poloni

Discovery of chemosynthesis-based association on the Cretaceous basal leatherback sea turtle from Japan

We report a Late Cretaceous chemosynthetic community fueled by decomposing basal leatherback sea turtle on the ocean floor in the western Pacific. The fossil association representing this community has been recovered from the matrix of a concretion containing a single carapace of Mesodermochelys sp. from Late Cretaceous outer shelf to upper slope deposit of northern Hokkaido, Japan. The carapace displays boreholes most likely performed by boring bivalves, and is associated with molluscan shells, mainly Provanna cf. nakagawensis and Thyasira tanabei. Since this association is similar to fauna already known from Late Cretaceous hydrocarbon seeps, sunken wood, and plesiosaur-falls in Hokkaido, it is suggested that all types of chemosynthesis-based communities in the Late Cretaceous of western Pacific may have belonged to the same regional pool of animals and were not yet fully differentiated into three independent types of communities as it is known today. This finding also indicates that the sulfophilic stage of the vertebrate-fall communities was supported not only by plesiosaur carcasses, which were previously reported, but also by sea turtle carcasses. It highlights the possibility of surviving vertebrate-fall communities through the end-Cretaceous mass extinction event on carcasses of sea turtles which are the only large marine vertebrates surviving this event

Antioxidant and neuroprotective activity of vitamin E homologues : in vitro study

Here we present comparative data on the inhibition of lipid peroxidation by a variety of tocochromanols in liposomes. We also show for the first time the potential neuroprotective role of all the vitamin E homologues investigated on the neuronally differentiated human neuroblastoma SH-SY5Y cell line. α-Tocopherol had nearly no effect in the inhibition of lipid peroxidation, while β-, γ-, and δ-tocopherols inhibited the reaction completely when it was initiated in a lipid phase. Similar effects were observed for tocotrienol homologues. Moreover, in this respect plastochromanol-8 was as effective as β-, γ-, and δ-tocochromanols. When the prenyllipids were investigated in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) test and incorporated into different lipid carriers, the radical oxidation was most pronounced in liposomes, followed by mixed micelles and the micellar system. When the reaction of tocochromanols was examined in niosomes, the oxidation was most pronounced for α-tocopherol and plastochromanol-8, followed by α-tocotrienol. Next, using retinoic acid-differentiated SH-SY5Y cells, we tested the protective effects of the compounds investigated on hydrogen peroxide (H(2)O(2))-induced cell damage. We showed that tocotrienols were more active than tocopherols in the oxidative stress model. Plastochromanol-8 had a strong inhibitory effect on H(2)O(2)-induced lactate dehydrogenase (LDH) release and H(2)O(2)-induced decrease in cell viability. The water-soluble α-tocopherol phosphate had neuroprotective effects at all the concentrations analyzed. The results clearly indicate that structural differences between vitamin E homologues reflect their different biological activity and indicate their potential application in pharmacological treatments for neurodegenerative diseases. In this respect, the application of optimal tocochromanol-carrying structures might be critical

Oxygen-glucose deprivation in organotypic hippocampal cultures leads to cytoskeleton rearrangement and immune activation : link to the potential pathomechanism of ischaemic stroke

Ischaemic stroke is characterized by a sudden loss of blood circulation to an area of the brain, resulting in a corresponding loss of neurologic function. As a result of this process, neurons in the ischaemic core are deprived of oxygen and trophic substances and are consequently destroyed. Tissue damage in brain ischaemia results from a complex pathophysiological cascade comprising various distinct pathological events. Ischaemia leads to brain damage by stimulating many processes, such as excitotoxicity, oxidative stress, inflammation, acidotoxicity, and apoptosis. Nevertheless, less attention has been given to biophysical factors, including the organization of the cytoskeleton and the mechanical properties of cells. Therefore, in the present study, we sought to evaluate whether the oxygen-glucose deprivation (OGD) procedure, which is a commonly accepted experimental model of ischaemia, could affect cytoskeleton organization and the paracrine immune response. The abovementioned aspects were examined ex vivo in organotypic hippocampal cultures (OHCs) subjected to the OGD procedure. We measured cell death/viability, nitric oxide (NO) release, and hypoxia-inducible factor $1\alpha$ (HIF-$1\alpha$) levels. Next, the impact of the OGD procedure on cytoskeletal organization was evaluated using combined confocal fluorescence microscopy (CFM) and atomic force microscopy (AFM). Concurrently, to find whether there is a correlation between biophysical properties and the immune response, we examined the impact of OGD on the levels of crucial ischaemia cytokines (IL-$1\beta$, IL-6, IL-18, TNF-$\alpha$, IL-10, IL-4) and chemokines (CCL3, CCL5, CXCL10) in OHCs and calculated Pearsons’ and Spearman’s rank correlation coefficients. The results of the current study demonstrated that the OGD procedure intensified cell death and nitric oxide release and led to the potentiation of HIF-$1\beta$ release in OHCs. Moreover, we presented significant disturbances in the organization of the cytoskeleton (actin fibers, microtubular network) and cytoskeleton-associated protein 2 (MAP-2), which is a neuronal marker. Simultaneously, our study provided new evidence that the OGD procedure leads to the stiffening of OHCs and a malfunction in immune homeostasis. A negative linear correlation between tissue stiffness and branched IBA1 positive cells after the OGD procedure suggests the pro-inflammatory polarization of microglia. Moreover, the negative correlation of pro- and positive anti-inflammatory factors with actin fibers density indicates an opposing effect of the immune mediators on the rearrangement of cytoskeleton induced by OGD procedure in OHCs. Our study constitutes a basis for further research and provides a rationale for integrating biomechanical and biochemical methods in studying the pathomechanism of stroke-related brain damage. Furthermore, presented data pointed out the interesting direction of proof-of-concept studies, in which follow-up may establish new targets for brain ischemia therapy

Palaeoenvironmental reconstruction of Bathonian (Middle Jurassic) ore-bearing clays at Gnaszyn

Multidisciplinary studies of the Middle–Upper Bathonian ore-bearing clays at Gnaszyn revealed variable palaeoenvi- ronmental conditions during the deposition of this seemingly monotonous sequence. We interpret the conditions in the bottom environment and the photic zone, and also evaluate the influence of the adjacent land areas, based on sedi- mentology, geochemistry, sporomorphs and palynofacies composition, benthic (foraminifera, gastropods, bivalves, scaphopods, echinoderms), planktonic (calcareous nannoplankton, dinoflagellate cysts), and nektonic (sharks) fossils. The Gnaszyn succession originated relatively close to the shore, within reach of an intense supply of terrestrial fine clas- tic and organic particles. The latter are mainly of terrestrial origin and range from 1.5 to 2.5 wt.%. The precise water depth is difficult to estimate but most likely ranges from several tens of metres to a few hundred metres. All fossil groups show minor changes throughout the succession. As the climate seems to have been quite stable during this period we consider sea-level fluctuations to have been the main factor responsible for the changes. The terrestrial input, includ- ing freshwater and land-derived clastic and organic particles (sporomorphs and cuticles), increased during periods of sea-level lowstand. As a consequence, stress conditions (lower salinity, higher nutrient availability, lower water trans- parency) in the photic zone caused blooms of opportunistic planktonic taxa. Furthermore, a faster sedimentation rate led to oxygen depletion and deterioration of the living conditions in the bottom environment due to an increased accumulation of organic matter. As a result, the benthic biota became taxonomically impoverished and commonly dominated by juvenile forms. During periods of high sea level, the source areas were shifted away from the basin, resulting in a decrease in the terrestrial influx, increase in the salinity of surface waters, the appearance of more diverse phytoplank- ton assemblages, a lower sedimentation rate, and an improvement of living conditions at the bottom

Olenekian (Early Triassic) fossil assemblage from eastern Julian Alps (Slovenia)

New palaeontological and sedimentological data from the Lower Triassic strata of the eastern Julian Alps in Slovenia are presented., They are unusual for the Early Triassic of the Alps in representing a relatively deeper, unrestricted marine (mid-ramp) setting. There are two basic microfacies types in the section investigated (types A and B), which are organized as couplets with coarse-grained tempestitic deposits (microfacies A), overlain by laminated or bioturbated lime mudstones and/or marls (microfacies B), frequently containing ammonoids. This pattern is interpreted as storm deposition with occasional winnowing of bottom sediments and the formation of coarse-grained skeletal deposits (lags), followed by the slow settling of suspended particles, when the storm waned, in addition to background deposition. Dominantly lime mud deposition and the presence of ammonoids indicate deposition on a more distal, deeper ramp with an unrestricted connection to the open sea. Intense reworking of bottom skeletal-rich sediment and accumulation of storm lags suggest deposition above the storm wave base, possibly in a wide low-energy mid-ramp environment. Faunas from such settings have been reported relatively rarely from the Early Triassic of the Alps. The macrofauna contains ammonoids, bivalves and gastropods, whereas the microfauna is represented by foraminifer tests and conodont elements; rare fish remains also occur. In the foraminifer assemblages, species of Ammodiscus, Hoyenella, Glomospirella dominated, corresponding to the widespread “Glomospira-Glomospirella” foraminifer community, with some miliolids and nodosariids. The conodont fauna is characterized by Triassospathodus hungaricus (Kozur et Mostler), indicating an early Spathian (Olenekian) age. The fossil assemblage highlights the wide distribution of Early Triassic taxa in the Tethys and facilitates its worldwide correlation. Its relatively low diversity by comparison with shallow marine settings is interpreted as an evolutionary proximal-distal trend in the wake of the end-Permian mass extinction. Re-diversification first occurred in nearshore settings and expanded into deeper/distal marine environments through geological time

A new Miocene whale-fall community dominated by the bathymodiolin mussel Adipicola from the Hobetsu area, Hokkaido, Japan

金沢大学理工研究域地球社会基盤学系We report the fourth record of a fossil whale-fall community in Japan. The new material consists of a single whale bone in association mainly with small bathymodiolin mussels, Adipicola sp., found in the Karumai Formation (late middle Miocene—early late Miocene) in the Hobetsu area of Hokkaido, Japan. This association of whale bone and Adipicola sp. and its mode of occurrence resembles the description of some other ancient whale-fall communities dominated by small mussels from the Olympic Peninsula in Washington State (early Oligocene), Shosanbetsu in Hokkaido (early middle Miocene) and Carpineti in northern Italy (middle Miocene) and constitutes an example of a chemosynthesis-based community sustained by whale-fall decay in the Miocene deep sea. The new example extends the Miocene distribution of bathymodiolin-dominated whale-fall communities to the northwestern Pacific Ocean

Late Jurassic–Early Cretaceous hydrocarbon seep boulders from Novaya Zemlya and their faunas

The paper describes Late Jurassic–Early Cretaceous seep carbonate boulders from the Russian Arctic island of Novaya Zemlya, collected in 1875 by A.E. Nordenskiöld during his expedition to Siberia. The carbonates are significantly depleted in heavy carbon isotopes (δ13C values as low as ca. − 40‰) and show textures typical for carbonates formed under the influence of hydrocarbons, such as fibrous carbonate cements and corrosion cavities. The rocks contain index fossils of Late Oxfordian–Early Kimmeridgian, Late Tithonian (Jurassic) and latest Berriasian–Early Valanginian (Cretaceous) age. The fossil fauna is species rich and dominated by molluscs, with subordinate brachiopods, echinoderms, foraminifera, serpulids and ostracods. Most of the species, including two chemosymbiotic bivalve species, likely belong to the ‘background’ fauna. Only a species of a hokkaidoconchid gastropod, and a possible abyssochrysoid gastropod, can be interpreted as restricted to the seep environment. Other seep faunas with similar taxonomic structure are suggestive of rather shallow water settings, but in case of Novaya Zemlya seep faunas such structure might result also from high northern latitude

Discovery of chemosynthesis-based association on the Cretaceous basal leatherback sea turtle from Japan

金沢大学国際基幹教育院 GS教育系We report a Late Cretaceous chemosynthetic community fueled by decomposing basal leatherback sea turtle on the ocean floor in the western Pacific. The fossil association representing this community has been recovered from the matrix of a concretion containing a single carapace of Mesodermochelys sp. from Late Cretaceous outer shelf to upper slope deposit of northern Hokkaido, Japan. The carapace displays boreholes most likely performed by boring bivalves, and is associated with molluscan shells, mainly Provanna cf. nakagawensis and Thyasira tanabei. Since this association is similar to fauna already known from Late Cretaceous hydrocarbon seeps, sunken wood, and plesiosaur-falls in Hokkaido, it is suggested that all types of chemosynthesis-based communities in the Late Cretaceous of western Pacific may have belonged to the same regional pool of animals and were not yet fully differentiated into three independent types of communities as it is known today. This finding also indicates that the sulfophilic stage of the vertebrate-fall communities was supported not only by plesiosaur carcasses, which were previously reported, but also by sea turtle carcasses. It highlights the possibility of surviving vertebrate-fall communities through the end-Cretaceous mass extinction event on carcasses of sea turtles which are the only large marine vertebrates surviving this event. Copyright © 2017 R.G. Jenkins et al