Fluctuation theorem for entropy production during effusion of a relativistic ideal gas

The probability distribution of the entropy production for the effusion of a relativistic ideal gas is calculated explicitly. This result is then extended to include particle and anti-particle pair production and annihilation. In both cases, the fluctuation theorem is verified.Comment: 6 pages, no figure

Dermatillomania: Strategies for developing protective biomaterials/cloth

Dermatillomania or skin picking disorder (SPD) is a chronic, recurrent, and treatment resistant neuropsychiatric disorder with an underestimated prevalence that has a concerning negative impact on an individual’s health and quality of life. The current treatment strategies focus on behavioral and pharmacological therapies that are not very effective. Thus, the primary objective of this review is to provide an introduction to SPD and discuss its current treatment strategies as well as to propose biomaterial-based physical barrier strategies as a supporting or alternative treatment. To this end, searches were conducted within the PubMed database and Google Scholar, and the results obtained were organized and presented as per the following categories: prevalence, etiology, conse-quences, diagnostic criteria, and treatment strategies. Furthermore, special attention was provided to alternative treatment strategies and biomaterial-based physical treatment strategies. A total of six products with the potential to be applied as physical barrier strategies in supporting SPD treatment were shortlisted and discussed. The results indicated that SPD is a complex, underestimated, and underemphasized neuropsychiatric disorder that needs heightened attention, especially with regard to its treatment and care. Moreover, the high synergistic potential of biomaterials and nanosystems in this area remains to be explored. Certain strategies that are already being utilized for wound healing can also be further exploited, particularly as far as the prevention of infections is concerned

Modified Fluctuation-dissipation theorem for non-equilibrium steady-states and applications to molecular motors

We present a theoretical framework to understand a modified fluctuation-dissipation theorem valid for systems close to non-equilibrium steady-states and obeying markovian dynamics. We discuss the interpretation of this result in terms of trajectory entropy excess. The framework is illustrated on a simple pedagogical example of a molecular motor. We also derive in this context generalized Green-Kubo relations similar to the ones derived recently by Seifert., Phys. Rev. Lett., 104, 138101 (2010) for more general networks of biomolecular states.Comment: 6 pages, 2 figures, submitted in EP

General properties of response functions of nonequilibrium steady states

We derive general properties, which hold for both quantum and classical systems, of response functions of nonequilibrium steady states. We clarify differences from those of equilibrium states. In particular, sum rules and asymptotic behaviors are derived, and their implications are discussed. Since almost no assumptions are made, our results are applicable to diverse physical systems. We also demonstrate our results by a molecular dynamics simulation of a many-body interacting system.Comment: After publication of this paper, several typos were found, which have been fixed in the erratum (J. Phys. Soc. Jpn., 80 (2011) 128001). All the corrections have been made in this updated arXive version. 13 pages with 3 figure

Universal Properties of Nonlinear Response Functions of Nonequilibrium Steady States

We derive universal properties of nonlinear response functions of nonequilibrium steady states. In particular, sum rules and asymptotic behaviors are derived. Their consequences are illustrated for nonlinear optical materials and nonlinear electrical conductors.Comment: 10 pages, 1 figure; added a few sentences and references to explain detail

A meaningful expansion around detailed balance

We consider Markovian dynamics modeling open mesoscopic systems which are driven away from detailed balance by a nonconservative force. A systematic expansion is obtained of the stationary distribution around an equilibrium reference, in orders of the nonequilibrium forcing. The first order around equilibrium has been known since the work of McLennan (1959), and involves the transient irreversible entropy flux. The expansion generalizes the McLennan formula to higher orders, complementing the entropy flux with the dynamical activity. The latter is more kinetic than thermodynamic and is a possible realization of Landauer's insight (1975) that, for nonequilibrium, the relative occupation of states also depends on the noise along possible escape routes. In that way nonlinear response around equilibrium can be meaningfully discussed in terms of two main quantities only, the entropy flux and the dynamical activity. The expansion makes mathematical sense as shown in the simplest cases from exponential ergodicity.Comment: 19 page

Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo

Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations. In vitro studies implicated Grb2-associated binder 2 (GAB2) as FLT3-ITD effector. Utilizing a Flt3-ITD knock-in, Dnmt3a haploinsufficient mouse model, we demonstrate that Gab2 is essential for the development of Flt3-ITD driven AML in vivo, as Gab2 deficient mice displayed prolonged survival, presented with attenuated liver and spleen pathology and reduced blast counts. Furthermore, leukemic bone marrow from Gab2 deficient mice exhibited reduced colony-forming unit capacity and increased FLT3 inhibitor sensitivity. Using transcriptomics, we identify the genes encoding for Axl and the Ret co-receptor Gfra2 as targets of the Flt3-ITD/Gab2/Stat5 axis. We propose a pathomechanism in which Gab2 increases signaling of these receptors by inducing their expression and by serving as downstream effector. Thereby, Gab2 promotes AML aggressiveness and drug resistance as it incorporates these receptor tyrosine kinases into the Flt3-ITD signaling network. Consequently, our data identify GAB2 as a promising biomarker and therapeutic target in human AML

Current fluctuations in stochastic systems with long-range memory

We propose a method to calculate the large deviations of current fluctuations in a class of stochastic particle systems with history-dependent rates. Long-range temporal correlations are seen to alter the speed of the large deviation function in analogy with long-range spatial correlations in equilibrium systems. We give some illuminating examples and discuss the applicability of the Gallavotti-Cohen fluctuation theorem.Comment: 10 pages, 1 figure. v2: Minor alterations. v3: Very minor alterations for consistency with published version appearing at http://stacks.iop.org/1751-8121/42/34200

Quantum Fluctuation Relations for the Lindblad Master Equation

An open quantum system interacting with its environment can be modeled under suitable assumptions as a Markov process, described by a Lindblad master equation. In this work, we derive a general set of fluctuation relations for systems governed by a Lindblad equation. These identities provide quantum versions of Jarzynski-Hatano-Sasa and Crooks relations. In the linear response regime, these fluctuation relations yield a fluctuation-dissipation theorem (FDT) valid for a stationary state arbitrarily far from equilibrium. For a closed system, this FDT reduces to the celebrated Callen-Welton-Kubo formula

Features caused by ground ice growth and decay in Late Pleistocene fluvial deposits, Paris Basin, France

Last Glacial fluvial sequences in the Paris Basin show laminated lacustrine deposits OSL and radiocarbon dated to between 24.6 and 16.6 ka in one site and overlying alluvial sandy gravel. A thermokarst origin of the lakes is supported by abundant traces of ground ice, particularly ice wedge pseudomorphs beneath the lacustrine layers and synsedimentary deformation caused by thaw settlement. The features include brittle deformation (normal and reverse faults) resulting from ground subsidence owing to ice melting and ductile deformations caused by slumping of the sediments heaved by the growth of ice-cored mounds. These correspond to lithalsas (or lithalsa plateaus) and/or to open system pingos. At least two generations of thermokarst are recorded and may reflect the millennial climate variability typical of the Last Glacial. The structures studied in quarries are associated with an undulating topography visible in 5-m DEMs and a spotted pattern in aerial photographs. The search for similar patterns in the Paris Basin indicates that many other potential thermokarst sites exist in the Last Glacial terrace (Fy) of rivers located north of 48°N when they cross the lower Cretaceous sands and marls. In some sites, the presence of organic-poor, fine-grained deposits presumably of lacustrine origin was confirmed by borehole data. The site distribution coincides broadly with that already known for ice wedge pseudomorphs. This study provides new evidence of permafrost-induced ground deformations in France and strongly suggests that thermokarst played a significant and probably largely underestimated role in the genesis of Late Pleistocene landscapes