El museo: Arte en un espacio proyectado

En este artículo reflexionamos sobre el aspecto multisensorial de la visita al museo. Abordando tanto la visita física, en la que la experiencia del arte ocurre en el contexto no única­mente de la obra, sino también, en el espacio proyectado que la rodea, preparando psicológi­camente al individuo a través de la promenade architecturale y la psicogeografía urbana; como la visita virtual, donde la atención se centra únicamente en la obra de arte y la simulación del entorno en el que se ubica. De este modo la realidad que el usuario recibe es sesgada, ya que lo percibido ha sido manipulado por diversos medios de captura, representación y comunicación antes de llegar a los sentidos. Durante el texto analizamos diversos casos que ejemplifican por­qué el espacio contextual forma un papel activo al experimentar una obra de arteIn this article we reflect on the multisensory aspect of the museum visit. Talking about the physical visit, in wich the experience of art occurs in the context, not only of the work, but also projected in the space that surrounds it, psychologically preparing the individual through the promenade architecturale and urban psychogeography; and also the virtual tour, where the focus is only on the artwork and the environment simulation in wich it is located. Thus the fact that the user receives is biased, since what is perceived has been manipulated by various means of capture, representation and communication before reaching the senses. In the text we analyze some cases that illustrate why the surrounding space takes an active role when experiencing an artwork

El museo: arte en un espacio proyectado

En este artículo reflexionamos sobre el aspecto multisensorial de la visita al museo. Abordando tanto la visita física, en la que la experiencia del arte ocurre en el contexto no única'mente de la obra, sino también, en el espacio proyectado que la rodea, preparando psicológi'camente al individuo a través de la promenade architecturale y la psicogeografía urbana; como la visita virtual, donde la atención se centra únicamente en la obra de arte y la simulación del entorno en el que se ubica. De este modo la realidad que el usuario recibe es sesgada, ya que lo percibido ha sido manipulado por diversos medios de captura, representación y comunicación antes de llegar a los sentidos. Durante el texto analizamos diversos casos que ejemplifican por'qué el espacio contextual forma un papel activo al experimentar una obra de arte.; In this article we reflect on the multisensory aspect of the museum visit. Talking about the physical visit, in which the experience of art occurs in the context, not only of the work, but also projected in the space that surrounds it, psychologically preparing the individual through the promenade architecturale and urban psychogeography; and also the virtual tour, where the focus is only on the artwork and the environment simulation in which it is located. Thus the fact that the user receives is biased, since what is perceived has been manipulated by various means of capture, representation and communication before reaching the senses. In the text we analyze some cases that illustrate why the surrounding space takes an active role when experiencing an artwork

Integrated Optical Interferometric Biosensors based on Microelectronics technology for biosensing applications

6 páginas, 8 figuras.-- Comunicación oral presentada al Ibersensors´2002 celebrado en Lima (Perú) en 2002.Integrated optical sensors have reached a great importance during last years since they can be used for the direct detection of biomolecular interactions. Moreover, Silicon microelectronics technology allows mass production as well as the fabrication of microsystems by hybrid integration of sources, sensors, photodelectors and CMOS electronics. For the fabrication of an evanescent field sensor with an integrated Mach-Zehnder interferometric (MZI) configuration, the optical waveguides must verify two main characteristics: monomode behaviour and high surface sensitivity. In this paper we present the development of a MZI sensor based on two different optical waveguides: TIR (Total Internal Reflection) and ARROW (Antiresonant Reflecting Optical Waveguides). The advantages of both structures are discussed and experimental results of the devices are presented.Peer reviewe

Multimodality approach to the nipple-areolar complex : a pictorial review and diagnostic algorithm

The anatomic and histologic characteristics of the nipple-areolar complex make this breast region special. The nipple-areolar complex can be affected by abnormal development and a wide spectrum of pathological conditions, many of which have unspecific clinical and radiological presentations that can present a challenge for radiologists. The nipple-areolar complex requires a specific imaging workup in which a multimodal approach is essential. Radiologists need to know the different imaging modalities used to study the nipple-areolar complex, as well as their advantages and limitations. It is essential to get acquainted with the acquisition technique for each modality and the spectrum of findings for the different conditions. This review describes and illustrates a combined clinical and radiological approach to evaluate the nipple-areolar complex, emphasizing the findings for the normal morphology, developmental abnormalities, and the most common benign and malignant diseases that can affect this region. We also present a diagnostic algorithm that enables a rapid, practical approach to diagnosing condition involving the nipple-areolar complex

The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors

FtsZ is a widely conserved tubulin-like GTPase that directs bacterial cell division and a new target for antibiotic discovery. This protein assembly machine cooperatively polymerizes forming single-stranded filaments, by means of self-switching between inactive and actively associating monomer conformations. The structural switch mechanism was proposed to involve a movement of the C-terminal and N-terminal FtsZ domains, opening a cleft between them, allosterically coupled to the formation of a tight association interface between consecutive subunits along the filament. The effective antibacterial benzamide PC190723 binds into the open interdomain cleft and stabilizes FtsZ filaments, thus impairing correct formation of the FtsZ ring for cell division. We have designed fluorescent analogs of PC190723 to probe the FtsZ structural assembly switch. Among them, nitrobenzoxadiazole probes specifically bind to assembled FtsZ rather than to monomers. Probes with several spacer lengths between the fluorophore and benzamide moieties suggest a binding site extension along the interdomain cleft. These probes label FtsZ rings of live Bacillus subtilis and Staphylococcus aureus, without apparently modifying normal cell morphology and growth, but at high concentrations they induce impaired bacterial division phenotypes typical of benzamide antibacterials. During the FtsZ assembly-disassembly process, the fluorescence anisotropy of the probes changes upon binding and dissociating from FtsZ, thus reporting open and closed FtsZ interdomain clefts. Our results demonstrate the structural mechanism of the FtsZ assembly switch, and suggest that the probes bind into the open clefts in cellular FtsZ polymers preferably to unassembled FtsZ in the bacterial cytosol

Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ

Cell division protein FtsZ is the organizer of the cytokinetic Z-ring in most bacteria and a target for new antibiotics. FtsZ assembles with GTP into filaments that hydrolyze the nucleotide at the association interface between monomers and then disassemble. We have replaced FtsZ's GTP with non-nucleotide synthetic inhibitors of bacterial division. We searched for these small molecules among compounds from the literature, from virtual screening (VS), and from our in-house synthetic library (UCM), employing a fluorescence anisotropy primary assay. From these screens we have identified the polyhydroxy aromatic compound UCM05 and its simplified analogue UCM44 that specifically bind to Bacillus subtilis FtsZ monomers with micromolar affinities and perturb normal assembly, as examined with light scattering, polymer sedimentation, and negative stain electron microscopy. On the other hand, these ligands induce the cooperative assembly of nucleotide-devoid archaeal FtsZ into distinct well-ordered polymers, different from GTP-induced filaments. These FtsZ inhibitors impair localization of FtsZ into the Z-ring and inhibit bacterial cell division. The chlorinated analogue UCM53 inhibits the growth of clinical isolates of antibiotic-resistant Staphylococcus aureus and Enterococcus faecalis. We suggest that these interfacial inhibitors recapitulate binding and some assembly-inducing effects of GTP but impair the correct structural dynamics of FtsZ filaments and thus inhibit bacterial division, possibly by binding to a small fraction of the FtsZ molecules in a bacterial cell, which opens a new approach to FtsZ-based antibacterial drug discovery.This work was supported by grants from Plan Nacional de Investigación BFU 2011-23416 (J.M.A.), BFU2099-09552 (P.C.), and SAF2010-22198 (M.L.L.-R.), grant CM S2010/BMD-2353 (M.L.L.-R, P.C., J.M.A.), and fellowships FPI (L.B.R.-A.), FPU (M.A.) and CSIC-JAE (E.R.-A.)

Targeting bacterial cell division protein FtsZ with small molecules and fluorescent probes

Trabajo presentado en el 248th National Meeting of the American-Chemical-Society (ACS), celebrado en San Francisco, CA (Estados Unidos), del 10 al 14 de agosto de 201

Isolo : a new concept of privacy

Isolo es un conjunto de cuatro productos interactivos, diseñados por los estudiantes del Grado de Diseño de EINA, que exploran y aplican el concepto “privacidad”. Los proyectos ofrecen diferentes formas de aislamiento respetando los hábitos de los usuarios y recreando atmósferas de intimidad, desde el individuo hasta el colectivo. Los proyectos presentados son: Köllen Eget es un espacio de trabajo adaptado a los nuevos hábitos de trabajo y al uso de las de las nuevas tecnologías. La interactividad del producto permite reorganizar el espacio y generar un ambiente personalizado, adaptándose a cada usuario gracias a la iluminación, la acústica y la presencia de diferentes elementos móviles. Còdol es un separador de espacios que contempla el contraste entre el vacío y la plenitud. Consigue crear un ambiente privado dentro de un entorno interior y concurrido gracias a su estructura envolvente de paneles móviles con propiedades acústicas y tonalidades suaves. Petal es una silla versátil y adaptable al usuario, inspirada en las formas orgánicas de las flores. En cada lateral hay un panel flexible que permite ser regulado en diferentes posiciones y de esta manera convertirlo en un espacio del almacenamiento personalizado acorde con las necesidades del usuario. Kodama es un panel decorativo, que se presenta como una arboleda de influencia oriental coronada por los elementos más distintivos de todo el conjunto: los asientos, que están colocados aleatoriamente por toda la estructura a disposición del usuario.Isolo és un conjunt de quatre productes interactius, dissenyats pels estudiants del Grau de Disseny d’EINA, que exploren i apliquen el concepte “privacitat”. Els projectes ofereixen diferents formes d’aïllament respectant els hàbits dels usuaris i recreant atmosferes d’intimitat, des de l’individu fins al col·lectiu. Els projectes presentats són: Köllen Eget és un espai de treball adaptat als nous hàbits de treball i a l’ús de les noves tecnologies. La interactivitat del producte permet reorganitzar l’espai i generar un ambient personalitzat, adaptant-se a cada usuari a través de la il·luminació, l’acústica i la presència de diferents elements mòbils. Còdol és un separador d’espais que contempla el contrast entre el buit i el ple. Aconsegueix crear un ambient privat dins d’un entorn interior i concorregut gràcies a la seva estructura envoltant de panells mòbils amb propietats acústiques i tonalitats suaus. Petal és una cadira versàtil i adaptable a l’usuari, inspirada en les formes orgàniques de les flors. A cada lateral hi ha un panell flexible que permet ser regulat en diferents posicions i d’aquesta manera convertir-lo en un espai d’emmagatzematge personalitzat d’acord amb les necessitats de l’usuari. Kodama és un panell decoratiu, que es presenta com una arbreda d’influència oriental, coronada pels elements més distintius de tot el conjunt: els seients, que estan disposats aleatòriament per tota l’estructura a disposició de l’usuari.Isolo is a set of four interactive products, designed by students on the EINA Bachelor’s Degree in Design, that explore and apply the concept of “privacy”. The projects offer different forms of isolation, respecting users’ habits and recreating atmospheres of intimacy, from the individual to the group. The projects presented are: Köllen Eget is a workspace adapted to new working habits and the use of new technologies. The interactivity of the product allows users to reorganise their space and create a personalised ambience, adapting to each user through light, sound and the presence of different mobile elements. Còdol is a space divider that considers the contrast between empty and full. It manages to create a private ambience in an interior and busy environment thanks to its structure, surrounded by moveable panels with sound properties and soft tones. Petal is a versatile chair that is adaptable to the user, inspired by the organic shapes of flowers. On each side is a flexible panel that can be regulated in different positions, so turning it into a personalised storage space in line with your needs. Kodama is a decorative panel displayed as an Oriental-influenced woodland crowned by the most distinctive elements of the entire piece: the seats, which are placed at random throughout the whole structure for use by the user

PhDay Educación 2020. VI Jornadas de Investigación. Libro de Actas

Todas las contribuciones presentadas en este Libro de Actas forman parte de la evaluación de seguimiento de los doctorandos de segundo año a tiempo completo y tercer año a tiempo parcial del Programa de Doctorado en Educación de la Universidad Complutense de Madrid. Cada trabajo ha sido revisado formalmente por el comité organizador y valorado por los directores y tutores de tesis. Asimismo, cada doctorando ha recibido mejoras por otros estudiantes del programa que han podido incluir antes de la finalización del presente documento