Evaluación del desarrollo clínico psicomotriz de recién nacidos prematuros, de la UCIN, en un hospital del MINSA, Punchana - 2020

Annually 15 million premature infants are born, which in the last 30 years, its percentage is estimated between 5 and 7%. However, complications related to it have been responsible for approximately one million deaths. To this is added the greater susceptibility of having problems during the neonatal period, increasing their risk of morbidity and mortality even beyond the first months of life; as well as, the readmission rates of late preterm newborns that are 1.5 to three times higher than those of term newborns, in addition to being vulnerable to presenting some type of disability such as intellectual, motor and sensory level. Objective: To determine the relationship between the evaluation of psychomotor clinical development (motor disability, sensory disability, learning difficulties) and premature newborns in the Neonatal Intensive Care Unit in a MINSA Hospital, 2020. Materials and methods: the study It has a nonexperimental, quantitative, observational, analytical correlational, retrospective design. The study population will be assessed with the "Peruvian Test for the evaluation of the development of the child in infants and in premature Capurro", correlated with prenatal, natal and postnatal clinical history from which information on the child's psychomotor development will be obtained.Anualmente se ha observado el ascenso de nacimietos prematuros durante los últimos 30 años, con un estimado de 15 millones de nacimientos anuales que representan el 5 y 7% de todos los nacidos vivos. Sin embargo, estos son altamente vulnerables a complicaciones y muerte, debido a su escaso desarrollo. Favoreciendo la tasa de ingresos y reingresos en hasta mas de 3 veces a comparacion de los recien nacidos a término; ademas de ser el causante de una deficiencia motriz, sensitiva y cognitiva. “Objetivo: Determinar la relación entre la evaluación del desarrollo clínico psicomotriz (discapacidad motora, discapacidad sensorial, dificultades para el aprendizaje) y los recién nacidos prematuros de la Unidad de Cuidados Intensivos Neonatales en un Hospital del MINSA, 2020”. Materiales y métodos: el estudio tiene un diseño no experimental, cuantitativo, observacional, correlacional analítico, retrospectivo. Se valorará a la población de estudio con el “Test Peruano de evaluación del desarrollo del niño en lactantes y en prematuros Capurro”, correlacionado con historia clínica prenatal, natal y postnatal de donde se obtendrá la información sobre el desarrollo psicomotor del niño

Effect of Sunflower and Marine Oils on Ruminal Microbiota, In vitro Fermentation and Digesta Fatty Acid Profile

Funding This work has been funded by Consejería de Educación, Junta de Castilla y León (research project LE007A07). Acknowledgments We acknowledge support of the publication fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICI). Support received from CICYT project AGL2005-04760-C02-02 is gratefully acknowledged.Peer reviewedPublisher PD

How do galaxies populate haloes in high-density environments? An analysis of the Halo Occupation Distribution in future virialized structures

There are hints suggesting that properties of galaxy populations in dark matter haloes may depend on their large-scale environment. Recent works point out that very low-density environments influence halo occupation distribution (HOD), however there is not a similar analysis focused on high-density environments. Here we use a simulated set of future virialized superstructures (FVS) to analyse the occupation of galaxies in haloes within these high globally dense regions. We use a publicly available simulated galaxy set constructed with a semi-analytical model to identify FVS in the simulation. Then, we computed the HOD within these superstructures for different absolute magnitude thresholds and make several analysis including the comparison to the global HOD results. We study the dependence on the results on properties of the FVS such as density and volume as well as consider the morphology of galaxies. We also analysed the properties of the stellar content of galaxies and the formation time of the haloes inside FVS. We find a significant increase in the HOD inside FVS. This result is present for all absolute magnitude thresholds explored. The effect is larger in the densest regions of FVS, but does not depend on the volume of the superstructure. We also find that the stellar-mass content of galaxies considerably differs inside the superstructures. Low mass haloes have their central and satellite galaxies with a higher stellar mass content (50%), and exhibit mean star ages (20%) older than average. For massive haloes in FVS we find that only the stellar mass of satellite galaxies varies considerably corresponding to a decrease of 50%. We find a significant statistical difference between the formation times of haloes in FVS and the average population. Haloes residing in superstructures formed earlier, a fact that leads to several changes in the HOD and their member galaxy properties.Comment: 12 pages, 14 figures, the paper has been accepted to be published by the A&

Validation and Search of the Ideal Cut-Off of the Sysmex UF-1000i (R) Flow Cytometer for the Diagnosis of Urinary Tract Infection in a Tertiary Hospital in Spain

Urinary tract infections (UTI) are one of the most prevalent infections. A rapid and reliable screening method is useful to screen out negative samples. The objective of this study was to validate the Sysmex flow cytometer UF-1000i by evaluating its accuracy, linearity and carry-over; and define an optimal cut-off value to be used in routine practice in our hospital. For the validation of the UF-1000i cytometer, precision, linearity and carry-over were studied in samples with different counts of bacteria, leukocytes and erythrocytes. Between March and June 2016, urine samples were tested in the Clinical Microbiology Laboratory at University Miguel Servet Hospital, in Spain. Samples were analyzed with the Sysmex UF-1000i cytometer, and cultured. Growth of >= 10(5) CFUs/mL was considered positive. The validation study reveals that the precision in all the variables is acceptable; that there is a good linearity in the dilutions performed, obtaining values almost identical to those theoretically expected; and for the carry-over has practically null values. A total of 1, 220 urine specimens were included, of which 213 (17.4%) were culture positive. The optimal cut-off point of the bacteria-leukocyte combination was 138.8 bacteria or 119.8 leukocytes with an S and E of 95.3 and 70.4%, respectively. The UF-1000i cytometer is a valuable method to screen urine samples to effectively rule out UTI and, may contribute to the reduction of unnecessary urine cultures

Comparing Two Automated Techniques for the Primary Screening-Out of Urine Culture

Urinary tract infection is the most common human infection with a high morbidity. In primary care and hospital services, conventional urine culture is a key part of infection diagnosis but results take at least 24 h. Therefore, a rapid and reliable screening method is still needed to discard negative samples as quickly as possible and to reduce the laboratory workload. In this aspect, this study aims to compare the diagnostic performance between Sysmex OF-1000i and FUS200 systems in comparison to urine culture as the gold standard. From March to June 2016, 1, 220 urine samples collected at the clinical microbiology laboratory of the "Miguel Servet" hospital were studied in parallel with both analysers, and some technical features were evaluated to select the ideal equipment. The most balanced cut-off values taking into account bacteria or leukocyte counts were 138 bacteria/mu L or 119.8 leukocyte/pl for the OF-1000i (95.3% SE and 70.4% SP), and 5.7 bacteria/mu L or 4.3 leukocyte/mu L for the FUS200 (95.8% SE and 44.4% SP). The reduction of cultured plates was 37.4% with the FUS200 and 58.3% with the UF-1000i. This study shows that both techniques improve the workflow in the laboratory, but the OF-1000i has the highest specificity at any sensitivity and the FUS200 needs a shorter processing time

High Photocurrent in Gated Graphene-Silicon Hybrid Photodiodes

Graphene/silicon (G/Si) heterojunction based devices have been demonstrated as high responsivity photodetectors that are potentially compatible with semiconductor technology. Such G/Si Schottky junction diodes are typically in parallel with gated G/silicon dioxide (SiO$_2$)/Si areas, where the graphene is contacted. Here, we utilize scanning photocurrent measurements to investigate the spatial distribution and explain the physical origin of photocurrent generation in these devices. We observe distinctly higher photocurrents underneath the isolating region of graphene on SiO$_2$ adjacent to the Schottky junction of G/Si. A certain threshold voltage (V$_T$) is required before this can be observed, and its origins are similar to that of the threshold voltage in metal oxide semiconductor field effect transistors. A physical model serves to explain the large photocurrents underneath SiO$_2$ by the formation of an inversion layer in Si. Our findings contribute to a basic understanding of graphene / semiconductor hybrid devices which, in turn, can help in designing efficient optoelectronic devices and systems based on such 2D/3D heterojunctions.Comment: 25 pages, 5 figure

Gestation and COVID-19 : clinical and microbiological observational study (Gesta-COVID19)

The Coronavirus Disease 2019 (COVID-19) is a novel disease which has been having a worldwide affect since December 2019. Evidence regarding the effects of SARS-CoV-2 during pregnancy is conflicting. The presence of SARS-CoV-2 has been demonstrated in biological samples during pregnancy (placenta, umbilical cord or amniotic fluid); however, maternal and fetal effects of the virus are not well known. Descriptive, multicentre, longitudinal, observational study in eight tertiary care hospitals throughout Spain, that are referral centres for pregnant women with COVID-19. All pregnant women with positive SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction during their pregnancy or 14 days preconception and newborns born to mothers infected with SARS-CoV-2 will be included. They will continue to be followed up until 4 weeks after delivery. The aim of the study is to investigate both the effect of COVID-19 on the pregnancy, and the effect of the pregnancy status with the evolution of the SARS-CoV-2 disease. Other samples (faeces, urine, serum, amniotic fluid, cord and peripheral blood, placenta and breastmilk) will be collected in order to analyse whether or not there is a risk of vertical transmission and to describe the behaviour of the virus in other fluids. Neonates will be followed until 6 months after delivery to establish the rate of neonatal transmission. We aim to include 150 pregnant women and their babies. Ethics approval will be obtained from all the participating centres. There is little information known about COVID-19 and its unknown effects on pregnancy. This study will collect a large number of samples in pregnant women which will allow us to demonstrate the behaviour of the virus in pregnancy and postpartum in a representative cohort of the Spanish population

Evaluation of the performance of message routing protocols in delay tolerant networks (DTN) in Colombian scenario

Certain vehicles need to send information to their monitoring stations constantly, this information is usually sent by the vehicles, through the cellular network. The use of these wireless networks depends on coverage that it is not usually available in all geographic areas. This is the case of road segments where the coverage of data service of cellular networks is partial or zero, making transmission impossible. A particular case is the roads between the municipality of Juan de Acosta and the city of Barranquilla in Atlántico department (Colombia). As a solution, Delay-Tolerant Networks (DTN) emerge, which allow the transmission of data to the monitoring stations when there is no cellular network coverage. In this work, a simulated evaluation of the performance of some message routing protocols for DTN is performed, in the Juan de Acosta – Barranquilla scenario. Using “The Opportunistic Networking Environment”, we determined the performance of these message routing protocols. The results show that the first contact message routing protocol, presents the highest rate of delivery messages (delivery rate) and the lowest delivery latency (delivery latency). In addition, the Spray and Wait protocol presents better results in System message overload (overhead) than the first one. The Opportunistic Networking Environment simulator, the performance of these message routing protocols was determined in this scenario. The results show that the Firstcontact message routing protocol presents the highest rate of delivery (deliveryrate) and the lowest delivery delay (deliverylatency). In addition, the Spray and Wait protocol has a better result in system overhead than the first one

La Imagen y la Narrativa como Herramientas para el Abordaje Psicosocial en Escenarios de Violencia. Municipios de Bogotá, Cartagena y San Estanislao de Kostka

El propósito de este proyecto es el acompañamiento psicosocial en contextos de violencia, se abordaron problemáticas relacionadas con la violencia y su impacto psicosocial, para el desarrollo de este se hace una revisión bibliográfica desde la cual se logra un conocimiento de los diferentes contextos que han de tenerse en cuenta para la comprensión de las implicaciones de las experiencias de violencia en lo personal como grupal. En la construcción de las diferentes etapas se precisa de un abordaje a situaciones diversas en las que la violencia es el factor común y tomando como recurso la narrativa para desde esta conocer las experiencias de vida de personas que vivieron experiencias traumáticas derivadas del conflicto armado y que dan cuenta de su proceso inicial como víctima y posteriormente en su discurso reconocerlos como sobrevivientes, formulando una serie de preguntas reflexivas, circulares y estratégicas con el propósito de un acercamiento psicosocial. Se presenta un análisis a partir del caso Pandurí que funciona como reflejo de la realidad de muchas comunidades expuestas al desplazamiento forzado posterior a la incursión militar, desde esta narración se hace una identificación de los emergentes psicosociales y los impactos para las personas que experimentan estas situaciones; frente a este punto se logra reconocer los cambios en la forma de vida, producto del desarraigo del territorio y lo que para ello representa, desde el rol que tiene la psicología en la atención y acompañamiento de estas problemáticas sociales, se proponen acciones de apoyo y estrategias de acción psicosocial para afrontar la situación. Concluyendo como parte fundamental a la hora de la intervención y acompañamiento psicosocial, la fotografía y la narrativa, en las diferentes experiencias y significados que sólo pueden ser comprendidos desde las palabras y el lenguaje de sus protagonistas que acercan a la historia de vida de cada uno de ellos, siendo destacable la capacidad de reponerse a pesar de las adversidades, partiendo del apoyo social, la relación con el otro, la comunicación y demás aspectos que funcionan como estrategia para continuar el camino de la esperanza, fortaleza y la recuperación.The purpose of this project is the psychosocial accompaniment in the context of violence, where the different problems and psychosocial impact were addressed, in the development of this is a bibliographic review from which a knowledge of the different contexts to be taken into account is achieved for the understanding of the implications of the experiences of violence personally as a group. In the construction of the different stages an approach is needed to different situations in which violence is the common factor and taking as a resource the narrative to know the life experiences of people who lived traumatic experiences arising from armed conflict and who account for their initial process as a victim and subsequently in their speech recognize them as survivors, asking a series of thoughtful, circular and strategic questions for the purpose of a psychosocial approach. An analysis is presented from the Pandurí case that functions as a reflection of the reality of narrative is made an identification of forced displacement after the military incursion, since this narrative is made an identification of the emerging psychosocial and the impacts for the people who experience these situations; at the point it is possible to recognize the changes in the way of life, the result of the uprooting of the territory and what it represents, from the role that psychosocial action strategies are proposed to deal with the situation. Concluding as a fundamental part when it comes to invention and psychosocial accompanied, photography and narrative in the different experiences and meanings that can only be understood from the words and language of its protagonists that bring the life story of each of them closer, the ability to recover despite adversity, based on social support, relationship with each other, communication and other aspects that function as a strategy to continue the path of hope, strength and recover

EcID. A database for the inference of functional interactions in E. coli

The EcID database (Escherichia coli Interaction Database) provides a framework for the integration of information on functional interactions extracted from the following sources: EcoCyc (metabolic pathways, protein complexes and regulatory information), KEGG (metabolic pathways), MINT and IntAct (protein interactions). It also includes information on protein complexes from the two E. coli high-throughput pull-down experiments and potential interactions extracted from the literature using the web services associated to the iHOP text-mining system. Additionally, EcID incorporates results of various prediction methods, including two protein interaction prediction methods based on genomic information (Phylogenetic Profiles and Gene Neighbourhoods) and three methods based on the analysis of co-evolution (Mirror Tree, In Silico 2 Hybrid and Context Mirror). EcID associates to each prediction a specifically developed confidence score. The two main features that make EcID different from other systems are the combination of co-evolution-based predictions with the experimental data, and the introduction of E. coli-specific information, such as gene regulation information from EcoCyc. The possibilities offered by the combination of the EcID database information are illustrated with a prediction of potential functions for a group of poorly characterized genes related to yeaG. EcID is available online at http://ecid.bioinfo.cnio.es