Central mass and luminosity of Milky Way satellites in the LCDM model

It has been pointed out that the Galactic satellites all have a common mass around 1e7 Msun within 300 pc (M03), while they span almost four order of magnitudes in luminosity (Mateo et al. 1993, Strigari et al. 2008). It is argued that this may reflect a specific scale for galaxy formation or a scale for dark matter clustering. Here we use numerical simulations coupled with a semi-analytic model for galaxy formation, to predict the central mass and luminosity of galactic satellites in the LCDM model. We show that this common mass scale can be explained within the Cold Dark Matter scenario when the physics of galaxy formation is taken into account. The narrow range of M03 comes from the narrow distribution of circular velocities at time of accretion (peaking around 20 km/s) for satellites able to form stars and the not tight correlation between halo concentration and circular velocity. The wide range of satellite luminosities is due to a combination of the mass at time of accretion and the broad distribution of accretion redshifts for a given mass. This causes the satellites baryonic content to be suppressed by photo-ionization to very different extents. Our results favor the argument that the common mass M03 reflects a specific scale (circular velocity ~ 20 km/s) for star formation.Comment: 5 pages, 3 figures. References added, discussion enlarged, new version of Figure 3. Minor changes to match the version accepted for publication on ApJ Letter

Constraints on the relationship between stellar mass and halo mass at low and high redshift

We use a statistical approach to determine the relationship between the stellar masses of galaxies and the masses of the dark matter halos in which they reside. We obtain a parameterized stellar-to-halo mass (SHM) relation by populating halos and subhalos in an N-body simulation with galaxies and requiring that the observed stellar mass function be reproduced. We find good agreement with constraints from galaxy-galaxy lensing and predictions of semi-analytic models. Using this mapping, and the positions of the halos and subhalos obtained from the simulation, we find that our model predictions for the galaxy two-point correlation function (CF) as a function of stellar mass are in excellent agreement with the observed clustering properties in the SDSS at z=0. We show that the clustering data do not provide additional strong constraints on the SHM function and conclude that our model can therefore predict clustering as a function of stellar mass. We compute the conditional mass function, which yields the average number of galaxies with stellar masses in the range [m, m+dm] that reside in a halo of mass M. We study the redshift dependence of the SHM relation and show that, for low mass halos, the SHM ratio is lower at higher redshift. The derived SHM relation is used to predict the stellar mass dependent galaxy CF and bias at high redshift. Our model predicts that not only are massive galaxies more biased than low mass ones at all redshifts, but the bias increases more rapidly with increasing redshift for massive galaxies than for low mass ones. We present convenient fitting functions for the SHM relation as a function of redshift, the conditional mass function, and the bias as a function of stellar mass and redshift.Comment: 21 pages, 17 figures, discussion enlarged, one more figure, updated references, accepted for publication in Ap

The effect of Warm Dark Matter on galaxy properties: constraints from the stellar mass function and the Tully-Fisher relation

In this paper we combine high resolution N-body simulations with a semi analytical model of galaxy formation to study the effects of a possible Warm Dark Matter (WDM) component on the observable properties of galaxies. We compare three WDM models with a dark matter mass of 0.5, 0.75 and 2.0 keV, with the standard Cold Dark Matter case. For a fixed set of parameters describing the baryonic physics the WDM models predict less galaxies at low (stellar) masses, as expected due to the suppression of power on small scales, while no substantial difference is found at the high mass end. However these differences in the stellar mass function, vanish when different set of parameters are used to describe the (largely unknown) galaxy formation processes. We show that is possible to break this degeneracy between DM properties and the parameterization of baryonic physics by combining observations on the stellar mass function with the Tully-Fisher relation (the relation between stellar mass and the rotation velocity at large galactic radii as probed by resolved HI rotation curves). WDM models with a too warm candidate (m<0.75 keV) cannot simultaneously reproduce the stellar mass function and the Tully-Fisher relation. We conclude that accurate measurements of the galaxy stellar mass function and the link between galaxies and dark matter haloes down to the very low-mass end can give very tight constraints on the nature of DM candidates.Comment: 8 pages, 5 figures, minor changes, accepted for publication on Ap

Seroprevalence of Zika virus in wild African green monkeys and baboons

ABSTRACT Zika virus (ZIKV) has recently spread through the Americas and has been associated with a range of health effects, including birth defects in children born to women infected during pregnancy. Although the natural reservoir of ZIKV remains poorly defined, the virus was first identified in a captive “sentinel” macaque monkey in Africa in 1947. However, the virus has not been reported in humans or nonhuman primates (NHPs) in Africa outside Gabon in over a decade. Here, we examine ZIKV infection in 239 wild baboons and African green monkeys from South Africa, the Gambia, Tanzania, and Zambia using combinations of unbiased deep sequencing, quantitative reverse transcription-PCR (qRT-PCR), and an antibody capture assay that we optimized using serum collected from captive macaque monkeys exposed to ZIKV, dengue virus, and yellow fever virus. While we did not find evidence of active ZIKV infection in wild NHPs in Africa, we found variable ZIKV seropositivity of up to 16% in some of the NHP populations sampled. We anticipate that these results and the methodology described within will help in continued efforts to determine the prevalence, natural reservoir, and transmission dynamics of ZIKV in Africa and elsewhere. IMPORTANCE Zika virus (ZIKV) is a mosquito-borne virus originally discovered in a captive monkey living in the Zika Forest of Uganda, Africa, in 1947. Recently, an outbreak in South America has shown that ZIKV infection can cause myriad health effects, including birth defects in the children of women infected during pregnancy. Here, we sought to investigate ZIKV infection in wild African primates to better understand its emergence and spread, looking for evidence of active or prior infection. Our results suggest that up to 16% of some populations of nonhuman primate were, at some point, exposed to ZIKV. We anticipate that this study will be useful for future studies that examine the spread of infections from wild animals to humans in general and those studying ZIKV in primates in particular. Podcast: A podcast concerning this article is available

Universal IMF vs dark halo response in early-type galaxies: breaking the degeneracy with the fundamental plane

We use the relations between aperture stellar velocity dispersion (\sigma_ap), stellar mass (M_sps), and galaxy size (R_e) for a sample of \sim 150,000 early-type galaxies from SDSS/DR7 to place constraints on the stellar initial mass function (IMF) and dark halo response to galaxy formation. We build LCDM based mass models that reproduce, by construction, the relations between galaxy size, light concentration and stellar mass, and use the spherical Jeans equations to predict \sigma_ap. Given our model assumptions (including those in the stellar population synthesis models), we find that reproducing the median \sigma_ap vs M_sps relation is not possible with {\it both} a universal IMF and a universal dark halo response. Significant departures from a universal IMF and/or dark halo response are required, but there is a degeneracy between these two solutions. We show that this degeneracy can be broken using the strength of the correlation between residuals of the velocity-mass (\Delta log \sigma_ap) and size-mass (\Delta log R_e) relations. The slope of this correlation, d_vr \equiv \Delta log \sigma_ap/\Delta log R_e, varies systematically with galaxy mass from d_vr \simeq -0.45 at M_sps \sim 10^{10}M_sun, to d_vr \simeq -0.15 at M_sps \sim 10^{11.6} M_sun. The virial fundamental plane (FP) has d_vr=-1/2, and thus we find the tilt of the observed FP is mass dependent. Reproducing this tilt requires {\it both} a non-universal IMF and a non-universal halo response. Our best model has mass-follows-light at low masses (Msps < 10^{11.2}M_sun) and unmodified NFW haloes at M_sps \sim 10^{11.5} M_sun. The stellar masses imply a mass dependent IMF which is "lighter" than Salpeter at low masses and "heavier" than Salpeter at high masses.Comment: 19 pages, 16 figures, accepted to MNRAS. More extensive discussion, 4 new figures, conclusions unchange

A direct measurement of the baryonic mass function of galaxies & implications for the galactic baryon fraction

We use both an HI-selected and an optically-selected galaxy sample to directly measure the abundance of galaxies as a function of their "baryonic" mass (stars + atomic gas). Stellar masses are calculated based on optical data from the Sloan Digital Sky Survey (SDSS) and atomic gas masses are calculated using atomic hydrogen (HI) emission line data from the Arecibo Legacy Fast ALFA (ALFALFA) survey. By using the technique of abundance matching, we combine the measured baryonic function (BMF) of galaxies with the dark matter halo mass function in a LCDM universe, in order to determine the galactic baryon fraction as a function of host halo mass. We find that the baryon fraction of low-mass halos is much smaller than the cosmic value, even when atomic gas is taken into account. We find that the galactic baryon deficit increases monotonically with decreasing halo mass, in contrast with previous studies which suggested an approximately constant baryon fraction at the low-mass end. We argue that the observed baryon fractions of low mass halos cannot be explained by reionization heating alone, and that additional feedback mechanisms (e.g. supernova blowout) must be invoked. However, the outflow rates needed to reproduce our result are not easily accommodated in the standard picture of galaxy formation in a LCDM universe.Comment: Accepted to ApJ. 45 pages (aastex), 19 figures; added references and updated fig.18 for version

Altered angiogenesis as a common mechanism underlying preterm birth, small for gestational age, and stillbirth in women living with HIV

Background Angiogenic processes in the placenta are critical regulators of fetal growth and impact birth outcomes, but there are limited data documenting these processes in HIV-infected women or women from low-resource settings. Objective We sought to determine whether angiogenic factors are associated with adverse birth outcomes in HIV-infected pregnant women started on antiretroviral therapy. Study Design This is a secondary analysis of samples collected as part of a clinical trial randomizing pregnant women and adolescents infected with HIV to lopinavir/ritonavir-based (n = 166) or efavirenz-based (n = 160) antiretroviral therapy in Tororo, Uganda. Pregnant women living with HIV were enrolled between 12-28 weeks of gestation. Plasma samples were evaluated for angiogenic biomarkers (angiopoietin-1, angiopoietin-2, vascular endothelial growth factor, soluble fms-like tyrosine kinase-1, placental growth factor, and soluble endoglin) by enzyme-linked immunosorbent assay between: 16-<20, 20-<24, 24-<28, 28-<32, 32-<36, 36-<37 weeks of gestation. The primary outcome was preterm birth. Results In all, 1115 plasma samples from 326 pregnant women and adolescents were evaluated. There were no differences in angiogenic factors according to antiretroviral therapy group (P > .05 for all). The incidence of adverse birth outcomes was 16.9% for spontaneous preterm births, 25.6% for small-for-gestational-age births, and 2.8% for stillbirth. We used linear mixed effect modelling to evaluate longitudinal changes in angiogenic factor concentrations between birth outcome groups adjusting for gestational age at venipuncture, maternal age, body mass index, gravidity, and the interaction between treatment arm and gestational age. Two angiogenic factors–soluble endoglin and placental growth factor–were associated with adverse birth outcomes. Significantly higher concentrations of soluble endoglin throughout gestation were found in study participants destined to deliver preterm [likelihood ratio test, χ2(1) = 12.28, P < .0005] and in those destined to have stillbirths [χ2(1) = 5.67, P < .02]. By contrast, significantly lower concentrations of placental growth factor throughout gestation were found in those destined to have small-for-gestational-age births [χ2(1) = 7.89, P < .005] and in those destined to have stillbirths [χ2(1) = 21.59, P < .0001]. Conclusion An antiangiogenic state in the second or third trimester is associated with adverse birth outcomes, including stillbirth in women and adolescents living with HIV and receiving antiretroviral therapy

Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria.

Background. Host responses to infection are critical determinants of disease severity and clinical outcome. The development of tools to risk stratify children with malaria is needed to identify children most likely to benefit from targeted interventions.Methods. This study investigated the kinetics of candidate biomarkers of mortality associated with endothelial activation and dysfunction (angiopoietin-2 [Ang-2], soluble FMS-like tyrosine kinase-1 [sFlt-1], and soluble intercellular adhesion molecule-1 [sICAM-1]) and inflammation (10 kDa interferon γ-induced protein [CXCL10/IP-10] and soluble triggering receptor expressed on myeloid cells-1 [sTREM-1]) in the context of a randomized, double-blind, placebo-controlled, parallel-arm trial evaluating inhaled nitric oxide versus placebo as adjunctive therapy to parenteral artesunate for severe malaria. One hundred eighty children aged 1–10 years were enrolled at Jinja Regional Referral Hospital in Uganda and followed for up to 6 months.Results. There were no differences between the 2 study arms in the rate of biomarker recovery. Median levels of Ang-2, CXCL10, and sFlt-1 were higher at admission in children who died in-hospital (n = 15 of 180; P < .001, P = .027, and P = .004, respectively). Elevated levels of Ang-2, sTREM-1, CXCL10, and sICAM-1 were associated with prolonged clinical recovery times in survivors. The Ang-2 levels were also associated with postdischarge mortality (P < .0001). No biomarkers were associated with neurodisability.Conclusions. Persistent endothelial activation and dysfunction predict survival in children admitted with severe malaria

Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women.

Preterm birth (PTB) is the leading cause of perinatal mortality worldwide, with the greatest burden occurring in resource-constrained settings. Based on the hypothesis that altered placental angiogenesis and inflammation early in pregnancy lead to PTB, we examined whether levels of inflammatory and angiogenic mediators, measured early in pregnancy, were predictive of spontaneous PTB (sPTB).\ud Plasma samples were collected from a prospective cohort of primigravid Tanzanian women between 12-27 weeks gestation. A panel of 18 markers was screened on a training cohort of 426 women. Markers associated with sPTB in the training cohort were repeated in a test cohort of 628 women. All markers were measured by ELISA. In both the training and test cohorts plasma levels of IL-18BP, sICAM-1, sEndoglin and CHI3L1 were elevated and Leptin was lower at enrollment in women who subsequently experienced sPTB. In multivariate analysis women with plasma levels of CHI3L1, C5a, sICAM-1, AngptL3, sEndgolin, sFlt-1 and IL-18BP in the highest quartile had an increased risk of sPTB compared with those in the lowest quartile. Women with Leptin and Ang2 in the highest quartile had a reduced risk of sPTB compared with women in the lowest quartile. Levels of angiogenic and inflammatory mediators measured at mid-pregnancy were associated with subsequent sPTB. These findings provide insight into mechanisms underlying sPTB and suggest biomarkers that may have clinical utility in risk-stratifying pregnancies

Relación entre enfermedad periodontal y disfunción eréctil en pacientes atendidos en un centro de salud

Objetivo: Determinar la relación entre Enfermedad Periodontal y Disfunción Eréctil en pacientes atendidos en un Centro de Salud. Materiales y métodos: Se realizó un estudio analítico con la finalidad de observar una posible relación entre la Enfermedad Periodontal y la Disfunción Eréctil en pacientes que acuden al Centro de Salud Andromed Lima-Perú 2023, para ello se hizo una exhaustiva revisión de historias clínicas. Se utilizó la Prueba no Paramétrica de Chi cuadrado de Pearson, con un nivel de confianza del 95% y significancia del 5%. Resultados: La muestra estuvo conformada por 101 pacientes de sexo masculino la media de edad fue 50 años. No se encontró relación significativa entre la Enfermedad Periodontal y la Disfunción Eréctil. Conclusión: Los resultados obtenidos en esta investigación no respaldan una asociación entre la Enfermedad Periodontal y la Disfunción Eréctil, pero se sugiere seguir investigando