Fondaparinux in Percutaneous Coronary Intervention for the Treatment of Acute Coronary Syndrome

ABSTRACTBackgroundFondaparinux is an agent that has a well-established safety and efficacy profile in the treatment of non-ST segment elevation acute coronary syndromes. When used alone, however, it is associated with a higher incidence of thrombotic complications during invasive coronary procedures, requiring the supplementation of an anti-IIa agent. This study aimed to evaluate the efficacy and safety of percutaneous coronary intervention (PCI) in patients with non-ST segment elevation acute coronary syndromes that were previously treated with fondaparinux.MethodsThis was a prospective, controlled registry, enrolling 127 consecutive patients submitted to an early invasive stratification during treatment with fondaparinux with the supplementation of intravenous unfractionated heparin at a dose of 85 U/kg at the time of PCI.ResultsThe composite primary endpoint rate, including death, acute myocardial infarction, stroke, stent thrombosis, or emergency myocardial revascularisation was 3.2%. The cumulative incidence of major bleeding and vascular complications was 3.2%. There were no cases of guide catheter thrombosis or abrupt vessel closure.ConclusionsPCI in patients with acute coronary syndromes receiving fondaparinux was associated with a low rate of major adverse cardiovascular ischaemic events and severe haemorrhagic complications. Supplementation with unfractionated heparin during the invasive procedures eliminated the risk of catheter-related thrombosis

A disciplina de OTTP como elo de ligação com a pedagogia revolucionária

Rural Education has as its principle an education for the revolution, one of its inspirations being the School of Labour by Moisey Pistrak, and the discipline of OTTP is one of the links that connects education with the labour in the field. The methodology applied was a bibliographic research, in which authors such as Pistrak (2000), Freire (1987), Caldart (2003; 2012) and Nascimento and Teixeira (2021) were used as a theoretical basis. We show in this work that the OTTP discipline carries within itself the struggles of social movements, as well as the theoretical and practical essence of the Schools of Labour defended by Pistrak, especially the student's ability to self-organize. Therefore, it was concluded that the OTTP discipline presents itself as a link between Rural School and School of Labour, since its contents are associated to contribute to the construction of the human formation of students.A Educação do Campo tem com princípio uma educação para a revolução, sendo uma de suas inspirações a Escola do Trabalho de Moisey Pistrak, sendo que a disciplina de OTTP é um dos elos que liga a educação com o trabalho no campo. A metodologia aplicada foi uma pesquisa bibliográfica, no qual foram utilizados como base teórica autores como Pistrak (2000), Freire (1987), Caldart (2003; 2012) e Nascimento e Teixeira (2021). Evidenciamos nesse trabalho que a disciplina de OTTP carrega dentro de si as lutas dos movimentos sociais, como também a essência teórica e prática das escolas do trabalho defendidas por Pistrak, em especial a capacidade de auto-organização do estudante. Portanto, concluiu-se que a disciplina de OTTP se apresenta como elo de ligação entre a Escola do Campo e a Escola do Trabalho, já que seus conteúdos se associam para contribuir na construção da formação humana dos estudantes

Morphophysiology of the passion fruit ‘BRS Rubi do Cerrado’ irrigated with saline waters and nitrogen fertilization

This study aimed to evaluate the gas exchanges and growth of the purple passion fruit cultivar ‘BRS Rubi do Cerrado’ as a function of the salinity levels of the irrigation water and nitrogen fertilization. The research was conducted in pots adapted as drainage lysimeters, placed within a plant nursery, using a Regolithic Neosol of sandy texture, in the municipality of Pombal-PB, Brazil. A randomized block design was used, testing five levels of electrical conductivity of irrigation water (0.3, 1.1, 1.9, 2.7, and 3.5 dS m-1) associated with four doses of nitrogen (50, 75, 100, and 125% of the recommendation). The irrigation water salinity above 0.3 dS m-1 compromised the leaf area and the relative water content of the purple passion fruit ‘BRS Rubi do Cerrado’. High doses of nitrogen enhance the deleterious effects of irrigation water salinity on stomatal conductance, transpiration, internal CO2 concentration, CO2 assimilation rate, number of leaves, stem diameter, and height of purple passion fruit plants. When waters with salinity levels of up to 1.3 dS m-1 are used, the dose of 125 mg of N kg-1 of soil is recommendation for providing increases in the CO2 assimilation rate of the purple passion fruit ‘BRS Rubi do Cerrado’ at 70 days after sowing (DAS). Water salinity increases electrolyte leakage, regardless of nitrogen doses.This study aimed to evaluate the gas exchanges and growth of the purple passion fruit cultivar ‘BRS Rubi do Cerrado’ as a function of the salinity levels of the irrigation water and nitrogen fertilization. The research was conducted in pots adapted as drainage lysimeters, placed within a plant nursery, using a Regolithic Neosol of sandy texture, in the municipality of Pombal-PB, Brazil. A randomized block design was used, testing five levels of electrical conductivity of irrigation water (0.3, 1.1, 1.9, 2.7, and 3.5 dS m-1) associated with four doses of nitrogen (50, 75, 100, and 125% of the recommendation). The irrigation water salinity above 0.3 dS m-1 compromised the leaf area and the relative water content of the purple passion fruit ‘BRS Rubi do Cerrado’. High doses of nitrogen enhance the deleterious effects of irrigation water salinity on stomatal conductance, transpiration, internal CO2 concentration, CO2 assimilation rate, number of leaves, stem diameter, and height of purple passion fruit plants. When waters with salinity levels of up to 1.3 dS m-1 are used, the dose of 125 mg of N kg-1 of soil is recommendation for providing increases in the CO2 assimilation rate of the purple passion fruit ‘BRS Rubi do Cerrado’ at 70 days after sowing (DAS). Water salinity increases electrolyte leakage, regardless of nitrogen doses

Tuberculosis diagnosis in the aged: barriers to accessing health services

Este estudo tem como objetivo analisar as barreiras ao diagnóstico da tuberculose em idosos relacionadas aos serviços de saúde no município de João Pessoa-PB. Trata-se de pesquisa qualitativa que envolveu sete pessoas idosas doentes de tuberculose. Entrevistas foram utilizadas para coletar informações. O material empírico foi organizado com o software Atlas.tiversão 6.0 e analisado conforme a técnica de análise de discurso. As barreiras relacionadas ao acesso para confirmação diagnóstica foram: horário de funcionamento das unidades de saúde da família; transferência de responsabilidades; visitas domiciliares sem controle de comunicantes; demora do serviço de saúde em suspeitar da doença e repetidas idas do doente ao serviço de saúde para a obtenção do diagnóstico. Apesar de terem sido identificadas barreiras comuns às encontradas por doentes de tuberculose de um modo geral, em virtude da vulnerabilidade dos idosos, sugerem-se que ações de controle sejam empreendidas pelos serviços de saúde de modo a evitar que a doença torne-se um agravo comum para essa população.Se objetiva analizar las barreras al diagnóstico de tuberculosis en ancianos relacionadas a servicios de salud en João Pessoa-Paraíba. Investigación cualitativa involucrando siete ancianos enfermos de tuberculosis. Informaciones recolectadas mediante entrevistas. El material empírico fue organizado con el software Atlas.ti 6.0 y sometido a técnica de análisis de discurso. Las barreras relacionadas al acceso para confirmación diagnóstica fueron: horario de funcionamiento de las unidades de salud de la familia; transferencia de responsabilidades; visitas domiciliarias sin control de comunicantes; demora del servicio sanitario en sospechar la enfermedad y repetidas visitas del enfermo al servicio de salud para obtener el diagnóstico. A pesar de haber sido identificados obstáculos similares a los encontrados por tuberculosos en general, en virtud de su vulnerabilidad, se sugiere que las acciones de control en ancianos sean emprendidas por los servicios de salud intentando evitar que la enfermedad se convierta en una patología común en dicho segmento poblacional.This study was performed with the objective to analyze the barriers to diagnosing tuberculosis in the aged and access to health services in the city of João Pessoa, Paraíba, Brazil. This qualitative study included the participation of seven aged women with tuberculosis. Interviews were used for data collection. The empirical material was organized using Atlas.ti 6.0, and analyzed according to the techniques of discourse analysis. The identified barriers related to the access to health services to confirm the diagnosis were: the operating hours of family health units; transferred responsibilities; home visits without controlling communicants; delay of the health service in suspecting the disease and the patient's repeated visits to the health center before being informed about the diagnosis. Despite the identification of common barriers that tuberculosis patients of all ages must deal with, because of the vulnerability of the elderly, health services should implement control actions so as to prevent the disease becoming a common condition in this population

Uso potencial de folhas de batata-doce para consumo humano

The objective of this work was to select sweet potato (Ipomoea batatas) genotypes with leaves with potential to be used for human consumption. Twenty-six experimental genotypes and four commercial cultivars were tested in a randomized complete block design with three replicates and ten plants per plot. The trial was carried out in the municipality of Lavras, in the state of Minas Gerais, Brazil. Leaf shape and lobe, aerial-part yield, edible-leaf yield, edible-leaf percentage, edible-leaf dry mass, and latex production, as well as leaf total chlorophyll, pH, soluble solids contents, titratable acidity, total phenolic compounds, and anthocyanin contents, were evaluated. Roots were characterized as to their pulp and peel colors. Fifteen genotypes presented the highest aerial-part (29.6 to 51.8 Mg ha-1) and edible‑leaf (7.8 to 12.7 Mg ha-1) yields. In the biochemical analysis, high contents of chlorophyll, total phenolics, and anthocyanins were observed. In addition, pH, soluble solids, and leaf titratable acidity did not differ significantly among the evaluated genotypes. Leaves of ten genotypes are recommended for human consumption.O objetivo deste trabalho foi selecionar genótipos de batata-doce (Ipomoea batatas) com folhas com potencial para serem usadas para consumo humano. Vinte e seis genótipos experimentais e quatro cultivares comerciais foram testados em delineamento de blocos ao acaso, com três repetições e dez plantas por parcela. O ensaio foi realizado no município de Lavras, no estado de Minas Gerais, Brasil. Foram avaliados formato e lóbulo da folha, produção da parte aérea, produção de folhas comestíveis, percentagem de folha comestível, massa seca de folha comestível e produção de látex, bem como clorofila total, pH, conteúdo de sólidos solúveis, acidez titulável, compostos fenólicos totais e teor de antocianinas das folhas. As raízes foram caracterizadas quanto às cores da sua polpa e casca. Quinze genótipos apresentaram as maiores produtividades de parte aérea (29,6 a 51,8 Mg ha-1) e de folhas comestíveis (7,8 a 12,7 Mg ha-1). Nas análises bioquímicas, foram observados altos teores de clorofila, compostos fenólicos totais e antocianinas. Além disso, pH, sólidos solúveis e acidez titulável foliar não diferiram significativamente entre os genótipos avaliados. As folhas de dez genótipos são recomendadas para alimentação humana

Integral health care for transgender adolescents: subsidies for nursing practice

Objetivo: analizar la atención integral a la salud de los adolescentes transgénero desde la perspectiva de sus responsables. Método: estudio cualitativo basado en el marco de la Red Social propuesto por Lia Sanicola, desarrollado con 22 responsables de adolescentes transgénero en Brasil a partir de entrevistas en línea individuales semiestructuradas. El material empírico fue analizado mediante la técnica de análisis de contenido, modalidad temática. Resultados: se ha evidenciado la falta de ambiente y preparación técnica de los profesionales de la salud con relación al tema en todos los niveles de atención, transfobia, centralización del cuidado en los pocos servicios habilitados para personas trans en el período infantojuvenil, invisibilidad del apoyo a la familia, ausencia de acciones de promoción de la salud en el ámbito comunitario, especialmente en la escuela, y la acogida comúnmente por las iniciativas no gubernamentales. Conclusión: la centralización de acciones en los pocos servicios especializados del país y la transfobia estructural pueden comprometer la atención integral en salud de los adolescentes trans. Urge una línea de cuidado capaz de auxiliar la acción conjunta de un equipo multi e interdisciplinario, con mayor proactividad del enfermero con el adolescente transgénero y sus responsables en acciones individuales y colectivas; ambiente; promoción de la salud en las escuelas para la visibilidad y acogida en la Atención Primaria de la Salud desde la infancia.Objective: to analyze the integral health care for transgender adolescents from the perspective of their guardians. Method: qualitative research based on the Social Network framework proposed by Lia Sanicola, developed with 22 guardians of transgender adolescents in Brazil through semi-structured individual online interviews. The empirical material was analyzed using the content analysis technique, thematic modality. Results: lack of ambience was observed, in addition to technical unpreparedness of health professionals in relation to the theme at all levels of care, transphobia, centralization of care in scarce qualified services for transgender children and youth, absence of family support, lack of health promotion actions within the community, especially in the school environment, and the common support from non-governmental initiatives. Conclusion: the centralization of actions in scarce specialized services in the country, and the structural transphobia can compromise the integral health care for transgender adolescents. There is an urgent need for a network of care capable of assisting the joint action by multi and interdisciplinary teams, with greater proactivity of the nurse with the transgender adolescent and their guardians in individual and collective actions; ambience; health promotion in schools for visibility and support in Primary Health Care since childhood.Objetivo: analisar a atenção integral à saúde dos adolescentes transgêneros na perspectiva dos seus responsáveis. Método: estudo qualitativo fundamentado no referencial Rede Social proposto por Lia Sanicola, desenvolvido com 22 responsáveis por adolescentes transgêneros no Brasil por meio de entrevistas online individuais semiestruturadas. O material empírico foi analisado com a utilização da técnica de análise de conteúdo na modalidade temática. Resultados: Foram evidenciados a falta de ambiência e despreparo técnico de profissionais da saúde em relação à temática em todos os níveis de atenção, transfobia, centralização do cuidado em escassos serviços habilitados para pessoas trans no período infantojuvenil, invisibilidade do apoio à família, ausência de ações de promoção da saúde no âmbito comunitário, sobretudo, escolar, e, ainda, o acolhimento promovido, comumente, pelas iniciativas não governamentais. Conclusão: a centralização de ações em escassos serviços especializados no país e a transfobia estrutural podem comprometer a atenção integral à saúde dos adolescentes trans. Urge a necessidade de uma linha de cuidado capaz de auxiliar a atuação conjunta por equipe multi e interdisciplinar com maior proatividade do enfermeiro junto ao adolescente trans e seus responsáveis por meio de ações individuais e coletivas; ambiência; promoção da saúde nas escolas para visibilidade e acolhimento na Atenção Primária à Saúde desde a infância

Evaluation of the Genotoxicity of Endodontic Materials for Deciduous Teeth Using the Comet Assay

Objective: To evaluate genotoxicity of zinc oxide, P. A. calcium hydroxide, mineral trioxide aggregate and an iodoform paste using comet assay on human lymphocytes. Material and Methods: Two positive controls were used: methyl-methanesulfonate for the P.A. calcium hydroxide and mineral trioxide aggregate; and doxorubicin for the iodoform paste and zinc oxide. There were also two negative controls: distilled water for the P.A. calcium hydroxide and mineral trioxide aggregate; and DMSO for the iodoform paste and zinc oxide. Comets were identified using fluorescence microscopy and 100 of them were counted on each of the three slides analyzed per drug test. A damage index was established, taking into consideration the score pattern that had previously been determined from the size and intensity of the comet tail. Analysis of variance, followed by Tukey’s test, was used to compare the means of the DNA damage indices. Results: The DNA damage index observed for mineral trioxide aggregate (7.08 to 8.58) and P.A. calcium hydroxide (6.50 to 8.33), which were similar to negative control index. On the other hand, damage index for zinc oxide (104.7 to 218.50) and iodoform paste (115.7 to 210.7) were similar to positive control index. Conclusion: Iodoform paste and zinc oxide showed genotoxicity at all concentrations used

Benchmarking Anchor-Based and Anchor-Free State-of-the-Art Deep Learning Methods for Individual Tree Detection in RGB High-Resolution Images

rban forests contribute to maintaining livability and increase the resilience of cities in the face of population growth and climate change. Information about the geographical distribution of individual trees is essential for the proper management of these systems. RGB high-resolution aerial images have emerged as a cheap and efficient source of data, although detecting and mapping single trees in an urban environment is a challenging task. Thus, we propose the evaluation of novel methods for single tree crown detection, as most of these methods have not been investigated in remote sensing applications. A total of 21 methods were investigated, including anchor-based (one and two-stage) and anchor-free state-of-the-art deep-learning methods. We used two orthoimages divided into 220 non-overlapping patches of 512 × 512 pixels with a ground sample distance (GSD) of 10 cm. The orthoimages were manually annotated, and 3382 single tree crowns were identified as the ground-truth. Our findings show that the anchor-free detectors achieved the best average performance with an AP50 of 0.686. We observed that the two-stage anchor-based and anchor-free methods showed better performance for this task, emphasizing the FSAF, Double Heads, CARAFE, ATSS, and FoveaBox models. RetinaNet, which is currently commonly applied in remote sensing, did not show satisfactory performance, and Faster R-CNN had lower results than the best methods but with no statistically significant difference. Our findings contribute to a better understanding of the performance of novel deep-learning methods in remote sensing applications and could be used as an indicator of the most suitable methods in such applications