Поверхностные скорости и айсберговый сток ледникового купола Академии Наук на Северной Земле

We have determined the ice-surface velocities of the Academy of Sciences Ice Cap, Severnaya Zemlya, Russian Arctic, during the period November 2016 – November 2017, using intensity offset-tracking of Sentinel-1 synthetic-aperture radar images. We used the average of 54 pairs of weekly velocities (with both images in each pair separated by a12-day period) to estimate the mean annual ice discharge from the ice cap. We got an average ice discharge for 2016–2017 of 1,93±0,12 Gt a−1, which is equivalent to −0,35±0,02 m w.e. a−1 over the whole area of the ice cap. The difference from an estimate of ~1,4 Gt a−1 for 2003–2009 can be attributed to the initiation of ice-stream flow in Basin BC sometime between 2002 and 2016. Since the front position changes between both periods have been negligible, ice discharge is equivalent to calving flux. We compare our results for calving flux with those of previous studies and analyse the possible drivers of the changes observed along the last three decades. Since these changes do not appear to have responded to environmental changes, we conclude that the observed changes are likely driven by the intrinsic characteristics of the ice cap governing tidewater glacier dynamics.По 54 парам космических снимков Sentinel‐1, сделанных с ноября 2016 г. по ноябрь 2017 г., определены скорости движения ледникового купола Академии Наук на Северной Земле. На этой основе оценён среднегодовой расход льда в море этого купола (1,93±0,12 Гт/год), установлены основные пути стока льда, проведено сравнение с прежними оценками

The competitive ability of weed communities in selected crucifer oilseed crops under different water and nitrogen

Durante los años 2012 y 2013, se llevó a cabo un experimento en el centro de la península cuyo objetivo fue el estudio de la flora arvense en 3 especies de “Brassica” (“B. carinata”, “B. juncea” y “B. nigra”). Las malas hierbas se evaluaron con 2 niveles de riego, con y sin aporte de agua, y con tres dosis de fertilización diferentes: 0, 75 y 150 kg N ha-1. El establecimiento del cultivo de las tres especies de “Brassica” varió en función del año. Las escasas lluvias de 2012 redujeron la densidad y biomasa de la flora arvense en comparación con el año 2013 en el que la pluviometría fue mayor. Los resultados sugieren que la especie “B. nigra” no estaba bien adaptada a nuestras condiciones climáticas continentales, mostrando un rendimiento más bajo que el resto de los cultivares. Por otro lado, la infestación de malas hierbas fue menor en todas las parcelas donde se cultivaba “B. carinata”.A field study was undertaken to examine the interaction and relationships between weeds and three “Brassica” species (“B. carinata”, “B. juncea” and “B. nigra”) grown in 2012 and 2013. We evaluated the weed density, fresh and dry biomass of weeds with 2 water regimes: with and without irrigation, and three different doses of fertilization: 0, 75 and 150 kg N ha-1. Crop establishment of “Brassica” species varied significantly each year. Lower rainfall in 2012 led to lower density, fresh and dry biomass of weeds compared to 2013. The results confirmed that “B. nigra” was not well adapted to our continental climatic conditions, and thus the yield was lower than the other cultivars. The lowest weed infestation occurred in plots where “B. carinata” was grown in all cases

Microscopic dynamics of glycerol in its crystalline and glassy states

The dynamics of crystalline glycerol are studied by means of Raman spectroscopy and lattice dynamics calculations employing a semiflexible model to represent the low-lying molecular vibrations. The latter is validated against structural, thermodynamic, and spectroscopic data. The results serve to set an absolute frequency scale for glassy glycerol, which is also studied by Raman and incoherent inelastic-neutron scattering. Some implications of the present findings regarding ensuing discussions on glassy dynamics are finally commented on.Dirección General de Investigaciones Científicas y Técnicas PB92- 0114-C0

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.PostprintPostprintPeer reviewe

Hypoacusia in a Patient Treated by Isotretinoin

Isotretinoin is the most effective treatment for severe acne, but there are several adverse effects associated with its use, some of them very exceptional (<1/10000). We report one case of hypoacusia and tinnitus in a 15-year-old boy treated with isotretinoin during 6 weeks, who quickly improved after isotretinoin withdrawal. Also, we comment other publications about hearing alterations in patients treated with isotretinoin and other retinoids

Ages and Metallicities of Star Clusters and Surrounding Fields in the Outer Disk of the Large Magellanic Cloud

We present Washington system C,T_1 CMDs of 13 star clusters and their surrounding fields which lie in the outer parts of the LMC disk. Ages are determined by means of the magnitude difference between the giant branch clump and the turnoff, while metallicities are derived from the location of the giant and subgiant branches as compared to fiducial star clusters. We find that in most cases the stellar population of each star cluster is quite similar to that of the field where it is embedded. Three particular fields present remarkable properties: (i) The so far unique cluster ESO121-SC03 at ~9 Gyr has a surrounding field which shares the same properties. (ii) The field surrounding the far eastern intermediate age cluster OHSC37 is noteworthy in the sense that we do not detect any evidence of LMC stars. (iii) The fields of SL388 and SL509 present CMDs with a secondary clump ~0.45 mag fainter than the dominant intermediate age clump, suggesting a stellar population component located behind the LMC disk at a distance comparable to that of the SMC. The mean metallicity derived for the intermediate age outer disk clusters is =-0.7 and for their surrounding fields =-0.6. These values are significantly lower than found by Olszewski et al. (1991, AJ, 101, 515) for a sample of clusters of similar age, but are in good agreement with several recent studies. A few clusters stand out in the age--metallicity relation in the sense that they are intermediate age clusters at relatively low metallicity ([Fe/H]~-1).Comment: LaTeX, to be published in July, 1998 Astronomical Journa

Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses

BACKGROUND AND PURPOSEExposure to an ototoxic level of an aminoglycoside can result in hearing loss. In this we study investigated the otoprotective efficacy of dexamethasone (DXM), melatonin (MLT) and tacrolimus (TCR) in gentamicin (GM)-treated animals and cultures.EXPERIMENTAL APPROACHWistar rats were divided into controls (treated with saline); exposed to GM only (GM); and three GM-exposed groups treated with either DXM, MLT or TCR. Auditory function and cochlear surface preparations were studied. In vitro studies of oxidative stress, pro-inflammatory cytokine mRNA levels, the MAPK pathway and caspase-3 activation were performed in organ of Corti explants from 3-day-old rats.KEY RESULTSDXM, MLT and TCR decreased levels of reactive oxygen species in GM-exposed explants. The mRNA levels of TNF-α, IL-1β and TNF-receptor type 1 were significantly reduced in GM + DXM and GM + MLT groups. Phospho-p38 MAPK levels decreased in GM + MLT and GM + TCR groups, while JNK phosphorylation was reduced in GM + DXM and GM + MLT groups. Caspase-3 activation decreased in GM + DXM, GM + MLT and GM + TCR groups. These results were consistent with in vivo results. Local treatment of GM-exposed rat cochleae with either DXM, MLT or TCR preserved auditory function and prevented auditory hair cell loss.CONCLUSIONS AND IMPLICATIONSIn organ of Corti explants, GM increased oxidative stress and initiated an inflammatory response that led to the activation of MAPKs and apoptosis of hair cells. The three compounds tested demonstrated otoprotective properties that could be beneficial in the treatment of ototoxicity-induced hearing loss

SEOM clinical guidelines in early stage breast cancer (2018)

Breast cancer is the most common cancer in women in our country and it is usually diagnosed in the early and potentially curable stages. Nevertheless, around 20–30% of patients will relapse despite appropriate locoregional and systemic therapies. A better knowledge of this disease is improving our ability to select the most appropriate therapy for each patient with a recent diagnosis of an early stage breast cancer, minimizing unnecessary toxicities and improving long-term efficacy

Aharonov-Bohm interferences from local deformations in graphene

One of the most interesting aspects of graphene is the tied relation between structural and electronic properties. The observation of ripples in the graphene samples both free standing and on a substrate has given rise to a very active investigation around the membrane-like properties of graphene and the origin of the ripples remains as one of the most interesting open problems in the system. The interplay of structural and electronic properties is successfully described by the modelling of curvature and elastic deformations by fictitious gauge fields that have become an ex- perimental reality after the suggestion that Landau levels can form associated to strain in graphene and the subsequent experimental confirmation. Here we propose a device to detect microstresses in graphene based on a scanning-tunneling-microscopy setup able to measure Aharonov-Bohm inter- ferences at the nanometer scale. The interferences to be observed in the local density of states are created by the fictitious magnetic field associated to elastic deformations of the sample.Comment: Some bugs fixe