Electrohisterografia dinâmica intra-parto: contribuição para o desenvolvimento de um protótipo

O objecto do presente trabalho é a avaliação da actividade muscular uterina na gravidez, nomeadamente durante o trabalho de parto, através do estudo de sinais bioeléctricos do útero e do coração materno e fetal. Para o efeito foi construído um protótipo de um aparelho de monitorização não invasiva, o Electrohisterógrafo dinâmico (dEHG), que se destina a caracterizar não só a amplitude e a duração das contracções uterinas como a sua progressão permitindo uma melhor compreensão da fisiologia e fisiopatologia do trabalho de parto e da consequente resposta adaptativa fetal e materna.The objective of this study is to evaluate uterine muscle activity during pregnancy, primarily during labour and delivery, by studying the bioelectric signals transmitted by the uterus as well as the maternal and fetal heart. For this purpose, a prototype of a non-invasive monitoring device was built entitled the dynamic Electrohysterogram (dEHG). With this device, one should be able to characterize not only the amplitude and duration of uterine contractions but also their progression, allowing for a better understanding of the physiology and pathophysiology of labour work and consequently the fetal and maternal adaptive response

Design, Green Synthesis and Performance of L-Leucine-Molecularly Imprinted Polymers

The authors would like to acknowledge financial support from Fundação para a Ciência e a Tecnologia, Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES), Portugal, through projects PTDC/EQU-EQU/32473/2017, PTDC/MEC-ONC/29327/2017, and PTDC/QUI-QIN/30649/2017 (REALM). A.I.F. acknowledges her PhD grant (SFRH/BD/150696/2020) in the aim of the International Year of the Periodic Table─a protocol established between the Portuguese Chemical Society (SPQ) and the Portuguese Foundation for Science and Technology (FCT/MCTES). R.V. would like to acknowledge Individual Scientific Employment Stimulus (CEEC-IND), reference 2020.00377.CEECIND from the FCT/MCTES, Portugal. The Associate Laboratory Research Unit for Green Chemistry–Clean Technologies and Processes–LAQV-REQUIMTE is financed by national funds from FCT/MCTES (UIDB/50006/2020, UIDP/50006/2020, and UID/QUI/50006/2020) and cofinanced by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER–007265).Biopurification is a challenging and growing market. Despite great efforts in the past years, current purification strategies still lack specificity, efficiency, and cost-effectiveness. The development of more sustainable functional materials and processes needs to address pressing environmental goals, efficiency, scale-up, and cost. Herein, l-leucine (LEU)-molecularly imprinted polymers (MIPs), LEU-MIPs, are presented as novel biomolecular fishing polymers for affinity sustainable biopurification. Rational design was performed using quantum mechanics calculations and molecular modeling for selecting the most appropriate monomers. LEU-MIPs were synthesized for the first time by two different green approaches, supercritical carbon dioxide (scCO2) technology and mechanochemistry. A significant imprinting factor of 12 and a binding capacity of 27 mg LEU/g polymer were obtained for the LEU-MIP synthesized in scCO2 using 2-vinylpyridine as a functional monomer, while the LEU-MIP using acrylamide as a functional monomer synthesized by mechanochemistry showed an imprinting factor of 1.4 and a binding capacity of 18 mg LEU/g polymer, both systems operating at a low binding concentration (0.5 mg LEU/mL) under physiological conditions. As expected, at a higher concentration (1.5 mg LEU/mL), the binding capacity was considerably increased. Both green technologies show high potential in obtaining ready-to-use, stable, and low-cost polymers with a molecular recognition ability for target biomolecules, being promising materials for biopurification processes.publishersversionpublishe

Um programa de formação para a eficácia dos treinadores da iniciação e formação desportiva

[Excerto] Introdução: De uma forma verdadeiramente notável, em nenhum outro domínio ou contexto, como no desporto, encontramos tantos indivíduos (crianças, jovens e adultos) que voluntariamente se sujeitam e «subjugam» à autoridade de uma pessoa ou duas pessoas: os(as) seus (suas) treinadores(as) (Chelladurai, 1984; Cruz & Gomes, 1996). É particularmente saliente a confiança depositada pelos atletas na capacidade do treinador e nas suas técnicas motivacionais, para atingirem objectivos pessoais. Como salientaram Smoll e Smith (1984), a relação treinador-atleta determina a forma como os atletas são afectados pela sua participação no desporto. Se é verdade que a influência do treinador vai muito além do contexto desportivo (interferindo na vida, desenvolvimento e crescimento pessoal dos atletas), também é verdade que muitos treinadores, sobretudo por falta de formação e informação, não têm uma consciência clara de como e até que ponto afectam os seus atletas (Cruz & Gomes, 1996). [...

Um programa de formação para a eficácia dos treinadores da iniciação e formação desportiva

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Um programa de formação para a eficácia dos treinadores da iniciação e formação desportiva

Inexistenteinfo:eu-repo/semantics/publishedVersio

QuantSat-PT: an attitude determination and control system architecture for QKD

This article presents the QuantSaT-PT project, an effort to create the first Portuguese nanosatellite for space to ground quantum communication. Focused on the Attitude Determination and Control System, it describes the different elements that allow for the attainment of diverse accuracy levels required for separate mission stages. Given the harsh pointing precision necessary for establishing a quantum downlink, the implementation of this module presents a major challenge in the Cubesat field. Furthermore, the introduced architecture aims to reduce system cost by replacing the state-of-the-art star tracker with ground beacon detection

Genomic epidemiology of Mycobacterium tuberculosis in Santa Catarina, Southern Brazil

Mycobacterium tuberculosis (M.tb), the pathogen responsible for tuberculosis (TB) poses as the major cause of death among infectious diseases. The knowledge about the molecular diversity of M.tb enables the implementation of more effective surveillance and control measures and, nowadays, Whole Genome Sequencing (WGS) holds the potential to produce high-resolution epidemiological data in a high-throughput manner. Florianópolis, the state capital of Santa Catarina (SC) in south Brazil, shows a high TB incidence (46.0/100,000). Here we carried out a WGS-based evaluation of the M.tb strain diversity, drug-resistance and ongoing transmission in the capital metropolitan region. Resistance to isoniazid, rifampicin, streptomycin was identified respectively in 4.0% (n = 6), 2.0% (n = 3) and 1.3% (n = 2) of the 151 studied strains by WGS. Besides, resistance to pyrazinamide and ethambutol was detected in 0.7% (n = 1) and reistance to ethionamide and fluoroquinolone (FQ) in 1.3% (n = 2), while a single (0.7%) multidrug-resistant (MDR) strain was identified. SNP-based typing classified all isolates into M.tb Lineage 4, with high proportion of sublineages LAM (60.3%), T (16.4%) and Haarlem (7.9%). The average core-genome distance between isolates was 420.3 SNPs, with 43.7% of all isolates grouped across 22 genomic clusters thereby showing the presence of important ongoing TB transmission events. Most clusters were geographically distributed across the study setting which highlights the need for an urgent interruption of these large transmission chains. The data conveyed by this study shows the presence of important and uncontrolled TB transmission in the metropolitan area and provides precise data to support TB control measures in this region.publishersversionpublishe

Os retratos de Maria Isabel e Maria Francisca de Bragança, de Nicolas-Antoine Taunay

Nicolas-Antoine Taunay, French landscape painter, produced also several portraits during his stay at the Rio de Janeiro Court. In this city, in 1816, he paints the queen Carlota Joaquina and all her daughters. In this group, two portraits have a very special way: the paintings still today catalogued as Maria Francisca and Maria Teresa, but probably being Maria Isabel and Maria Francisca de Assis - princesses that, in this year, left Brazil to marry the Spanish King Fernando VII, and his brother Carlos Maria Isidro de Bourbon. In this article, beyond to describe these portraits (and analyse the identities of the portrayed princesses), I analyse their functions in the Court society and the mains artists of this gender in Europe. I will discuss, as well, the hypothesis about the Taunay choices. In this sense, I will analyse the possible circulation of the typologies of portrait between Italy, Portugal, Spain and France, understanding these productions by Taunay and the functions occupied by these portraits in the political relations between Brazil and Europe.Nicolas-Antoine Taunay, pintor de paisagens francês, também realizou alguns retratos durante sua estadia na corte do Rio de Janeiro. Nessa cidade, em 1816, ele pinta a rainha Carlota Joaquina e todas as suas filhas. Nesse conjunto, dois retratos sobressaem-se de modo especial: os hoje ainda inventariados como de Maria Francisca e de Maria Teresa, mas que provavelmente são o de Maria Isabel e o de Maria Francisca de Assis - princesas que, nesse ano, deixavam o Brasil para casar-se, respectivamente, com Fernando VII, o rei espanhol, e com seu irmão Carlos Isidro de Bourbon. Neste artigo, além de descrevermos os retratos (e analisarmos a questão da identidade das princesas retratadas), abordamos suas funções na sociedade das cortes e os principais artistas do gênero na Europa. Discutimos, também, as hipóteses que permeiam as escolhas de Taunay para sua execução. Nesse sentido, tratamos da possível circulação de tipologias entre Itália, Portugal, Espanha e França, buscando entender a forma como Taunay os realizou e as funções que doravante tais retratos ocupariam nas relações entre o Brasil e a Europa.Universidade Federal de São Paulo (UNIFESP)UNIFESPSciEL