A deep Chandra observation of the interacting star-forming galaxy Arp 299

We present results from a 90 ks Chandra ACIS-S observation of the X-ray luminous interacting galaxy system Arp 299 (NGC 3690/IC 694). We detect 25 discrete X-ray sources with luminosities above 4.0x10^38 erg s^-1 covering the entire Ultra Luminous X-ray source (ULX) regime. Based on the hard X-ray spectra of the non-nuclear discrete sources identified in Arp 299, and their association with young, actively star-forming region of Arp 299 we identify them as HMXBs. We find in total 20 off-nuclear sources with luminosities above the ULX limit, 14 of which are point-like sources. Furthermore we observe a marginally significant deficit in the number of ULXs, with respect to the number expected from scaling relations of X-ray binaries with the star formation rate (SFR). Although the high metalicity of the galaxy could result in lower ULX numbers, the good agreement between the observed total X-ray luminosity of ULXs, and that expected from the relevant scaling relation indicates that this deficit could be the result of confusion effects. The integrated spectrum of the galaxy shows the presence of a hot gaseous component with kT = 0.72+-0.03 keV, contributing 20% of the soft (0.1-2.0 keV) unabsorbed luminosity of the galaxy. A plume of soft X-ray emission in the west of the galaxy indicates a large scale outflow. We find that the AGN in NGC 3690 contributes only 22% of the observed broad-band X-ray luminosity of Arp 299.Comment: 20 pages, 14 figures, 9 tables. Accepted for publication in MNRA

Validation and comparison of two methods to Assess Human Energy Expenditure during Free-Living Activities

Background: The measurement of activity energy expenditure (AEE) via accelerometry is the most commonly used objective method for assessing human daily physical activity and has gained increasing importance in the medical, sports and psychological science research in recent years. Objective: The purpose of this study was to determine which of the following procedures is more accurate to determine the energy cost during the most common everyday life activities; a single regression or an activity based approach. For this we used a device that utilizes single regression models (GT3X, ActiGraph Manufacturing Technology Inc., FL., USA) and a device using activity-dependent calculation models (move II, movisens GmbH, Karlsruhe, Germany). Material and Methods: Nineteen adults (11 male, 8 female; 30.469.0 years) wore the activity monitors attached to the waist and a portable indirect calorimeter (IC) as reference measure for AEE while performing several typical daily activities. The accuracy of the two devices for estimating AEE was assessed as the mean differences between their output and the reference and evaluated using Bland-Altman analysis. Results: The GT3X overestimated the AEE of walking (GT3X minus reference, 1.26 kcal/min), walking fast (1.72 kcal/min), walking up2/downhill (1.45 kcal/min) and walking upstairs (1.92 kcal/min) and underestimated the AEE of jogging (2 1.30 kcal/min) and walking upstairs (22.46 kcal/min). The errors for move II were smaller than those for GT3X for all activities. The move II overestimated AEE of walking (move II minus reference, 0.21 kcal/min), walking up2/downhill (0.06 kcal/min) and stair walking (upstairs: 0.13 kcal/min; downstairs: 0.29 kcal/min) and underestimated AEE of walking fast (20.11 kcal/min) and jogging (20.93 kcal/min). Conclusions: Our data suggest that the activity monitor using activity-dependent calculation models is more appropriate for predicting AEE in daily life than the activity monitor using a single regression model

New Fisheries-related data from the Mediterranean Sea (November, 2016)

In this fourth Collective Article, with fisheries-related data from the Mediterranean, we present weight-length relationships for eight deep-sea fish species (Brama brama, Conger conger, Etmopterus spinax, Molva macrophthalma, Mora moro, Pagellus bogaraveo, Phycis blennoides) from the Eastern Ionian Sea; Scyliorhinus canicula from various locations in the Mediterranean Sea and weight-length relationships and condition factor of five Mugilidae species (Liza aurata, Liza saliens, Liza ramada, Mugil cephalus, Chelon labrosus) from a Mediterranean lagoon in the Ionian Sea. Moreover, we present otolith weight, fish length and otolith length relationships of the red mullet (Mullus barbatus) in the Aegean and Ionian Sea and otolith weight relationships in European hake (Merluccius merluccius) from the Greek Seas

The diet and feeding ecology of Conger conger (L. 1758) in the deep waters of the Eastern Ionian Sea

The diet of the European conger eel Conger conger was investigated for the first time in the Eastern Mediterranean. Fish dominated the European conger eel diet in the deep waters of E. Ionian Sea. All other prey taxa were identified as accidental preys. However, intestine analysis showed that Natantia, Brachyura and Cephalopoda might have a more important contribution in the diet of the species. C. conger exhibited a benthopelagic feeding behavior as it preyed upon both demersal and mesopelagic taxa. The high vacuity index and the low stomach and intestine fullness indicated that the feeding intensity of the species in the deep waters of Eastern Ionian Sea was quite low. C. conger feeding strategy was characterised by specialisation in various resource items. A between-phenotype contribution to niche width was observed for some prey categories. European Conger eel feeding specialisation seemed to be an adaptation to a food-scarce environment, as typified in deep-water habitat

Abundance and temperature of the outer hot circum-Galactic medium: The SRG/eROSITA view of the soft X-ray background in the eFEDS field

Despite their vital importance to understand galaxy evolution and our own Galactic ecosystem, our knowledge of the physical properties of the hot phase of the Milky Way is still inadequate. However, sensitive SRG/eROSITA large area surveys are now providing us with the long sought-after data needed to mend this state of affairs. We present the properties of the soft X-ray emission as observed by eROSITA in the eFEDS field. We measure the temperature and metal abundance of the hot circum-Galactic medium (CGM) to be within $kT_{CGM}=0.153-0.178$ keV and $Z_{CGM}=0.052-0.072$ $Z_\odot$, depending on the contribution of solar wind charge exchange (SWCX). Slightly larger CGM abundances $Z_{CGM}=0.05-0.10$ $Z_\odot$ are possible, considering the uncertain extrapolation of the extragalactic Cosmic X-ray background (CXB) emission below $\sim1$ keV. To recover CGM abundances as large as $Z_{CGM}=0.3$ $Z_\odot$, it must be postulated the presence of an additional component, likely associated with the warm-hot intergalactic medium, providing $\sim15-20$% of the flux in the soft X-ray band. The emission in the soft band is dominated by the CGM, with contributions from the CXB and the local hot bubble. Moreover, the eROSITA data require the presence of an additional component associated with the elusive Galactic corona plus a possible contribution from unresolved M dwarf stars. This component has a temperature of $kT\sim0.4-0.7$ keV and it might be out of thermal equilibrium. It contributes $\sim9$% to the total emission in the 0.6--2 keV band, therefore it is a likely candidate to produce part of the unresolved CXB flux observed in X-ray ultra-deep fields. We also observe a significant contribution to the soft X-ray flux due to SWCX, during periods characterised by stronger solar wind activity, and causing the largest uncertainty on the determination of the CGM temperature.Comment: Accepted for publication in Astronomy and Astrophysic

Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia : phenotypes, risk factors and genotypes

Publisher Copyright: © 2022 Ferrata Storti Foundation Published under a CC BY-NC license.Central nervous system (CNS) toxicity is common at diagnosis and during treatment of pediatric acute lymphoblastic leukemia (ALL). We studied CNS toxicity in 1, 464 children aged 1.0-17.9 years, diagnosed with ALL and treated according to the Nordic Society of Pediatric Hematology and Oncology ALL2008 protocol. Genome-wide association studies, and a candidate single-nucleotide polymorphism (SNP; n=19) study were performed in 1, 166 patients. Findings were validated in an independent Australian cohort of children with ALL (n=797) in whom two phenotypes were evaluated: diverse CNS toxicities (n=103) and methotrexate-related CNS toxicity (n=48). In total, 135/1, 464 (9.2%) patients experienced CNS toxicity for a cumulative incidence of 8.7% (95% confidence interval: 7.31-10.20) at 12 months from diagnosis. Patients aged ≥10 years had a higher risk of CNS toxicity than had younger patients (16.3% vs. 7.4%; P<0.001). The most common CNS toxicities were posterior reversible encephalopathy syndrome (n=52, 43 with seizures), sinus venous thrombosis (n=28, 9 with seizures), and isolated seizures (n=16). The most significant SNP identified by the genome-wide association studies did not reach genomic significance (lowest P-value: 1.11x10-6), but several were annotated in genes regulating neuronal functions. In candidate SNP analysis, ATXN1 rs68082256, related to epilepsy, was associated with seizures in patients <10 years (P=0.01). ATXN1 rs68082256 was validated in the Australian cohort with diverse CNS toxicities (P=0.04). The role of ATXN1 as well as the novel SNP in neurotoxicity in pediatric ALL should be further explored.Peer reviewe