Методика оценки регионального неравенства

The paper proposes the author's interpretation of the concept of "regional inequality" through the category of accessibility, namely the availability of goods and services that are assessed by residents of the regions as necessary for the implementation of their life strategies

New Format of the Final State Examination at Bachelor Graduates in the Field of «Pedagogical Education»

The purpose of this study is to build a model of fund tasks aimed at assessing general professional and universal competencies of bachelor's graduates studying in the field of training «Pedagogical education» at the stage of preparation and conduct of the final state exam. Systemic, action-oriented, competency-based and contextual approaches were used as methodological guidelines in the development of fundraising tasks. The authors defined the notions of "fund task", "key actions" and highlighted the types of fund tasks, justified the need to change the form and content of evaluation tools used in the preparation and conduct of the final state exam

Morphological Features of Russian Speech of Two Generations of Bilinguals and Monolinguals

The purpose of the study is to analyze the morphological features of the Russian speech of two generations of Russian-German bilinguals living in Germany and Russian monolinguals living in Russia. The relevance of this study is due to the need to study the state of the Russian language abroad, its preservation and development. Four groups of informants took part in the study: 22 bilingual adults, 26 their children, 19 monolingual adults, 23 their children. The age of the parents is 35-50 years, the age of the children is 10-15 years. The material of the study was transcripts of audio recordings of oral stories based on pictures from the book by M. Mayer “Frog: where are you?”. Research methods are directed sampling, descriptive, systematization, statistical and comparative. Deviations from morphological norms were grouped into two structural types: 1) deviations from the norms of constructing word forms; 2) deviations from the norms of the choice of word forms. The study determined the average number of deviations from morphological norms in the stories of four groups of informants. It was found that in families seeking to preserve the Russian language in conditions of emigration, the morphological system remains relatively stable. At the same time, the average proportion of deviations from morphological norms in the speech of bilinguals is higher than in the speech of monolinguals, and in the speech of children is higher than in the speech of their parents. The average values of the number of typical deviations from the norms in each of the groups were determined. The heterogeneity of the number of deviations from the norms in individual representatives of each of the groups of informants was revealed. It is established that in some families the literary language is preserved, and the influence of the German language is not revealed, in others the vernacular is the means of communication, and some deviations from morphological norms may be caused by interlanguage interference. It should be noted that the greatest difficulty for all native speakers of the Russian language is the norms of the use of case forms and prepositional-case

Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity

T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangement of a TRBV gene to the partially rearranged D-J gene. Unsuccessful V-D-J TRB rearrangements lead to apoptosis of the cell. Here, we performed deep sequencing of the poorly explored pool of partial TRBD1-TRBD2 rearrangements in T-cell genomic DNA. We reconstructed full repertoires of human partial TRBD1-TRBD2 rearrangements using novel sequencing and validated them by detecting V-D-J recombination-specific byproducts: excision circles containing the recombination signal (RS) joint 5’D2-RS – 3’D1-RS. Identified rearrangements were in compliance with the classical 12/23 rule, common for humans, rats, and mice and contained typical V-D-J recombination footprints. Interestingly, we detected a bimodal distribution of D-D junctions indicating two active recombination sites producing long and short D-D rearrangements. Long TRB D-D rearrangements with two D-regions are coding joints D1-D2 remaining classically on the chromosome. The short TRB D-D rearrangements with no D-region are signal joints, the coding joint D1-D2 being excised from the chromosome. They both contribute to the TRB V-(D)-J combinatorial diversity. Indeed, short D-D rearrangements may be followed by direct V-J2 recombination. Long D-D rearrangements may recombine further with J2 and V genes forming partial D1-D2-J2 and then complete V-D1-D2-J2 rearrangement. Productive TRB V-D1-D2-J2 chains are present and expressed in thousands of clones of human antigen-experienced memory T cells proving their capacity for antigen recognition and actual participation in the immune response

Место современных продуктов прикорма в критическом периоде формирования здоровья ребенка

The current development of medicine and the results of recent large-scale academic research in pediatrics provide the convincing conclusions that the formation of human health begins in the antenatal period of ontogenesis and continues throughout the infancy. The ideas and subsequent academic research on the influence of nutrition during the first thousand days of life on the programming of metabolism and the development of some chronic somatic diseases such as obesity, hypertension, coronary heart disease have become widespread. In addition, at the same period of life immune abnormalities with a predominance of one of the subpopulations, Th1 or Th2, can possibly form in children at risk of developing allergies when immune response is developing. The predominance of the Th2 cytokine profile (hyperproduction of interleukins 4, 5, 13, etc.) suggests the possibility of stable formation of the atopic status in a child afterwards. Consequently, the application of academic knowledge on the health status programming by nutrition during early ontogenesis is an important tool in preventive pediatric practice.Развитие современной медицины, результаты последних масштабных научных исследований в педиатрии приводят к убедительным выводам, что формирование здоровья человека начинается в антенатальном периоде онтогенеза и продолжается на протяжении раннего детского возраста. Широкое распространение получили идеи и последовавшие за ними научные исследования о влиянии питания первых тысячи дней жизни в программировании метаболизма и развитии некоторых хронических соматических болезней, таких как ожирение, гипертоническая болезнь, ишемическая болезнь сердца. Вместе с тем в этот же период жизни у детей групп риска по развитию аллергии при становлении иммунного ответа возможно программирование иммунных отклонений с преобладанием одной из субпопуляций — Th1 или Th2. Преобладание цитокинового профиля Th2 (гиперпродукция интерлейкинов 4, 5, 13 и др.) предполагает возможность стойкого формирования атопического статуса ребенка в дальнейшем. Следовательно, использование научных знаний о программировании состояния здоровья питанием в процессе раннего онтогенеза является важным инструментом в практической профилактической педиатрии.КОНФЛИКТ ИНТЕРЕСОВТ.В. Турти, Е.Г. Бокучава сотрудничают с АО «ПРОГРЕСС».И.А. Беляева сотрудничает с компанией «Пфайзер Инновации».Остальные авторы статьи подтвердили отсутствие конфликта интересов

Phenological shifts of abiotic events, producers and consumers across a continent

Ongoing climate change can shift organism phenology in ways that vary depending on species, habitats and climate factors studied. To probe for large-scale patterns in associated phenological change, we use 70,709 observations from six decades of systematic monitoring across the former Union of Soviet Socialist Republics. Among 110 phenological events related to plants, birds, insects, amphibians and fungi, we find a mosaic of change, defying simple predictions of earlier springs, later autumns and stronger changes at higher latitudes and elevations. Site mean temperature emerged as a strong predictor of local phenology, but the magnitude and direction of change varied with trophic level and the relative timing of an event. Beyond temperature-associated variation, we uncover high variation among both sites and years, with some sites being characterized by disproportionately long seasons and others by short ones. Our findings emphasize concerns regarding ecosystem integrity and highlight the difficulty of predicting climate change outcomes. The authors use systematic monitoring across the former USSR to investigate phenological changes across taxa. The long-term mean temperature of a site emerged as a strong predictor of phenological change, with further imprints of trophic level, event timing, site, year and biotic interactions.Peer reviewe

Chronicles of nature calendar, a long-term and large-scale multitaxon database on phenology

We present an extensive, large-scale, long-term and multitaxon database on phenological and climatic variation, involving 506,186 observation dates acquired in 471 localities in Russian Federation, Ukraine, Uzbekistan, Belarus and Kyrgyzstan. The data cover the period 1890-2018, with 96% of the data being from 1960 onwards. The database is rich in plants, birds and climatic events, but also includes insects, amphibians, reptiles and fungi. The database includes multiple events per species, such as the onset days of leaf unfolding and leaf fall for plants, and the days for first spring and last autumn occurrences for birds. The data were acquired using standardized methods by permanent staff of national parks and nature reserves (87% of the data) and members of a phenological observation network (13% of the data). The database is valuable for exploring how species respond in their phenology to climate change. Large-scale analyses of spatial variation in phenological response can help to better predict the consequences of species and community responses to climate change.Peer reviewe

Prospects for the use of the tomato genetic collection of the FSBSI ARRIBPP to develop varieties with group resistance to

The resistance of mutant tomato lines to the main diseases upon the provocative infectious background was assessed. We used as experimental material 22 lines of the tomato genetic collection of the FSBSI ARRIBPP, Krasnodar. According to the results of assessing the damage by Alternaria sp. in the field it was found that line 41 exhibitted high resistance, there were no signs of disease damage. Mutant lines 80, 387, 434, 568, 620 showed resistance, the degree of the disease development varied within 1–8 %. Lines 172, 467, 509, 518 with a degree of development of 12–23 % were characterized by semi-resistance. Lines 41, 387 showed high resistance to P. infestans. No visible signs of damage by P. infestans were detected in these genotypes. Lines 341, 509, 518, 568 had semi-resistance to the pathogen, the degree of development varied from 10 to 18 %. The genotypes Mo 41 and 387 that showed high and relatively high resistance to Alternaria sp. and P. infestans are of the greatest interest for breeding and genetic work as sources of group resistance

Models for the interaction between space services providers and manufacturers of space vehicles

International audienceThe authors have formed the space market structure which is distinguished by the junctional formation of the summed demand for a product or service between the participants at the same stage, which serves as a basis for the formation of demand at the next stages. The peculiarities of participants' interaction on the space services market are associated with incomplete awareness. It is advisable to use the methodological approach considered in the theory of contracts in the case of asymmetric information to develop models of interaction between market participants. Thus, based on the theory of contracts and taking into account the specifics of interaction in this article the authors have described the models for the generation of an optimal contract for the manufacturer of space vehicles and space services providers. The models are presented for the cases with symmetric and asymmetric information. As a result of solution of the task for the generation of an optimal contract, such parameters of the contract as satellite performance, the price of its information throughput unit, as well as the cumulative indicator of its technical and operational characteristics can be found in the course of interaction between these participants of the space market. The determined parameters of the contract allow maximizing the profit of the manufacturer of space vehicles

Regional Inequality Assessment Methodology

The paper proposes the author's interpretation of the concept of "regional inequality" through the category of accessibility, namely the availability of goods and services that are assessed by residents of the regions as necessary for the implementation of their life strategies