163 research outputs found

    Educación emocional en la formación inicial de profesores de pedagogía en Educación Básica: relato de una propuesta en construcción

    Get PDF
    Este trabajo presenta una reconstrucción evaluativa de la experiencia desarrollada en la carrera de Pedagogía de Educación Básica de la Universidad Academia de Humanismo Cristiano en el ámbito de la educación emocional. Se describe la experiencia realizada, las est rategias de enseñanza ut ilizadas, los aprendizajes de los estudiantes y se esbozan líneas posibles de seguir en la formación inicial de docentes

    Voltammetric characterization of [ReO]3+ containing complexes

    Get PDF
    In the present work, the voltammetric profiles of Au-pc in 1 mM solutions of K[ReVOCl2(L)] (L = dianions of H2hida or H2eida; hida, n-(2,6-dimethylphenyl carbamoylmethyl)imino diacetic acid, and eida, 2,6-diethyl ida) complexes were evaluated. The obtained electrochemical response was the result of the contributions coming from the [ReO]3+ core (Epa at ca. 0.2 V vs. Ag/AgNO3) and the carboxylic group of the ligand. There where also observed redox contributions ascribed to the presence of perrhenate coming from the decomposition of the complex with the lost of ligands, in agreement with the low stability of the studied complexes. copyright The Electrochemical Society.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasFacultad de Ciencias Exacta

    From planning to resilience: The role (and value) of the emergency plan

    Full text link
    This is the author’s version of a work that was accepted for publication in Technological Forecasting & Social Change. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Technological Forecasting & Social Change 121 (2017) 17–30. DOI 10.1016/j.techfore.2016.12.004.The study of resilience in the emergency management field is nowadays in effervescence. Traditionally, the robustness of organizations against disasters is based on several pillars: equipment, staff training, organization and, especially, planning. All of these dimensions are aimed at increasing the preparedness and recovery of organizations against disasters. While the approaches to resilience in emergency management focus on the processes that implement these dimensions, we approach resilience-building processes from a different perspective: instead of focusing on planning-related activities, we pay attention to the principal outcome of such activities, namely emergency plan. We show how the management of the emergency plan can contribute to reinforcing an organization's resilience. First, we identify the major resilience-related emergency plan components and suggest improved emergency plans that consider the characteristics that contribute to resilience. Secondly, we show how to reinforce the resilience of the organizations that have emergency plans. Our study is based on QuEP, a quality-based framework for the assessment and improvement of emergency plan management within organizations. We have extended and integrated the resilience characteristics as practices of the QuEP's maturity level hierarchy to make up QuEP + R. We describe its resilience model and give details of a supporting tool, currently under development. © 2016 Elsevier Inc. All rights reserved.The work of M. C. Penades and J. H. Canos& was partially funded by MINECO under grant CALPE (TIN2015-68608-R) and A.G. NCifiez received support from SENESCYT scholarship program of the Republic of Ecuador.Penadés Gramage, MC.; Núñez Ávila, AG.; Canos Cerda, JH. (2016). From planning to resilience: The role (and value) of the emergency plan. Technological Forecasting and Social Change. 121(3):17-30. https://doi.org/10.1016/j.techfore.2016.12.004S1730121

    Strategic planning for the management of social programs of the Ministerial Regional Secretariat of social development and the municipalities of the Bio-Bio Region

    Get PDF
    El siguiente estudio tiene como objetivo realizar una planificación estratégica para los programas sociales de la Secretaría Regional Ministerial (SEREMI) de Desarrollo Social, Región del Biobío, con el fin de mejorar la gestión de dicha organización. La metodología apunta a la utilización del modelo de gestión estratégica de David, Fred (2003), y mediante la utilización de fuentes primarias y secundarias e información descriptiva y exploratoria, se obtienen resultados que, traducidos y aplicados a la unidad en estudio, permite la formulación de objetivos, diseño de estrategias necesarias y requeridas para mejorar el desarrollo de los convenios entre la Seremi antes mencionada y las Municipalidades de la Región del Biobío.The following study aims to carry out a strategic planning for the social programs of the Regional Ministry of Social Development, of the Bio-Bío Region, in order to improve the management of said organization. The methodology aims to use the strategic management model of David, Fred (2003), and through the use of primary and secondary sources and descriptive and exploratory information, it gets results that, translated and applied to the unit under study, allow the formulation of objectives, design of necessary and required strategies to improve the development of the agreements between this SEREMI mentioned above and the Municipalities of the Biobío Region

    El mito del subterráneo: memoria, política y participación en un liceo secundario de Santiago

    Full text link

    Voltammetric characterization of [ReO]3+ containing complexes

    Get PDF
    In the present work, the voltammetric profiles of Au-pc in 1 mM solutions of K[ReVOCl2(L)] (L = dianions of H2hida or H2eida; hida, n-(2,6-dimethylphenyl carbamoylmethyl)imino diacetic acid, and eida, 2,6-diethyl ida) complexes were evaluated. The obtained electrochemical response was the result of the contributions coming from the [ReO]3+ core (Epa at ca. 0.2 V vs. Ag/AgNO3) and the carboxylic group of the ligand. There where also observed redox contributions ascribed to the presence of perrhenate coming from the decomposition of the complex with the lost of ligands, in agreement with the low stability of the studied complexes. copyright The Electrochemical Society.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasFacultad de Ciencias Exacta

    Fast, Low-Cost and Non-Destructive Physico-Chemical Analysis of Virgin Olive Oils Using Near-Infrared Reflectance Spectroscopy

    Get PDF
    Near-Infrared (NIR) Spectroscopy was used for the non-destructive assessment of physico-chemical quality parameters in olive oil. At the same time, the influence of the sample presentation mode (spinning versus static cup) was evaluated using two spectrophotometers with similar optical characteristics. A total of 478 olive oil samples were used to develop calibration models, testing various spectral signal pre-treatments. The models obtained by applying MPLS regression to spectroscopic data yielded promising results for olive oil quality measurements, particularly for acidity, the peroxide index and alkyl and ethyl ester content. The results obtained indicate that this non-invasive technology can be used successfully by the olive oil sector to categorize olive oils, to detect potential fraud and to provide consumers with more reliable information. Although both sample presentation modes yielded comparable results, equations constructed with samples scanned using the spinning mode provided greater predictive capacity

    Enhancement of quality of rainbow trout (Oncorhynchus mykiss) flesh incorporating barley on diet without negative effect on rearing parameters

    Full text link
    [EN] Barley concentrations ranging from 0 to 32% (0B, 40B, 80B, 160B, and 319B) were incorporated into rainbow trout, Oncorhynchus mykiss (Walbaum) diets. The experiment started with an initial average fish weight of 127.72 +/- 5.65 g and finished when they reached commercial weight (final weight between 312 and 330 g) after 84 days. The inclusion of barley in the diets did not show a significant effect on growth and biometric parameters, fat and carbohydrate digestibilities; however, protein digestibility decreased significantly with the incorporation of barley on diets. Glucose levels increased significantly with barley concentration in the diet, and lactate and cortisol levels were also significantly affected after a stress period regardless of the diet. Meat quality was influenced as well by barley concentration. Lower water activity values and an enhancement in textural and color properties were observed in fish fed with the diet containing the highest barley concentration. Trout fed feed with higher concentrations of barley (160B) showed lower lipid oxidation levels than those fed with lower concentrations (control and 40B). The sensory panel found that fish fed with diets higher than 8% in barley content (80B) exhibited a brighter red color in the gills and a better texture; also, meat color became redder with a higher barley inclusion (160B and 319B), being all these sensory parameters correlated with fish freshness. Thus, results indicate that barley can be substituted for wheat fraction without any detrimental effect on production efficiency and enhancing fish quality.This work has been co-funded with FEDER and INIA funds. The authors thanks Dr. Francisco Ciudad Bautista for providing barley variety obtained in ITACyL, IRTA, EEDF-CSIC, ITAP, and INIA (1FD97-0792 and RTA2006-00020-C04). Julia Pinedo has been granted with the FPI-INIA grant number 21 (call 2012, BOE-2012-13337).Pinedo-Gil, J.; Tomas-Vidal, A.; Larrán-García, AM.; Tomas-Almenar, C.; Jover Cerda, M.; Sanz-Calvo, M.; Martín-Diana, A. (2017). Enhancement of quality of rainbow trout (Oncorhynchus mykiss) flesh incorporating barley on diet without negative effect on rearing parameters. Aquaculture International. 25(3):1005-1023. https://doi.org/10.1007/s10499-016-0091-010051023253A.O.A.C., Association of Official Analytical Chemists (1990) Official methods of analysis, 15th edn. Association of Official Analytical Chemists, Arlington 1298 ppAi Q, Mai K, Zhang L, Tan B, Zhang W, Xu W, Li H (2007) Effects of dietary β-1,3- glucan on innate immune response on large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immun 22:394–402APROMAR 2014 La acuicultura en España 2013. Report by the Spanish Association of marine Aquaculture (APROMAR) and the Spanish Association of Freshwater Aquaculture (ESCUA). Available at: http://www.apromar.es/content/la-acuicultura-en-españa-2014Asghari M, Shabanpour B, Pakravan S (2014) Evaluation of some qualitative variations in frozen fillets of beluga (Huso huso) fed by different carbohydrate to lipid ratios. J Food Sci Tech 51(3):430–439Atkinson JL, Hilton JW, Slinger SJ (1984) Evaluation of acid-insoluble ash as an indicator of feed digestibility in rainbow trout (Salmo gairdneri). Can J Fish Aquat Sci 41:1384–1386Caballero MJ, Obach A, Rosenlund G, Montero D, Gisvold M, Izquierdo MS (2002) Impact of different dietary lipid sources on growth, lipid digestibility, tissue fatty acid composition and histology of rainbow trout, Oncorhynchus mykiss. Aquaculture 214:253–271Casas C, Martinez O, Guillen MD, Pin C, Salmeron J (2006) Textural properties of raw Atlantic salmon (Salmo salar) at three points along the fillet, determined by different methods. Food Control 17:511–515Chang C-F, Su M-S, Chen H-Y, Liao I-C (2003) Dietary β-1,3-glucan effectively improves immunity and survival of Penaeus monodon challenged with white spot syndrome virus. Fish Shellfish Immun 15:297–310Cheng ZJ, Hardy RW (2002) Effect of microbial phytase on apparent nutrient digestibility of barley, canola meal, wheat and wheat middlings, measured in vivo using rainbow trout (Oncorhynchus mykiss). Aquac Nutr 8:271–277Cheng ZJ, Hardy RW (2003) Effects of extrusion processing of feed ingredients on apparent digestibility coefficients of nutrients for rainbow trout (Oncorhynchus mykiss). Aquac Nutr 9:77–83Cho CY, Slinger SJ, Bayley HS (1982) Bioenergetics of salmonid fishes: energy intake, expenditure and productivity. Comp Biochem Physiol 73B:25–41Couto A, Peres H, Oliva-Teles A, Enes P (2016) Screening of nutrient digestibility, glycaemic response and gust morphology alterations in gilthead seabream (Sparus aurata) fed whole cereal meals. Aquaculture 450:31–37Dalmo RA, Bøgwald J (2008) Β-Glucans as conductors of immune symplhonies. Review. Fish Shellfish Immun 25:384–396Flores-Quintana C (2002) Respuestas neuroendocrinas al estrés en peces teleósteos. Rev ictiol 10(1/2):57–78García-Riera MP, Hemre G-I (1996) Effect of adaptation to three different levels of dietary carbohydrates on the incorporation of 14C-glucose in several organs of Atlantic halibut (Hippoglosus hippoglossus). Aquac Res 27:565–571Gatlin DM, Barrows F, Brown P, Dabrowski K, Gaylord TG, Hardy RW, Herman E, Hu G, Krogdahl Å, Nelson R, Overturf K, Rust M, Sealey W, Skonberg D, Souza EJ, Stone D, Wilson R, Wurtele E (2007) Expanding the utilization of sustainable plant products in aquafeeds: a review. Aquac Res 38:551–579Gaylord TG, Barrows FT, Rawles SD, Liu K, Bregitzer P, Hang A, Obert DE, Morris C (2009) Apparent digestibility of nutrients and energy in extruded diets from cultivars of barley and wheat selected for nutritional quality in rainbow trout Oncorhynchus mykiss. Aquac Nutr 15:306–312Ghaedi G, Keyvanshokooh S, Azarm HM, Akhlaghi M (2015) Effects of dietary β-glucan on maternal immunity and fry quality of rainbow trout (Oncorhynchus mykiss). Aquaculture 441:78–83Grisdale-Helland B, Helland SJ (1997) Replacemente of protein by fat and carbohydrate in diets for Atlantic salmon (Salmo salar) at the end of the freshwater stage. Aquaculture 152:167–180Gu M, Ma H, Mai K, Zhang W, Bai N, Wang X (2011) Effects of dietary β-glucan, mannan oligosaccharide and their combinations on growth performance, immunity and resistance against Vibrio splendidus of sea cucumber, Apostichopus japonicus. Fish Shellfish Immun 31:303–309Hai NV, Fotedar R (2009) Comparison of the effects of the prebiotics (Bio-Mos® and β-1,3-D-glucan) and the customized probiotics (Pseudomonas synxantha and P. aeruginosa) on the culture of juvenile western king prawns (Penaeus latisulcatus kishinouye, 1896). Aquaculture 289:310–316Heidarieh M, Mivaghefi AR, Akbari A, Sheikhzadeh N, Kamyabi-Moghaddam Z, Askari H, Shahbazfar AA (2012) Evaluation of Hilyses™, fermented Saccharomyces cerevisiae, on rainbow trout (Oncorhynchus mykiss) growth performance, enzymatic activities and gastrointestinal structure. Aquac Nutr 19:343–348. doi: 10.1111/j.1365-2095.2012.00973.xHemre G-I (1992) Studies on carbohydrate nutrition in Cod (Gadus morhua). Dr. scientiarum Thesis. Institute of Nutrition, University of Bergen, NorwayHemre G-I, Krogdahl Å (1996) The effect of handling and fish size on the secondary changes in carbohydrate metabolism in Atlantic salmon (Salmo salar). Aquac Nutr 2:249–252Hemre G-I, Mommsen TP, Krogdahl Å (2002) Carbohydrates in fish nutrition: effects on growth, glucose metabolism and hepatic enzymes. Aquac Nutr 8:175–194Hixson SM (2014) Fish nutrition and current issues in aquaculture: the balance in providing safe and nutritious seafood, in an environmentally sustainable manner. J Aquac Res Dev 5:234. doi: 10.4172/2155-9546.1000234ISO 8586-1:2001 (2001) Sensory analysis—general guidance for the selection, training and monitoring of assessors—part 1: selected assessors (International Organization for Standardization)ISO 8586-2: 2008 (2008) Sensory analysis—general guidance for the selection, training and monitoring of assessors—part 2: expert sensory assessors (International Organization for Standardization)ISO 8589: 2007 (2007) Sensory analysis—general guidance for the design of test rooms (International Organization for Standardization)Jeney G, Galeotti M, Volpatti D, Anderson DP (1997) Prevention of stress in rainbow trout (Oncorhynchus mykiss) fed diets containing different doses of glucan. Aquaculture 154:1–15Kaplan LA, Pesce AJ (1984) Clinical chemistry: theory, analysis, and correlation. Mosby, St. Louis, pp 1032–1036Krogdahl Å, Sundby A, Olli JJ (2004) Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss) digest and metabolize nutrients differently. Effects of water salinity and dietary starch level. Aquaculture 229:335–360Krogdahl Å, Hemre GI, Mommsen TP (2005) Carbohydrates in fish nutrition: digestion and absorption in postlarval stages. Aquac Nutr 11:103–122Kumar V, Sinha AK, Makkar HPS, De Boeck G, Becker K (2012) Phytate and phytase in fish nutrition. Review article. J Anim Physiol An N 96:335–364Lakshmanan PT (2000) Fish spoilage and quality assessment. In: Lyre TSG, Kandoran MK, Thomas M, Mathew PT (eds) Quality assurance in seafood processing. Society Fisher Techno (India), Cochin, pp 26–40Lazaridou A, Biliaderis CG (2007) Molecular aspects of cereal β-glucan functionality: physical properties, technological applications and physiological effects. J Cereal Sci 46:101–118Lin S, Pan Y, Luo L, Luo L (2011) Effects of dietary β-1,3-glucan, chitosan or raffinose on the growth, innate immunity and resistance of loi (Cyprinus carpio koi). Fish Shellfish Immun 31:788–794Lokesh J, Fernandes JMO, Korsnes K, Bergh Ø, Brinchmann MF (2012) Transcriptional regulation of cytokines in the intestine of Atlantic cod fed yeast derived mannan oligosaccharide or β-glucan and challenged with Vibrio anguillarum. Fish Shellfish Immun 33:626–631MAGRAMA. Ministerio de Agricultura, Alimentación y Medio Ambiente (2015) Gobierno de España. Available at: http://www.mapama.gob.es/es/pesca/temas/acuicultura/produccion-de-acuicultura/default.aspxMartinsdóttir E, Sveinsdóttir K, Luten J, Schelvis-Smit R, Hyldig G (2001) La evaluación sensorial de la frescura del pescado. Manual de referencia para el sector pesquero. Icelandic Fisheries Laboratories. Available at: QIM Eurofish. URL http://qim-eurofish.comMeena DK, Das P, Kumar S, Mandal SC, Prusty AK, Singh SK, Akhtar MS, Behera BK, Kumar K, Pal AK, Mukherjee SC (2013) Beta-glucan: an ideal immunostimulant in aquaculture. Fish Physiol Biochem 39:431–457Mommsen TP, Vijayan MM, Moon TW (1999) Cortisol in teleosts: dynamics, mechanisms of action and metabolic regulation. Rev Fish Biol Fisher 9:211–268Morken T, Kraugerud OF, Barrows FT, Sørensen M, Storebakken T, Øverland M (2011) Sodium diformate and extrusion temperature affect nutrient digestibility and physical quality of diets with fish meal and barley protein concentrate for rainbow trout (Oncorhynchus mykiss). Aquaculture 317:138–145Ortiz J, Lemus-Mondaca R, Vega-Gálvez A, Ah-hen K, Puente-Díaz L, Zura-Bravo L, Aubourg S (2013) Influence of air-drying temperature on drying kinetics, colour, firmness and biochemical characteristics of Atlantic salmon (Salmo salar L.) fillets. Food Chem 139:162–169Overturf K, Raboy V, Cheng ZJ, Hardy RW (2003) Mineral availability from barley low phytic acid grains in rainbow trout (Oncorhynchus mykiss) diets. Aquac Nutr 9:239–246Popelka M, Marcinčák S, Maskal’ová I, Guothová L, Čertík M (2014) Comparison of the chemical composition and nutritional values of fresh and frozen rainbow trout. Slov Vet Res 51(2):73–80Pratoomyot J, Bendiksen EÅ, Bell JG, Tocher DR (2010) Effects of increasing replacement of dietary fishmeal with plant protein sources on growth performance and body lipid composition of Atlantic salmon (Salmo salar L.). Aquaculture 305:124–132Sealey WM, Barrows FT, Hang A, Johansen KA, Overturf K, LaPatra SE, Hardy RW (2008) Evaluation of the ability of barley genotypes containing different amounts of β-glucan to alter growth and disease resistance of rainbow trout Oncorhynchus mykiss. Anim Feed Sci Tech 141:115–128Skrede G, Storebakken T, Skrede A, Sahlstrøm S, Sørensen M, Shearer KD, Slinde E (2002) Lactic acid fermentation of wheat and barley whole meal flours improves digestibility of nutrients and energy in Atlantic salmon (Salmo salar L.) diets. Aquaculture 210:305–321Stone DAJ (2003) Dietary carbohydrate utilization by fish. Rev Fish Sci 11(4):337–369Storebakken T, Shearer KD, Refstie S, Lagocki S, McCool J (1998) Interactions between salinity, dietary carbohydrate source and carbohydrate concentration on the digestibility of macronutrients and energy in rainbow trout (Oncorhynchus mykiss). Aquaculture 163:347–359Thomas L (Hrsg.) (1992) Labor und Diagnose, 4. Auflage. Marburg; Die MedizinischeVerlagsgesellschaftValente LMP, Rema P, Ferraro V, Pintado M, Sousa-Pinto I, Cunha LM, Oliveira MB, Araújo M (2015) Iodine enrichment of rainbow trout flesh by dietary supplementation with the red seaweed Gracilaria vermiculophylla. Aquaculture 446:132–139Vyncke W (1975) Evaluation of the direct thiobarbituric acid extraction method for determining oxidative rancidity in mackerel (Scomber scombrus L.). Fette, Seifen, Anstrichmittel 77(6):239–240Walton MJ (1986) Metabolic effects of feeding a high protein/low carbohydrate diet as compared to a low protein/high carbohydrate diet in rainbow trout (Salmo gairdneri). Fish Physiol Biochem 1(1):7–15Xu Y, Liu Y, Zhang C, Li X, Yi S, Li J (2015) Physicochemical responses and quality changes of turbot (Psetta maxima) during refrigerated storage. Int J Food Prop. doi: 10.1080/1094.2912.2015.1022260. In pressYildiz M (2004) The study of fillet quality and the growth performance of rainbow trout (Oncorhynchus mykiss) fed with diets containing different amounts of vitamin E. Turk J Fish Aquat Sc 4:81–8

    Identification of 34 novel mutations in propionic acidemia: Functional characterization of missense variants and phenotype associations

    Full text link
    Propionic acidemia (PA) is caused by mutations in the PCCA and PCCB genes, encoding α and β subunits, respectively, of the mitochondrial enzyme propionyl-CoA carboxylase (PCC). Up to date, >200 pathogenic mutations have been identified, mostly missense defects. Genetic analysis in PA patients referred to the laboratory for the past 15 years identified 20 novel variants in the PCCA gene and 14 in the PCCB gene. 21 missense variants were predicted as probably disease-causing by different bioinformatics algorithms. Structural analysis in the available 3D model of the PCC enzyme indicated potential instability for most of them. Functional analysis in a eukaryotic system confirmed the pathogenic effect for the missense variants and for one amino acid deletion, as they all exhibited reduced or null PCC activity and protein levels compared to wild-type constructs. PCCB variants p.E168del, p.Q58P and p.I460T resulted in medium-high protein levels and no activity. Variants p.R230C and p.C712S in PCCA, and p.G188A, p.R272W and p.H534R in PCCB retained both partial PCC activity and medium-high protein levels. Available patients-derived fibroblasts carriers of some of these mutations were grown at 28 °C or 37 °C and a slight increase in PCC activity or protein could be detected in some cases at the folding-permissive conditions. Examination of available clinical data showed correlation of the results of the functional analysis with disease severity for most mutations, with some notable exceptions, confirming the notion that the final phenotypic outcome in PA is not easily predictedWe thank the following physicians/clinicians for sending samples for genetic analysis: Dr. Wilson (Auckland, New Zealand), Dr. Parini (Rome, Italy), Dr. Vilaseca (Barcelona, Spain), Dr. Gockay (Istanbul, Turkey), Dr. Al Sannaa (Saudi Arabia), Dr. Pedrón (Madrid, Spain), Dr. Savvapoulou (Tesalonica, Greece), Dr. Martínez-Pardo (Madrid, Spain), Dr. Lama (Madrid, Spain), Dr. Lemes (Montevideo, Uruguay), Dr. Van Calcar (Madison, USA), Dr. Pintos (Badalona, Spain), Dr. Laszlo (Szeged, Hungary), Dr. Kuijtmans (Nijmegen, The Netherlands), Dr. Schatz (München, Germany), Dr. EL Khateeb (Jordan), Dr. de las Heras (Baracaldo, Spain), Dr. Miñana (Buenos Aires, Argentina). The technical assistance of A. Sánchez is gratefully acknowledged. This work was supported by Spanish Ministry of Economy and Competitiveness and European Regional Development Fund (grant number SAF2016-76004-R). Centro de Biología Molecular Severo Ochoa receives an institutional grant from Fundación Ramón Arece

    Polymeric nanoparticles for drug delivery: Recent developments and future prospects

    Get PDF
    The complexity of some diseases—as well as the inherent toxicity of certain drugs—has led to an increasing interest in the development and optimization of drug-delivery systems. Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system. In this review, a summary of the state-of-the-art panorama of polymeric nanoparticles as drug-delivery systems has been conducted, focusing mainly on those applications in which the corresponding disease involves an important morbidity, a considerable reduction in the life quality of patients—or even a high mortality. A revision of the use of polymeric nanoparticles for ocular drug delivery, for cancer diagnosis and treatment, as well as nutraceutical delivery, was carried out, and a short discussion about future prospects of these systems is includedMinisterio de Ciencia e Innovación PID2019-109371GB-I0
    corecore