Tech Support Workshops for Seniors: Bridging the Digital Divide

Unequal access to technology for seniors makes already-existing inequalities worse by preventing seniors from taking advantage of opportunities. A key element of Loaves, Fishes & Computers program is the digital literacy department, which assists seniors in overcoming any technological barriers. Seniors can get one-on-one help with any questions they may have about any technology device they possess. Additionally, they collaborate with other organizations to offer tools that might support the well-being of elders. For example, low-cost wifi resources. By offering workshops tailored to the needs of seniors, my project aims to contribute to ending the digital divide. I researched various subjects that would be beneficial and interesting. Since artificial intelligence is still relatively new, we created a presentation on it. The purpose of this workshop was to provide knowledge that participants could use to overcome any challenges and improve their daily lives. It is recommended that the organization keeps developing workshops that assist with everyday problems

Interactions between DNA damage and metabolism

Over the past decades, life expectancy has dramatically increased worldwide. Because of this, the causes of mortality have shifted from infectious diseases towards chronic metabolic diseases such as type 2 diabetes and cardiovascular disease. While some of the causes underlying the development of chronic metabolic diseases can be changed, such as dietary and physical behavior, other causes such as genetics, ethnicity and aging cannot be changed. Although the knowledge of the mechanisms driving aging is still limited, progeroid syndromes have shown that inadequate repair of DNA damage contributes to features of accelerated aging. In this thesis, we have investigated the interactions between DNA damage and metabolism as a potential underlying mechanism for the age-related risk to develop metabolic diseases. Using mouse models with a deficiency in DNA damage repair, we have shown that accumulation of DNA damage can lead to metabolic impairments. Moreover, we provide evidence that DNA damage in specific cell populations can be sufficient to drive systemic impairments. This is highlighted by mice with a deficiency in DNA damage repair in pancreatic beta-cells which develop impairments in insulin secretion and glucose tolerance but also develop obesity, inflammation and senescence in peripheral tissues. Collectively, the research performed in this thesis provides evidence of a tight link between DNA damage, cell function and the development of chronic metabolic diseases

Teaching Hispanic restaurant workers: Translanguaging as culturally sustaining pedagogy

In this article, we make a case for incorporating translanguaging pedagogy into the framework of Culturally Sustaining Pedagogy (CSP). Drawing on data from a one-year ethnographic study of an adult ESL program, we show how teachers believed in and attempted to create spaces for translanguaging and CSP, but in practice fell short. We conclude that translanguaging is most powerful when understood as a component of CSP but call for more research in this area.Accepted manuscrip

El retrato de Lady Anne Clifford

The Real Academia de Bellas Artes de San Fernando holds a portrait of a young woman long identified as Barbara de Braganza. Originally, the canvas was attributed to the Italian painter Jacopo Amigoni, later to the Frenchman Pierre Subleyras. With the discovery of the cargo of the English ship the Westmorland, full of art and antiques, we can now reconstruct the history of this portrait. Since it was shipped in a crate labeled W.C., the intended owner of this work, we may now identify the sitter as Anne Clifford, Countess of Mahony, the cousin of a British aristocrat, William Constable. In 1778, William Constable commissioned a painter named Domenico Cherubini to copy an original portrait of the young woman by Pierre Subleyras through the Scottish agent James Byres. Since the Westmorland had been captured in the Mediterranean en route to Great Britain, Constable was unable to recover the lost work, so he commissioned a second copy from Pompeo Girolamo Batoni, completed in 1785 and also based on the original by Subleyras. Today three variant portraits exist.The original by Subleyras is in the Musée de Beaux Arts de Caén (France), the copy by Cherubini hangs in the Real Academia de Bellas Artes de San Fernando, Madrid, and finally, the copy by Batoni in the home of the intended owner, William Constable, in Burton Constable Hall (England).En la Real Academia de Bellas Artes de San Fernando se conserva el retrato de una joven que durante años fue identificada como Bárbara de Braganza. El lienzo fue atribuido en un principio al pintor italiano Jacopo Amigoni y, posteriormente, al pintor francés Pierre Subleyras. Con el descubrimiento de un cargamento de obras de arte y antigüedades que viajaba en un barco inglés llamado Westmorland se ha logrado recomponer la historia de este retrato, el cual viajaba en el interior de un cajón marcado con las iniciales W.C. Gracias a este dato se logró averiguar que se trataba del retrato de Anne Clifford, condesa de Mahony, prima de un aristócrata británico llamado William Constable, quien encargó en 1778, a través del agente escocés James Byres, una copia de un retrato, de este mismo personaje, realizado anteriormente por Pierre Subleyras, a un pintor llamado Domenico Cherubini. Debido a que el barco fue capturado en el Mediterráneo, el paradero de dicha obra había sido hasta ahora desconocido. De hecho, su propietario, ante la imposibilidad de recuperarlo, encargó de nuevo otra copia, en esta ocasión, a Pompeo Girolamo Batoni, quien la realizó en 1785, tomando también como referencia el primer retrato de Pierre Subleyras. Por tanto, en la actualidad existen tres retratos similares. El original de Pierre Subleyras se encuentra en el Musée de Beaux Arts de Caén (Francia); la copia conservada en la Real Academia de Bellas Artes de San Fernando de Madrid, aquella que se pensaba desaparecida y que, sin embargo, se corresponde con la copia de Domenico Cherubini, y por último, la segunda copia de Pompeo Girolamo Batoni conservada en la residencia de William Constable, Burton Constable Hall (Inglaterra)

El Grand Tour: un viaje emprendido con la mirada de Ulises

The cultural splendor of the 18th century was most notably marked by a phenomenon known as the Grand Tour. In this article we will discuss the significance of this term as well as the motivations that drove vast numbers of people to embark on this long journey across Europe. To better contextualize this voyage, we will discuss one unique case to which Spain is a direct witness. Though it has never reached a “tourist” level of interest, the history surrounding this case has afforded us the wonderful opportunity to serve as narrators of this exceptional storyEl siglo XVIII fue la centuria de máximo esplendor de un fenómeno cultural denominado Grand Tour. A lo largo de este artículo hablaremos de lo que significa este término y de las motivaciones que condujeron a gran cantidad de personas a emprender un largo viaje a través de Europa. Para contextualizar este periplo trataremos un caso singular del que España es testigo directo, pues, si bien no entraba en el circuito de interés “turístico”, la historia caprichosamente nos ha brindado la oportunidad de ser los narradores de un hecho singular. La colección Westmorland

Emotion Identification Ability and Perspective-Taking in Children with Autism Spectrum Disorder

Autism spectrum disorder (ASD) is characterized by persistent deficits in social interaction. Perspective-taking and emotion identification are important skills to develop appropriate social interactions. Previous research has shown that children with ASD may lack the ability to relate emotionally to others. Research has also shown a deficit in perspective-taking skills in children with ASD. The selected studies reviewed in this thesis analyze seven articles that show research on children with ASD regarding their emotional identification and perspective-taking skills. Articles searched under the words “emotion identification,” “perspective-taking,” and “autism” obtained from the Psychology and Behavioral Sciences Collection using the EBSCO database provided by The University of Rio Grande Valley. The review of selected studies examines the capability of children with ASD to learn perspective-taking by teaching emotion identification and theory of mind. The review of selected articles also examines the ability of children with ASD to identify emotion in comparison to typically developing children. The purpose of the review of selected studies is, therefore, to evaluate and summarize the findings and provide recommendations for future research

Begomovirus quasispecies adapt to hosts by exploring different sequence space without changing their consensus sequences

Geminiviruses possess single-stranded circular DNA genomes that depend on cellular polymerases for replication in the host nucleus. In plant hosts, geminivirus populations behave as ensembles of mutant and recombinant genomes. This favours the emergence of new geminivirus strains able to produce new diseases or overcome the genetic resistance of cultivars. In warm and temperate areas several whitefly-transmitted geminiviruses of the genus Begomovirus cause the tomato yellow leaf curl disease (TYLCD) with important economic consequences. TYLCD is frequently controlled in commercial tomato production using the Ty-1 resistance gene. Over a 45 day period we studied the evolution of infectious clones from three TYLCD-associated begomoviruses: Tomato yellow leaf curl Sardinia virus, Tomato yellow leaf curl virus and the recombinant Tomato yellow leaf curl Axarquia virus. The evolution of their viral progeny was examined in susceptible tomato (ty1/ty1), resistant tomato (Ty1/ty1), common bean, and the wild reservoir Solanum nigrum. We found that in addition to affecting viral accumulation kinetics, the host influenced the sequence space explored by these begomoviruses. In tomato, viral dynamics was not influenced by the presence of the Ty-1 gene. Interestingly, positive adaptation of the coat protein gene was only observed in the common bean and S. nigrum, which correlates with these plants having viral quasispecies with the highest degree of complexity and heterogeneity. Our results underline the importance of analysing the mutant spectra of begomovirus infections, especially in wild reservoirs, which have the potential to give rise to large numbers of emergent variants in spite of the invariance of their consensus sequences.Junta de Andalucía proyecto: P10-CVI-6561. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression.

The Western diet contains a high ratio of omega-6 (ω6) to omega-3 (ω3) polyunsaturated fatty acids (PUFA). The prototypical aryl hydrocarbon receptor (AHR) ligand, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), induces CYP1 family enzymes, which can metabolize PUFA to epoxides. Mice fed ω3-rich or ω6-rich diets were treated with TCDD and injected subcutaneously with AHR-competent Hepa1-GFP hepatoma cells or AHR-deficient LLC lung cancer cells. TCDD reduced the growth rates of the resulting tumors in ω3-fed mice and inhibited their metastasis to the liver and/or lung, but had the opposite effects in mice fed ω6 PUFA. These responses were likely attributable to the corresponding PUFA epoxides generated in tumor cells and/or host, since many depended upon co-administration of a soluble epoxide hydrolase (EPHX2) inhibitor in males, and/or were associated with increases in epoxide levels in tumors and sites of metastasis. Equivalent effects occurred in females in the absence of EPHX2 inhibition, probably because this sex expressed reduced levels of EPHX2. The responses elicited by TCDD were associated with effects on tumor vascularity, tumor cell proliferation and/or apoptosis. Thus environmental AHR agonists, and potentially also endogenous, nutritional, and microbiome-derived agonists, may reduce or enhance cancer progression depending on the composition of dietary PUFA, particularly in females

Causas de referencias para resolución obstétrica en mujeres embarazadas atendidas en el centro especializado de atención primaria a la salud de San Miguel Chapultepec Bicentenario durante 2012

El acceso a una atención de calidad durante el embarazo y el resultado maternoperinatal no sólo son indicadores de desarrollo en los países, sino que deben abordarse como parte de un proceso de atención prenatal-resolución del embarazo, ya que por la complejidad del embarazo como fenómeno biosociocultural, las mujeres embarazadas corren el riesgo de sufrir complicaciones que pongan en peligro sus vidas