Intravenous infusion of magnesium sulfate and its effect on horses with trigeminal-mediated headshaking.

BackgroundTrigeminal-mediated headshaking results from low-threshold firing of the trigeminal nerve resulting in apparent facial pain. Magnesium may have neuroprotective effects on nerve firing that potentially dampen signs of neuropathic pain. This hypothesis has not been investigated in horses with trigeminal-mediated headshaking.ObjectiveTo investigate head-shaking behavior in affected horses after IV magnesium sulfate infusion.AnimalsSix geldings with trigeminal-mediated headshaking.MethodsProspective randomized crossover study. Horses were controlled for diet and infused IV with 5% dextrose solution (DS; control solution at 2 mL/kg body weight [BW]) and MgSO4 50% solution (MSS at 40 mg/kg BW). Head-shaking behavior was recorded at times T0 (baseline, before infusion) and T15, T30, T60, and T120 minutes post-infusion. Venous blood variables such as pH, HCO3 - , standard base excess (SBE), Na+ , Cl- , K+ , Ca2+ , Mg2+ , total magnesium (tMg), glucose, and lactate were measured; strong ion difference (SID) and anion gap (AG) were calculated for each time point.ResultsBlood variables including pH, Na+ , Cl- , K+ , SID, AG, lactate, Ca2+ , tMg, and Mg2+ had significant changes with MSS as compared to DS treatment. Glucose, SBE, and HCO3 - did not have significant changes. A 29% reduction in head-shaking rate occurred after MSS treatment but no change occurred after DS treatment.Conclusions and clinical importanceAdministration of MSS IV increased plasma total and ionized magnesium concentrations and significantly decreased head-shaking behavior in horses with trigeminal-mediated headshaking

Una propuesta para la enseñanza y el aprendizaje de los sistemas de numeración

En este artículo se exponen algunas reflexiones sobre la enseñanza y el aprendizaje de las matemáticas escolares de grado sexto. Dichas reflexiones se refieren específicamente a la experiencia vivida al planear, diseñar y desarrollar una unidad temática sobre los sistemas de numeración, para estudiantes de grado sexto del colegio

Luteinizing hormone concentrations in healthy horses and horses with trigeminal-mediated headshaking over an 8-hour period.

BackgroundTrigeminal-mediated headshaking results from a low threshold for firing of the trigeminal nerve. A seasonal component has been implicated in onset of clinical signs, which occur during the spring and summer months. Geldings are overrepresented in the affected population and hormonal differences as compared to a healthy control population of geldings might contribute to headshaking.Objective/hypothesisTo assess concentrations of luteinizing hormone (LH) over an 8-hour period in gelded healthy controls and horses affected with headshaking. Our hypothesis was that geldings with seasonal headshaking would have higher concentrations of LH over an 8-hour period compared to control horses during the summer when affected horses manifested headshaking.AnimalsTwelve geldings (6 controls and 6 affected).MethodsProspective controlled trial. Blood samples were drawn every 15 minutes over an 8-hour time period during summer from all horses to measure circulating LH concentrations by using a radioimmunoassay for equine LH. All affected horses were actively affected by headshaking at the time of sample collection.ResultsNo statistically significant differences in LH concentrations were found throughout the study period in headshakers as compared to control horses. Time had no significant effect, but a slight decrease in LH concentrations was observed for all horses. The main limitation of the study was the low number of horses.Conclusions and clinical importanceHorses affected with headshaking did not have significant differences in circulating LH during the late summer as compared to control horses

Anti-aging activity of Lobophora variegata ethanolic and methanolic extracts and their fractions

Conference Report XVI International Symposium on Marine Natural Products | XI European Conference on Marine Natural Products, 1-5 September 2019, Peniche, Portugal.Seaweed have promising applications within food, cosmetic and health industries, which led to an increased interest in studying these organisms [1]. In several coastal areas, thousands of tons of macroalgae are cast on beaches and shorelines and it would be very interesting if this biomass could be managed, allowing the extraction of added-value compounds. In this context, polar extracts (methanol and ethanol) of a macroalgal beach cast sample mainly composed of “Lobophora variegate” were prepared and the anti-aging and antioxidant activities were evaluated. The preliminary results showed interesting results, and thus these crude extracts were then fractionated sequentially by their solubility in dichloromethane, acetone and ethyl acetate, resulting in 4 semi-pure fractions each, which were also tested. Fractions A1.1.1 and A1.2.3 were very good tyrosinase inhibitors (IC₅₀ = 37.87 and 24.01 μg/mL, respectively) and fractions A1.1.2 and A1.2.2 presented very good inhibition of elastase (IC₅₀ = 44.76 and 20.86 μg/mL, respectively). However, none of the fractions was active against collagenase. These results show that further purifications of these fractions can lead to the isolation of bioactive added-value compounds.info:eu-repo/semantics/publishedVersio

Proposta de Aplicação de um Sistema de Gestão da Responsabilidade Social segundo a Norma NP 4469-1:2008: O Caso da ESTG

O Ensino Superior é imprescindível na formação dos recursos humanos mais qualificados e responsáveis pelo bem comum no universo globalizado. Também, é, absolutamente, vital para o desenvolvimento do país e para a promoção da Responsabilidade Social. Assim, compreender e aceitar a importância da Responsabilidade Social, não é apenas uma questão em voga, necessidade, estratégia ou dever ético, mas é uma questão de sobrevivência. Assumir o compromisso com a Responsabilidade Social é, sem dúvida, o maior desafio que se coloca actualmente ao desenvolvimento global das organizações. De nada serve tentar promover a Responsabilidade Social nas organizações, se ela não é compreendida pelos recursos humanos mais qualificados daquelas. Falar sobre Responsabilidade Social num país só faz sentido se os seus alicerces básicos, como a educação, estiverem em conformidade com essa realidade. A preocupação já existente na ESTG para com a temática da Responsabilidade Social, fruto da consciencialização de que o Ensino Superior tem de estar preparado para as exigências de uma sociedade competitiva, globalizada que apela à Qualidade, Ética e Responsabilidade Social, revela-se ainda, na nossa opinião, muito tímida. Importa, pois, comunicar a boa ideia e a boa prática, contribuindo para que a Responsabilidade Social não se traduza por acções “avulso”, mas que seja assumida como um efectivo compromisso da organização com o comprometimento da gestão de topo e dos restantes colaboradores. Neste sentido, estamos conscientes da necessidade de incorporar a Responsabilidade Social no Ensino Superior. Assim, este Projecto Aplicado apresenta uma proposta de aplicação do sistema de gestão da Responsabilidade Social segundo a Norma NP 4469-1: 2008 na Escola Superior de Tecnologia e Gestão (ESTG) do Instituto Politécnico da Guarda (IPG)

Co-gasification of glycerol/fat mixtures in a downflow fixed bed reactor: Preliminary results

The aim of this work was to assess the technical viability of glycerol/fat co-gasification. The gasification performance was studied in a downflow fixed bed reactor using steam as oxidizing agent. Tests were performed with a mixture of 10% of fat and 52% of water, and the effect of temperature was evaluated in the 800 oC to 950 oC range. Samples of dry gas from the gasifier were collected and analysed by gas chromatography in order to determine the CO, CO2, CH4 and H2 content. The results revealed that the co-gasification of glycerol/fat mixtures seems to be a feasible technical option. Best results of the gasification parameters were obtained at the highest tested temperature, 950 ◦C.This work was supported by Portugal 2020 [POCI-01-0145-FEDER-024067] and Fundação para a Ciência e Tecnologia [SFRH/BD/137913/2018].info:eu-repo/semantics/publishedVersio

The impact of a curriculum for resilience promotion in deaf children and adolescents

Resilience is an interactive process involving internal skills that should be promoted, especially in the early stages of development. This study aims to adapt and implement two themes from the European Curriculum for Resilience Promotion – RESCUR, namely, ‘Developing Communication Skills’ and ‘Establishing and Maintaining Healthy Relationships’, for deaf and hard-of-hearing (DHH) students. The study included 37 children and adolescents from three Portuguese regions and its impact was evaluated through the perspectives of the students, their guardians and their teachers. Each 90-minute session was implemented weekly. The sessions followed the RESCUR curriculum structure with necessary adaptations to the mindfulness activities, stories, role-play and worksheets. The mean scores increased from pre- to post-intervention assessment on all instruments, namely, KIDSCREEN-10 (children/adolescents), KIDSCREEN-10 (guardians) and CYRM-28 (teachers). The implementation of adapted curricula promoting resilience seems to be beneficial to DHH children, allowing the development of specific resilience-associated skills, and thus enhancing health, well-being and quality of life.info:eu-repo/semantics/publishedVersio

Synthesis and characterization of Locust Bean Gum derivatives and their application in the production of nanoparticles

The development of LBG-based nanoparticles intending an application in oral immunization is presented. Nanoparticle production occurred by mild polyelectrolyte complexation, requiring the chemical modification of LBG. Three LBG derivatives were synthesized, namely a positively charged ammonium derivative (LBGA) and negatively charged sulfate (LBGS) and carboxylate (LBGC) derivatives. These were characterized by Fourier-transform infrared spectroscopy, elemental analysis, nuclear magnetic resonance spectroscopy, gel permeation chromatography, and x-ray diffraction. As a pharmaceutical application was aimed, a toxicological analysis of the derivatives was performed by both MTT test and LDH release assay. Several nanoparticle formulations were produced using LBGA or chitosan (CS) as positively charged polymers, and LBGC or LBGS as negatively charged counterparts, producing nanoparticles with adequate properties regarding an application in oral immunization.info:eu-repo/semantics/publishedVersio