InCl 3 -Catalyzed [2+3] Cycloaddition Reaction: A Rapid Synthesis of 5-Substituted 1H-tetrazole under Microwave Irradiation

Abstract: A series of 5-substituted 1H-tetrazole were efficiently prepared by InCl 3 catalyzed (10 mol %) from structurally divert organic nitriles with sodium azide under the influence of microwave irradiation. The present protocol was successfully applied to the aliphatic, aryl, benzylic and heterocyclic nitriles and corresponding 5-substituted 1H-tetrazole were obtained in good to excellent yield (70-96%). This method gives remarkable advantages such as short reaction time, simple work-up procedure and economical beneficial

Novel extractant impregnated resin for preconcentration and determination of uranium from environmental samples

A novel method based on impregnation of Amberlite XAD-4 with extractant isonitroso-4-methyl-2-pentanone (IMP) has been developed for U6 + extraction and determination in various samples. The prepared extractant im- pregnated resin (EIR) sorbent was characterized by the field emission scanning electron microscope. The sorbent was packed in a glass column and investigated for various parameters such as pH, eluent, sample and eluent flow rates to optimize sorption desorption conditions for U6+. U6+ is quantitatively determined at pH 4 with flow rate 2 mL/min which showed recovery of 98.9%. The sorption behaviour of U6 + by EIR was also studied using different equilibrium isotherms and kinetic models and the experimental data confirmed that it follows Freundlich iso- therm and Weber-Morris pore diffusion kinetic model. The investigation of foreign ions influence on U6+ sorp- tion showed least interference and thus, facilitated its extraction and determination in Uranmicrolite (leachate) ore tailing, synthetic mixtures and spiked water samples. The detection limit was 0.41 μg/L while the limit of quantification as 1.35 μg/L made the method quite accurate

InCl3-Catalyzed [2+3] Cycloaddition Reaction: A Rapid Synthesis of 5-Substituted 1H-tetrazole under Microwave Irradiation

A series of 5-substituted 1H-tetrazole were efficiently prepared by InCl3 catalyzed (10 mol %) from structurally divert organic nitriles with sodium azide under the influence of microwave irradiation. The present protocol was successfully applied to the aliphatic, aryl, benzylic and heterocyclic nitriles and corresponding 5-substituted 1H-tetrazole were obtained in good to excellent yield (70-96%). This method gives remarkable advantages such as short reaction time, simple work-up procedure and economical beneficial

An Improved and Scalable Synthesis of Insensitive High Explosive 4,10-Dinitro-2,6,8,12-tetraoxa-4,10-diazaisowurtzitane (TEX)

4,10-Dinitro-2,6,8,12-tetraoxa-4,10-diazaisowurtzitane (TEX), a well-known nitramine category explosive, is much less sensitive to impact and friction stimuli as compared to the familiar explosives, RDX and HMX. TEX is currently produced on pilot plant scale and is being pursued as an insensitive explosive. Herein a newer, improved, efficient, and high yielding protocol is developed for the synthesis of TEX by using solid acidic silica sulfuric acid as an efficient and recyclable catalyst. Sequentially for process parameters optimization, a study was carried out with variation of catalyst loading, nitric acid, and mole ratio of reactants. The process scale-up is also achieved successfully