Hip resurfacing: why does it fail? Early results and critical analysis of our first 60 cases

Resurfacing replacement represents the most conservative solution available for total arthroplasty of the hip. However, despite the excellent results reported by highly experienced surgeons, a small but not insignificant body of literature has been published on the more controversial aspects of this approach, mainly those related to the biological and mechanical vulnerability of the retained epiphysis. We report here our evaluation of most of the variables inherent to this procedure (surgical exposure, implant design, technical steps). Based on our results, we conclude that the short-term outcome is strongly related to the surgical approach and the relationship between implant design and cementing technique. Even if posterior approaches are currently widely accepted for resurfacing replacement, the ability to preserve the medial circumflex artery has been questioned, and an alternative exposure has been proposed with good results (antero-lateral, lateral and digastric trochanteric osteotomy). Moreover, a minimally invasive posterior approach could increase the risks of vascular damage. Alternatively, inner implant geometry could affect the distribution of cement over the epiphysis when other variables (direct or indirect cementing technique, viscosity) are not properly selected

Procedimentos de um banco de ossos e a aplicabilidade dos enxertos por ele proporcionados Procedures of a bank of bones and aplicability of the grafts offered by such

Os autores demonstram neste estudo a viabilidade e funcionabilidade de um Banco de Ossos e a experiência da utilização durante os dezessete anos de sua criação. O objetivo deste estudo é demonstrar a importância da manutenção de um serviço de Banco de Osso, bem como mostrar suas utilidades nos diversos tipos de intervenções ortopédicas. Ficando demonstrado, o protocolo para obtenção de possíveis doadores, métodos para retirada e armazenagem desses ossos, e a sua utilização em diversos procedimentos ortopédicos.<br>The authors demonstrate in this study the viability and functionality of a Bank of Bones and the experience of the use during the seventeen years of your creation. The objective of this study is to demonstrate the importance of the maintenance of a service of Bank of Bone, as well as to show your usefulness in the several types of orthopedical interventions. Being demonstrated, the protocol for the possible donors' obtaining, methods for retreat and storage of those bones, and your use in several orthopedical procedures

A highly multiplexed droplet digital PCR assay to measure the intact HIV-1 proviral reservoir.

Quantifying the replication-competent HIV reservoir is essential for evaluating curative strategies. Viral outgrowth assays (VOAs) underestimate the reservoir because they fail to induce all replication-competent proviruses. Single- or double-region HIV DNA assays overestimate it because they fail to exclude many defective proviruses. We designed two triplex droplet digital PCR assays, each with 2 unique targets and 1 in common, and normalize the results to PCR-based T&nbsp;cell counts. Both HIV assays are specific, sensitive, and reproducible. Together, they estimate the number of proviruses containing all five primer-probe regions. Our 5-target results are on average 12.1-fold higher than and correlate with paired quantitative VOA (Spearman's ρ&nbsp;= 0.48) but estimate a markedly smaller reservoir than previous DNA assays. In patients on antiretroviral therapy, decay rates in blood CD4+ T&nbsp;cells are faster for intact than for defective proviruses, and intact provirus frequencies are similar in mucosal and circulating T&nbsp;cells