Ventilatory function in young adults and dietary antioxidant intake

Artículo de publicación ISIDietary antioxidants may protect against poor ventilatory function. We assessed the relation between ventilatory function and antioxidant components of diet in young Chileans. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and the ratio FEV1/FVC were measured in 1232 adults aged 22-28 years, using a Vitalograph device. Dietary intake was ascertained with a food frequency questionnaire (FFQ) designed for this study, from which nutrient and flavonoid intakes were estimated. Dietary patterns were derived with Principal Component Analysis (PCA). After controlling for potential confounders, dietary intake of total catechins was positively associated with FVC (Regression coefficient (RC) of highest vs. lowest quintile of intake 0.07; 95% CI 0.01 to 0.15; p per trend 0.006). Total fruit intake was related to FVC (RC of highest vs. lowest quintile 0.08; 95% CI 0.003 to 0.15; p per trend 0.02). Intake of omega 3 fatty acids was associated with a higher FEV1 (RC for highest vs. lowest quintile 0.08; 95% CI 0.01 to 0.15 L; p per trend 0.02) and with FVC 0.08 (RC in highest vs. lowest quintile of intake 0.08, 95% CI 0.001 to 0.16; p per trend 0.04). Our results show that fresh fruits, flavonoids, and omega 3 fatty acids may contribute to maintain ventilatory function.Wellcome Trust 059448Z

Time-Series BVI Photometry for the Globular Cluster NGC 6981 (M72)

We present new BVI photometry of the globular cluster NGC 6981 (M72), based mostly on ground-based CCD archive images. We present a new color-magnitude diagram (CMD) that reaches almost four magnitudes below the turn-off level. We performed new derivations of metallicity and morphological parameters of the evolved sequences, in good agreement with previous authors, obtaining a value of [Fe/H] ~ -1.50 in the new UVES scale. We also identify the cluster's blue straggler population. Comparing the radial distribution of these stars with the red giant branch population, we find that the blue stragglers are more centrally concentrated, as found in previous studies of blue stragglers in globular clusters. Taking advantage of the large field of view covered by our study, we analyzed the surface density profile of the cluster, finding extratidal main sequence stars out to r ~ 14.1 arcmin or about twice the tidal radius. We speculate that this may be due to tidal disruption in the course of M72's orbit, in which case tidal tails associated with the cluster may exist. We also take a fresh look at the variable stars in the cluster, recovering all previous known variables, including three SX Phoenicis stars, and adding three previously unknown RR Lyrae (1 c-type and 2 ab-type) to the total census. Finally, comparing our CMD with unpublished data for M3 (NGC 5272), a cluster with similar metallicity and horizontal branch morphology, we found that both objects are essentially coeval.Comment: Accepted for publication in A

Changes in symptoms of asthma and rhinitis by sensitization status over ten years in a cohort of young Chilean adults

BACKGROUND: We investigated the net changes in prevalence of symptoms of asthma and rhinitis over 10 years in a cohort of young by baseline sensitization status. METHODS: One thousand one hundred ninety three Chilean adults subjects aged 22-28 living in a semi-rural area of central Chile answered a lifestyle and the European Community Respiratory Health Survey (ECRHS) questionnaires. Bronchial hyper-responsiveness (BHR) and skin prick test (SPT) to eight allergens were measured at baseline in 2001. Ten years later, 772 participants completed the questionnaires again. Estimates of adjusted net changes in prevalence of symptoms by sensitization status at baseline and association between sensitization status at baseline and respiratory symptoms ten years later were assessed. RESULTS: A quarter of the participants were sensitized to at least one allergen in 2001. Prevalence of wheeze had a net change per year of -0.37 % (95 % Confidence Interval -0.71 to 0.02 %; p = 0.067). Self-reported nasal allergies in the last 12 months increased by 0.83 % per year (95 % CI 0.49 to 1.17 %; p < 0.001). Those sensitized to either cat fur (OR 1.76; CI 1.01 to 3.05), cockroach, (OR 2.09; 1.13 to 3.86) blend of grass and pollens (1.78; 95 % CI 1.08 to 2.92), or weeds (OR 1.77; 95 % CI 1.01 to 3.12) in 2001 were more likely to have wheeze in the last 12 months 10 years later. CONCLUSION: Symptoms of asthma remained stable or slightly changed over 10 years in adults, whilst rhinitis and nasal allergies greatly increased. Being sensitized to at least one allergen is a risk factor for persistent symptoms of asthma and rhinitis, but not for determining net changes of symptoms over time. The underlying causes for the contrasting trends between asthma and nasal allergy are unknow

Absence of disparities in anthropometric measures among Chilean indigenous and non-indigenous newborns

<p>Abstract</p> <p>Background</p> <p>Studies throughout North America and Europe have documented adverse perinatal outcomes for racial/ethnic minorities. Nonetheless, the contrast in newborn characteristics between indigenous and non-indigenous populations in Latin America has been poorly characterized. This is due to many challenges, including a lack of vital registration information on ethnicity. The objective of this study was to analyze trends in anthropometric measures at birth in Chilean indigenous (Mapuche) and non-indigenous children over a 5-year period.</p> <p>Methods</p> <p>We examined weight and length at birth using information available through a national data base of all birth records for the years 2000 through 2004 (n = 1,166.513). Newborns were classified ethnically according to the origins of the parents' last names.</p> <p>Result</p> <p>The average birthweight was stable over the 5 year period with variations of less than 20 g in each group, and with mean values trivially higher in indigenous newborns. The proportion weighing less than 2500 g at birth increased modestly from 5.2% to 5.6% in non-indigenous newborns whereas the indigenous births remained constant at 5.2%. In multiple regression analyses, adjusting flexibly for gestational age and maternal characteristics, the occurrence of an indigenous surname added only 14 g to an average infant's birthweight while holding other factors constant. Results for length at birth were similar, and adjusted time trend variation in both outcomes was trivially small after adjustment. Anthropometric indexes at birth in Chile are quite favorable by international standards.</p> <p>Conclusion</p> <p>There is only a trivial degree of ethnic disparity in these values, in contrast to conditions for ethnic minorities in other countries. Moreover, these values remained roughly constant over the 5 years of observation in this study.</p

Formulation and constraints on decaying dark matter with finite mass daughter particles

Decaying dark matter cosmological models have been proposed to remedy the overproduction problem at small scales in the standard cold dark matter paradigm. We consider a decaying dark matter model in which one CDM mother particle decays into two daughter particles, with arbitrary masses. A complete set of Boltzmann equations of dark matter particles is derived which is necessary to calculate the evolutions of their energy densities and their density perturbations. By comparing the expansion history of the universe in this model and the free-streaming scale of daughter particles with astronomical observational data, we give constraints on the lifetime of the mother particle, $\Gamma^{-1}$, and the mass ratio between the daughter and the mother particles $m_{\rm D}/m_{\rm M}$. From the distance to the last scattering surface of the cosmic microwave background, we obtain $\Gamma^{-1}>$ 30 Gyr in the massless limit of daughter particles and, on the other hand, we obtain $m_{\rm D} >$ 0.97$m_{\rm M}$ in the limit $\Gamma^{-1}\to 0$. The free-streaming constraint tightens the bound on the mass ratio as $(\Gamma^{-1}/10^{-2}{\rm Gyr}) \lesssim ((1-m_{\rm D1}/m_{\rm M})/10^{-2})^{-3/2}$ for $\Gamma^{-1} < H^{-1}(z=3)$.Comment: 20 pages, 7 figure

Systems approaches to modelling pathways and networks.

Peer reviewedPreprin

Goldstini Can Give the Higgs a Boost

Supersymmetric collider phenomenology depends crucially on whether the lightest observable-sector supersymmetric particle (LOSP) decays, and if so, what the LOSP decay products are. For instance, in SUSY models where the gravitino is lighter than the LOSP, the LOSP decays to its superpartner and a longitudinal gravitino via supercurrent couplings. In this paper, we show that LOSP decays can be substantially modified when there are multiple sectors that break supersymmetry, where in addition to the gravitino there are light uneaten goldstini. As a particularly striking example, a bino-like LOSP can have a near 100% branching fraction to a higgs boson and an uneaten goldstino, even if the LOSP has negligible higgsino fraction. This occurs because the uneaten goldstino is unconstrained by the supercurrent, allowing additional operators to mediate LOSP decay. These operators can be enhanced in the presence of an R symmetry, leading to copious boosted higgs production in SUSY cascade decays.Comment: 30 pages, 12 figures; v2: title change, clarifications added, version to appear in JHE

Two Loop R-Symmetry Breaking

We analyze two loop quantum corrections for pseudomoduli in O'Raifeartaigh like models. We argue that R-symmetry can be spontaneously broken at two loop in non supersymmetric vacua. We provide a basic example with this property. We discuss on phenomenological applications.Comment: 13 pages, 5 figures, JHEP3.cls, reference adde