Development of Malay Culture Student Work Sheet to Improve Student Mathematics Critical Thinking Ability Elementary School

This study aims to describe the process of developing mathematical LKPD and determine the quality of the LKPD developed on geometrical material with Malay cultural nuances to improve students' critical thinking skills in learning mathematics. This study uses the Research and Development (R&D) method which is used to produce a product, namely developing LKPD. The development model applied in this study is the ADDIE model which consists of 5 stages, namely analysis (Analyze), design (Design), development (Development), implementation (Implementation), and evaluation (Evaluation). The subjects in this development research were two lecturers as validators consisting of material expert validators and media expert validators, teachers, and 29 students of class V-A as the target of using the product for a limited trial. The type of data used in this research is in the form of quantitative data and qualitative data. The instrument used in this study utilizes a questionnaire and a critical thinking ability test. Based on the results of the trials carried out, it was found that (1) The results of the average acquisition of the two validators namely material experts and media experts for the level of validity were 4.41 on the "Very Good" criteria. (2) The result of obtaining the average teacher response and student response to the LKPD for the practicality level is 4.65 on the "Very Good" criteria. (3) The level of effectiveness of the LKPD is obtained from the average score of the critical thinking ability test, which is 75.86 in the "Good" category and the proportion of students' completeness is 72.41 in the "Good" category. LKPD is good and LKPD is declared effective. The feasibility of LKPD can be seen in the average acquisition of the questionnaire instrument from validators, teachers, and students which is 4.53 with the "Very Eligible" category. It can be interpreted that the LKPD developed can improve students' critical thinking skills in mathematics, especially on geometry material and LKPD is suitable for use by teachers and students because LKPD is valid, practical, and effective

FAKTOR RISIKO KEJADIAN KANKER SERVIKS DI RSUP DR. M. DJAMIL PADANG TAHUN 2016

Tujuan Kanker serviks merupakan penyakit yang disebabkan oleh Human Papilloma Virus (HPV) dan menempati urutan kedua angka kematian terbanyak akibat kanker pada wanita di dunia. Tujuan penelitian ini adalah untuk mengetahui faktor risiko yang paling dominan mempengaruhi kejadian kanker serviks di RSUP DR. M. Djamil Padang tahun 2016. Metode Jenis penelitian yang digunakan adalah analitik observasional dengan desain penelitian case control study, dan dilakukan di RSUP DR. M. Djamil Padang tahun 2016. Sampel terdiri dari 58 responden dengan perbandingan kasus dan kontrol 1:1. Pengambilan sampel menggunakan teknik Consecutive Sampling. Pengolahan data menggunakan analisis multivariat dengan uji statistik regresi logistik. Hasil Hasil analisis faktor risiko kanker serviks yang berhubungan adalah usia pertama berhubungan seksual (ρ=0,002; OR=6), usia saat hamil pertama (ρ=0,018; OR=3,63), paritas (ρ=0,001; OR=6,27), jumlah pasangan seksual (ρ=0,001; OR=7), penggunaan kontrasepsi hormonal (ρ=0,009; OR=4,22), dan pendidikan (ρ=0,004; OR=5). Faktor risiko yang paling dominan adalah jumlah pasangan seksual (OR=4,47). Kesimpulan Jumlah pasangan seksual merupakan faktor risiko yang paling dominan di RSUP DR. M. Djamil Padang tahun 2016. RSUP DR. M Djamil Padang sebaiknya lebih mengoptimalkan kerjasama lintas sektor dengan Dinas Kesehatan Kota Padang agar lebih meningkatkan frekuensi promosi kesehatan mengenai faktor risiko kanker serviks khususnya mengoptimalkan penyuluhan mengenai tidak berganti pasangan atau memiliki banyak pasangan seksual. Daftar Pustaka : 44 (2002-2015) Kata Kunci : Faktor risiko, kanker serviks

HAIR GROWTH ACTIVITY AND SAFETY TEST OF ETHOSOMAL GEL ETHYL ACETATE FRACTION OF NOTHOPANAX LEAVES (NOTHOPANAX SCUTELLARIUM MERR.)

Objective: The aims of this study were to know the hair growth activity from the ethosomal gel of ethyl acetate fraction compared to the nonethosomal gel of ethyl acetate fraction, as well as its ability to penetrate into the skin and its safety from ethosomal gel testing.Methods: The hair growth activity was measured by three parameters: Hair length, hair thickness, and hair weight.Results: The results obtained are shown that the ethosomal gel with concentration 1% has better hair growth activity rather than the ethosomal gel with concentration 0.5% and the nonethosomal gel but it has similarity to the positive control (minoxidil gel with concentration 2%). In vitro penetration test using Franz diffusion cells shown that the ethosomal gel with concentration 1% has cumulative penetration of quercetin higher than nonethosomal gel, which value was 3.3175±0.02 μgcm−2 for the ethosomal gel with concentration 1%; and 2.7663±0.19 μgcm-2 for the nonethosomal gel with flux values for the ethosomal gel with concentration 1% and the nonethosomal gel, respectively, are 0.4147±0.01 μgcm−2h−1 and 0.3458±0.02 μgcm−2h−1.Conclusion: As for the safety test using hen's egg test-chorioallantoic membrane (HET- CAM) safety test) have shown that both concentrations 0.5% and 1% of the ethosomal gel can generate mild irritation for topical application

The Relationship Between Academic Stress and Class XII Students' Biology Learning Outcomes

Learning outcomes are the important matter in the learning process so that learning outcomes are often used as a determinant of success in achieving learning purposes. The learning outcomes achieved by each student will be different. This is due to several factors, one of which is related to student psychological conditions in the form of stress in an academic context. This study aims to determine the relationship between academic stress and biology learning outcomes of class XII students. The research was conducted at SMA Negeri 4 Bekasi City in the 2022/2023 academic year. The method used is a quantitative descriptive method with correlational studies. The sample used was 104 students of class XII who were selected through simple random sampling technique. The instruments used were questionnaires and multiple choice test questions. The prerequisite test results show that the data are normally distributed and homogeneous. The result of calculating the correlation coefficient is -0.473 and is included in the medium criteria. Thus, it can be concluded that there is a significant negative relationship between academic stress and the biology learning outcomes of class XII students. The higher the academic stress, the lower the biology learning outcomes of class XII students. The coefficient of determination is 0.224, which means that academic stress contributes 22.4% to the biology learning outcomes of class XII students

Intervention trial with calcium montmorillonite clay in a south Texas population exposed to aflatoxin

South Texas currently has the highest incidence of hepatocellular carcinoma (HCC) in the United States, a disease that disproportionately affects Latino populations in the region. Aflatoxin B(1) (AFB(1)) is a potent liver carcinogen that has been shown to be present in a variety of foods in the U.S., including corn and corn products. Importantly, it is a dietary risk factor contributing to a higher incidence of HCC in populations frequently consuming AFB(1)-contaminated diets. In a randomized double-blind placebo controlled trial, we evaluated the effects of a three-month administration of ACCS100 (refined calcium montmorillonite clay) on serum AFB(1)-lysine adduct level and serum biochemistry in 234 healthy men and women residing in Bexar and Medina Counties, Texas. Participants recruited from 2012–2014 received either a Placebo, 1.5 g, or 3 g ACCS100 each day for three months, and no treatment during the 4(th) month. Adverse event rates were similar across treatment groups and no significant differences were observed for serum biochemistry and hematology parameters. Differences in levels of AFB(1)-lysine adduct at 1, 3, and 4 months were compared between Placebo and active treatment groups. Although serum AFB(1)-lysine adduct levels were decreased by month 3 for both treatment groups, the Low dose was the only treatment that was significant (p=0.0005). In conclusion, the observed effect in the Low dose treatment group suggests that the use of ACCS100 may be a viable strategy to reduce dietary AFB(1) bioavailability during aflatoxin outbreaks and potentially in populations chronically exposed to this carcinogen

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat