Pengembangan Bahan Ajar Matakuliah Sistem Chasis, Suspensi Dan Kemudi

Penelitian pengembangan ini menghasilkanbahan ajar matakuliah Sistem Chasis, SuspensidanKemudi yang dapat memenuhi tuntutan pencapaian: (1) kuantitas isi/materi yang optimal, dan ke‑up to date‑an informasi dalam pembelajaran; (2) kualitas prestasi akademik dan hasil sosial. Bahan ajar dirancang terdiri dari: (a) tujuankhususpembelajaran; (b) materipembelajaran yang dipelajariolehmahasiswa; (c) rangkuman; (d) soallatihan. Karakteristik yang menandai bahan ajar ini adalah adanya penataan strategi pembelajaran yang jelas dan runtut, meliputi strategi penataan isi, strategi pengelolaan dan strategi penyampaian

Preliminary results on the nutritional evaluation of omega-3-HUFA-enriched <i>Artemia</i> nauplii for larvae of the sea bass, <i>Dicentrarchus labrax</i>

Freshly hatched San Pablo Bay and Great Salt Lake Artemia nauplii (omega-3-HUFA-poor) and enriched meta-nauplii (omega-3-HUFA-enriched)were compared to reference Artemia nauplii (omega-3-HUFA-rich) as a food source for the larvae of the sea bass, Dicentrarchus labrax. Significant differences in survival and biomass production between the treatments could be attributed to the omega-3-HUFA content of the food. A delayed mortality in fish larvae fed the Great Salt Lake Artemia is suspected to be caused by a high level of alpha-BHC in this Artemia source. Growth was not significantly different between the treatments, most probably due to the large variation in growth rate within the treatments, as well as the low number of surviving fish in some treatments

Developing An Entrepreneurship-loaded Productive Learning Model

This study was aimed at obtaining a pratical and effective Entrepreneurship-Loaded Productive Learning model (ELPL model) for graduates of the building construction department of the vocational schools to become entrepreneurs of their expertises as technopreneurs. The study was research and development, focused on developing ELPL model. It was done through the following phases: review of the existing models, needs assessment for model development; third, evaluation of model implementability, revision of the ELPL draft, and limited try-out of the ELPL model in Grade XII of the Wood Construction of Vocational School 2, Pengasih, Kulon Progo. Findings show that the ELPL model is implementable for learning, practical, and effective to develop the entrepreneurship skills of the XII grade students in the Wood Construction Subjects at SMK 2 Pengasih, related to their expertise as technopreneurs. PPBK model is feasible to use in teaching and learning processPENGEMBANGAN MODEL PEMBELAJARAN PRODUKTIF BERMUATAN KEWIRAUSAHAANPenelitian ini bertujuan untuk mengembangkan model pembelajaran kemampuan produktif bermuatan kewirausahaan (model PPBK) yang efektif dalam membekali lulusan SMK Program Keahlian Teknik Bangunan untuk menjadi wirausahawan sesuai dengan bidang keahliannya sebagai technopreneur. Penelitian ini merupakan jenis penelitian pengembangan (Research & Development). Penelitian berorientasi pada pengembangan produk yaitu model PPBK. Penelitian dilakukan melalui lima tahapan yaitu: kajian model pembelajaran kemampuan produktif yang telah dilaksanakan, asesmen kebutuhan pengembangan model, penilaian keterlaksanaan model, revisi draf model PPBK, dan uji coba model PPBK. Uji coba model dilakukan secara terbatas pada Kelas XII Paket Keahlian Teknik Konstruksi Kayu di SMK Negeri 2 Pengasih, Kulon Progo. Hasil penelitian menunjukkan bahwa model PPBK yang dikembangkan terbukti dapat diimplementasikan dalam pembelajaran. Model PPBK praktis dan efektif untuk memberikan bekal kemampuan berwirausaha bagi siswa SMK Kelas XII Paket Keahlian Teknik Konstruksi Kayu di SMK Negeri 2 Pengasih sesuai dengan bidang keahliannya sebagai technopreneur. Perangkat pembelajaran PPBK yang dikembangkan layak diimplementasika

Weakly-Private Information Retrieval

Private information retrieval (PIR) protocols make it possible to retrieve a file from a database without disclosing any information about the identity of the file being retrieved. These protocols have been rigorously explored from an information-theoretic perspective in recent years. While existing protocols strictly impose that no information is leaked on the file’s identity, this work initiates the study of the tradeoffs that can be achieved by relaxing the requirement of perfect privacy. In case the user is willing to leak some information on the identity of the retrieved file, we study how the PIR rate, as well as the upload cost and access complexity, can be improved. For the particular case of replicated servers, we propose two weakly-private information retrieval schemes based on two recent PIR protocols and a family of schemes based on partitioning. Lastly, we compare the performance of the proposed schemes

Green bottle flies (Calliphoridae, Luciliinae) of Ecuador: geographic distribution, checklist and DNA barcodes

Green bottle flies (Diptera, Calliphoridae, Luciliinae) comprise a diverse and cosmopolitan taxon, known from at least 1,500 species. They have become crucial elements in forensic investigations, as they spend part of their life cycle in decaying remains. Here, we review the distribution of eleven Luciliinae species in Ecuador: the monotypic Blepharicnema and ten Lucilia species. We identified specimens using morphological characters. Additionally, we DNA barcoded 43 specimens from three species using 658bp segments of the standard Cytochrome Oxidase I (COI) mitochondrial gen. Molecular and morphological identifications presented high correspondence, suggesting COI barcodes are an efficient tool for the identification of these three green bottle flies species. Geographical records are biased towards the northern Andean region, particularly near to large urban settlements. We remark the value to applied forensic research of continuous sampling of necrophagous flies under a variety of habitats and crime conditions.Fil: Moreno Coellar, Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Pontificia Universidad Católica del Ecuador; EcuadorFil: Amat, Eduardo. Tecnológico de Antioquia; ColombiaFil: Meneses, Pablo E.. Universidad Regional Amazónica Ikiam; EcuadorFil: Donoso, David A.. Escuela Politécnica Nacional; EcuadorFil: Barragán, Álvaro R.. Pontificia Universidad Católica del Ecuador; Ecuado

New perspectives on the treatment of hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the presence of painful nodules, abscesses, chronically draining fistulas, and scarring in apocrine gland-bearing areas of the body. The exact pathogenesis of HS is not yet well understood, but there is a consensus in considering HS a multifactorial disease with a genetic predisposition, an inflammatory dysregulation, and an influence of environmental modifying factors. Therapeutic approach of HS is challenging due to the wide clinical manifestations of the disease and the complex pathogenesis. This review describes evidence for effectiveness of current and emerging HS therapies. Topical therapy, systemic treatments, biological agents, surgery, and light therapy have been used for HS with variable results. Adalimumab is the only US Food and Drug Administration (FDA) approved biologic agent for moderate-to-severe HS, but new therapeutic options are being studied, targeting different specific cytokines involved in HS pathogenesis. Comparing treatment outcomes between therapies is difficult due to the lack of randomized controlled trials. Treatment strategy should be selected in concordance to disease severity and requires combination of treatments in most cases

Aquatic pollution may favor the success of the invasive species A. franciscana

The genus Artemia consists of several bisexual and parthenogenetic sibling species. One of them, A. franciscana, originally restricted to the New World, becomes invasive when introduced into ecosystems out of its natural range of distribution. Invasiveness is anthropically favored by the use of cryptobiotic eggs in the aquaculture and pet trade. The mechanisms of out-competition of the autochthonous Artemia by the invader are still poorly understood. Ecological fitness may play a pivotal role, but other underlying biotic and abiotic factors may contribute. Since the presence of toxicants in hypersaline aquatic ecosystems has been documented, our aim here is to study the potential role of an organophosphate pesticide, chlorpyrifos, in a congeneric mechanism of competition between the bisexual A. franciscana (AF), and one of the Old World parthenogenetic siblings, A. parthenogenetica (PD). For this purpose we carried out life table experiments with both species, under different concentrations of the toxicant (0.1, 1 and 5. μg/l), and analyzed the cholinesterase inhibition at different developmental stages. The results evidence that both, AF and PD, showed an elevated tolerance to high ranges of chlorpyrifos, but AF survived better and its fecundity was less affected by the exposure to the pesticide than that of PD. The higher fecundity of AF is a selective advantage in colonization processes leading to its establishment as NIS. Besides, under the potential selective pressure of abiotic factors, such as the presence of toxicants, its higher resistance in terms of survival and biological fitness also indicates out-competitive advantages. © 2015This research was supported by the Spanish Ministry for Science and Innovation projects (CGL2005-02306 and CGL2008-04737-E) “Biodiversidad de Artemia (Branchiopoda, Anostraca) en el Mediterráneo Occidental, archipiélagos Balear y Canario. Efectos de A. franciscana como especie invasora. Implicaciones ecológicas y de interés en acuicultura” y “Biodiversidad amenazada en salinas mediterráneas”. S. Redón was supported by a Ph.D grant (FPI) from the Spanish Ministry of Science and Innovation. D. Guinot was supported by BANCAJA contract.Peer Reviewe

A double blind randomised controlled trial comparing standard dose of iron supplementation for pregnant women with two screen-and-treat approaches using hepcidin as a biomarker for ready and safe to receive iron.

BACKGROUND: Until recently, WHO recommended daily iron supplementation for all pregnant women (60 mg/d iron combined with 400ug/d folic acid) where anaemia rates exceeded 40 %. Recent studies indicate that this may pose a risk to pregnant women. Therefore, there is a need to explore screen-and-treat options to minimise iron exposure during pregnancy using an overall lower dosage of iron that would achieve equivalent results as being currently recommended by the WHO. However, there is a lack of agreement on how to best assess iron deficiency when infections are prevalent. Here, we test the use of hepcidin a peptide hormone and key regulator of iron metabolism, as a potential index for 'safe and ready to receive' iron. DESIGN/METHODS: This is a 3-arm randomised-controlled proof-of-concept trial. We will test the hypothesis that a screen-and-treat approach to iron supplementation using a pre-determined hepcidin cut-off value of <2.5 ng/ml will achieve similar efficacy in preventing iron deficiency and anaemia at a lower iron dose and hence will improve safety. A sample of 462 pregnant women in rural Gambia will be randomly assigned to receive: a) UNU/UNICEF/WHO international multiple micronutrient preparation (UNIMMAP) containing 60 mg/d iron (reference arm); b) UNIMMAP containing 60 mg/d iron but based on a weekly hepcidin screening indicating if iron can be given for the next 7 days or not; c) or UNIMMAP containing 30 mg/d iron as in (b) for 12 weeks in rural Gambia. The study will test if the screen-and-treat approach is non-inferior to the reference arm using the primary endpoint of haemoglobin levels at a non-inferiority margin of 0.5 g/dl. Secondary outcomes of adverse effects, compliance and the impact of iron supplementation on susceptibility to infections will also be assessed. DISCUSSION: This trial is expected to contribute towards minimising the exposure of pregnant women to iron that may not be needed and therefore potentially harmful. If the evidence in this study shows that the overall lower dosage of iron is non-inferior to 60 mg/day iron, this may help decrease side-effects, improve compliance and increase safety. The potential for the use of hepcidin for a simple point-of-care (PoC) diagnostic for when it is most safe and effective to give iron may improve maternal health outcomes. TRIAL REGISTRATION: ISRCTN21955180

Aquatic pollution may favor the success of the invasive species A. franciscana

The genus Artemia consists of several bisexual and parthenogenetic sibling species. One of them, A. franciscana, originally restricted to the New World, becomes invasive when introduced into ecosystems out of its natural range of distribution. Invasiveness is anthropically favored by the use of cryptobiotic eggs in the aquaculture and pet trade. The mechanisms of out-competition of the autochthonous Artemia by the invader are still poorly understood. Ecological fitness may play a pivotal role, but other underlying biotic and abiotic factors may contribute. Since the presence of toxicants in hypersaline aquatic ecosystems has been documented, our aim here is to study the potential role of an organophosphate pesticide, chlorpyrifos, in a congeneric mechanism of competition between the bisexual A. franciscana (AF), and one of the Old World parthenogenetic siblings, A. parthenogenetica (PD). For this purpose we carried out life table experiments with both species, under different concentrations of the toxicant (0.1, 1 and 5 μg/l), and analyzed the cholinesterase inhibition at different developmental stages. The results evidence that both, AF and PD, showed an elevated tolerance to high ranges of chlorpyrifos, but AF survived better and its fecundity was less affected by the exposure to the pesticide than that of PD. The higher fecundity of AF is a selective advantage in colonization processes leading to its establishment as NIS. Besides, under the potential selective pressure of abiotic factors, such as the presence of toxicants, its higher resistance in terms of survival and biological fitness also indicates out-competitive advantages.Spanish Ministry for Science and Innovation project, CGL2005-02306, CGL2008-04737-E