Meningkatkan Hasil Belajar Siswa dengan Model Snowball Throwing pada Pokok Bahasan Penyelesaian Pertidaksamaan Kuadrat

[Title: Improving Student Learning Outcomes with the Snowball Throwing Model in the Subject of Solving Inequality Squared] The problem raised in this study is the low student learning outcomes. The research objectives are to improve student learning outcomes. The researcher wants to solve this problem by applying the snowball throwing model on the subject of solving the inequality squared in class X IPA 1 Manda Elu Private High School. This type of research is classroom action research (CAR) with two planned cycles. For each cycle consists of five stages, namely planning, implementing actions, observing, evaluating, and reflecting. The research subjects were teachers (researchers) and students of class X IPA 1 at Manda Elu Private High School. Collecting data in this study using written tests and observation sheets. The research data were analyzed descriptively-quantitative for test result data and descriptive-qualitative data for observation. The results showed that student learning outcomes improved, this can be seen from the percentage of classical completeness that is the first cycle of 54.3% increased in the second cycle 80%. From the results of the first cycle and second cycle increased, which means that more and more students received grades ≥65 (KKM). Based on the results of the study it can be concluded that the application of the snowball throwing model on the subject of solving the inequality squared can improve learning outcomes of class X students of Manda Elu Private High School

Central obesity and diet quality in rural farming women of Ngamiland, Botswana

Rapid economic growth in Botswana like in other countries has led to the emergence of nutrition transition. Overweight/obesity, central adiposity and associated co-morbidities are on the rise, especially amongst women. Urban women have been shown to be more prone to overweight/obesity compared to men. However, the situation in rural women has not been studied. Therefore, this paper assesses the prevalence of central obesity in rural female farmers (N=113) of Ngamiland, Botswana over two years. Estimation of central obesity was made through assessment of waist circumference (WC) and waist hip ratios (WHR). The WHO Indicator cut-off points (WC: low risk= <80 cm; increased= 80-87.9 cm; and substantially increased= >88 cm and WHR: low risk= ≤0.85 and high risk=0.85+) for risk of metabolic complication were used to categorize women according to body fatness levels. A non-quantified dietary diversity questionnaire was also administered to individuals with responsibility over food, to assess the participant’s dietary diversity. Women were assigned dietary diversity scores (DDS) ranging from 0 to 8, depending on the number of food groups represented in their diet in the past 24 hours. The higher the number the more diversified the diet. These measurements were collected in August 2010 and September 2011. Between 2010 and 2011 the mean WC increased from 87±11.8 to 90.2±14.5 while the WHRs in 2010 increased from 0.83±0.1 to 0.86±0.1 respectively. Diets comprised mostly of starchy foods, milk and miscellaneous foods such as fats/oils, sugars, and condiments. Mean DDS for both periods was 3 showing poor quality diet and little change over the two years. Central adiposity was observed amongst the women as shown by a significant increase in WC between 2010 and 2011 (t=2.818, df=112, p=0.006). Contrary to expectations that rural female farmers in Ngamiland Botswana would be healthy compared to their non-farming counterparts, there seems to be an observable similar trend of overweight. Furthermore, quality of traditional diets seems to be deteriorating with less consumption of healthy protective and nutrient dense foods, which are likely to influence a rise in metabolic complications. The authors therefore recommend strategies that will facilitate reduction of waist sizes to 80.0 cm such as farming and consumption of healthier foods such as fruits and vegetables along with the commonly produced ones in the fields. Farming communities should also value and include traditional and wild foods in their diets to increase dietary diversity and reduce the risk of development of chronic diseases.Keywords: Central obesity, Rural Female Farmers, Overweight, Obesity, Ngamiland, Botswan

On modeling two immune effectors two strain antigen interaction

In this paper we consider the fractional order model with two immune effectors interacting with two strain antigen. The systems may explain the recurrence of some diseases e.g. tuberculosis (TB). The stability of equilibrium points are studied. Numerical solutions of this model are given. Using integer order system the system oscillates. Using fractional order system the system converges to a stable internal equilibrium. Ulam-Hyers stability of the system has been studied

Climate Change, Coming Soon to a Court Near You – Report Three: National Climate Change Legal Frameworks in Asia and the Pacific

National legal and policy frameworks underpin international climate action because they are the backbone of domestic responses to the climate emergency. Unless they support global objectives, local climate action stalls. Concerned by sluggish national responses to climate change or injured by its impacts, citizens are filing lawsuits, making courts central to national climate governance. To adjudicate these lawsuits, courts require current information about their climate change legal and policy frameworks. This report provides holistic syntheses of the climate legal and policy frameworks of 32 countries in Asia and the Pacific and discusses key legislative trends and climate-relevant constitutional rights

Physical disturbance enhances ecological networks for heathland biota: A multiple taxa experiment

Creation of ecological networks is advocated to increase the viability of regional populations and their resilience to climatic and land-use change with associated habitat fragmentation and loss. However, management of network elements should be appropriate for the regional biota conserved, requiring evidence from multiple taxa. We examined the response of carabids, spiders, ants and vascular plants, to six physical disturbance treatments ranging in intensity plus controls, replicated across 63 plots in a plantation trackway network of a heathland region in England. Over two years, 73 182 invertebrates from 256 species were identified and 23 241 observations of 222 vascular plant species made. Abundance and richness of stenotopic carabids and plants (respectively associated with heath and dune, or unshaded physically-disturbed low-nutrient soils) increased with disturbance intensification. Ant assemblages were similar among treatments and control plots, only differing from heathland sites through addition of generalist species. Spider assemblages were less resilient; overall abundance and richness reduced with greater disturbance. Generalist spiders recovered in year two, although incompletely in the most intensely disturbed treatment. Contrasting responses among taxonomic groups likely reflect differences in dispersal ability. Treatments that merely disrupted vegetation quickly regained plant cover and height, suggesting frequent reapplication will be required to maintain heath specialist species. Turf stripping, the most severe treatment, was quickly colonised by specialist carabid and plant species. Treatments that are more durable may allow stenotopic spider assemblages to develop in contrast to shorter-lived treatments. Effectiveness of early-successional habitat networks within regions supporting European lowland heathland will be enhanced by physical disturbance and turf stripping. Our results emphasise the importance of examining multiple taxonomic groups when assessing management outcomes

CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes.

CD4+ T cells are at the nexus of the innate and adaptive arms of the immune system. However, little is known about the evolutionary history of CD4+ T cells, and it is unclear whether their differentiation into specialized subsets is conserved in early vertebrates. In this study, we have created transgenic zebrafish with vibrantly labeled CD4+ cells allowing us to scrutinize the development and specialization of teleost CD4+ leukocytes in vivo. We provide further evidence that CD4+ macrophages have an ancient origin and had already emerged in bony fish. We demonstrate the utility of this zebrafish resource for interrogating the complex behavior of immune cells at cellular resolution by the imaging of intimate contacts between teleost CD4+ T cells and mononuclear phagocytes. Most importantly, we reveal the conserved subspecialization of teleost CD4+ T cells in vivo. We demonstrate that the ancient and specialized tissues of the gills contain a resident population of il-4/13b-expressing Th2-like cells, which do not coexpress il-4/13a Additionally, we identify a contrasting population of regulatory T cell-like cells resident in the zebrafish gut mucosa, in marked similarity to that found in the intestine of mammals. Finally, we show that, as in mammals, zebrafish CD4+ T cells will infiltrate melanoma tumors and obtain a phenotype consistent with a type 2 immune microenvironment. We anticipate that this unique resource will prove invaluable for future investigation of T cell function in biomedical research, the development of vaccination and health management in aquaculture, and for further research into the evolution of adaptive immunity.European Research Council (Grant IDs: ERC-2011-StG-282059 (PROMINENT), 677501 (ZF_Blood)), Biotechnology and Biological Sciences Research Council (Grant ID: BB/L007401/1), Dowager Countess Eleanor Peel Trust (Grant ID: TH-PRCL.FID2228), Medical Research Council, Department for International Development (Career Development Award Fellowship MR/J009156/1), Medical Research Foundation (Grant ID: R/140419), Cancer Research UK (Grant ID: C45041/A14953), Wellcome Trust and Medical Research Council to the Wellcome Trust–Medical Research Council Cambridge Stem Cell Institute (core support grant)This is the final version of the article. It first appeared from The American Association of Immunologists via https://doi.org/10.4049/​jimmunol.160095

Development of a coupled dynamics code with transport theory capability and application to accelerator driven systems transients

The VARIANT-K and DIF3D-K nodal spatial kinetics computer codes have been coupled to the SAS4A and SASSYS-1 liquid metal reactor accident and systems analysis codes. SAS4A and SASSYS-1 have been extended with the addition of heavy liquid metal (Pb and Pb-Bi) thermophysical properties, heat transfer correlations, and fluid dynamics correlations. The coupling methodology and heavy liquid metal modeling additions are described. The new computer code suite has been applied to analysis of neutron source and thermal-hydraulics transients in a model of an accelerator-driven minor actinide burner design proposed in an OECD/NEA/NSC benchmark specification. Modeling assumptions and input data generation procedures are described. Results of transient analyses are reported, with emphasis on comparison of P1 and P3 variational nodal transport theory results with nodal diffusion theory results, and on significance of spatial kinetics effects

Reversible hydration of CH(3)NH(3)Pbl(3) in films, single crystals, and solar cells

Solar cells composed of methylammonium lead iodide perovskite (MAPI) are notorious for their sensitivity to moisture. We show that (i) hydrated crystal phases are formed when MAPI is exposed to water vapor at room temperature and (ii) these phase changes are fully reversed when the material is subsequently dried. The reversible formation of CH3NH3PbI3·H2O followed by (CH3NH3)4PbI6·2H2O (upon long exposure times) was observed using time-resolved XRD and ellipsometry of thin films prepared using “solvent engineering”, single crystals, and state-of-the-art solar cells. In contrast to water vapor, the presence of liquid water results in the irreversible decomposition of MAPI to form PbI2. MAPI changes from dark brown to transparent on hydration; the precise optical constants of CH3NH3PbI3·H2O formed on single crystals were determined, with a bandgap at 3.1 eV. Using the single-crystal optical constants and thin-film ellipsometry measurements, the time-dependent changes to MAPI films exposed to moisture were modeled. The results suggest that the monohydrate phase forms independent of the depth in the film, suggesting rapid transport of water molecules along grain boundaries. Vapor-phase hydration of an unencapsulated solar cell (initially Jsc ≈ 19 mA cm–2 and Voc ≈ 1.05 V at 1 sun) resulted in more than a 90% drop in short-circuit photocurrent and ∼200 mV loss in open-circuit potential; however, these losses were fully reversed after the device was exposed to dry nitrogen for 6 h. Hysteresis in the current–voltage characteristics was significantly increased after this dehydration, which may be related to changes in the defect density and morphology of MAPI following recrystallization from the hydrate. Based on our observations, we suggest that irreversible decomposition of MAPI in the presence of water vapor only occurs significantly once a grain has been fully converted to the monohydrate phase

Human rotavirus replicates in salivary glands and primes immune responses in facial and intestinal lymphoid tissues of gnotobiotic pigs

Human rotavirus (HRV) is a leading cause of viral gastroenteritis in children across the globe. The virus has long been established as a pathogen of the gastrointestinal tract, targeting small intestine epithelial cells and leading to diarrhea, nausea, and vomiting. Recently, this classical infection pathway was challenged by the findings that murine strains of rotavirus can infect the salivary glands of pups and dams and transmit via saliva from pups to dams during suckling. Here, we aimed to determine if HRV was also capable of infecting salivary glands and spreading in saliva using a gnotobiotic (Gn) pig model of HRV infection and disease. Gn pigs were orally inoculated with various strains of HRV, and virus shedding was monitored for several days post-inoculation. HRV was shed nasally and in feces in all inoculated pigs. Infectious HRV was detected in the saliva of four piglets. Structural and non-structural HRV proteins, as well as the HRV genome, were detected in the intestinal and facial tissues of inoculated pigs. The pigs developed high IgM antibody responses in serum and small intestinal contents at 10 days post-inoculation. Additionally, inoculated pigs had HRV-specific IgM antibody-secreting cells present in the ileum, tonsils, and facial lymphoid tissues. Taken together, these findings indicate that HRV can replicate in salivary tissues and prime immune responses in both intestinal and facial lymphoid tissues of Gn pigs.Instituto de VirologíaFil: Nyblade, Charlotte. Virginia Polytechnic Institute and State University. Virginia-Maryland College of Veterinary Medicine. Department of Biomedical Sciences and Pathobiology; Estados UnidosFil: Zhou, Peng. Virginia Polytechnic Institute and State University. Virginia-Maryland College of Veterinary Medicine. Department of Biomedical Sciences and Pathobiology; Estados UnidosFil: Frazier, Maggie. Virginia Polytechnic Institute and State University. Virginia-Maryland College of Veterinary Medicine. Department of Biomedical Sciences and Pathobiology; Estados UnidosFil: Frazier, Annie. Virginia Polytechnic Institute and State University. Virginia-Maryland College of Veterinary Medicine. Department of Biomedical Sciences and Pathobiology; Estados UnidosFil: Hensley, Casey. Virginia Polytechnic Institute and State University. Virginia-Maryland College of Veterinary Medicine. Department of Biomedical Sciences and Pathobiology; Estados UnidosFil: Fantasia-Davis, Ariana. Virginia Polytechnic Institute and State University. Virginia-Maryland College of Veterinary Medicine. Department of Biomedical Sciences and Pathobiology; Estados UnidosFil: Shahrudin, Shabihah. Indiana University. Department of Biology; Estados UnidosFil: Hoffer, Miranda. Indiana University. Department of Biology; Estados UnidosFil: Agbemabiese, Chantal Ama. Indiana University. Department of Biology; Estados UnidosFil: LaRue, Lauren. GIVAX Inc.; Estados UnidosFil: Barro, Mario. GIVAX Inc.; Estados UnidosFil: Patton, John T. Indiana University. Department of Biology; Estados UnidosFil: Parreño, Gladys Viviana. Virginia Polytechnic Institute and State University. Virginia-Maryland College of Veterinary Medicine. Department of Biomedical Sciences and Pathobiology; Estados UnidosFil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). INCUINTA. Instituto de Virologia e Innovaciones Tecnologicas (IVIT); ArgentinaFil: Parreño, Gladys Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Yuan, Lijuan. Virginia Polytechnic Institute and State University. Center for Emerging, Zoonotic, and Arthropod‑Borne Pathogens; Estados Unido