Virtual Library of Cultural Heritage of Central Asian Turks in Written Sources of the XIX Century

The purpose of this article is the creation of specialized databases virtual university unique full-text library of scientific and educational resources on the cultural heritage of the Central Asian Turks, which are reflected in the written sources of the XIX century and the development of a virtual environment through the establishment of an effective and efficient search of remote access to the necessary sources

A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis

AbstractAcquisition of the membrane and genome encapsidation is an important step in the replication of enveloped viruses. The biogenesis of the poxviral primary membrane and the core as well as the mechanisms of their maturation are poorly understood. Using RNA interference approach, we demonstrate that a cellular trans-Golgi network membrane protein, golgin-97, is essential for virus replication. Analysis of the virion morphology in the cells depleted of golgin-97 shows that the protein is required for the virus morphogenesis and, in particular, for the formation of the first infectious virus form, mature virus, but not its precursor, immature virus. This suggests that golgin-97 may be involved in the maturation of the virus core and, potentially, the virus membrane

Effectiveness of nurse-led clinics for patients with coronary heart disease A systematic review and meta-analysis

Objective: Coronary heart disease (CHD) is a primary cause of cardiovascular disease and a critical public health concern with increased burden on health care. Nurse-led clinics (NLCs) can potentially contribute in providing effective secondary prevention in patients with CHD. This review aims to determine effectiveness of NLCs in managing patients with CHD compared to usual care. Nurse-led clinics offer a healthcare service that is staffed and coordinated primarily by registered nurses, advanced practice nurses and/or nurse practitioners. They provide specialised healthcare, comprising assessment and evaluation, counselling, education, empowerment, treatment and/or case management for a range of health conditions, including CHD. Introduction: This review presents the best available evidence in relation to NLCs for patients with CHD by updating an existing systematic review (SR) published in 2010. There is a growing evidence base of clinical trials with novel care components in NLCs that have not yet been incorporated into any of the more recent reviews in this area, which are consequently now outdated and/or have addressed different patient populations. Hence, there is a clear need to update the existing SR. Inclusion criteria: Randomised controlled trials examining patients aged 18 years and above with existing or newly diagnosed CHD such as angina pectoris and myocardial infarction were included in the review. The intervention is NLCs for cardiac patients, whereas usual care may be managed by medical practitioners such as General Practitioners (GPs) or specialists and any other non-nursing healthcare professional. Methods: Databases of unpublished and published literature have been searched for the period January 2008 until February 2022. Methodological quality assessment, data extraction and synthesis were undertaken using the SR management tools available through the Joanna Briggs Institute (JBI-SUMARI) and Revman. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to assess the quality of evidence. Results: From 1390 records, 16 studies published between 2008 and 2022 were eligible for inclusion, in addition to the 13 studies from the previous review. Of the additional 16 studies, five evaluated all-cause mortality, two investigated symptoms such as chest pain exacerbations, including those requiring medical treatment. Twelve trials measured changes in risk factors for cardiac patients, eight trials provided self-reported measurements of health behaviour, 6 studies investigated patients’ compliance to the treatment. Ten trials provided self-reported measurements of quality of life for cardiac patients. Nurse-led clinics may slightly reduce all-cause mortality among cardiac patients in comparison to usual care at the 12 months follow-up (odds ratio (OR) of 0.78; 95% confidence interval (CI), 0.54-1.13, P=0.19). Attendance at NLCs may slightly reduce symptoms of chest pain in the long term (OR 0.81; 95% CI, 0.64-1.04; P=0.10). Mean systolic blood pressure (BP) in the medium term (6-11 months) was 10.96 mmHg lower in NLCs (95% CI -15.49, -6.43, P<0.00001). For diastolic BP in the medium term, the mean BP was 8.47 mmHg lower in NLCs (95% CI - 13.83, -3.12, P=0.002). There is little or no difference between NLCs and usual care in the likelihood of improving depression and anxiety. Patient satisfaction and utilisation of health service were not synthesised due to limited data. Conclusion: The evidence of this review suggests that NLCs may play a significant role in providing care to patients with CHD and may have similar or better effects on the prevention and treatment of CHD compared to usual care. The current analysis suggested a favourable effect of NLCs on mortality, chest pain, and some cardiac risk factors. However, transformations in health behaviours, compliance to medications and health-related quality of life were less evident. Nevertheless, NLCs should be considered for delivering care to patients with CHD and establishing specialised healthcare services in the community.Thesis (MClinSc) -- University of Adelaide, Adelaide Nursing School, 202

Research of Social Inequality of the Population in the Regions of Kazakhstan

Under the conditions of the negative impact of global economic geopolitical climatic and epidemiological risks the income gap between different social strata of the population in different regions of the Kazakhstan is growing Therefore the reduction of social inequality of the population is an important problem The purpose of the article is to study theoretical and practical issues of social inequality and develop recommendations for its reduction in Kazakhstan The hypothesis of the study is the assumption about the growing inequality of the population living in different regions of Kazakhstan The article summarizes the theoretical views of scientists on the problems of inequality examines the dynamics of key indicators reflecting the standard of living of the population in the regions of Kazakhstan The conclusion is made about the strengthening of social inequality of the population living in different regions of the country Measures have been developed to reduce i

X-ray Diffraction Investigation of Sio2/Si Track Templates with Deposited Zn

Si/SiO2 /Zn structures are fabricated by the track template synthesis. SEM and AFM images of the surface after electrochemical deposition of zinc were obtained. XRD analysis of the deposited samples showed the creation of zinc oxide nanocrystals with Miller indexes (200) at θ=62,30 and (201) at θ=69,50 (PDF#361451-etalon)

Genetic requirements for the assembly and cell-to-cell movement of the beet yellows virus

Beet yellows virus (BYV) is a filamentous, positive-strand RNA virus that belongs to the family Closteroviridae. BYV particles encapsidate a 15.5 kb RNA and posses complex polar architecture. A long virion body is formed by the major capsid protein(CP), whereas the minor capsid protein (CPm) assembles a short tail that encapsidates the 5'-terminal region of BYV RNA. In addition to proteins required for viral RNA replication and encapsidation, BYV encodes four proteins whose role in the virus life cycle was unknown. These proteins include a small, 6-kDa, hydrophobic protein (p6), a homolog of the cellular 70-kDa heat shock proteins (Hsp7Oh), a 64-kDa protein (p64), and a 20-kDa protein (p20). It was found recently that Hsp7Oh, p64, and p20 are incorporated into BYV virions, and that Hsp7Oh is required for the virus movement from cell to cell. In this study, we characterized genetic requirements for BYV assembly and cell-to-cell movement, and determined relationships between these two processes. It was demonstrated that in addition to Hsp7Oh, p6, p64, CP, and CPm are each essential, but not sufficient for virus movement. These results indicated that five-component movement machinery of BYV is the most complex among plant viruses. Extensive mutational analysis of CP and CPm revealed strong correlation between abilities of BYV to assemble tailed virions and to move from cell to cell, suggesting that formation of functional virions is a prerequisite for virus translocation. We have found that CPm, Hsp7Oh, and p64 are necessary for the efficient virion tail formation. Assembly of the virion tails and bodies was shown to occur independent of each other and likely to involve two separate packaging signals within the genomic RNA. Our work demonstrated that BYV encodes one conventional movement protein, p6, whose only known function is to mediate virus movement. The other four movement associated proteins of BYV, CP, CPm, Hsp7Oh, and p64 are the virion components, each of which is required for assembly of the tailed, movement-competent virions. Based on these and other data, we propose that BYV and other closteroviruses evolved virion tails as a specialized device for the directional cell-to-cell movement of large RNA genomes

Density Fuctional Theory Study of Graphene-Like ZnO Nanoclusters-Adsorbed Si (111) Surface

The adsorption energy was calculated with the growth of ZnO nanoclusters in two and three layers on the Si (111) terminated surface, and the density of electronic states as a func-tion of energy was analyzed

The Value of the Fossil Remains of the Paleozoic Fauna in the Mukry Mountains to Study the Relative Age of Rocks and of Organic Evolution

The article describes the importance of the study of fossil organisms to reconstruct the physico-geographical conditions of the past on the example of paleofauna korbonski sediments of the Eastern part of Mukry (Western spur Zhetysu (Dzhungar) Alatau). The relevance of studying this topic is due to the small study of paleofauna korbonski sediments of the study area, and the insufficient literature data on the problem. The main results on the study of brachiopods brachiopods-paleontological monument mountain Mukri