Tests for exponentiality against NBUE alternatives: a Monte Carlo comparison

Testing of various classes of life distributions has been addressed in the literature for more than 45 years. In this paper, we consider the problem of testing exponentiality (which essentially implies no ageing) against positive ageing which is captured by the fairly large class of new better than used in expectation (NBUE) distributions. These tests of exponentiality against NBUE alternatives are discussed and compared. The empirical size of the tests is obtained by simulations. Power comparisons for different popular alternatives are done using Monte Carlo simulations. These comparisons are made for both small and large sample sizes. The paper concludes with a discussion in which suggestions are made regarding the choices of the test when a particular alternative is suspected

CERTAIN BIOLOGICAL ASPECTS, THRESHOLD OF DEVELOPMENT AND THERMAL UNITS FOR HYMENIA recurvalis (FAB.), (LEPIDOPTERA: PYRALLIDAE)

Biological studies on the Hawaiian beet webworm, Hymenia recurvalis were carried out under laboratory conditions of 18.6 ± 2°C and 70 ± 5% R. H. The incubation period ranged between 5 and 7 days with a mean of 6.0 ± 0.3 days. The mean durations of larval, prepupal and pupal stages were 26.29 ± 0.3, 5.04 ± 0.08 and 16.86 ± 0.18 days, respectively. Mean adult longevities were 28.42 ± 1.80 and 26.08 ± 1.83 days, ranging between 19-41 and 15-37 days for female and male, respectively. The sex ratio was about 1 : 1.3 (♀ : ♂ ). Accumulative thermal units needed for certain biological features of H. recuurvalis were calculated and the estimated thermal thresholds were 10.97, 12.14, 10.49 and 13.55°C for egg, larval, pre – pupal and pupal stages, respectively. The corresponding values for the thermal units needed for development of these stages were 51.49, 168.47, 47.88 and 102.59 day degree at 25°C for the respective stages

Diagnostisch hulpmiddel dementie bij mensen met (Z)EV(M)B voor gedragskundigen en psychodiagnostisch medewerkers

Mensen met (zeer) ernstige verstandelijke (en meervoudige) beperkingen ((Z)EV(M)B) worden steeds ouder. Aangezien leeftijd de belangrijkste risicofactor is voor dementie, komt dementie vaker voor bij deze doelgroep. Daarbij komt ook dat mensen met downsyndroom (trisomie 21) een hoog genetisch bepaald risico hebben op dementie door de ziekte van Alzheimer (Ballard et al., 2016). 20-30% van alle mensen met het downsyndroom heeft een ernstige of zeer ernstige verstandelijke beperking.Het signaleren en diagnosticeren van dementie bij mensen met (Z)EV(M)B is complex. Om dementie te diagnosticeren, moet er sprake zijn van cognitieve achteruitgang ten opzichte van een eerder, hoger niveau van functioneren die impact heeft op het dagelijks functioneren. Bij mensen met (Z)EV(M)B is het ingewikkeld om achteruitgang door dementie te onderscheiden van de al aanwezige (zeer) ernstige beperkingen in het functioneren.Bij mensen zonder verstandelijke beperking worden neuropsychologische testen gebruikt voor het vaststellen van dementiegerelateerde cognitieve achteruitgang. Deze testen zijn echter niet geschikt voor mensen met (Z)EV(M)B door hun beperkte begrip van de testinstructie en beperkingen in verbale vaardigheden. Ook eerder ontwikkelde dementie-screeningsinstrumenten voor mensen met verstandelijke beperkingen (VB) zijn niet als geheel bruikbaar voor mensen met (Z)EV(M)B (Wissing, Dijkstra, et al., 2022).Dit diagnostisch hulpmiddel is ontwikkeld om dementiegerelateerde veranderingen bij mensen met (Z)EV(M)B in kaart te brengen ter ondersteuning van het diagnostisch traject bij (een vermoeden van) dementie.Inclusief handleidin

In vitro evaluation of electroporated gold nanoparticles and extremely-low frequency electromagnetic field anticancer activity against Hep-2 laryngeal cancer cells

Introduction. The extremely-low frequency electromagnetic field (ELFEMF) has been proposed for use in cancer therapy since it was found that magnetic waves interfere with many biological processes. Gold nanoparticles (Au-NPs) have been widely used for drug delivery during cancer in vitro studies due to their low cytotoxity and high biocompatibility. The electroporation of cancer cells in a presence of Au-NPs (EP Au-NPs) can induce cell apoptosis, alterations of cell cycle profile and morphological changes. The impact of ELFEMF and EP Au-NPs on morphology, cell cycle and activation of apoptosis-associated genes on Hep-2 laryngeal cancer cell line has not been studied yet. Materials and methods. ELFEMF on Hep-2 cells were carried out using four different conditions: 25/50 mT at 15/30 min, while Au-NPs were used as direct contact (DC) or with electroporation (EP, 10 pulses at 200V, equal time intervals of 4 sec). MTT assay was used to check the toxicity of DC Au-NPs. Expression of CASP3, P53, BAX and BCL2 genes was quantified using qPCR. Cell cycle was analyzed by flow cytometry. Hematoxylin and eosin (HE) staining was used to observe cell morphology. Results. Calculated IC50 of DC Au-NPs 24.36 μM (4.79 μg/ml) and such concentration was used for further DC and EP AuNPs experiments. The up-regulation of pro-apoptotic genes (CASP3, P53, BAX) and decreased expression of BCL2, respectively, was observed for all analyzed conditions with the highest differences for EP AuNPs and ELFEMF 50 mT/30 min in comparison to control cells. The highest content of cells arrested in G2/M phase was observed in ELFEMF-treated cells for 30 min both at 25 or 50 mT, while the cells treated with EP AuNPs or ELFEMF 50 mT/15 min showed highest ratios of apoptotic cells. HE staining of electroporated cells and cells exposed to ELFEMF’s low and higher frequencies for different times showed nuclear pleomorphic cells. Numerous apoptotic bodies were observed in the irregular cell membrane of neoplastic and necrotic cells with mixed euchromatin and heterochromatin. Conclusions. Our observations indicate that treatment of Hep-2 laryngeal cancer cells with ELFEMF for 30 min at 25–50 mT and EP Au-NPs can cause cell damage inducing apoptosis and cell cycle arrest

Dementia in People with Severe/Profound Intellectual (and Multiple) Disabilities:Applicability of Items in Dementia Screening Instruments for People with Intellectual Disabilities

Introduction: Diagnosing dementia in people with severe/profound intellectual (and multiple) disabilities (SPI(M)D) is complex. Whereas existing dementia screening instruments as a whole are unsuitable for this population, a number of individual items may apply. Therefore, this study aimed to identify applicable items in existing dementia screening instruments. Methods: Informant interviews about 40 people with SPI(M)D were conducted to identify applicable items in the Dementia Scale for Down Syndrome, Behavioral and Psychological Symptoms of Dementia in Down Syndrome II scale, Dementia Questionnaire for persons with Mental Retardation and Social competence Rating scale for people with Intellectual Disabilities. Results: Among 193 items, 101 items were found applicable, categorized in 5 domains: behavioral and psychological functioning (60 items), cognitive functioning (25), motor functioning (6), activities of daily living (5) and medical comorbidities (5). Conclusion: Identifying applicable items for people with SPI(M)D is an essential step in developing a dedicated dementia screening instrument for this population

Electric current circuits in astrophysics

Cosmic magnetic structures have in common that they are anchored in a dynamo, that an external driver converts kinetic energy into internal magnetic energy, that this magnetic energy is transported as Poynting fl ux across the magnetically dominated structure, and that the magnetic energy is released in the form of particle acceleration, heating, bulk motion, MHD waves, and radiation. The investigation of the electric current system is particularly illuminating as to the course of events and the physics involved. We demonstrate this for the radio pulsar wind, the solar flare, and terrestrial magnetic storms

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019 : a systematic analysis from the Global Burden of Disease Study 2019

Background: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings: Globally in 2019, 1.14 billion (95% uncertainty interval 1.13-1.16) individuals were current smokers, who consumed 7.41 trillion (7.11-7.74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27.5% [26. 5-28.5] reduction) and females (37.7% [35.4-39.9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0.99 billion (0.98-1.00) in 1990. Globally in 2019, smoking tobacco use accounted for 7.69 million (7.16-8.20) deaths and 200 million (185-214) disability-adjusted life-years, and was the leading risk factor for death among males (20.2% [19.3-21.1] of male deaths). 6.68 million [86.9%] of 7.69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation: In the absence of intervention, the annual toll of 7.69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a dear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens

Accretion, Outflows, and Winds of Magnetized Stars

Many types of stars have strong magnetic fields that can dynamically influence the flow of circumstellar matter. In stars with accretion disks, the stellar magnetic field can truncate the inner disk and determine the paths that matter can take to flow onto the star. These paths are different in stars with different magnetospheres and periods of rotation. External field lines of the magnetosphere may inflate and produce favorable conditions for outflows from the disk-magnetosphere boundary. Outflows can be particularly strong in the propeller regime, wherein a star rotates more rapidly than the inner disk. Outflows may also form at the disk-magnetosphere boundary of slowly rotating stars, if the magnetosphere is compressed by the accreting matter. In isolated, strongly magnetized stars, the magnetic field can influence formation and/or propagation of stellar wind outflows. Winds from low-mass, solar-type stars may be either thermally or magnetically driven, while winds from massive, luminous O and B type stars are radiatively driven. In all of these cases, the magnetic field influences matter flow from the stars and determines many observational properties. In this chapter we review recent studies of accretion, outflows, and winds of magnetized stars with a focus on three main topics: (1) accretion onto magnetized stars; (2) outflows from the disk-magnetosphere boundary; and (3) winds from isolated massive magnetized stars. We show results obtained from global magnetohydrodynamic simulations and, in a number of cases compare global simulations with observations.Comment: 60 pages, 44 figure

Design and field procedures for the clinical reappraisal of the Composite International Diagnostic Interview version 3.3 in Qatar's national mental health study

Background The Composite International Diagnostic Interview (CIDI) has been clinically reappraised in several studies conducted mainly in the US and Europe. This report describes the methodology used to conduct one of the Middle East's largest clinical reappraisal studies. The study was carried out in conjunction with the World Mental Health Qatar—the first national psychiatric epidemiological study of common mental disorders in the country. This study aimed to evaluate the diagnostic consistency of core modules of the newly translated and adapted Arabic version of the CIDI 5.0 against the independent clinical diagnoses based on the Structured Clinical Interview for DSM-5 (SCID-5). Methods Telephone follow-up interviews were administered by trained clinicians using the latest research edition of the SCID for DSM-5. Telephone administered interviews were key in the data collection, as the study took place during the COVID-19 pandemic. Results Overall, within 12 months, 485 interviews were completed. The response rate was 52%. Quality control monitoring documented excellent adherence of clinical interviews to the rating protocol. Conclusions The overall methods used in this study proved to be efficient and effective. For future research, instrument cultural adaptation within the cultural context is highly recommended