Bisector and zero-macrospin co-rotational systems for shell elements

A principal issue in any co-rotational approach for large displacement analysis of plates and shells is associated with the specific choice of the local reference system in relation to the current deformed element configuration. Previous approaches utilised local co-rotational systems, which are invariant to nodal ordering, a characteristic that is deemed desirable on several fronts; however, the associated definitions of the local reference system suffered from a range of shortcomings, including undue complexity, dependence on the local element formulation and possibly an asymmetric tangent stiffness matrix. In this paper, new definitions of the local co-rotational system are proposed for quadrilateral and triangular shell elements, which achieve the invariance characteristic to the nodal ordering in a relatively simple manner and address the aforementioned shortcomings. The proposed definitions utilise only the nodal coordinates in the deformed configuration, where two alternative definitions, namely, bisector and zero-macrospin definitions, are presented for each of quadrilateral and triangular finite elements. In each case, the co-rotational transformations linking the local and global element entities are presented, highlighting the simplicity of the proposed approach. Several numerical examples are finally presented to demonstrate the effectiveness and relative accuracy of the alternative definitions proposed for the local co-rotational system

Quantum radiation reaction force on a one-dimensional cavity with two relativistic moving mirrors

We consider a real massless scalar field inside a cavity with two moving mirrors in a two-dimensional spacetime, satisfying Dirichlet boundary condition at the instantaneous position of the boundaries, for arbitrary and relativistic laws of motion. Considering vacuum as the initial field state, we obtain formulas for the exact value of the energy density of the field and the quantum force acting on the boundaries, which extend results found in previous papers. For the particular cases of a cavity with just one moving boundary, non-relativistic velocities, or in the limit of infinity length of the cavity (a single mirror), our results coincide with those found in the literature.Comment: 6 pages 9 figure

A dynamical model for the dusty ring in the Coalsack

Lada et al. recently presented a detailed near-infrared extinction map of Globule G2 in the Coalsack molecular cloud complex, showing that this starless core has a well-defined central extinction minimum. We propose a model for G2 in which a rapid increase in external pressure is driving an approximately symmetric compression wave into the core. The rapid increase in external pressure could arise because the core has recently been assimilated by the Coalsack cloud complex, or because the Coalsack has recently been created by two large-scale converging flows. The resulting compression wave has not yet converged on the centre of the core, so there is a central rarefaction. The compression wave has increased the density in the swept-up gas by about a factor of ten, and accelerated it inwards to speeds of order $0.4 {\rm km} {\rm s}^{-1}$. It is shown that even small levels of initial turbulence destroy the ring seen in projection almost completely. In the scenario of strong external compression that we are proposing this implies that the initial turbulent energy in this globule is such that $E_{{\rm turb}} / E_{{\rm grav}} \le 2$. Protostar formation should occur in about $40,000 {\rm years}$.Comment: Accepted for publication in A&

Integrated design for integrated photonics: from the physical to the circuit level and back

Silicon photonics is maturing rapidly on a technology basis, but design challenges are still prevalent. We discuss these challenges and explain how design of photonic integrated circuits needs to be handled on both the circuit as on the physical level. We also present a number of tools based on the IPKISS design framework

Rugged Metropolis Sampling with Simultaneous Updating of Two Dynamical Variables

The Rugged Metropolis (RM) algorithm is a biased updating scheme, which aims at directly hitting the most likely configurations in a rugged free energy landscape. Details of the one-variable (RM$_1$) implementation of this algorithm are presented. This is followed by an extension to simultaneous updating of two dynamical variables (RM$_2$). In a test with Met-Enkephalin in vacuum RM$_2$ improves conventional Metropolis simulations by a factor of about four. Correlations between three or more dihedral angles appear to prevent larger improvements at low temperatures. We also investigate a multi-hit Metropolis scheme, which spends more CPU time on variables with large autocorrelation times.Comment: 8 pages, 5 figures. Revisions after referee reports. Additional simulations for temperatures down to 220

Systematic identification of transcription factors associated with patient survival in cancers

<p>Abstract</p> <p>Background</p> <p>Aberrant activation or expression of transcription factors has been implicated in the tumorigenesis of various types of cancer. In spite of the prevalent application of microarray experiments for profiling gene expression in cancer samples, they provide limited information regarding the activities of transcription factors. However, the association between transcription factors and cancers is largely dependent on the transcription regulatory activities rather than mRNA expression levels.</p> <p>Results</p> <p>In this paper, we propose a computational approach that integrates microarray expression data with the transcription factor binding site information to systematically identify transcription factors associated with patient survival given a specific cancer type. This approach was applied to two gene expression data sets for breast cancer and acute myeloid leukemia. We found that two transcription factor families, the steroid nuclear receptor family and the ATF/CREB family, are significantly correlated with the survival of patients with breast cancer; and that a transcription factor named T-cell acute lymphocytic leukemia 1 is significantly correlated with acute myeloid leukemia patient survival.</p> <p>Conclusion</p> <p>Our analysis identifies transcription factors associating with patient survival and provides insight into the regulatory mechanism underlying the breast cancer and leukemia. The transcription factors identified by our method are biologically meaningful and consistent with prior knowledge. As an insightful tool, this approach can also be applied to other microarray cancer data sets to help researchers better understand the intricate relationship between transcription factors and diseases.</p

Direct observation of a sharp transition to coherence in Dense Cores

We present NH3 observations of the B5 region in Perseus obtained with the Green Bank Telescope (GBT). The map covers a region large enough (~11'x14') that it contains the entire dense core observed in previous dust continuum surveys. The dense gas traced by NH3(1,1) covers a much larger area than the dust continuum features found in bolometer observations. The velocity dispersion in the central region of the core is small, presenting subsonic non-thermal motions which are independent of scale. However, it is thanks to the coverage and high sensitivity of the observations that we present the detection, for the first time, of the transition between the coherent core and the dense but more turbulent gas surrounding it. This transition is sharp, increasing the velocity dispersion by a factor of 2 in less than 0.04 pc (the 31" beam size at the distance of Perseus, ~250 pc). The change in velocity dispersion at the transition is ~3 km/s/pc. The existence of the transition provides a natural definition of dense core: the region with nearly-constant subsonic non-thermal velocity dispersion. From the analysis presented here we can not confirm nor rule out a corresponding sharp density transition.Comment: Accepted for publication in ApJ Letters. 6 pages, 5 figure

Intrinsic Charm Contribution to Double Quarkonium Hadroproduction

Double $J/\psi$ production has been observed by the NA3 collaboration in $\pi N$ and $p N$ collisions with a cross section of the order of 20-30 pb. The $\psi \psi$ pairs measured in $\pi^-$ nucleus interactions at 150 and 280 GeV$/c$ are observed to carry an anomalously large fraction of the projectile momentum in the laboratory frame, $x_{\psi \psi} \geq 0.6$ at 150 GeV$/c$ and $\geq 0.4$ at 280 GeV$/c$. We postulate that these forward $\psi \psi$ pairs are created by the materialization of Fock states in the projectile containing two pairs of intrinsic $c \overline c$ quarks. We calculate the overlap of the charmonium states with the $|\overline u d c \overline c c \overline c \rangle$ Fock state as described by the intrinsic charm model and find that the $\pi^- N \rightarrow \psi \psi$ longitudinal momentum and invariant mass distributions are both well reproduced. We also discuss double $J/\psi$ production in $pN$ interactions and the implications for other heavy quarkonium production channels in QCD.Comment: Revtex, APS style, 7 pages, 3 figures in uuencoded fil