The effects of ILFN-exposure on voice acoustic parameters of commercial cabin crewmembers

Background: Long-term exposure to infrasound and low frequency noise (ILFN <500 Hz, including infrasound) can lead to the development of vibroacoustic disease (VAD). VAD is a systemic pathology characterized by the abnormal growth of extracellular matrices in the absence of inflammatory processes, namely of collagen and elastin, both of which are abundant in the basement membrane zone of the vocal folds. ILFN-exposed workers include pilots, cabin crewmembers, restaurant workers, ship machinists and, in previous studies, even though they did not present vocal symptoms, ILFN-exposed workers had significant different voice acoustic patterns (perturbation and temporal measures) when compared with normative population. Study Aims: The present study investigates the effects of age and years of occupational ILFN-exposure on voice acoustic parameters of 37 cabin crewmembers: 12 males and 25 females. Specifically, the goals of this study are to: 1) Verify if acoustic parameters change over the age and years of ILFN-exposure and 2) Determine if there is any interaction between age and years of ILFNexposure on voice acoustic parameters of crewmembers. Materials and Methods: Spoken phonatory tasks were recorded with a C420III PP AKG head-worn microphone and a DA-P1 Tascam DAT. Acoustic analyses were performed using KayPENTAX Computer Speech Lab and Multi-Dimensional Voice Program. Acoustic parameters included speaking fundamental frequency, perturbation measures (jitter, shimmer and harmonicto- noise ratio), temporal measures (maximum phonation time and s/z ratio) and voice tremor frequency. Results: One-way ANOVA analysis revealed that as the number of ILFN-exposure years increased male cabin crewmembers presented significant different shimmer values of /i/ as well as tremor frequency of /u/. Females presented significantly different jitter % of /i, a, O/ (p <0.05). Lastly, Two-way ANOVA analysis revealed that for females, there was a significant interaction between age and occupational ILFN-exposure for voice acoustic parameters, namely for jitter’s mean for /a, O/ and shimmer’s (%) mean for /a, i/ (p <0.05). Discussion and Conclusion: These perturbation measure patterns may be indicative of histological changes within the vocal folds as a result of ILFN-exposure. The results of this study suggest that voice acoustic analysis may be an important tool for confirming ILFN-induced health effects

Atuação da Nutrição na Atenção Primária no enfrentamento da pandemia de Covid-19.

O estudo tem por objetivo relatar a atuação da nutrição na atenção primária no enfrentamento da Covid-19, com a elaboração de materiais informativos para serem disponibilizados nos meios de comunicação. Parte integrante do projeto de extensão +Nutrição &amp; Saúde iniciado em agosto de 2019, teve as suas ações reformuladas. Neste momento, a atenção principal foi minimizar o distanciamento social mantendo o contato com a população e compartilhar informações por meio de materiais informativos disponibilizados em diferentes meios de comunicação. No total foram elaborados dois e-books e dois banners com temas para o enfrentamento da Covid-19 e quatro vídeos sobre nutrição e saúde. Reforça-se que a atuação da Nutrição na Atenção Primária deve buscar alternativas em tempos de crise sanitária e que a educação em saúde seja ampliada com o uso dos diferentes meios de comunicação e ficar atenta com a população que possui dificuldades ao acesso às mídias sociais

Relationship of schooling level, age group and mother profession with offer of pacifier and baby's bottles to your children

OBJETIVO: avaliar a relação do grau de escolaridade, faixa etária e a profissão das mães com a oferta de chupeta e mamadeira a seus filhos MÉTODO: participaram deste estudo 190 mães de crianças entre 0 e 10 anos de idade, com idades de 20 a 45 anos que responderam a um questionário com questões fechadas a respeito de profissão, nível de escolaridade e uso de chupeta e mamadeira de seus filhos RESULTADOS: não foi observada diferença significante entre o grau de escolaridade quanto ao uso de chupeta (p= 0,915). O uso de mamadeira foi significantemente maior nos filhos de mães com ensino superior (p= 0,0124). Não houve diferença significante quanto à faixa etária das mães e a presença desses hábitos nos filhos (chupeta: p=0,427; mamadeira: p=0,427); e, entre mães que trabalham em casa e que trabalham fora de casa (chupeta: p=0,061; mamadeira: p=0,798). Não houve diferença entre mães que trabalham na área da saúde e em outras áreas (chupeta: p=0,339; mamadeira: p=0,455) CONCLUSÃO: as mães com nível superior de escolaridade oferecem significantemente mais mamadeira aos seus filhos, o que não ocorreu quanto ao uso de chupeta. Não foi observada diferença significante quanto ao uso de chupeta e mamadeira em relação à faixa etária e profissão de mães.PURPOSE: to evaluate the relationships among schooling level, age group and mother profession with offer of pacifier and baby's bottles to your children. METHOD: 190 mothers with ages varying from 20 to 45 having children from 0 to 10 took part in this study. Mothers answered a questionnaire with questions regarding profession, schooling level and use of nipples and baby's bottles by their children. RESULTS: no significant differences were found between mothers having primary or secondary education and mothers with higher education regarding the use of nipples (p= 0.915). On the other hand, baby's bottle use was significantly higher among children of mothers with higher education (p= 0.0124). No significant difference regarding age group of mothers and the presence of these habits in children or between mothers who work in the house and those who work outside as regards the use of nipples (p=0.427; p=0.061) and baby's bottles (p=0.427; p=0.798). We also observed no difference among mothers who work in the health area and those working in other fields (nipples: p=0.339; baby's bottles: p=0.455). CONCLUSION: mothers with higher education offer significantly more baby's bottles to their children, but not nipples. No significant difference was observed as for the use of nipples and baby's bottles as related to age group and mothers' profession

Recover and They’ll Come: Flower Visiting Bees Benefit from the Continuous of Micro-Environments Set by Regenerating Forest Fragments

Forest habitats are important sources of food and nesting resources for pollinators, primarily in urban areas and landscapes with intense agricultural activity. The forest fragmentation and environmental changes occurring in these green refuges are known to impose survival challenges to pollinating bees, leading to species loss. However, it is not well known how the species of bees that visit flowers are distributed in forest micro-environments. To fill this gap, we sampled flower visiting bees in a continuous forest matrix with micro-environments of two forest types (mature and regenerating forest). We examined how the local environmental changes and climatic conditions affect the composition and uniformity of bee communities in the different micro-environments. Our results indicated that both abundance and richness were similar between forest types studied here, however climatic conditions and plant flowering patterns affect the composition of bees. Thus, our results demonstrated that the continuous micro-environments can favor floral visits and the reintegration of bee communities, and still, that this strategy can be used to minimize the impacts of environmental changes at local scales

A inserção da criança de seis anos no ensino fundamental de nove anos: uma perspectiva pedagógica

A inserção da criança de seis anos no ensino fundamental no Brasil ocorre tardiamente, considerando os pressupostos teórico-metodológicos divulgados a partir do ano de 1970. Até então, não acreditávamos que as crianças de seis anos tivessem competências e/ou habilidades para o aprendizado e desenvolvimento da linguagem escrita. Outro aspecto que contribui para esse atraso tem relação com as políticas de financiamento da educação, pois o Fundo de Desenvolvimento de Manutenção e Desenvolvimento do Ensino Fundamental e de Valorização do Magistério (FUNDEF) 4 , instituído em 1997, não financiava a educação de crianças menores de sete anos de idade

High Inter- and Intra- Diversity of Amino Acid Content and Protein Digestibility Disclosed in Five Cool Season Legume Species with a Growing Market Demand

Funding Information: This research was funded by the Fundação Para a Ciência e Tecnologia through R&D Research Unit GREEN-IT-Bioresources for Sustainability (UIDB/04551/2020 and UIDP/04551/2020), Portugal 2020 through the Portuguese Mass Spectrometry Network (LISBOA-01-0145-FEDER-402-022125); and European Union through the project LEGumes for the Agriculture of TOmorrow (LEGATO), FP7 Framework Program (Grant Agreement 613551) and project Co-constructing interactive short and mid-tier food chains to value agrobiodiversity in healthy plant-based food (DIVINFOOD), Horizon 2020 (Grant Agreement 101000383). iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020) and the Associate Laboratories LS4FUTURE (LA/P/0087/2020). Spanish AEI support through the PID2020-114668RB-I00 project is also acknowledged. Publisher Copyright: © 2023 by the authors.Legumes have been sought as alternative protein sources to ensure food security and environmental sustainability. Characterizing their protein content and quality, including in underutilized grain legumes, e.g., grass pea, gives value to the legumes’ underexplored variability. To fill the gap of knowledge in legumes’ protein quality, for the first time, five extensive collections of cool season grain legumes were cropped under the same environmental conditions and further analyzed. Multivariate analysis showed the existent intra- and inter-species variability. The legume species with the highest protein content, grass pea, Lathyrus sativus (LS), was not the one with the overall highest individual amino acids content and in vitro protein digestibility. With these last characteristics lentil, Lens culinaris (LC), was highlighted. The highest average values of arginine (Arg), glutamic acid (Glu), and threonine (Thr) were found in LS and Vicia faba (VF). Cicer arietinum (CA) stood out as the species with the highest values of Thr and methionine (Met). Regarding the in vitro protein digestibility (IVPD), LC, followed by Pisum sativum (PS) and LS, were the legume species with the highest values. Ultimately, this study bought to the fore legume species that are not commonly used in western diets but have high adaptability to the European agricultural systems.publishersversionpublishe

Módulo VIII: Linhas de cuidado: oncologia (câncer de mama, câncer de colo de útero e tumores de próstata)

Ministério da Saúd

Multi-target analysis of cytostatics in hospital effluents over a 9-month period

The consumption of cytostatics, pharmaceuticals prescribed in chemotherapy, is increasing every year and worldwide, along with the incidence of cancer. The presence and the temporal evolution of cytostatics in wastewaters from a Portuguese hospital center was evaluated through a 9-month sampling campaign, comprising a total of one hundred and twenty-nine samples, collected from May 2019 to February 2020. Eleven cytostatics out of thirteen pharmaceuticals were studied, including flutamide, mycophenolate mofetil and mycophenolic acid, which have never been monitored before. Target analytes were extracted and quantified by solid-phase extraction coupled to liquid-chromatography-tandem mass spectrometry analysis; the method was fully validated. All pharmaceuticals were detected in at least one sample, bicalutamide being the one found with higher frequency (detected in all samples), followed by mycophenolic acid, which was also the compound detected at higher concentrations (up to 5340 ± 211 ng/L). Etoposide, classified as carcinogenic to humans, was detected in 60% of the samples at concentrations up to 142 ± 15 ng/L. The risk from exposure to cytostatics was estimated for aquatic organisms living in receiving bodies. Cyclophosphamide, doxorubicin, etoposide, flutamide, megestrol and mycophenolic acid are suspected to induce risk. Long-term and synergic effects should not be neglected, even for the cytostatics for which no risk was estimated.publishe

Application of derivative spectrophotometric method in identification and simultaneous analysis of multi-component system

Neste trabalho, demonstrou-se a aplicação do método da espectrofotometria de derivadas no doseamento simultâneo de alguns fármacos em produtos farmacêuticos comerciais. Os métodos desenvolvidos apresentaram-se precisos, sensíveis, seletivos, reprodutivos e de baixo custo.The application of the derivative spectrophotometric method in the simultaneous determinations of some drugs in commercial pharmaceutical products is demonstrated in this work. The developed methods proved to be selective, reproductive and of low cost

Prevalence of carotid artery calcifications among 2,500 digital panoramic radiographs of an adult Brazilian population

The aim of the present study was to analyze the epidemiological data of digital panoramic radiographs revealing suggestive images of carotid artery calcifications (CAC) from a Northeast Brazilian population. A cross-sectional retrospective study was conducted with 2,500 digital panoramic radiographs obtained from a single imaging reference center in Northeast Brazil. Images from individuals of both sexes and older than 18 years were included and those that did not cover the region of cervical vertebrae or presented low radiographic quality were excluded. Data were analyzed regarding prevalence, location (bilateral, right or left), sex, and age using the Chi-square test at the significance level of 5%. An amount of 96 (4%) patients presented suggestive images of CAC. The female sex (p=0.003) and individuals aged up to 70 years (p=0.002) were statically significant. 40.4% were found bilaterally, 37.6% on the right side (p<0.001) and 22% on the left side. In conclusion, this study showed a low prevalence of suggestive images of CAC in digital panoramic radiographs from a Northeast Brazilian population. It was observed a higher prevalence of CAC associated with female sex, older patients, and right side location