Estabilización del adobe con fibra de platanal y viruta de ciprés para mejorar su resistencia en viviendas de Celendín, Cajamarca 2020

La investigación está basada en la estabilización del adobe incorporando la fibra de platanal y viruta de ciprés en su composición, estos estudios realizados están hechos para una mejora del material para ser utilizadas en el departamento de Cajamarca, distrito de Celendín ya que en la mayor parte de esta zona existen viviendas construidas de este material fabricado artesanalmente a base de arcillas y algunas fibras de la zona, para dar resistencia a dicho componente, ya que esta zona suelen ocurrir muchas precipitaciones pluviales debilitando de dicha manera a las viviendas que están construidos de este material. La metodología utilizada en este proyecto de investigación buscó dar un aporte y está basada en la norma E- 080, que se basa en el uso de materiales en arcillas; el boceto de este trabajo está basado en la parte experimental debido a que la variable independiente fue dirigida para cumplir los objetivos propuesto en dicha investigación. Los porcentajes de la fibra de platanal y viruta de ciprés, añadidos a dicho material (adobe), fueron del 1%,1.5% y 2% con respecto al peso seco de la muestra. Los resultados obtenido en el laboratorio mostraron una proliferación a la compresión dando un porcentaje de, 48.36%, 80.39% y 137.25% con respecto al adobe guía de 15.3 kg/cm2, por consiguiente en el ensayo a la flexión este también llego a un incremento del, 7.14%,15.78% y 20.90% con respecto al adobe guía de 5.74 kg/cm2 añadiendo dichos materiales y por parte del ensayo a la absorción de líquidos en el adobe estabilizado se obtuvo muestras constantes de un,15.7%, 15.4% y 15.2% al adobe guía por lo que es recomendable la utilización de los materiales de la fibra de platanal y viruta de ciprés para la elaboración de dicho componente

Detección de virus asociados al material de siembra de tomate de árbol en Colombia

La virosis del tomate de árbol es uno de los problemas más limitantes de este cultivo en Colombia. Esta investigación evaluó como posible fuente de inóculo la semilla de frutos colectados en campo, así como en material de vivero de Antioquia, Cundinamarca, Nariño y Putumayo y en plántulas ger- minadas bajo condiciones de invernadero. Estas evaluaciones se realizaron mediante pruebas de ELISA y estuvieron complementadas con la secuen- ciación del gen de la cápside de los virus detectados más frecuentemente. Para la semilla de frutos colectados en campo se observó una alta incidencia de potyvirus (16%), PLRV (26%) y la presencia en al menos una muestra de los virus AMV, CMV y ToMV. No se encontraron los virus TSWV y ToRSV. La detección en plántulas de vivero indicó la presencia de PLRV (24%), potyvirus (35%), ToRSV (22%) y CMV (0,6%) en las muestras analizadas. En las plántulas obtenidas en los ensayos de invernadero, nuevamente se detectaron PLRV y potyvirus. Estos resultados plantean la posibilidad de considerar la transmisión por semilla de virus en este cultivo y representan el primer reporte mundial de transmisión por semilla de PLRV

Análisis de Las Capacidades Emprendedoras Potenciales y Efectivas en Alumnos de Centros de Educación Superior

There were identified four factors that determine the enterprising potential capacity of a pupil belonging to higher education centers (attributes of the entrepreneur, interpersonal capacities, capacities opposite to the risk and attitude of the entrepreneur). On having organized into a hierarchy using the AHP method, it concluded the vectors of priority giving a major importance for attitude and attributes of the entrepreneur, which as a whole represent 76%. The index of enterprising potential capacity was 74% and the percentage of pupils with effective enterprising capacity was 16%. This gap of development of enterprising capacity represents a strategic challenge for each higher education centers, to contribute to its value and in addition to the local, regional and national development. There proposes a model of analysis of the enterprising capacities, who would allow significant achievements in the formation of effective enterprising capacities

Safety and pharmacokinetic assessments of a novel ivermectin nasal spray formulation in a pig model

Recently published data indicates that high ivermectin (IVM) concentrations suppress in vitro SARS-CoV-2 replication. Nasal IVM spray administration may contribute to attaining high drug concentrations in nasopharyngeal tissue, a primary site of virus entrance/replication. The safety and pharmacokinetic performances of a novel IVM spray formulation were assessed in a pig model. Piglets received IVM either orally (0.2 mg/kg) or by one or two nasal spray doses. The overall safety, and histopathology of the IVM-spray application site tissues, were assessed. The IVM concentration profiles measured in plasma and respiratory tract tissues after the nasal spray were compared with those achieved after the oral administration. Animals tolerated well the nasal spray formulation. No local/systemic adverse events were observed. After nasal administration, the highest IVM concentrations were measured in nasopharyngeal and lung tissues. The nasal/oral IVM concentration ratios in nasopharyngeal and lung tissues markedly increased by repeating (12 h apart) the spray application. The fast attainment of high and persistent IVM concentrations in nasopharyngeal tissue is the main advantage of the nasal over the oral route. These original results support the undertaking of future clinical trials to evaluate the safety/efficacy of the nasal IVM spray application in the prevention and/or treatment of COVID-19.Fil: Errecalde, Jorge Oscar. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. INCAM S.A; ArgentinaFil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Vecchioli, Graciela Isabel. INCAM S.A; ArgentinaFil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Errecalde, Francisco. INCAM S.A; ArgentinaFil: Ballent, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Marin, Gustavo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Daniele, Martin Rafael. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Farmacología, Farmacotecnia y Terapéutica; ArgentinaFil: Turic, Esteban. Biogenesis Bago S.a..; ArgentinaFil: Spitzer, Eduardo. Laboratorio Elea Phoenix S.a.; ArgentinaFil: Toneguzzo, Fernando. Laboratorio Elea Phoenix S.a.; ArgentinaFil: Gold, Silvia. Laboratorio Elea Phoenix S.a.; ArgentinaFil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentin

Impact of the COVID-19 pandemic in the early-onset colorectal cancer

COVID-19 pandemic; Early-onset colorectal cancerPandemia de COVID-19 Cáncer colorrectal precozPandèmia de COVID-19; Càncer colorectal precoçThe COVID19 pandemic has affected the spectrum of cancer care worldwide. Early onset colorectal cancer (EOCRC) is defined as diagnosis below the age of 50. Patients with EOCRC faced multiple challenges during the COVID19 pandemic and in some institutions it jeopardized cancer diagnosis and care delivery. Our study aims to identify the clinicopathological features and outcomes of patients with EOCRC in our Centre during the first wave of the pandemic in comparison with the same period in 2019 and 2021. Patients with EOCRC visited for the first time at Vall d'Hebron University Hospital in Spain from the 1st March to 31st August of 2019, 2020 and 2021 were included in the analysis. 177 patients with EOCRC were visited for the first time between 2019 and 2021, of which 90 patients met the inclusion criteria (2019: 30 patients, 2020: 29 patients, 2021: 31 patients). Neither differences in frequency nor in stage at diagnosis or at first visit during the given periods were observed. Of note, indication of systemic therapy in the adjuvant or metastatic setting was not altered. Days to treatment initiation and enrollment in clinical trials in this subpopulation was not affected due to the COVID-19 outbreak.This work was supported by the Cancer Research UK (CRUK) grant OPTIMISTICC (C10674/A27140)

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary file