Analyzing HTTP requests for web intrusion detection

Many web application security problems related to intrusion have resulted from the rapid development of web applications. To reduce the risk of web application problems, web application developers need to take measures to write secure applications to prevent known attacks. When such measures fail, it is important to detect such attacks and find the source of the attacks to reduce the estimated risks. Intrusion detection is one of the powerful techniques designed to identify and prevent harm to the system. Most defensive techniques in Web Intrusion Systems are not able to deal with the complexity of cyber-attacks in web applications. However, machine learning approaches could help to detect known and unknown web application attacks. In this paper, we present machine learning techniques to classify the HTTP requests in the well-known dataset CSIC 2010 HTTP (Giménez et al., 2012) as normal or abnormal traffic, and we compare our experimental results with the results reported by Pham et al. in 2016 and Nguyen et al. in 2011. These experiments produce results for overlapping sets of machine-learning techniques and different sets of features, allowing us to compare how good the various feature sets are for the various machine-learning techniques, at least on this dataset. Keywords: intrusion detection system; anomaly detection; web application attacks; machine learning

BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses

p53 is a tumor suppressor that prevents the emergence of transformed cells by inducing apoptosis or senescence, among other responses. Its functions are regulated tightly by posttranslational modifications. Here we show that Bruton's tyrosine kinase (BTK) is a novel modulator of p53. We found that BTK is induced in response to DNA damage and p53 activation. BTK induction leads to p53 phosphorylation, which constitutes a positive feedback loop that increases p53 protein levels and enhances the transactivation of its target genes in response to stress. Inhibiting BTK reduced both p53-dependent senescence and apoptosis. Further, BTK expression also upregulated DNA damage signals and apoptosis. We conclude that despite being involved in oncogenic signals in blood malignancies, BTK has antineoplastic properties in other contexts, such as the enhancement of p53's tumor suppressor responses. Along with evidence that BTK expression correlates with good prognosis in some epithelial tumors, our findings may encourage a reevaluation of the clinical uses of BTK inhibitors in cancer therapy

Graduate Medical Students’ Mental Health Concerns During COVID-19 Pandemic

Medical students are more likely than the general population to experience perceived stress during the pandemic due to many variables. This study aimed to evaluate the stress levels and prevalence of different mental health conditions among graduate medical students in Al Kharj City. An anonymous online survey was conducted among graduate medical students of Prince Sattam bin Abdulaziz University (PSAU). For this investigation, the following scales were used to measure the prevalence of common mental health issues: DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure-Adult (CCSM-A); Perceived Stress Scale (PSS-10-C), to measure COVID-19-related student stress; and the COVID-19 Student Stress Questionnaire to get the global stress score (GSS). Two hundred twenty-one students were contacted, and 214(96.8%) consented to participate in the study. According to the CCSM-A scale, anxiety (73%) and depressive symptoms (71%) were the most frequently reported symptoms by the students. After correcting for age and self-perceived COVID-19 risk, there was a significant relationship between anger, suicidal ideation, and substance use, on one hand, and the study year on the other graduate medical students who have mental health issues bear a heavy load. In the post-pandemic recovery period, regular mental health assessments and providing early and adequate mental health assistance to needy people are imperative

Laser-assisted decay spectroscopy for the ground states of 180,182Au^180,182Au

status: publishe

Hyperfine anomaly in gold and magnetic moments of Ipi=11/2−I^pi=11/2^- gold isomers

status: publishe

Laser-assisted decay spectroscopy and mass spectrometry of 178Au^178Au

A comprehensive study of the isotope 178Au has been made at the CERN-ISOLDE facility, using resonance laser ionization. Two long-lived states in 178Au were identified—a low-spin ground state and a high-spin isomer—each of which were produced as pure beams. Using the ISOLTRAP precision Penning trap, the excitation energy of the isomeric state in 178Au was determined to be E∗=189(14)keV. The α-decay fine structure patterns of the two states were studied using the Windmill decay station, providing information on the low-lying states in the daughter nucleus 174Ir. Nuclear spin assignments of I(178Aug)=(2,3) and I(178Aum)=(7,8) are made based on the observed β-decay feeding and hyperfine structure intensity patterns. These spin assignments are used for fitting the hyperfine structures of the two states from which values for the magnetic dipole moments are extracted. The extracted moments are compared with calculations using additivity relations to establish the most probable configurations for 178Aug,m

Laser-assisted nuclear decay spectroscopy of 176,177,179Au

A study of the laser-ionized and mass-separated neutron-deficient isotopes Au-176,Au-177,Au-179 was performed using the Resonance Ionization Laser Ion Source and the Windmill detection setup at ISOLDE, CERN. New and improved data on complex fine-structure alpha decays of the three isotopes were deduced, providing insight into the low-lying levels in the daughter nuclei Ir-172,Ir-173,Ir-175. New information on the properties of beta-decay daughter products Pt-177,Pt-179 was also obtained. From the first in-source laser spectroscopy measurements of the hyperfine structure in the atomic 267.6-nm transition of Au-176, the nuclear magnetic moments for both high- and low-spin alpha-decaying states were deduced. Together with the values determined from the additivity relations, they were used to propose the most probable spins and configurations for both states. The a-decay branching ratios were determined as b(alpha)(Au-176(1s)) = 58(5)% and b(alpha)(Au-176(hs)) = 29 (5)%

Laser Spectroscopy of Neutron-Rich 207,208Hg Isotopes : Illuminating the Kink and Odd-Even Staggering in Charge Radii across the N =126 Shell Closure

International audienceThe mean-square charge radii of Hg207,208 (Z=80, N=127, 128) have been studied for the first time and those of Hg202,203,206 (N=122, 123, 126) remeasured by the application of in-source resonance-ionization laser spectroscopy at ISOLDE (CERN). The characteristic kink in the charge radii at the N=126 neutron shell closure has been revealed, providing the first information on its behavior below the Z=82 proton shell closure. A theoretical analysis has been performed within relativistic Hartree-Bogoliubov and nonrelativistic Hartree-Fock-Bogoliubov approaches, considering both the new mercury results and existing lead data. Contrary to previous interpretations, it is demonstrated that both the kink at N=126 and the odd-even staggering (OES) in its vicinity can be described predominately at the mean-field level and that pairing does not need to play a crucial role in their origin. A new OES mechanism is suggested, related to the staggering in the occupation of the different neutron orbitals in odd- and even-A nuclei, facilitated by particle-vibration coupling for odd-A nuclei