D-term Uplifts in Non-Supersymmetric Heterotic String Models

Recently, we proposed that the one-loop tadpole diagram in perturbative non-supersymmetric heterotic string vacua that contain an anomalous $U(1)$ symmetry, leads to an analog of the Fayet-Iliopoulos $D$-term in $\mathcal{N}=1$ supersymmetric models, and may uplift the vacuum energy from negative to positive value. In this paper, we extend this analysis to new types of vacua, including those with Stringy Scherk-Schwarz (SSS) spontaneous supersymmetry breaking versus those with explicit breaking. We develop a criteria that facilitates the extraction of vacua with Scherk-Schwarz breaking. We develop systematic tools to analyse the T-duality property of some of the vacua and demonstrate them in several examples. The extraction of the anomalous $U(1)$ $D$-terms is obtained in two ways. The first utilises the calculation of the $U(1)$-charges from the partition function, whereas the second utilises the free fermionic classification methodology to classify large spaces of vacua and analyse the properties of the massless spectrum. The systematic classification method also ensures that the models are free from physical tachyons. We provide a systematic tool to relate the free fermionic basis vectors and one-loop Generalised GSO phases that define the string models, to the one-loop partition function in the orbifold representation. We argue that a $D$-term uplift, while rare, is possible for both the SSS class of models, as well as in those with explicit breaking. We discuss the steps needed to further develop the arguments presented here.Comment: 38 pages, 15 figure

Propuesta de plan de gestión del cronograma, recursos y calidad, con criterios del sistema último planificador del proyecto casa blanca, Chiclayo

La presente investigación se basa en elaborar una propuesta de plan de gestión del cronograma, recursos y calidad con criterios del sistema ultimo planificador aplicado al proyecto Casablanca habilitación urbana etapa I ubicado en el distrito Leonardo Ortiz, Chiclayo. Este estudio parte de datos tomados en campo y del proyecto consistentes en planos de lotización, redes de agua, redes de alcantarillado, pistas y veredas, memorias descriptivas, presupuesto que incluye planilla de metrados y especificaciones técnicas donde nos refleja el trabajo realizado, los cuales utilizamos para realizar la situación ideal de gestión del cronograma, recursos y calidad aplicando la herramienta Ultimo planificador que facilitara la gestión de la construcción tendiente a evitar pérdidas y lograr eficacia y eficiencia en los procesos; con la implementación de esta herramienta de control y mejora continua en el cual utilizamos un esquema de los planes necesarios en el proyecto, los cuales son Plan maestro, plan intermedio y plan semanal, esto nos ayudara a tener un mejor control en las actividades, suministro de recursos y calidad. Luego de obtener los resultados de la propuesta con la herramienta “Ultimo planificador” (“Last Planner”), hemos logrado optimizar tiempos y recursos, así como disminuir las perdidas en obra gracias al haber implementado una mejor organización, gestión, comunicación y control de las actividades. Al haber realizado las propuestas hemos notado una mejora en la productividad en la construcción de la habilitación urbana Casablanca.This research is based on preparing a proposal for a management plan for the schedule, resources and quality with the criteria of the last planner applied to the Casablanca urbanization stage I project located in the Leonardo Ortiz district, Chiclayo. This study is based on data taken in the field and the project consisting of lotization plans, water networks, sewerage networks, tracks and paths, descriptive reports, budget that includes metrados form and technical specifications where it reflects the work done, which we use to realize the ideal situation of management of the schedule, resources and quality applying the tool “Last planner” that will facilitate the management of the construction tending to avoid losses and achieve efficiency and effectiveness in the processes; with the implementation of this tool of control and continuous improvement in which we use an outline of the necessary plans in the project, which are Master plan, intermediate plan and weekly plan, this will help us to have a better control in the activities, supply of resources and quality. After obtaining the results of the proposal with the tool “Last Planner”, we have managed to optimize time and resources, as well as reduce the losses in work thanks to having implemented a better organization, management, communication and control of the activities. Having made the proposals we have noticed an improvement in productivity in the construction of the Casablanca urbanization.Tesi

Proyecto PETICHAY

En el presente proyecto, se procede a desarrollar el procedimiento que toma el poder validar la idea de negocio nombrada PetiChay, la cual se centra en una aplicación que permite la cotización, localización y separación en tiempo real de citas y consultas veterinarias, a través de una plataforma interactiva, simple y amigable. De modo que, sirva para que el proceso de atención sea más ligero y sencillo en comparación a los que se tienen tradicionalmente. Asimismo, el presente modelo de negocio va dirigido a hombres y mujeres de sectores socioeconómicos de nivel A y B, que necesiten y estén en la condición de optar por un servicio que le brinde facilidades para una atención veterinaria segura y rápida. Es por esto, que, en el transcurso de la investigación realizada, se recurrieron a diversas fuentes, entrevistas y experimentos, que nos permitieron conocer sugerencias, críticas constructivas y demás aspectos que nos brindaban información sobre lo que requería el público objetivo. Además, se realizaron y validaron algunas herramientas y sus elementos, como en el caso de Value Proposition Canvas y el Business Model Canvas, los cuales sirvieron de apoyo para recopilar resultados valiosos, generar mejoras a través de retroalimentaciones y motivarnos al percibir la buena acogida de la idea al tener comentarios del público, en su mayoría, favorables. Finalmente, se procedió a realizar el plan financiero del proyecto con un alcance de 5 años, sirviéndose también de algunos indicadores financieros como apoyo para proyectar y verificar así la viabilidad de la idea de negocio, que es este caso resultó positiva.In this project, we proceed to develop the procedure that takes power to validate the business idea named PetiChay, which focuses on an application that allows real-time listing, location and separation of appointments and veterinary consultations, through an interactive, simple and friendly platform. So, it serves to make the care process lighter and easier compared to those traditionally held. Likewise, this business model is aimed at men and women from socioeconomic sectors of level A and B, who need and are in a position to opt for a service that provides facilities for safe and fast veterinary care. This is why, in the course of the research carried out, various sources, interviews and experiments were used, which allowed us to learn about suggestions, constructive criticism and other aspects that provided us with information about what the target audience required. In addition, some tools and their elements were made and validated, as in the case of the Value Proposition Canvas and the Business Model Canvas, which served as support to collect valuable results, generate improvements through feedback and motivate us by perceiving the good reception of the idea by having comments from the public, mostly favorable. Finally, the financial plan of the project was carried out with a scope of 5 years, also using some financial indicators as support to project and thus verify the viability of the business idea, which in this case was positive.Trabajo de investigació

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

Modelli cosmologici che imitano l'evoluzione del background del modello standard LambdaCDM. Cosmological models mimicking the standard LambdaCDM background evolution

Diverse osservazioni cosmologiche mostrano che l'Universo sta attraversando un periodo di espansione accelerata, che iniziò a tempi molto recenti. Qual è la fonte fisica di tale accelerazione è probabilmente uno dei più grandi enigmi che affrontano la cosmologia. Sono stati proposti vari modelli in cui la gravità, come la conosciamo, viene modificata su scale cosmologiche. Recentemente sono stati proposti i cosiddetti modelli di gravità "mimetici", che sono in grado di riprodurre la storia di espansione del background del modello cosmologico standard di LambdaCDM che tiene conto dei componenti oscuri dell'Universo (materia oscura ed energia oscura) esclusivamente tramite effetti gravitazionali. Lo scopo di questa tesi è, in primo luogo, di familiarizzare con alcune basi della cosmologia, come ad esempio le equazioni che governano la storia di espansione del background, e quindi essere in grado di riprodurre alcune delle principali caratteristiche dei modelli della gravità mimetica (a livello dell'evoluzione del background). Come terzo possibile passo, alcune caratteristiche semplici dei modelli mimetici possono essere studiato alla luce dei recenti vincoli imposti a molte classi di modelli di gravità modificati dai recenti forti limiti sul velocità delle onde gravitazionali ottenute dall'ultimo evento dell'onda gravitazionale GW170817 misurato da LIGO e VIRGO collaborazione

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Stability is an important concern for vehicles which move heavy loads, accelerate or brake aggressively, turn at speed, or operate on sloped terrain. In many cases, vehicles face more than one of these challenges simultaneously. Some are obliged to execute these maneuvers when their high centers of gravity leave them particularly vulnerable to tipover or rollover. A methodology is presented to estimate proximity to tipover for autonomous field robots that must be productive, effective, and self-reliant under such challenging circumstances. While the physical principles governing the computation of stability margin have been known for some time, the realization of these principles in practice raises issues which are at once similar to those of attitude estimation while contrasting heavily with inertial guidance. The problem of stability margin estimation is posed in the fairly general case of accelerated articulating motion over roug

Interview with Robert A. Diaz

Vietnam War, 1961-1975 Branch of Service: Air Force Unit of Service: 366th MMS-Tactical Fighter Wing Location of Service: Da Nang Air Field, Vietnam Highest Rank: Staff Sergeant Dates of Service: 1962-1982 Military Status: Veteranhttps://scholarworks.utrgv.edu/veterans/1013/thumbnail.jp

Analisis de la accion de indemnizacion por error judicial en Chile y su eficacia juridica-procesal

81 p.El desarrollo de la siguiente memoria, equivale al trabajo realizado al termino de la carrera de Derecho, con el objeto de optar al grado de Licenciado en Ciencias Jurídicas y Sociales. Su contenido analiza la Acción de Indemnización por Error Judicial en Chile y su eficacia jurídica procesal, en tres capítulos. La explicación de la acción constitucional en nuestro país y su normativa vigente, el tratamiento en el Derecho Comparado y en el Derecho Internacional de los Derechos Humanos y finalmente, una recopilación jurisprudencial en la materia, con sus respectivos comentarios y alcances interpretativos, destacando los criterios utilizados por el Poder Judicial. Por su parte, se presenta una conclusión determinante y certera fruto de la investigación realizada y una conclusión personal