Evaluation of Phytochemical and Antibacterial properties of leaf extract of Cinnamomum tamala oil

Cinnamomum tamala, commonly known as tej patta is widely used as a spice in Indian cuisine for its aroma and flavoring property as the leaves contain essential oil. The essential oil is extracted with the help of the Clevenger apparatus using dry leaves. This oil is mainly used as medicine for releasing gas as well as a carminative agent and diuretic agent.  It also improves the digestive system and helps in increasing appetite. This study aimed to determine the phytochemical properties and antibacterial potential of different extracts (aqueous, methanol, and acetone) and oil of C. tamala leaves. The phytochemical evaluation shows the presence and absence of alkaloids, flavonoids, phenolic compounds, steroids, tannins, glycosides, terpenoids, saponins, proteins, and carbohydrates in the aqueous, methanol, and acetone extracts. The efficacy of antibacterial properties of prepared extracts was examined against E. coli and Salmonella typhi (gram-negative bacteria) and Staphylococcus aureus and Bacillus subtilis (gram-positive bacteria). These bacterial cultures were obtained from IMTech Chandigarh. From the results of the antibacterial study it has become evident that among three extracts, the maximum zone of inhibition was obtained in the aqueous extract which was followed by methanolic and acetone extract. With the help of a Clevenger apparatus, Bay leaf oil was extracted to establish antibacterial properties. Henceforth, to analyze the antibacterial potential of the oil sample, the test was performed against the mentioned bacterial species (E. coli, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis) and reported significant antibacterial activities. From the outcome of this study, it has become clear that Bay leaf oil has potent antibacterial properties against selected bacterial species

The prevalence of osteopenia and osteoporosis in out-patients above 40 years of a tertiary care hospital in Delhi

Background: Osteoporosis is a common bone disorder among Indian population but is still underdiagnosed. Being a treatable disease, early diagnosis can significantly reduce osteoporotic fractures and other morbidities. Despite multiple studies globally regarding the prevalence of osteoporosis and osteopenia, the data about Indian population especially in males is limited. In this study, we aim to calculate the prevalence of osteoporosis in patients over 40 years of age attending the out-patients department of a tertiary care hospital in New Delhi.Methods: A cross-sectional study was done including 231 patients (147 females and 84 males) over the age of 40 years. Calcaneal quantitative ultrasonography (QUS) was used to measure the bone mineral density and the results were divided into normal, osteopenic and osteoporotic groups on the based on equivalent heel T score.Results: Of the total 231 patients, 78 patients had a normal bone mass density as measured by calcaneal QUS. 123 patients (53.2%) were found to be osteopenic while 30 patients (13.1%) were osteoporotic. Of the 147 females, 84 (57%) were osteopenic while 27 (18%) patients were found to be osteoporotic. Among the 84 males, 39 (46%) were osteopenic and 3 (4%) were found to be osteoporotic.Conclusions: The prevalence of osteoporosis and osteopenia in outpatients over 40 years was high in our study and similar in values with other studies involving the Indian population. Hence, we recommend regular screening and early detection of osteoporosis to reduce the burden of the disease

An empirical study to identify and develop constructive model of e-supply chain risks based on Indian mechanical manufacturing industries

Management towards control of risk issues appeared as an important area in E-supply chain for researchers in the present fast growing market. Extensive research has been accomplished in this area, but still there are several risks and uncertainties. The present research aims to identify and consolidate various e-supply risk factors for developing a constructive measurement model. The study also assesses the influence of risk factors over e-supply chain operation in Indian mechanical industries. Thus, after a thorough research and detailed discussion, 38 Risks factors are identified through literature to prepare the questionnaire. A questionnaire based survey is carried out for collecting the primary data from 148 experts of mechanical manufacturing industries located in the national capital region of India. The research methodology is combined with descriptive statistics and factor analysis. SPSS 21 software tools is used for investigating the reliability and Amos Graphics 21 software is used for the fitment validation of the theoretical construct. The results suggest that all risk issues create significant negative influence e-supply chain process. The results also show negative effects of risks over e-supply chain performance. The current research outcome develops a stochastic model based on the e-supply chain risk factors used for reducing risks in e-supply chain operation

Histone deacetylase inhibitors: pharmacotherapeutic implications as epigenetic modifier

Epigenetic modifications such as acetylation and deacetylation of histone proteins play a decisive role in transcriptional alteration and expression of genes. Acetylation is catalysed by the histone acetyl transferases enzymes and activates expression of genes by converting chromatin into a less compact, transcriptionally active state. Histone deacetylases enzymes catalyze deacetylation that condenses chromatin into a closed structure .Consequently transcriptional factors are unable to access DNA and gene expression is suppressed. Balanced activity of HATs and HDACS is essential for normal gene expression. Increased HDAC activity can lead to imbalance in protein acetylation resulting in hypoacetylation, tight chromatin structure and suppression of various genes. This aberrant suppression of genes is the hallmark of several malignant and other diseases including neurodegenerative disorders. Histone Deacetylase Inhibitors (HDACIs) have potential to restore the balance of histone acetylation that reverses the silencing of pathological genes. Thus HDACIs modify expression of genes without affecting sequence of DNA and act as epigenetic modifiers. Vorinostat and romidepsin are FDA approved HDACIs. Valproic acid, belinostat and many others are in different phases of clinical trials. This review article explores the target based epigenetic mechanisms as well as existing and potential therapeutic role of HDACIs in various malignant and non-malignant diseases. Data sources were articles published in medical journals and bibliographic database Medline

Occurrence and risk factors of Vitamin D deficiency in Indian children living with HIV – A case–control study

Background: Vitamin D deficiency (VDD) is highly prevalent in healthy individuals. Studies suggest that Vitamin D plays an important role in immune system. Objective: The objective of this study was to assess the frequency of VDD in Indian children living with HIV (CLHIV) and to find out the risk factors associated with it. Materials and Methods: It was a cross-sectional comparative study conducted in a tertiary care teaching hospital of North India. A total of 52 CLHIV were enrolled consecutively from the pediatric HIV center and an equal number of age- and sex-matched controls were enrolled from the pediatric outpatient department. Serum Vitamin D levels of cases and controls were assessed and compared. Various risk factors, both classical (age, sex, sunlight exposure, average dietary intake of calcium, and Vitamin D) and disease related (WHO and immunological stage, duration, and regimen of treatment), were evaluated for VDD in CLHIV. Results: The prevalence of VDD in cases and controls was 69.23% and 19.23%, respectively (p<0.001). The mean serum Vitamin D level of the cases (18.24±11.2 ng/dL) was significantly lower than that of controls (31.58±17.31 ng/dL) (p<0.001). The risk factor that predicted the occurrence VDD in CLHIV was a poor intake of Vitamin D. Conclusion: CLHIV are more prone to VDD; hence, there is a need to regularly evaluate, supplement, and monitor for Vitamin D status in these children

Structural examination of historical heritage bridges

Culture and heritage are important aspects of a civilization after meeting basic needs. The heritage structures also called monuments are generally quite old and may be ever older than hundred years. In case of bridges, the life span as stated by codes/ standards is 50 years to 75 years. Further, the material used in heritage structures are unique in sense the composition at the time of construction is generally not available. Therefore, it is a challenging task to assess the performance of the heritage structures including bridges. In this respect, some of the heritage bridge s in Delhi have been studied and results of one bridge connecting the Red fort and Salimgarh fort namely Mangi Bridge are discussed. The methodology of study involves collection of site data (geometry), numerical modelling, experimental studies at the site and useful inferences. The vibration study and the ongoing traffic affects the bridge as the bridge lies on the major arterial road called Ring Road in Delhi. The study will be helpful for continued use of the bridge

Structural examination of historical heritage bridges

76-79Culture and heritage are important aspects of a civilization after meeting basic needs. The heritage structures also called monuments are generally quite old and may be ever older than hundred years. In case of bridges, the life span as stated by codes/ standards is 50 years to 75 years. Further, the material used in heritage structures are unique in sense the composition at the time of construction is generally not available. Therefore, it is a challenging task to assess the performance of the heritage structures including bridges. In this respect, some of the heritage bridge s in Delhi have been studied and results of one bridge connecting the Red fort and Salimgarh fort namely Mangi Bridge are discussed. The methodology of study involves collection of site data (geometry), numerical modelling, experimental studies at the site and useful inferences. The vibration study and the ongoing traffic affects the bridge as the bridge lies on the major arterial road called Ring Road in Delhi. The study will be helpful for continued use of the bridge

Role of Human Oral Microbiome in Diseases

The human oral microbiome represents a diverse and intricate ecosystem comprising bacteria, fungi, viruses, and protozoa. It plays a vital role in numerous physiological processes, ranging from digestion to immunity. Recent research endeavors have focused on delineating the composition and functions of the oral microbiome. Changes in the oral microbiome have been associated with both oral diseases (such as dental caries, periodontitis, halitosis) and systemic conditions (including cardiovascular disease, diabetes, and cancer). Despite significant advancements, numerous questions about the role of the oral microbiome in health and disease remain unanswered. Further research is imperative to explore the intricate interactions between the oral microbiome and other microbiomes within the body. Additionally, there is a need to develop targeted interventions capable of selectively modulating the oral microbiome without disrupting other beneficial microorganisms. In summary, delving into the study of the human oral microbiome has the potential to revolutionize our comprehension of health and disease, opening avenues for innovative approaches to preventive and therapeutic medicine

Bounds on fourth generation induced Lepton Flavour Violating double insertions in Supersymmetry

We derive bounds on leptonic double mass insertions of the type $\delta^{l}_{i4} \delta^{l}_{4j}$ in four generational MSSM, using the present limits on $l_i \to l_j + \gamma$. Two main features distinguish the rates of these processes in MSSM4 from MSSM3 : (a) tan$\beta$ is restricted to be very small $\lesssim 3$ and (b) the large masses for the fourth generation leptons. In spite of small $\tan\beta$, there is an enhancement in amplitudes with $llrr$($\delta_{i4}^{ll}\delta_{4j}^{rr}$) type insertions which pick up the mass of the fourth generation lepton, $m_{\tau'}$. We find these bounds to be at least two orders of magnitude more stringent than those in MSSM3.Comment: Latex, 15 pages and 7 figures, Published versio

Analysis of \Lambda_b \rar \Lambda \ell^+ \ell^- transition in SM4 using form factors from Full QCD

Using the responsible form factors calculated via full QCD, we analyze the $\Lambda_{b}\rightarrow \Lambda \ell^{+}\ell^{-}$ transition in the standard model containing fourth generation quarks (SM4). We discuss effects of the presence of $t'$ fourth family quark on related observables like branching ratio, forward-backward asymmetry, baryon polarization as well as double lepton polarization asymmetries. We also compare our results with those obtained in the SM as well as with predictions of the SM4 but using form factors calculated within heavy quark effective theory. The obtained results on branching ratio indicate that the $\Lambda_{b}\rightarrow \Lambda \ell^{+}\ell^{-}$ transition is more probable in full QCD comparing to the heavy quark effective theory. It is also shown that the results on all considered observables in SM4 deviate considerably from the SM predictions when $m_{t'}\geq 400 GeV$.Comment: 22 Pages and 21 Figure